IN2015DN00950A - - Google Patents

Info

Publication number
IN2015DN00950A
IN2015DN00950A IN950DEN2015A IN2015DN00950A IN 2015DN00950 A IN2015DN00950 A IN 2015DN00950A IN 950DEN2015 A IN950DEN2015 A IN 950DEN2015A IN 2015DN00950 A IN2015DN00950 A IN 2015DN00950A
Authority
IN
India
Prior art keywords
processes
formula
production
pharmaceutical compositions
relates
Prior art date
Application number
Inventor
Gebhard Thoma
Peter Buehlmayer
Maurice Van Eis
Alexander Baxter Smith
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2015DN00950A publication Critical patent/IN2015DN00950A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to bicyclic heteroaryl cycloalkyldiamine derivatives to processes for their production to their use as SYK inhibitors and to pharmaceutical compositions comprising them. Formula (I)
IN950DEN2015 2012-08-13 2013-08-12 IN2015DN00950A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261682392P 2012-08-13 2012-08-13
PCT/IB2013/056589 WO2014027300A1 (en) 2012-08-13 2013-08-12 Bicyclic heteroaryl cycloalkyldiamine derivatives as inhibitors of spleen tyrosine kinases (syk)

Publications (1)

Publication Number Publication Date
IN2015DN00950A true IN2015DN00950A (en) 2015-06-12

Family

ID=49385306

Family Applications (1)

Application Number Title Priority Date Filing Date
IN950DEN2015 IN2015DN00950A (en) 2012-08-13 2013-08-12

Country Status (14)

Country Link
US (2) US9315500B2 (en)
EP (1) EP2882747B1 (en)
JP (1) JP6236083B2 (en)
KR (1) KR20150042256A (en)
CN (1) CN104520297B (en)
AU (1) AU2013303824B2 (en)
BR (1) BR112015003058A2 (en)
CA (1) CA2880790C (en)
EA (1) EA201590372A1 (en)
ES (1) ES2576692T3 (en)
HK (1) HK1209421A1 (en)
IN (1) IN2015DN00950A (en)
MX (1) MX2015002006A (en)
WO (1) WO2014027300A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201590372A1 (en) * 2012-08-13 2015-05-29 Новартис Аг Bicyclic heteroaryl cycloalkyldiamine derivatives produced as spleen tyrosine kinase inhibitors
CN114364798A (en) 2019-03-21 2022-04-15 欧恩科斯欧公司 Combination of Dbait molecules with kinase inhibitors for the treatment of cancer
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2023170680A1 (en) 2022-03-08 2023-09-14 Equashield Medical Ltd Fluid transfer station in a robotic pharmaceutical preparation system

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) 1976-05-11 1978-09-13 Ici Ltd Polypeptide
EP0100172B1 (en) 1982-07-23 1987-08-12 Imperial Chemical Industries Plc Amide derivatives
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
KR100781704B1 (en) 2005-04-20 2007-12-03 에스케이케미칼주식회사 Novel pyridine derivatives, process for preparing thereof and pharmaceutical compositions containing them
JP2009530342A (en) 2006-03-20 2009-08-27 エフ．ホフマン−ラ ロシュ アーゲー Methods of inhibiting BTK and SYK protein kinases
TW200942537A (en) * 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
EP2459558A2 (en) * 2009-07-30 2012-06-06 Irm Llc Compounds and compositions as syk kinase inhibitors
TW201105669A (en) * 2009-07-30 2011-02-16 Irm Llc Compounds and compositions as Syk kinase inhibitors
JP5993742B2 (en) * 2009-10-29 2016-09-14 ジェノスコ Kinase inhibitor
WO2012097479A1 (en) * 2011-01-21 2012-07-26 Abbott Laboratories Bicyclic inhibitors of anaphastic lymphoma kinase
EA201590372A1 (en) * 2012-08-13 2015-05-29 Новартис Аг Bicyclic heteroaryl cycloalkyldiamine derivatives produced as spleen tyrosine kinase inhibitors

Also Published As

Publication number Publication date
JP6236083B2 (en) 2017-11-22
JP2015524838A (en) 2015-08-27
MX2015002006A (en) 2015-06-02
ES2576692T3 (en) 2016-07-08
BR112015003058A2 (en) 2017-07-04
CA2880790A1 (en) 2014-02-20
EA201590372A1 (en) 2015-05-29
AU2013303824A1 (en) 2015-02-26
EP2882747A1 (en) 2015-06-17
CN104520297A (en) 2015-04-15
US20160213670A1 (en) 2016-07-28
EP2882747B1 (en) 2016-04-27
AU2013303824B2 (en) 2016-03-31
US20150218157A1 (en) 2015-08-06
KR20150042256A (en) 2015-04-20
CA2880790C (en) 2020-09-08
HK1209421A1 (en) 2016-04-01
WO2014027300A1 (en) 2014-02-20
US9315500B2 (en) 2016-04-19
CN104520297B (en) 2016-08-24

Similar Documents

Publication Publication Date Title
PH12017500408A1 (en) Heteroaryl compunds as btk inhibitors and uses thereof
MX2015013042A (en) Organic compounds.
TN2014000138A1 (en) Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases.
EA201400833A1 (en) NEW INDOLESINE COMPOUNDS, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PH12015501289A1 (en) Novel benzimidazole derivatives as ep4 antagonists
PH12014502772A1 (en) Substituted tricyclic compounds as fgfr inhibitors
MY177344A (en) Compounds and their methods of use
PH12014000179A1 (en) New pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
GEP201706688B (en) Cdk8/cdk19 selective inhibitors and their use in anti- metastatic and chemopreventative methods for cancer
AU2012213775A8 (en) 7-azaindole derivatives
PH12015501175A1 (en) Substituted pyridopyrazines as syk inhibitors
MX2016000906A (en) Novel indolizine derivatives, method for the production thereof and pharmaceutical compositions containing same.
MY186599A (en) Substituted pyridopyrazines as novel syk inhibitors
MX2017007377A (en) Organic compounds.
MX2016000900A (en) Novel derivatives of indole and pyrrole, method for the production thereof and pharmaceutical compositions containing same.
WO2013178322A8 (en) Spiro tetrahydro - benzothiophen derivatives useful for the treatment neurodegenerative diseases
IN2015DN00950A (en)
AU2013347232A8 (en) 3-Aminocyclopentane carboxamide derivatives
MX2017007380A (en) Organic compounds.
MX348841B (en) Pyrimidooxazocine derivatives as mtor - inhibitors.
IN2013MU04056A (en)
MX2014004210A (en) 2-oxo-piperidinyl derivatives.
IN2015DN02660A (en)
IN2014DN07498A (en)
IN2013CH05770A (en)