PL3334841T3 - Sposoby badania kwasów nukleinowych - Google Patents

Sposoby badania kwasów nukleinowych

Info

Publication number
PL3334841T3
PL3334841T3 PL16760659T PL16760659T PL3334841T3 PL 3334841 T3 PL3334841 T3 PL 3334841T3 PL 16760659 T PL16760659 T PL 16760659T PL 16760659 T PL16760659 T PL 16760659T PL 3334841 T3 PL3334841 T3 PL 3334841T3
Authority
PL
Poland
Prior art keywords
methods
nucleic acids
studying nucleic
studying
acids
Prior art date
Application number
PL16760659T
Other languages
English (en)
Inventor
Christoph Bock
Christian SCHMIDL
Original Assignee
Cemm - Forschungszentrum Für Molekulare Medizin Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cemm - Forschungszentrum Für Molekulare Medizin Gmbh filed Critical Cemm - Forschungszentrum Für Molekulare Medizin Gmbh
Publication of PL3334841T3 publication Critical patent/PL3334841T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/327—RNAse, e.g. RNAseH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
    • C12Q2522/10—Nucleic acid binding proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Structural Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
PL16760659T 2015-08-12 2016-08-11 Sposoby badania kwasów nukleinowych PL3334841T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15180705 2015-08-12
EP15189788 2015-10-14
PCT/EP2016/069121 WO2017025594A1 (en) 2015-08-12 2016-08-11 Methods for studying nucleic acids
EP16760659.9A EP3334841B1 (en) 2015-08-12 2016-08-11 Methods for studying nucleic acids

Publications (1)

Publication Number Publication Date
PL3334841T3 true PL3334841T3 (pl) 2020-05-18

Family

ID=56876995

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16760659T PL3334841T3 (pl) 2015-08-12 2016-08-11 Sposoby badania kwasów nukleinowych

Country Status (17)

Country Link
US (1) US10934636B2 (pl)
EP (2) EP3674414A1 (pl)
JP (1) JP6697070B2 (pl)
CN (1) CN108368540B (pl)
CA (1) CA2995305A1 (pl)
CY (1) CY1122632T1 (pl)
DK (1) DK3334841T3 (pl)
ES (1) ES2779798T3 (pl)
HR (1) HRP20200062T1 (pl)
HU (1) HUE047175T2 (pl)
LT (1) LT3334841T (pl)
PL (1) PL3334841T3 (pl)
PT (1) PT3334841T (pl)
RS (1) RS59838B1 (pl)
SI (1) SI3334841T1 (pl)
SM (1) SMT202000037T1 (pl)
WO (1) WO2017025594A1 (pl)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0719620D0 (en) 2007-10-08 2007-11-14 Isis Innovation Mutant Enzymes
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9938524B2 (en) 2011-11-22 2018-04-10 Active Motif, Inc. Multiplex isolation of protein-associated nucleic acids
US10689643B2 (en) 2011-11-22 2020-06-23 Active Motif, Inc. Targeted transposition for use in epigenetic studies
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
CN114891871A (zh) 2012-08-14 2022-08-12 10X基因组学有限公司 微胶囊组合物及方法
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR20230003659A (ko) 2013-02-08 2023-01-06 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
US10059989B2 (en) 2013-05-23 2018-08-28 The Board Of Trustees Of The Leland Stanford Junior University Transposition of native chromatin for personal epigenomics
US9694361B2 (en) 2014-04-10 2017-07-04 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
KR20170026383A (ko) 2014-06-26 2017-03-08 10엑스 제노믹스, 인크. 핵산 서열의 분석
EP4574974A3 (en) 2014-06-26 2025-10-08 10x Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
JP2017532042A (ja) 2014-10-29 2017-11-02 10エックス ゲノミクス,インコーポレイテッド 標的化核酸配列決定のための方法及び組成物
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
AU2016207023B2 (en) 2015-01-12 2019-12-05 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
EP4286516A3 (en) 2015-02-24 2024-03-06 10X Genomics, Inc. Partition processing methods and systems
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
KR102723865B1 (ko) 2015-12-04 2024-10-29 10엑스 제노믹스, 인크. 핵산 분석을 위한 방법 및 조성물
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4310183B1 (en) 2017-01-30 2025-07-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
US10914729B2 (en) 2017-05-22 2021-02-09 The Trustees Of Princeton University Methods for detecting protein binding sequences and tagging nucleic acids
CN116064732A (zh) 2017-05-26 2023-05-05 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
WO2019018385A1 (en) * 2017-07-17 2019-01-24 The Board Of Trustees Of The Leland Stanford Junior University EPIGENETIC PROFILING USING THE TARGETED LIGATION OF CHROMATIN
WO2019060907A1 (en) 2017-09-25 2019-03-28 Fred Hutchinson Cancer Research Center HIGH PERFORMANCE TARGETED IN SITU PANGENOMIC PROFILING
WO2019076768A1 (en) * 2017-10-16 2019-04-25 Tervisetehnoloogiate Arenduskeskus As METHOD AND KIT FOR PREPARING DNA BANK
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
CN107841533B (zh) * 2017-11-13 2021-11-05 深圳先进技术研究院 一种染色质破碎方法及其应用
EP3625361A1 (en) 2017-11-15 2020-03-25 10X Genomics, Inc. Functionalized gel beads
WO2019099908A1 (en) 2017-11-17 2019-05-23 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
CN108300774A (zh) * 2017-12-01 2018-07-20 苏州睿迈英基因检测科技有限公司 一种改进的开放染色质检测方法及其试剂盒和应用
WO2019116306A1 (en) 2017-12-13 2019-06-20 Ecole Polytechnique Federale De Lausanne (Epfl) System for capture or immunoprecipitation of a protein-dna complex
CN108220394B (zh) * 2018-01-05 2021-03-23 清华大学 基因调控性染色质相互作用的鉴定方法、系统及其应用
WO2019152108A1 (en) 2018-02-05 2019-08-08 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for multiplexed measurements in single and ensemble cells
CN108285494B (zh) * 2018-02-11 2021-09-07 北京大学 一种融合蛋白、试剂盒以及CHIP-seq检测方法
EP3752832A1 (en) 2018-02-12 2020-12-23 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
EP3775271B1 (en) 2018-04-06 2025-03-12 10X Genomics, Inc. Systems and methods for quality control in single cell processing
CA3097976A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company High throughput multiomics sample analysis
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
CN108913712B (zh) * 2018-07-17 2021-04-02 厦门生命互联科技有限公司 一种重组Tn5转座酶的表达纯化方法
US12163179B2 (en) 2018-08-03 2024-12-10 10X Gemomics, Inc. Methods and systems to minimize barcode exchange
US12065688B2 (en) 2018-08-20 2024-08-20 10X Genomics, Inc. Compositions and methods for cellular processing
CN111269284B (zh) * 2018-12-04 2023-07-25 中国科学院大连化学物理研究所 同步分离细胞质和细胞核中蛋白质和rna的试剂及方法
US12297565B2 (en) 2018-12-17 2025-05-13 Illumina, Inc. Methods and means for preparing a library for sequencing
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
CN111440843A (zh) * 2019-01-16 2020-07-24 中国科学院生物物理研究所 一种利用微量临床穿刺样本进行染色质免疫共沉淀文库制备的方法及其应用
GB2581152A (en) 2019-02-05 2020-08-12 Univ Oxford Innovation Ltd Production of 3C library
EP3924508A4 (en) * 2019-02-11 2022-11-16 Epicypher, Inc. CHROMATIN MAPPING TESTS AND KITS USING LONG READ SEQUENCING
WO2020168013A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Methods for processing nucleic acid molecules
WO2020167866A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transposon loading
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
CN113677712A (zh) * 2019-02-15 2021-11-19 爱披萨佛公司 染色质相关蛋白的定量作图
CN109880887A (zh) * 2019-03-20 2019-06-14 嘉兴菲沙基因信息有限公司 一种适用于植物ATAC-seq测序技术的文库构建方法
WO2020198664A1 (en) * 2019-03-28 2020-10-01 The Regents Of The University Of California Methods and systems for sequencing cell-free microbiome dna
KR102192455B1 (ko) * 2019-04-05 2020-12-17 한국과학기술원 개인의 전이효소-접근가능한 염색질 시퀀싱 정보를 이용한 암 진단 마커 및 이의 용도
WO2021011433A1 (en) * 2019-07-12 2021-01-21 New York Genome Center, Inc Methods and compositions for scalable pooled rna screens with single cell chromatin accessibility profiling
CA3147297A1 (en) * 2019-07-16 2021-01-21 Meliolabs Inc. Methods and devices for single-cell based digital high resolution melt
JP2022545821A (ja) * 2019-08-27 2022-10-31 ベルジアン ボリション エスアールエル 循環ヌクレオソームを単離する方法
CN115176026A (zh) 2019-09-06 2022-10-11 分子医学研究中心责任有限公司 Rna寡核苷酸的测序方法
EP4055160B1 (en) 2019-11-08 2024-04-10 Becton Dickinson and Company Using random priming to obtain full-length v(d)j information for immune repertoire sequencing
EP4752521A3 (en) 2019-12-23 2026-08-12 10X Genomics, Inc. Reversible fixing reagents and methods of use thereof
EP4081656A1 (en) * 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
CN115279919A (zh) 2020-01-13 2022-11-01 贝克顿迪金森公司 使用含有du的寡核苷酸的细胞捕获
EP4215618A4 (en) * 2020-09-16 2024-07-10 BGI Shenzhen Method for analyzing cell epigenomics from multiple dimensions
TW202242130A (zh) * 2020-12-29 2022-11-01 比利時商比利時意志有限公司 循環轉錄因子分析
EP4288534A1 (en) * 2021-02-05 2023-12-13 Ospedale San Raffaele S.r.l. Engineered transposase and uses thereof
CN112795563A (zh) * 2021-03-23 2021-05-14 上海欣百诺生物科技有限公司 生物素化的转座体在回收CUT&Tag或ATAC-seq产物中的用途及方法
CN113186174B (zh) * 2021-04-23 2022-04-15 江南大学 一种Tn5突变酶的制备和应用
CN113774052A (zh) * 2021-09-30 2021-12-10 首都医科大学附属北京安贞医院 mtDNA的提取和建库试剂
AU2023313304A1 (en) * 2022-07-27 2024-10-03 Illumina, Inc. Tagmentation workflow
CN115948363B (zh) * 2022-08-26 2024-02-27 武汉影子基因科技有限公司 Tn5转座酶突变体及其制备方法和应用
CN116590283B (zh) * 2023-07-17 2023-11-07 北京微岩医疗器械有限公司 一种细胞结合增强剂和去除人源游离核酸的方法
CN117106857B (zh) * 2023-10-24 2024-02-09 北京大学 一种血浆游离染色质的检测方法、试剂盒及其应用
WO2025151541A1 (en) * 2024-01-08 2025-07-17 Massachusetts Eye And Ear Infirmary Extraction of genomic dna from fixed cells
WO2026136388A1 (en) * 2024-12-19 2026-06-25 Illumina, Inc. Genomic analysis using tagmentation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677170A (en) 1994-03-02 1997-10-14 The Johns Hopkins University In vitro transposition of artificial transposons
US5965443A (en) 1996-09-09 1999-10-12 Wisconsin Alumni Research Foundation System for in vitro transposition
US5925545A (en) 1996-09-09 1999-07-20 Wisconsin Alumni Research Foundation System for in vitro transposition
US6159736A (en) 1998-09-23 2000-12-12 Wisconsin Alumni Research Foundation Method for making insertional mutations using a Tn5 synaptic complex
US6406896B1 (en) 1999-08-02 2002-06-18 Wisconsin Alumni Research Foundation Transposase enzyme and method for use
EP1339863A2 (en) 2000-12-05 2003-09-03 Wisconsin Alumni Research Foundation Double transposition methods for manipulating nucleic acids
US7527966B2 (en) 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
US7316903B2 (en) 2003-03-28 2008-01-08 United States Of America As Represented By The Department Of Health And Human Services Detection of nucleic acid sequence variations using phase Mu transposase
WO2004093645A2 (en) 2003-04-17 2004-11-04 Wisconsin Alumni Research Foundation Tn5 transposase mutants and the use thereof
US7608434B2 (en) 2004-08-04 2009-10-27 Wisconsin Alumni Research Foundation Mutated Tn5 transposase proteins and the use thereof
US9080211B2 (en) 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
EP2668273B9 (en) 2011-01-28 2017-03-29 Illumina, Inc. Oligonucleotide replacement for di-tagged and directional libraries
WO2014190214A1 (en) 2013-05-22 2014-11-27 Active Motif, Inc. Targeted transposition for use in epigenetic studies
WO2013078470A2 (en) 2011-11-22 2013-05-30 MOTIF, Active Multiplex isolation of protein-associated nucleic acids
CN102703426A (zh) * 2012-05-21 2012-10-03 吴江汇杰生物科技有限公司 构建核酸库的方法、试剂及试剂盒
US20160208323A1 (en) 2013-06-21 2016-07-21 The Broad Institute, Inc. Methods for Shearing and Tagging DNA for Chromatin Immunoprecipitation and Sequencing

Also Published As

Publication number Publication date
CA2995305A1 (en) 2017-02-16
EP3674414A1 (en) 2020-07-01
EP3334841B1 (en) 2019-10-30
EP3334841A1 (en) 2018-06-20
JP2018532373A (ja) 2018-11-08
WO2017025594A1 (en) 2017-02-16
DK3334841T3 (da) 2020-01-20
HRP20200062T1 (hr) 2020-04-03
JP6697070B2 (ja) 2020-05-20
HUE047175T2 (hu) 2020-04-28
SMT202000037T1 (it) 2020-03-13
RS59838B1 (sr) 2020-02-28
LT3334841T (lt) 2020-02-10
ES2779798T3 (es) 2020-08-19
US10934636B2 (en) 2021-03-02
PT3334841T (pt) 2020-01-30
US20180237951A1 (en) 2018-08-23
CY1122632T1 (el) 2021-03-12
CN108368540A (zh) 2018-08-03
SI3334841T1 (sl) 2020-03-31
CN108368540B (zh) 2022-10-11

Similar Documents

Publication Publication Date Title
SMT202000037T1 (it) Metodi per studiare gli acidi nucleici
ZA201700142B (en) Antisense nucleic acids
ZA201605864B (en) Antisense nucleic acids
IL249619A0 (en) Analysis of nucleic acid sequences
SG10201913629VA (en) Artificial nucleic acid molecules
GB2537077B (en) Methods for sequencing nucleic acids
IL258065B (en) Nucleic acids against the coding strand
GB201507119D0 (en) Nucleic Acid Construct
GB201507115D0 (en) Nucleic Acid Construct
GB201507111D0 (en) Nucleic acid construct
GB201507104D0 (en) Nucleic acid construct
GB201507108D0 (en) Nucleic acid construct
GB201405226D0 (en) Nucleic acid preparation method
SI3094731T1 (sl) S saharidom spremenjene molekule nukleinske kisline
GB201403216D0 (en) Nucleic acid sample preparation
EP3209777A4 (en) Methods for nucleic acid assembly
GB201408841D0 (en) Nucleic acid processing
GB201513128D0 (en) Nucleic acid detection method
PL3183174T3 (pl) Układ do pipetowania
GB201413318D0 (en) Nucleic acid sample preparation
GB201717445D0 (en) Method for determining nucleotide sequence
GB201517241D0 (en) DNA modification
GB201415674D0 (en) Nucleic acid analysis
EP3230477A4 (en) Methods for capturing nucleic acids
GB2553907B (en) Nucleic acid analyzer