EP4143535A4 - Method for index sorting unique phenotypes and systems for same - Google Patents

Method for index sorting unique phenotypes and systems for same Download PDF

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Publication number
EP4143535A4
EP4143535A4 EP21796586.2A EP21796586A EP4143535A4 EP 4143535 A4 EP4143535 A4 EP 4143535A4 EP 21796586 A EP21796586 A EP 21796586A EP 4143535 A4 EP4143535 A4 EP 4143535A4
Authority
EP
European Patent Office
Prior art keywords
systems
same
index sorting
unique phenotypes
sorting unique
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21796586.2A
Other languages
German (de)
French (fr)
Other versions
EP4143535A1 (en
Inventor
David Alexander Roberts
Lingjie WEI
Peter MAGE
Keegan Owsley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of EP4143535A1 publication Critical patent/EP4143535A1/en
Publication of EP4143535A4 publication Critical patent/EP4143535A4/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1447—Spatial selection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP21796586.2A 2020-04-28 2021-04-09 Method for index sorting unique phenotypes and systems for same Pending EP4143535A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063016702P 2020-04-28 2020-04-28
PCT/US2021/026616 WO2021221884A1 (en) 2020-04-28 2021-04-09 Method for index sorting unique phenotypes and systems for same

Publications (2)

Publication Number Publication Date
EP4143535A1 EP4143535A1 (en) 2023-03-08
EP4143535A4 true EP4143535A4 (en) 2023-09-13

Family

ID=78221989

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21796586.2A Pending EP4143535A4 (en) 2020-04-28 2021-04-09 Method for index sorting unique phenotypes and systems for same

Country Status (5)

Country Link
US (1) US11662297B2 (en)
EP (1) EP4143535A4 (en)
JP (1) JP2023524474A (en)
CN (1) CN115735111A (en)
WO (1) WO2021221884A1 (en)

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EP0786080B1 (en) * 1994-10-14 2004-01-07 University Of Washington System for sensing droplet formation time delay in a flow cytometer
US20090042737A1 (en) * 2007-08-09 2009-02-12 Katz Andrew S Methods and Devices for Correlated, Multi-Parameter Single Cell Measurements and Recovery of Remnant Biological Material
WO2012068287A2 (en) * 2010-11-16 2012-05-24 1087 Systems, Inc. System for identifying and sorting living cells
WO2016134078A1 (en) * 2015-02-19 2016-08-25 Becton, Dickinson And Company High-throughput single-cell analysis combining proteomic and genomic information

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US5620842A (en) 1995-03-29 1997-04-15 Becton Dickinson And Company Determination of the number of fluorescent molecules on calibration beads for flow cytometry
US6821740B2 (en) 1998-02-25 2004-11-23 Becton, Dickinson And Company Flow cytometric methods for the concurrent detection of discrete functional conformations of PRB in single cells
US6372506B1 (en) 1999-07-02 2002-04-16 Becton, Dickinson And Company Apparatus and method for verifying drop delay in a flow cytometer
US6813017B1 (en) 1999-10-20 2004-11-02 Becton, Dickinson And Company Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer
US6809804B1 (en) 2000-05-11 2004-10-26 Becton, Dickinson And Company System and method for providing improved event reading and data processing capabilities in a flow cytometer
US6683314B2 (en) 2001-08-28 2004-01-27 Becton, Dickinson And Company Fluorescence detection instrument with reflective transfer legs for color decimation
US7362424B2 (en) 2002-04-24 2008-04-22 The Institute For Systems Biology Compositions and methods for drop boundary detection and radiation beam alignment
US7201875B2 (en) 2002-09-27 2007-04-10 Becton Dickinson And Company Fixed mounted sorting cuvette with user replaceable nozzle
US20040260157A1 (en) * 2003-06-20 2004-12-23 Montes Miguel A. Method for automated screening of cervical/endocervical malignant and premalignant epithelial lesions using flow cytometry with HPV DNA fluorescent in-situ hybridization ( FISH) technology
US7655421B2 (en) * 2005-06-17 2010-02-02 Ciencia, Inc. Cytometer on a chip
US7738094B2 (en) 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
US8409509B2 (en) * 2007-04-12 2013-04-02 Regents Of The University Of Minnesota Systems and methods for analyzing a particulate
US8140300B2 (en) 2008-05-15 2012-03-20 Becton, Dickinson And Company High throughput flow cytometer operation with data quality assessment and control
US8233146B2 (en) 2009-01-13 2012-07-31 Becton, Dickinson And Company Cuvette for flow-type particle analyzer
US8936762B2 (en) * 2009-09-01 2015-01-20 Trustees Of Boston University High throughput multichannel reader and uses thereof
US8528427B2 (en) 2010-10-29 2013-09-10 Becton, Dickinson And Company Dual feedback vacuum fluidics for a flow-type particle analyzer
US8941062B2 (en) * 2010-11-16 2015-01-27 1087 Systems, Inc. System for identifying and sorting living cells
US20120258488A1 (en) * 2011-04-11 2012-10-11 The Regents Of The University Of California Systems and Methods for Electrophysiological Activated Cell Sorting and Cytometry
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EP2943778B1 (en) 2013-01-09 2020-10-28 The Regents of The University of California Apparatus and methods for fluorescence imaging using radiofrequency-multiplexed excitation
BR112015022073B1 (en) 2013-04-12 2020-10-06 Becton, Dickinson And Company AUTOMATED CELL CLASSIFICATION ORGANIZATION
ES2959506T3 (en) 2014-03-18 2024-02-26 Univ California Parallel flow cytometer using radiofrequency multiplexing, and method
CN104158208A (en) 2014-07-15 2014-11-19 阳光电源股份有限公司 Single-stage photovoltaic grid-connected inverter, as well as control method and application thereof
KR20180137506A (en) 2016-04-15 2018-12-27 벡톤 디킨슨 앤드 컴퍼니 Closed droplet sorter and its use
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0786080B1 (en) * 1994-10-14 2004-01-07 University Of Washington System for sensing droplet formation time delay in a flow cytometer
US20090042737A1 (en) * 2007-08-09 2009-02-12 Katz Andrew S Methods and Devices for Correlated, Multi-Parameter Single Cell Measurements and Recovery of Remnant Biological Material
WO2012068287A2 (en) * 2010-11-16 2012-05-24 1087 Systems, Inc. System for identifying and sorting living cells
WO2016134078A1 (en) * 2015-02-19 2016-08-25 Becton, Dickinson And Company High-throughput single-cell analysis combining proteomic and genomic information

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANDREA COSSARIZZA ET AL: "Guidelines for the use of flow cytometry and cell sorting in immunological studies : Guidelines for the use of flow cytometry and cell sorting in immunological studies", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 47, no. 10, 1 October 2017 (2017-10-01), Hoboken, USA, pages 1584 - 1797, XP055434198, ISSN: 0014-2980, DOI: 10.1002/eji.201646632 *
See also references of WO2021221884A1 *

Also Published As

Publication number Publication date
US11662297B2 (en) 2023-05-30
US20210333192A1 (en) 2021-10-28
JP2023524474A (en) 2023-06-12
WO2021221884A1 (en) 2021-11-04
EP4143535A1 (en) 2023-03-08
CN115735111A (en) 2023-03-03

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