HK1206673A1 - Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material - Google Patents

Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material

Info

Publication number
HK1206673A1
HK1206673A1 HK15107167.5A HK15107167A HK1206673A1 HK 1206673 A1 HK1206673 A1 HK 1206673A1 HK 15107167 A HK15107167 A HK 15107167A HK 1206673 A1 HK1206673 A1 HK 1206673A1
Authority
HK
Hong Kong
Prior art keywords
correlated
recovery
methods
devices
single cell
Prior art date
Application number
HK15107167.5A
Other languages
English (en)
Chinese (zh)
Inventor
‧卡茲
‧張
‧安
Original Assignee
Celula Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celula Inc filed Critical Celula Inc
Publication of HK1206673A1 publication Critical patent/HK1206673A1/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1484—Electro-optical investigation, e.g. flow cytometers microstructural devices
    • G01N15/149—
HK15107167.5A 2007-08-09 2015-07-27 Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material HK1206673A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95494607P 2007-08-09 2007-08-09

Publications (1)

Publication Number Publication Date
HK1206673A1 true HK1206673A1 (en) 2016-01-15

Family

ID=40341779

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107167.5A HK1206673A1 (en) 2007-08-09 2015-07-27 Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material

Country Status (6)

Country Link
US (1) US20090042737A1 (xx)
EP (1) EP2178641B1 (xx)
JP (1) JP5547071B2 (xx)
CN (2) CN101842159B (xx)
HK (1) HK1206673A1 (xx)
WO (1) WO2009021215A1 (xx)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP2009536313A (ja) 2006-01-11 2009-10-08 レインダンス テクノロジーズ， インコーポレイテッド ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法
US9562837B2 (en) * 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530168B1 (en) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Microfluidic Devices
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
CA2677833C (en) * 2007-01-22 2016-05-03 Wafergen, Inc. Apparatus for high throughput chemical reactions
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
EP2356249B1 (en) * 2008-10-10 2016-02-17 Picovitro Ab Genetic analysis in microwells
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
EP2719774B8 (en) 2008-11-07 2020-04-22 Adaptive Biotechnologies Corporation Methods of monitoring conditions by sequence analysis
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
DK3059337T3 (da) 2009-01-15 2019-07-22 Adaptive Biotechnologies Corp Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier
US9645010B2 (en) 2009-03-10 2017-05-09 The Regents Of The University Of California Fluidic flow cytometry devices and methods
WO2010104993A2 (en) 2009-03-10 2010-09-16 The Regents Of The University Of California Fluidic flow cytometry devices and particle sensing based on signal-encoding
EP3415235A1 (en) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation of microfluidic droplets
KR20120044941A (ko) 2009-06-25 2012-05-08 프레드 헛친슨 켄서 리서치 센터 적응 면역의 측정방법
WO2011002319A2 (en) * 2009-07-02 2011-01-06 Zygem Corporation Limited Combined nucleic acid blocking, extraction, and detection in a single reaction vessel
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
EP4191227A1 (en) 2010-01-15 2023-06-07 On-chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and flow cytometer using the same
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド デジタル検体分析
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP5807004B2 (ja) * 2010-02-24 2015-11-10 公益財団法人神奈川科学技術アカデミー 細胞分析装置
GB201006180D0 (en) * 2010-04-14 2010-06-02 Advanced Sensors Ltd Imaging apparatus
KR101368463B1 (ko) * 2010-04-23 2014-03-03 나노바이오시스 주식회사 2개의 열 블록을 포함하는 ｐｃｒ 장치
US20110312676A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc device with integral driver for excitation of electrochemiluminescent luminophores
US9182353B2 (en) 2010-07-22 2015-11-10 Hach Company Lab-on-a-chip for alkalinity analysis
US9861985B2 (en) 2010-08-31 2018-01-09 Canon U.S. Life Sciences, Inc. Slug control during thermal cycling
EP3447155A1 (en) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwich assays in droplets
JP5798631B2 (ja) * 2010-10-04 2015-10-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｒｔ−ｐｃｒ反応緩衝液中での細胞溶解のための方法
CN103124797B (zh) * 2010-10-04 2015-04-22 霍夫曼-拉罗奇有限公司 用于在相同反应容器内的细胞裂解和pcr的方法
WO2012045670A1 (en) * 2010-10-04 2012-04-12 Roche Diagnostics Gmbh Method for cell lysis in a pcr reaction buffer
US10024819B2 (en) 2010-10-21 2018-07-17 The Regents Of The University Of California Microfluidics with wirelessly powered electronic circuits
WO2012073114A2 (en) * 2010-11-30 2012-06-07 Quantumdx Group Limited The design, fabrication and use of a microfluidics multitemperature flexible reaction device
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
CN102680679B (zh) * 2011-03-15 2014-08-27 中国科学院上海生命科学研究院 检测单细胞特异性抗体分泌的细胞微孔芯片及其制备方法
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
WO2013010134A2 (en) * 2011-07-14 2013-01-17 Celula, Inc. Systems, apparatus and methods for biochemical analysis
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
KR101664201B1 (ko) * 2011-08-22 2016-10-11 파나소닉 주식회사 마이크로 유체 디바이스
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
EP3904536A1 (en) 2011-12-09 2021-11-03 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US9429500B2 (en) 2012-02-29 2016-08-30 Fluidigm Corporation Methods, systems and devices for multiple single-cell capturing and processing using microfluidics
EP2823060B1 (en) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
JP5756247B1 (ja) 2012-05-08 2015-07-29 アダプティブ バイオテクノロジーズ コーポレイション マルチプレックスｐｃｒ反応における増幅バイアスを測定し校正する組成物及び方法
CA2874343C (en) * 2012-05-21 2021-11-09 Fluidigm Corporation Single-particle analysis of particle populations
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
NL2017959B1 (en) 2016-12-08 2018-06-19 Illumina Inc Cartridge assembly
EP2904111B1 (en) 2012-10-01 2017-12-06 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
CN110579435B (zh) 2012-10-15 2023-09-26 纳诺赛莱克特生物医药股份有限公司 颗粒分选的系统、设备和方法
US10150996B2 (en) 2012-10-19 2018-12-11 Adaptive Biotechnologies Corp. Quantification of adaptive immune cell genomes in a complex mixture of cells
EP3633349B1 (en) * 2012-10-24 2023-09-06 The Regents of the University of California System for deforming and analyzing particles
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
CN103060193A (zh) * 2012-12-31 2013-04-24 苏州汶颢芯片科技有限公司 一种新型温度响应性微流控细胞层培养芯片及其制备方法
JP2016514047A (ja) * 2013-03-06 2016-05-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 比較的単分散の液滴を形成するためのデバイスおよび方法
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
ITRM20130700A1 (it) * 2013-12-19 2015-06-20 Stichting Katholieke Univ Metodo per il rilevamento di cellule tumorali circolanti
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
US10117563B2 (en) 2014-01-09 2018-11-06 Gyrus Acmi, Inc. Polyp detection from an image
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3167061B1 (en) * 2014-07-07 2019-02-20 Astrego Diagnostics AB Phenotypic characterization and in situ genotyping of a library of genetically different cells
CN106536750A (zh) * 2014-08-01 2017-03-22 深圳华大基因科技有限公司 确定容器中核酸是否来源于单个细胞的方法及其装置和用途
CA2997906A1 (en) * 2014-09-09 2016-03-17 The Broad Institute, Inc. A droplet-based method and apparatus for composite single-cell nucleic acid analysis
CA2962861A1 (en) 2014-09-29 2016-04-07 Chipcare Corporation Methods and devices for cell detection
WO2016069886A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corporation Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10227650B2 (en) 2014-11-14 2019-03-12 Athena Diagnostics, Inc. Methods to detect a silent carrier of a null allele genotype
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
EP3498866A1 (en) 2014-11-25 2019-06-19 Adaptive Biotechnologies Corp. Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
KR102414336B1 (ko) 2014-11-28 2022-06-29 칩케어 코포레이션 멀티플렉스 비드 어레이 분석
WO2016138122A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
CN105936930A (zh) * 2015-03-04 2016-09-14 松下知识产权经营株式会社 Dna检测方法和dna检测装置
WO2016145409A1 (en) 2015-03-11 2016-09-15 The Broad Institute, Inc. Genotype and phenotype coupling
AU2016242967B2 (en) 2015-04-01 2021-07-01 Adaptive Biotechnologies Corp. Method of identifying human compatible T cell receptors specific for an antigenic target
WO2016164244A1 (en) * 2015-04-08 2016-10-13 Indiana University Research And Technology Corporation Flow assembly for cells
CN107850542B (zh) * 2015-08-21 2023-10-24 株式会社日立制作所 光检测装置
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
US11092607B2 (en) 2015-10-28 2021-08-17 The Board Institute, Inc. Multiplex analysis of single cell constituents
US11460405B2 (en) 2016-07-21 2022-10-04 Takara Bio Usa, Inc. Multi-Z imaging and dispensing with multi-well devices
JP7020689B2 (ja) * 2016-09-16 2022-02-16 株式会社オンチップ・バイオテクノロジーズ 微粒子分注装置、微粒子解析装置、及び反応検出装置、並びにそれらを用いる方法
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
IL290157B2 (en) 2016-10-14 2023-09-01 Illumina Inc cartridge kit
JP6990456B2 (ja) * 2017-05-02 2022-01-12 国立大学法人 東京大学 細胞またはその由来物の動的変化のモニタリング方法およびそれを用いた細胞分類方法
CN110678558B (zh) * 2017-05-02 2023-06-02 国立大学法人东京大学 整体性检测单个细胞的非破坏性测量信息和基因组相关信息的方法
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
US11255770B2 (en) 2018-01-30 2022-02-22 Kyocera Corporation Measurement apparatus
EP3762494B1 (en) * 2018-03-07 2022-11-23 Wisconsin Alumni Research Foundation High throughput nucleic acid profiling of single cells
CN108712352A (zh) * 2018-05-04 2018-10-26 上海理工大学 基于同轴型微流控芯片的摩斯码转换及可视化装置
CN108579830A (zh) * 2018-05-04 2018-09-28 上海理工大学 摩斯码生成的十字交叉型微流控芯片装置
CN108696462A (zh) * 2018-05-04 2018-10-23 上海理工大学 基于十字交叉型微流控芯片的摩斯码转换及可视化装置
CN108704678A (zh) * 2018-05-04 2018-10-26 上海理工大学 摩斯码生成的t型微流控芯片装置
US11040347B2 (en) * 2018-06-14 2021-06-22 Owl biomedical, Inc. Microfabricated droplet dispensor with immiscible fluid
JP7279885B2 (ja) * 2018-11-07 2023-05-23 国立大学法人 東京大学 １種以上の被検物質と共存した細胞のゲノム関連情報を検出する方法
US20220244182A1 (en) * 2019-04-29 2022-08-04 Lexagene, Inc. Methods for identifying nucleic acids in a sample
FR3100033B1 (fr) * 2019-08-23 2021-11-05 Commissariat Energie Atomique Appareil pour mise en œuvre d'un procédé de traitement de fluide dans des conditions stériles
WO2021097456A1 (en) * 2019-11-17 2021-05-20 The Regents Of The University Of California Guided Microfluidic Flow for Cell Capture, Indexing, and Directed Release
EP4143535A4 (en) * 2020-04-28 2023-09-13 Becton, Dickinson and Company METHOD FOR SORTING UNIQUE PHENOTYPES AND CORRESPONDING SYSTEMS

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2612048A (en) * 1950-09-13 1952-09-30 Gen Electric Thermometer
US4893886A (en) * 1987-09-17 1990-01-16 American Telephone And Telegraph Company Non-destructive optical trap for biological particles and method of doing same
US5994056A (en) * 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
BR9710054A (pt) * 1996-06-28 2000-01-11 Caliper Techn Corp Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio.
AU4113297A (en) * 1996-09-04 1998-03-26 Technical University Of Denmark A micro flow system for particle separation and analysis
US6534308B1 (en) * 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
US6632619B1 (en) * 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US6540895B1 (en) * 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
CA2307016A1 (en) * 1997-10-24 1999-05-06 Life Technologies, Inc. Recombinational cloning using nucleic acids having recombination sites
US6174675B1 (en) * 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6251343B1 (en) * 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6780617B2 (en) * 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
KR100604510B1 (ko) * 1998-08-06 2006-07-25 스펙트랄 다이아그나스틱스, 인크. 분석 시험 장치 및 방법
US6086740A (en) * 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6887693B2 (en) * 1998-12-24 2005-05-03 Cepheid Device and method for lysing cells, spores, or microorganisms
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6303343B1 (en) * 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
WO2000070080A1 (en) * 1999-05-17 2000-11-23 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
JP2003524183A (ja) * 2000-02-23 2003-08-12 カリパー・テクノロジーズ・コープ． マルチリザーバ圧力コントロールシステム
WO2002022878A1 (en) * 2000-09-14 2002-03-21 Caliper Technologies Corp. Microfluidic devices and methods for performing temperature mediated reactions
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6784420B2 (en) * 2000-11-13 2004-08-31 Genoptix, Inc. Method of separating particles using an optical gradient
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US6833542B2 (en) * 2000-11-13 2004-12-21 Genoptix, Inc. Method for sorting particles
US6744038B2 (en) * 2000-11-13 2004-06-01 Genoptix, Inc. Methods of separating particles using an optical gradient
US20020132360A1 (en) * 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
US6778724B2 (en) * 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US20020114739A1 (en) * 2000-12-26 2002-08-22 Weigl Bernard H. Microfluidic cartridge with integrated electronics
US7291698B2 (en) * 2001-09-04 2007-11-06 Stephen Eliot Zweig Synthetic substrate for high specificity enzymatic assays
US6783647B2 (en) * 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate
US20050014201A1 (en) * 2001-10-25 2005-01-20 Mordechai Deuthsch Interactive transparent individual cells biochip processor
AU2003216175A1 (en) * 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
WO2003085379A2 (en) * 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US6877528B2 (en) * 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US6808075B2 (en) * 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
EP2302389B1 (en) * 2002-05-09 2018-01-24 The University of Chicago Device and method for pressure-driven plug transport and reaction
JP2006507921A (ja) * 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US7041481B2 (en) * 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
DE10319045A1 (de) * 2003-04-25 2004-12-09 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten
ES2920892T3 (es) * 2003-06-12 2022-08-11 Accupath Diagnostic Laboratories Inc Método para formar matrices de células
CN104069784B (zh) * 2003-08-27 2017-01-11 哈佛大学 流体物种的电子控制
CN1860363B (zh) * 2003-08-28 2011-12-28 赛路拉公司 用于在微流通道网络中使用光学开关将细胞分类的方法和设备
WO2005028635A2 (en) * 2003-09-19 2005-03-31 Microfluidic Systems Inc. Microfluidic differential extraction cartridge
US20050074506A1 (en) * 2003-10-02 2005-04-07 Brainsgate Ltd. Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
CA2542219A1 (en) * 2003-10-10 2005-04-21 Biophysical Corporation Generation of biochemical images and methods of use
WO2005049787A2 (en) * 2003-11-24 2005-06-02 Yeda Research And Development Co.Ltd. Compositions and methods for in vitro sorting of molecular and cellular libraries
NZ530972A (en) * 2004-02-05 2005-04-29 Embrionics Ltd A method and apparatus for orientating and selecting cells
US20050244837A1 (en) * 2004-04-28 2005-11-03 Cepheid Method and device for sample preparation control
WO2005108963A1 (en) * 2004-05-06 2005-11-17 Nanyang Technological University Microfluidic cell sorter system
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
JP4570945B2 (ja) * 2004-12-02 2010-10-27 一般社団法人オンチップ・セロミクス・コンソーシアム 液滴操作装置及び操作方法
CN1312477C (zh) * 2004-09-13 2007-04-25 王占科 不同阻抗系列免疫微球及制备方法、以及对其进行检测的方法与装置
US7968287B2 (en) * 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
AU2006247752B2 (en) * 2005-05-11 2012-04-12 Advanced Liquid Logic, Inc. Method and device for conducting biochemical or chemical reactions at multiple temperatures
JP4233557B2 (ja) * 2005-10-12 2009-03-04 独立行政法人科学技術振興機構 セルソーターチップおよびセルソーター
EP2530168B1 (en) * 2006-05-11 2015-09-16 Raindance Technologies, Inc. Microfluidic Devices
US7923265B2 (en) * 2006-11-28 2011-04-12 Taiwan Semiconductor Manufacturing Company, Ltd. Method and system for improving critical dimension proximity control of patterns on a mask or wafer
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
JP2008278791A (ja) * 2007-05-10 2008-11-20 Tokyo Medical & Dental Univ 核酸増幅装置、方法および細胞培養・核酸増幅方法
GB2501238B (en) * 2012-03-16 2018-10-24 Cambridge Entpr Ltd Methods for obtaining liquid from a solid phase

Also Published As

Publication number Publication date
WO2009021215A1 (en) 2009-02-12
EP2178641B1 (en) 2018-04-11
CN101842159A (zh) 2010-09-22
CN104307581B (zh) 2017-04-12
EP2178641A4 (en) 2013-10-30
JP2010535511A (ja) 2010-11-25
JP5547071B2 (ja) 2014-07-09
CN101842159B (zh) 2014-09-24
US20090042737A1 (en) 2009-02-12
CN104307581A (zh) 2015-01-28
EP2178641A1 (en) 2010-04-28

Similar Documents

Publication Publication Date Title
HK1206673A1 (en) Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material
HK1145878A1 (en) Improved methods and devices for cellular analysis
EP2142078A4 (en) IMPROVED METHOD AND DEVICES FOR MATERIAL CHECK
AP2954A (en) Devices and methods for detecting cells and other analytes
IL205315A0 (en) Apparatus and method for electrochemical detection
EP2204643A4 (en) Cell analysis apparatus and cell analysis method
EP2174135A4 (en) DEVICE AND METHOD FOR DETECTING ELECTROCHEMICAL ANALYTES
PL2304020T3 (pl) Sposób i urządzenie do sortowania komórek
EP2316022A4 (en) APPARATUS AND METHODS FOR CELL ANALYSIS
HK1135715A1 (en) Method of drying biological material
EP2107373A4 (en) CHIP OF ANALYSIS AND METHOD OF ANALYSIS
GB2459822B (en) Separator for downhole measuring and method therefor
EP2201355A4 (en) IDENTIFICATION METHOD FOR ELECTROCHEMICAL TEST STRIPS
EP2510948A4 (en) T-LYMPHOCYTE ACTIVATION INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND SCREENING METHOD FOR T-LYMPHOCYTE ACTIVATION-INHIBITING SUBSTANCE
EP2176651A4 (en) ELECTROCHEMICAL TEST STRIPS
GB0812789D0 (en) Materials and methods for cell growth
GB0904267D0 (en) Method for cell analysis
EP2147290A4 (en) CELL SAMPLE PREPARATION AND DEVICE
EP2224241A4 (en) SUPPORT FOR USE IN THE MEASUREMENT OF A SUBSTANCE TO BE ANALYZED, AND METHOD FOR MANUFACTURING THE SAME
EP1916310A4 (en) METHOD FOR ANALYZING THE FUNCTION OF AN NKT CELL
IL203196A0 (en) Method for screening cells
EP2121042A4 (en) COMPOUNDS AND METHOD FOR THE DETECTION OF CELLS
HK1127807A1 (en) Method for measuring the penetrating ability of electrolyte in electrode material
IL201346A0 (en) Newcompositions and methods for cell killing
EP2167938A4 (en) SPECIMEN CELL FOR SPECTROMETRY ANALYSIS AND USE PROCEDURES