IN2015DN01547A - - Google Patents
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- IN2015DN01547A IN2015DN01547A IN1547DEN2015A IN2015DN01547A IN 2015DN01547 A IN2015DN01547 A IN 2015DN01547A IN 1547DEN2015 A IN1547DEN2015 A IN 1547DEN2015A IN 2015DN01547 A IN2015DN01547 A IN 2015DN01547A
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- IN
- India
- Prior art keywords
- compounds
- methods
- compositions
- variables
- articles
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 abstract 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940100243 oleanolic acid Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Lubricants (AREA)
- Steroid Compounds (AREA)
- Epidemiology (AREA)
Abstract
Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid including those of the formula (I): wherein the variables are defined herein. Also provided are pharmaceutical compositions kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds and methods of using the compounds for example as antioxidant inflammation modulators and compositions thereof are also provided.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261699199P | 2012-09-10 | 2012-09-10 | |
| PCT/US2013/059015 WO2014040056A1 (en) | 2012-09-10 | 2013-09-10 | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN01547A true IN2015DN01547A (en) | 2015-07-03 |
Family
ID=49253401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1547DEN2015 IN2015DN01547A (en) | 2012-09-10 | 2013-09-10 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20140088163A1 (en) |
| EP (1) | EP2892911B1 (en) |
| JP (1) | JP6272870B2 (en) |
| KR (1) | KR102237364B1 (en) |
| CN (1) | CN104768965B (en) |
| AU (1) | AU2013312102B2 (en) |
| BR (1) | BR112015005200B1 (en) |
| CA (1) | CA2882417C (en) |
| CY (1) | CY1119762T1 (en) |
| DK (1) | DK2892911T3 (en) |
| EA (1) | EA029069B1 (en) |
| ES (1) | ES2644615T3 (en) |
| HR (1) | HRP20171565T1 (en) |
| HU (1) | HUE036797T2 (en) |
| IL (1) | IL237638B (en) |
| IN (1) | IN2015DN01547A (en) |
| LT (1) | LT2892911T (en) |
| ME (1) | ME02911B (en) |
| MX (1) | MX366954B (en) |
| NZ (1) | NZ705213A (en) |
| PL (1) | PL2892911T3 (en) |
| PT (1) | PT2892911T (en) |
| RS (1) | RS56563B1 (en) |
| SG (1) | SG11201501800UA (en) |
| SI (1) | SI2892911T1 (en) |
| SM (1) | SMT201700501T1 (en) |
| WO (1) | WO2014040056A1 (en) |
| ZA (1) | ZA201501203B (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI492745B (en) | 2008-01-11 | 2015-07-21 | Reata Pharmaceuticals Inc | Synthetic triterpenoid compounds and methods for treating diseases thereof |
| DK2276493T3 (en) | 2008-04-18 | 2019-01-02 | Reata Pharmaceuticals Inc | ANTIOXIDATIVE INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH AMINO AND OTHER MODIFICATIONS BY C-17 |
| MX2010011435A (en) | 2008-04-18 | 2011-01-25 | Reata Pharmaceuticals Inc | Compounds including an anti-inflammatory pharmacore and methods of use. |
| NZ612788A (en) | 2010-12-17 | 2015-10-30 | Reata Pharmaceuticals Inc | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
| SI3444261T1 (en) | 2012-04-27 | 2021-04-30 | Reata Pharmaceuticals, Inc. | 2,2-difluoropropionamide derivative of bardoxolone methyl, pharmaceutical compositions and polymorphs thereof for use in treating certain conditions |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| PL2892912T3 (en) | 2012-09-10 | 2019-10-31 | Reata Pharmaceuticals Inc | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| UY35534A (en) | 2013-04-24 | 2014-10-31 | Abbvie Inc | DERIVATIVES OF 2,2-DIFLUOROPROPANAMIDE AND METHYL BARDOXOLONE, POLYMODIC FORMS AND METHODS OF USE |
| NZ734292A (en) | 2015-02-12 | 2022-09-30 | Reata Pharmaceuticals Inc | Imidazolyl tricyclic enones as antioxidant inflammation modulators |
| MX386256B (en) | 2015-09-23 | 2025-03-18 | Reata Pharmaceuticals Inc | C4-MODIFIED OLEANOLIC ACID DERIVATIVES FOR IL-17 INHIBITION AND OTHER USES. |
| WO2019055119A1 (en) | 2017-09-14 | 2019-03-21 | Phoenix Biotechnology, Inc. | Method and composition for treating viral infection |
| MX2019005401A (en) | 2016-11-08 | 2019-08-05 | Reata Pharmaceuticals Inc | METHODS FOR TREATING ALPORT'S SYNDROME WITH BARDOXOLONE METHYL OR ANALOGS |
| CN106632574B (en) * | 2016-12-07 | 2018-05-29 | 广东天键生物科技有限公司 | A kind of compound, preparation method and the usage |
| TWI831738B (en) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORγ AND OTHER USES |
| MX2020002884A (en) | 2017-09-14 | 2020-10-05 | Phoenix Biotechnology Inc | Method and improved neuroprotective composition for treating neurological conditions. |
| IL279348B2 (en) | 2018-06-15 | 2026-01-01 | Reata Pharmaceuticals Inc | Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of il-17 and rorgamma |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
| MX2021003643A (en) * | 2018-09-28 | 2021-08-19 | Sichuan Haisco Pharmaceutical Co Ltd | Terpinoid derivatives and uses thereof. |
| WO2021016191A1 (en) * | 2019-07-19 | 2021-01-28 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
| EP4009981B1 (en) | 2020-03-31 | 2023-08-16 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
| RU2020130238A (en) | 2020-03-31 | 2022-03-14 | Феникс Байотекнолоджи, Инк. | METHOD AND COMPOSITIONS FOR TREATMENT OF CORONAVIRUS INFECTION |
| JP7214696B2 (en) * | 2020-10-01 | 2023-01-30 | 一般財団法人 化学物質評価研究機構 | New in vitro skin sensitization test method |
| EP4259155A1 (en) | 2020-12-11 | 2023-10-18 | Reata Pharmaceuticals Holdings, LLC | Synthetic triterpenoids for use in therapy |
| US20240140986A1 (en) | 2021-01-18 | 2024-05-02 | Reata Pharmaceuticals, Inc. | Synthetic ursolic acid derivatives and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) * | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US6974801B2 (en) * | 2002-05-13 | 2005-12-13 | The Trustees Of Dartmounth College | Inhibitors and methods of use thereof |
| TWI492745B (en) | 2008-01-11 | 2015-07-21 | Reata Pharmaceuticals Inc | Synthetic triterpenoid compounds and methods for treating diseases thereof |
| EA022588B1 (en) * | 2008-04-18 | 2016-01-29 | Ритэ Фамэсутикл, Инк. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring |
| TW201004627A (en) | 2008-04-18 | 2010-02-01 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| WO2009129548A1 (en) * | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
| DK2276493T3 (en) | 2008-04-18 | 2019-01-02 | Reata Pharmaceuticals Inc | ANTIOXIDATIVE INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH AMINO AND OTHER MODIFICATIONS BY C-17 |
| EP2683731B1 (en) * | 2011-03-11 | 2019-04-24 | Reata Pharmaceuticals, Inc. | C4-monomethyl triterpenoid derivatives and methods of use thereof |
| WO2013188818A1 (en) * | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
-
2013
- 2013-09-10 CA CA2882417A patent/CA2882417C/en active Active
- 2013-09-10 HR HRP20171565TT patent/HRP20171565T1/en unknown
- 2013-09-10 SG SG11201501800UA patent/SG11201501800UA/en unknown
- 2013-09-10 PL PL13767175T patent/PL2892911T3/en unknown
- 2013-09-10 IN IN1547DEN2015 patent/IN2015DN01547A/en unknown
- 2013-09-10 JP JP2015531317A patent/JP6272870B2/en active Active
- 2013-09-10 WO PCT/US2013/059015 patent/WO2014040056A1/en not_active Ceased
- 2013-09-10 BR BR112015005200-2A patent/BR112015005200B1/en active IP Right Grant
- 2013-09-10 HU HUE13767175A patent/HUE036797T2/en unknown
- 2013-09-10 KR KR1020157009160A patent/KR102237364B1/en active Active
- 2013-09-10 SM SM20170501T patent/SMT201700501T1/en unknown
- 2013-09-10 ME MEP-2017-254A patent/ME02911B/en unknown
- 2013-09-10 SI SI201330818T patent/SI2892911T1/en unknown
- 2013-09-10 EP EP13767175.6A patent/EP2892911B1/en active Active
- 2013-09-10 MX MX2015003078A patent/MX366954B/en active IP Right Grant
- 2013-09-10 ES ES13767175.6T patent/ES2644615T3/en active Active
- 2013-09-10 DK DK13767175.6T patent/DK2892911T3/en active
- 2013-09-10 EA EA201590539A patent/EA029069B1/en unknown
- 2013-09-10 US US14/022,843 patent/US20140088163A1/en not_active Abandoned
- 2013-09-10 CN CN201380057684.2A patent/CN104768965B/en active Active
- 2013-09-10 AU AU2013312102A patent/AU2013312102B2/en active Active
- 2013-09-10 RS RS20171140A patent/RS56563B1/en unknown
- 2013-09-10 LT LTEP13767175.6T patent/LT2892911T/en unknown
- 2013-09-10 NZ NZ705213A patent/NZ705213A/en unknown
- 2013-09-10 PT PT137671756T patent/PT2892911T/en unknown
-
2015
- 2015-02-23 ZA ZA2015/01203A patent/ZA201501203B/en unknown
- 2015-03-09 IL IL237638A patent/IL237638B/en active IP Right Grant
-
2017
- 2017-11-03 CY CY20171101157T patent/CY1119762T1/en unknown
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