HK1211295A1 - 齊墩果酸的 -雜芳基衍生物和其使用方法 - Google Patents
齊墩果酸的 -雜芳基衍生物和其使用方法Info
- Publication number
- HK1211295A1 HK1211295A1 HK15112022.0A HK15112022A HK1211295A1 HK 1211295 A1 HK1211295 A1 HK 1211295A1 HK 15112022 A HK15112022 A HK 15112022A HK 1211295 A1 HK1211295 A1 HK 1211295A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- oleanolic acid
- heteroaryl derivatives
- heteroaryl
- derivatives
- Prior art date
Links
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 title 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 title 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 title 1
- 229940100243 oleanolic acid Drugs 0.000 title 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261699199P | 2012-09-10 | 2012-09-10 | |
| PCT/US2013/059015 WO2014040056A1 (en) | 2012-09-10 | 2013-09-10 | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1211295A1 true HK1211295A1 (zh) | 2016-05-20 |
Family
ID=49253401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15112022.0A HK1211295A1 (zh) | 2012-09-10 | 2015-12-07 | 齊墩果酸的 -雜芳基衍生物和其使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20140088163A1 (zh) |
| EP (1) | EP2892911B1 (zh) |
| JP (1) | JP6272870B2 (zh) |
| KR (1) | KR102237364B1 (zh) |
| CN (1) | CN104768965B (zh) |
| AU (1) | AU2013312102B2 (zh) |
| BR (1) | BR112015005200B1 (zh) |
| CA (1) | CA2882417C (zh) |
| CY (1) | CY1119762T1 (zh) |
| DK (1) | DK2892911T3 (zh) |
| EA (1) | EA029069B1 (zh) |
| ES (1) | ES2644615T3 (zh) |
| HK (1) | HK1211295A1 (zh) |
| HR (1) | HRP20171565T1 (zh) |
| HU (1) | HUE036797T2 (zh) |
| IL (1) | IL237638B (zh) |
| IN (1) | IN2015DN01547A (zh) |
| LT (1) | LT2892911T (zh) |
| ME (1) | ME02911B (zh) |
| MX (1) | MX366954B (zh) |
| NZ (1) | NZ705213A (zh) |
| PL (1) | PL2892911T3 (zh) |
| PT (1) | PT2892911T (zh) |
| RS (1) | RS56563B1 (zh) |
| SG (1) | SG11201501800UA (zh) |
| SI (1) | SI2892911T1 (zh) |
| WO (1) | WO2014040056A1 (zh) |
| ZA (1) | ZA201501203B (zh) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX356760B (es) | 2008-01-11 | 2018-06-12 | Dartmouth College | Triterpenoides sinteticos y metodos de uso en el tratamiento de enfermedad. |
| MX339476B (es) | 2008-04-18 | 2016-05-27 | Reata Pharmaceuticals Inc | Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso. |
| TWI453023B (zh) | 2008-04-18 | 2014-09-21 | Reata Pharmaceuticals Inc | 抗氧化發炎調節劑：在ｃ－１７處具有胺基及其他修飾之齊墩果酸衍生物 |
| PL2651902T3 (pl) | 2010-12-17 | 2018-04-30 | Reata Pharmaceuticals, Inc. | Pirazolilowe i pirymidynylowe tricykliczne enony jako modulatory zapalenia o działaniu przeciwutleniającym |
| EP2841445B1 (en) | 2012-04-27 | 2017-06-14 | Reata Pharmaceuticals, Inc. | 2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| JP6243428B2 (ja) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | オレアノール酸のｃ１７−アルカンジイルおよびアルケンジイル誘導体ならびにその使用方法 |
| TW201936625A (zh) | 2013-04-24 | 2019-09-16 | 美商艾伯維有限公司 | 甲基巴多索龍之2,2-二氟丙醯胺衍生物、其多晶形及其使用方法 |
| US11059792B2 (en) | 2015-02-12 | 2021-07-13 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant inflammation modulators |
| JP7074674B2 (ja) | 2015-09-23 | 2022-05-24 | リアタ ファーマシューティカルズ インコーポレイテッド | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
| BR112019009256A2 (pt) | 2016-11-08 | 2019-07-16 | Reata Pharmaceuticals Inc | métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo |
| CN106632574B (zh) * | 2016-12-07 | 2018-05-29 | 广东天键生物科技有限公司 | 一种化合物、其制备方法及用途 |
| CA3046183C (en) | 2016-12-16 | 2024-02-20 | Reata Pharmaceuticals, Inc. | Pyrimidine tricyclic enone derivatives for inhibition of ror.gamma. and other uses |
| KR102295179B1 (ko) | 2017-09-14 | 2021-08-30 | 피닉스 바이오테크놀러지 인코포레이티드. | 바이러스 감염 치료를 위한 방법 및 조성물 |
| AU2018334467B2 (en) | 2017-09-14 | 2022-10-20 | Phoenix Biotechnology, Inc. | Method and improved neuroprotective composition for treating neurological conditions |
| AU2019346395A1 (en) * | 2018-09-28 | 2021-04-22 | Sichuan Haisco Pharmaceutical Co., Ltd. | Terpinoid derivatives and uses thereof |
| AU2020316351A1 (en) * | 2019-07-19 | 2022-02-17 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
| SG11202105728YA (en) | 2020-03-31 | 2021-11-29 | Phoenix Biotechnology Inc | Method and compositions for treating coronavirus infection |
| EP4295854A3 (en) | 2020-03-31 | 2024-04-03 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
| JP7214696B2 (ja) * | 2020-10-01 | 2023-01-30 | 一般財団法人 化学物質評価研究機構 | 新規ｉｎ ｖｉｔｒｏ皮膚感作性試験法 |
| WO2022126129A1 (en) | 2020-12-11 | 2022-06-16 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids for use in therapy |
| CN117015548A (zh) | 2021-01-18 | 2023-11-07 | 里亚塔医药公司 | 合成的熊果酸衍生物和其使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) * | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| CA2485565A1 (en) * | 2002-05-13 | 2004-08-05 | Trustees Of Dartmouth College | Inhibitors and methods of use thereof |
| MX356760B (es) | 2008-01-11 | 2018-06-12 | Dartmouth College | Triterpenoides sinteticos y metodos de uso en el tratamiento de enfermedad. |
| WO2009129545A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring |
| US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| ME02751B (me) * | 2008-04-18 | 2018-01-20 | Reata Pharmaceuticals Inc | Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline |
| TWI453023B (zh) | 2008-04-18 | 2014-09-21 | Reata Pharmaceuticals Inc | 抗氧化發炎調節劑：在ｃ－１７處具有胺基及其他修飾之齊墩果酸衍生物 |
| CA2829618C (en) * | 2011-03-11 | 2019-07-09 | Reata Pharmaceuticals, Inc. | C4-monomethyl triterpenoid derivatives and methods of use thereof |
| WO2013188818A1 (en) * | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
-
2013
- 2013-09-10 CA CA2882417A patent/CA2882417C/en active Active
- 2013-09-10 PT PT137671756T patent/PT2892911T/pt unknown
- 2013-09-10 KR KR1020157009160A patent/KR102237364B1/ko active IP Right Grant
- 2013-09-10 JP JP2015531317A patent/JP6272870B2/ja active Active
- 2013-09-10 NZ NZ705213A patent/NZ705213A/en unknown
- 2013-09-10 BR BR112015005200-2A patent/BR112015005200B1/pt active IP Right Grant
- 2013-09-10 EA EA201590539A patent/EA029069B1/ru unknown
- 2013-09-10 WO PCT/US2013/059015 patent/WO2014040056A1/en active Application Filing
- 2013-09-10 US US14/022,843 patent/US20140088163A1/en not_active Abandoned
- 2013-09-10 LT LTEP13767175.6T patent/LT2892911T/lt unknown
- 2013-09-10 AU AU2013312102A patent/AU2013312102B2/en active Active
- 2013-09-10 MX MX2015003078A patent/MX366954B/es active IP Right Grant
- 2013-09-10 SG SG11201501800UA patent/SG11201501800UA/en unknown
- 2013-09-10 HU HUE13767175A patent/HUE036797T2/hu unknown
- 2013-09-10 CN CN201380057684.2A patent/CN104768965B/zh active Active
- 2013-09-10 RS RS20171140A patent/RS56563B1/sr unknown
- 2013-09-10 EP EP13767175.6A patent/EP2892911B1/en active Active
- 2013-09-10 SI SI201330818T patent/SI2892911T1/sl unknown
- 2013-09-10 ES ES13767175.6T patent/ES2644615T3/es active Active
- 2013-09-10 ME MEP-2017-254A patent/ME02911B/me unknown
- 2013-09-10 IN IN1547DEN2015 patent/IN2015DN01547A/en unknown
- 2013-09-10 DK DK13767175.6T patent/DK2892911T3/en active
- 2013-09-10 PL PL13767175T patent/PL2892911T3/pl unknown
-
2015
- 2015-02-23 ZA ZA2015/01203A patent/ZA201501203B/en unknown
- 2015-03-09 IL IL237638A patent/IL237638B/en active IP Right Grant
- 2015-12-07 HK HK15112022.0A patent/HK1211295A1/zh unknown
-
2017
- 2017-10-16 HR HRP20171565TT patent/HRP20171565T1/hr unknown
- 2017-11-03 CY CY20171101157T patent/CY1119762T1/el unknown
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