HK1209318A1 - Pharmaceutical compositions of (r)-1-(2,2- diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6- fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof (r)-1-(22-[d][13]-5-)-n-(1-(23-)-6--2- (1--2--2-)-1 --5-) - Google Patents
Pharmaceutical compositions of (r)-1-(2,2- diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6- fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof (r)-1-(22-[d][13]-5-)-n-(1-(23-)-6--2- (1--2--2-)-1 --5-)Info
- Publication number
- HK1209318A1 HK1209318A1 HK15109966.4A HK15109966A HK1209318A1 HK 1209318 A1 HK1209318 A1 HK 1209318A1 HK 15109966 A HK15109966 A HK 15109966A HK 1209318 A1 HK1209318 A1 HK 1209318A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- diflurorbenzo
- cyclopropanecarboxamide
- methylpropan
- dioxol
- dihydroxypropyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261671932P | 2012-07-16 | 2012-07-16 | |
US201361822781P | 2013-05-13 | 2013-05-13 | |
PCT/US2013/050557 WO2014014841A1 (en) | 2012-07-16 | 2013-07-15 | Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1209318A1 true HK1209318A1 (en) | 2016-04-01 |
Family
ID=48906494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15109966.4A HK1209318A1 (en) | 2012-07-16 | 2015-10-13 | Pharmaceutical compositions of (r)-1-(2,2- diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6- fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof (r)-1-(22-[d][13]-5-)-n-(1-(23-)-6--2- (1--2--2-)-1 --5-) |
Country Status (8)
Country | Link |
---|---|
US (3) | US9012496B2 (de) |
EP (1) | EP2872122A1 (de) |
AR (1) | AR092857A1 (de) |
AU (2) | AU2013290444B2 (de) |
CA (1) | CA2878057A1 (de) |
HK (1) | HK1209318A1 (de) |
TW (1) | TW201408295A (de) |
WO (1) | WO2014014841A1 (de) |
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RS57476B9 (sr) | 2014-04-15 | 2021-10-29 | Vertex Pharma | Farmaceutske kompozicije za lečenje bolesti posredovanih transmembranskim regulatorom provodljivosti cistične fibroze |
WO2016057572A1 (en) | 2014-10-06 | 2016-04-14 | Mark Thomas Miller | Modulators of cystic fibrosis transmembrane conductance regulator |
JP6746569B2 (ja) | 2014-10-07 | 2020-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶 |
MA41031A (fr) | 2014-11-26 | 2017-10-03 | Catabasis Pharmaceuticals Inc | Conjugués cystéamine-acide gras et leur utilisation comme activateurs de l'autophagie |
WO2016086136A1 (en) | 2014-11-26 | 2016-06-02 | Catabasis Pharmaceuticals, Inc. | Fatty acid cysteamine conjugates of cftr modulators and their use in treating medical disorders |
EP3277647A1 (de) | 2015-03-31 | 2018-02-07 | Vertex Pharmaceuticals (Europe) Limited | Deuteriertes vx-661 |
-
2013
- 2013-07-15 CA CA2878057A patent/CA2878057A1/en not_active Abandoned
- 2013-07-15 AR ARP130102524A patent/AR092857A1/es unknown
- 2013-07-15 US US13/942,617 patent/US9012496B2/en active Active
- 2013-07-15 AU AU2013290444A patent/AU2013290444B2/en active Active
- 2013-07-15 WO PCT/US2013/050557 patent/WO2014014841A1/en active Application Filing
- 2013-07-15 EP EP13742782.9A patent/EP2872122A1/de not_active Withdrawn
- 2013-07-16 TW TW102125434A patent/TW201408295A/zh unknown
-
2015
- 2015-03-12 US US14/656,043 patent/US20150182517A1/en not_active Abandoned
- 2015-10-13 HK HK15109966.4A patent/HK1209318A1/xx unknown
-
2016
- 2016-11-03 US US15/342,999 patent/US10058546B2/en active Active
-
2018
- 2018-07-26 AU AU2018208694A patent/AU2018208694A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2018208694A1 (en) | 2018-08-09 |
WO2014014841A1 (en) | 2014-01-23 |
AU2013290444A1 (en) | 2015-01-29 |
CA2878057A1 (en) | 2014-01-23 |
TW201408295A (zh) | 2014-03-01 |
AU2013290444B2 (en) | 2018-04-26 |
US9012496B2 (en) | 2015-04-21 |
EP2872122A1 (de) | 2015-05-20 |
AR092857A1 (es) | 2015-05-06 |
US20140088160A1 (en) | 2014-03-27 |
US20170266176A1 (en) | 2017-09-21 |
US20150182517A1 (en) | 2015-07-02 |
US10058546B2 (en) | 2018-08-28 |
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