SG11201501800UA - C17-heteroaryl derivatives of oleanolic acid and methods of use thereof - Google Patents
C17-heteroaryl derivatives of oleanolic acid and methods of use thereofInfo
- Publication number
- SG11201501800UA SG11201501800UA SG11201501800UA SG11201501800UA SG11201501800UA SG 11201501800U A SG11201501800U A SG 11201501800UA SG 11201501800U A SG11201501800U A SG 11201501800UA SG 11201501800U A SG11201501800U A SG 11201501800UA SG 11201501800U A SG11201501800U A SG 11201501800UA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- oleanolic acid
- heteroaryl derivatives
- heteroaryl
- derivatives
- Prior art date
Links
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 title 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 title 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 title 1
- 229940100243 oleanolic acid Drugs 0.000 title 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Lubricants (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261699199P | 2012-09-10 | 2012-09-10 | |
| PCT/US2013/059015 WO2014040056A1 (en) | 2012-09-10 | 2013-09-10 | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201501800UA true SG11201501800UA (en) | 2015-04-29 |
Family
ID=49253401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201501800UA SG11201501800UA (en) | 2012-09-10 | 2013-09-10 | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20140088163A1 (en) |
| EP (1) | EP2892911B1 (en) |
| JP (1) | JP6272870B2 (en) |
| KR (1) | KR102237364B1 (en) |
| CN (1) | CN104768965B (en) |
| AU (1) | AU2013312102B2 (en) |
| BR (1) | BR112015005200B1 (en) |
| CA (1) | CA2882417C (en) |
| CY (1) | CY1119762T1 (en) |
| DK (1) | DK2892911T3 (en) |
| EA (1) | EA029069B1 (en) |
| ES (1) | ES2644615T3 (en) |
| HK (1) | HK1211295A1 (en) |
| HR (1) | HRP20171565T1 (en) |
| HU (1) | HUE036797T2 (en) |
| IL (1) | IL237638B (en) |
| IN (1) | IN2015DN01547A (en) |
| LT (1) | LT2892911T (en) |
| ME (1) | ME02911B (en) |
| MX (1) | MX366954B (en) |
| NZ (1) | NZ705213A (en) |
| PL (1) | PL2892911T3 (en) |
| PT (1) | PT2892911T (en) |
| RS (1) | RS56563B1 (en) |
| SG (1) | SG11201501800UA (en) |
| SI (1) | SI2892911T1 (en) |
| WO (1) | WO2014040056A1 (en) |
| ZA (1) | ZA201501203B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX356760B (en) | 2008-01-11 | 2018-06-12 | Dartmouth College | Synthetic triterpenoids and methods of use in the treatment of disease. |
| MX339476B (en) | 2008-04-18 | 2016-05-27 | Reata Pharmaceuticals Inc | Compounds including an anti-inflammatory pharmacore and methods of use. |
| TWI453023B (en) | 2008-04-18 | 2014-09-21 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 |
| PL2651902T3 (en) | 2010-12-17 | 2018-04-30 | Reata Pharmaceuticals, Inc. | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
| EP2841445B1 (en) | 2012-04-27 | 2017-06-14 | Reata Pharmaceuticals, Inc. | 2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| JP6243428B2 (en) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| TW201936625A (en) | 2013-04-24 | 2019-09-16 | 美商艾伯維有限公司 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
| US11059792B2 (en) | 2015-02-12 | 2021-07-13 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant inflammation modulators |
| JP7074674B2 (en) | 2015-09-23 | 2022-05-24 | リアタ ファーマシューティカルズ インコーポレイテッド | C4 modified oleanolic acid derivative for inhibition of IL-17 and other uses |
| BR112019009256A2 (en) | 2016-11-08 | 2019-07-16 | Reata Pharmaceuticals Inc | methods for treating alport syndrome using methyl bardoxolone or analogs thereof |
| CN106632574B (en) * | 2016-12-07 | 2018-05-29 | 广东天键生物科技有限公司 | A kind of compound, preparation method and the usage |
| CA3046183C (en) | 2016-12-16 | 2024-02-20 | Reata Pharmaceuticals, Inc. | Pyrimidine tricyclic enone derivatives for inhibition of ror.gamma. and other uses |
| KR102295179B1 (en) | 2017-09-14 | 2021-08-30 | 피닉스 바이오테크놀러지 인코포레이티드. | Methods and compositions for the treatment of viral infections |
| AU2018334467B2 (en) | 2017-09-14 | 2022-10-20 | Phoenix Biotechnology, Inc. | Method and improved neuroprotective composition for treating neurological conditions |
| AU2019346395A1 (en) * | 2018-09-28 | 2021-04-22 | Sichuan Haisco Pharmaceutical Co., Ltd. | Terpinoid derivatives and uses thereof |
| AU2020316351A1 (en) * | 2019-07-19 | 2022-02-17 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
| SG11202105728YA (en) | 2020-03-31 | 2021-11-29 | Phoenix Biotechnology Inc | Method and compositions for treating coronavirus infection |
| EP4295854A3 (en) | 2020-03-31 | 2024-04-03 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
| JP7214696B2 (en) * | 2020-10-01 | 2023-01-30 | 一般財団法人 化学物質評価研究機構 | New in vitro skin sensitization test method |
| WO2022126129A1 (en) | 2020-12-11 | 2022-06-16 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids for use in therapy |
| CN117015548A (en) | 2021-01-18 | 2023-11-07 | 里亚塔医药公司 | Synthetic ursolic acid derivatives and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) * | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| CA2485565A1 (en) * | 2002-05-13 | 2004-08-05 | Trustees Of Dartmouth College | Inhibitors and methods of use thereof |
| MX356760B (en) | 2008-01-11 | 2018-06-12 | Dartmouth College | Synthetic triterpenoids and methods of use in the treatment of disease. |
| WO2009129545A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring |
| US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| ME02751B (en) * | 2008-04-18 | 2018-01-20 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
| TWI453023B (en) | 2008-04-18 | 2014-09-21 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 |
| CA2829618C (en) * | 2011-03-11 | 2019-07-09 | Reata Pharmaceuticals, Inc. | C4-monomethyl triterpenoid derivatives and methods of use thereof |
| WO2013188818A1 (en) * | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
-
2013
- 2013-09-10 CA CA2882417A patent/CA2882417C/en active Active
- 2013-09-10 PT PT137671756T patent/PT2892911T/en unknown
- 2013-09-10 KR KR1020157009160A patent/KR102237364B1/en active IP Right Grant
- 2013-09-10 JP JP2015531317A patent/JP6272870B2/en active Active
- 2013-09-10 NZ NZ705213A patent/NZ705213A/en unknown
- 2013-09-10 BR BR112015005200-2A patent/BR112015005200B1/en active IP Right Grant
- 2013-09-10 EA EA201590539A patent/EA029069B1/en unknown
- 2013-09-10 WO PCT/US2013/059015 patent/WO2014040056A1/en active Application Filing
- 2013-09-10 US US14/022,843 patent/US20140088163A1/en not_active Abandoned
- 2013-09-10 LT LTEP13767175.6T patent/LT2892911T/en unknown
- 2013-09-10 AU AU2013312102A patent/AU2013312102B2/en active Active
- 2013-09-10 MX MX2015003078A patent/MX366954B/en active IP Right Grant
- 2013-09-10 SG SG11201501800UA patent/SG11201501800UA/en unknown
- 2013-09-10 HU HUE13767175A patent/HUE036797T2/en unknown
- 2013-09-10 CN CN201380057684.2A patent/CN104768965B/en active Active
- 2013-09-10 RS RS20171140A patent/RS56563B1/en unknown
- 2013-09-10 EP EP13767175.6A patent/EP2892911B1/en active Active
- 2013-09-10 SI SI201330818T patent/SI2892911T1/en unknown
- 2013-09-10 ES ES13767175.6T patent/ES2644615T3/en active Active
- 2013-09-10 ME MEP-2017-254A patent/ME02911B/en unknown
- 2013-09-10 IN IN1547DEN2015 patent/IN2015DN01547A/en unknown
- 2013-09-10 DK DK13767175.6T patent/DK2892911T3/en active
- 2013-09-10 PL PL13767175T patent/PL2892911T3/en unknown
-
2015
- 2015-02-23 ZA ZA2015/01203A patent/ZA201501203B/en unknown
- 2015-03-09 IL IL237638A patent/IL237638B/en active IP Right Grant
- 2015-12-07 HK HK15112022.0A patent/HK1211295A1/en unknown
-
2017
- 2017-10-16 HR HRP20171565TT patent/HRP20171565T1/en unknown
- 2017-11-03 CY CY20171101157T patent/CY1119762T1/en unknown
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