HK1200438A1 - 苯基取代的環烷胺作為元胺再攝取抑制劑 - Google Patents

苯基取代的環烷胺作為元胺再攝取抑制劑

Info

Publication number
HK1200438A1
HK1200438A1 HK15100806.7A HK15100806A HK1200438A1 HK 1200438 A1 HK1200438 A1 HK 1200438A1 HK 15100806 A HK15100806 A HK 15100806A HK 1200438 A1 HK1200438 A1 HK 1200438A1
Authority
HK
Hong Kong
Prior art keywords
phenyl substituted
reuptake inhibitors
monoamine reuptake
substituted cycloalkylamines
cycloalkylamines
Prior art date
Application number
HK15100806.7A
Other languages
English (en)
Inventor
邵黎明
王鳳江
．瑪爾科姆
．赫維特
馬建國
．萊布
．瓦尼
．坎貝爾
．恩格爾
．哈迪
．科克
．施雷伯
．斯皮爾
Original Assignee
Sunovion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunovion Pharmaceuticals Inc filed Critical Sunovion Pharmaceuticals Inc
Publication of HK1200438A1 publication Critical patent/HK1200438A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK15100806.7A 2007-05-31 2015-01-23 苯基取代的環烷胺作為元胺再攝取抑制劑 HK1200438A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94124207P 2007-05-31 2007-05-31

Publications (1)

Publication Number Publication Date
HK1200438A1 true HK1200438A1 (zh) 2015-08-07

Family

ID=40094167

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15100806.7A HK1200438A1 (zh) 2007-05-31 2015-01-23 苯基取代的環烷胺作為元胺再攝取抑制劑

Country Status (15)

Country Link
US (3) US8669291B2 (zh)
EP (3) EP2154962A4 (zh)
JP (3) JP5420534B2 (zh)
KR (1) KR101581289B1 (zh)
CN (3) CN101686672A (zh)
AU (1) AU2008259841B2 (zh)
BR (1) BRPI0811639A2 (zh)
CA (1) CA2688493C (zh)
HK (1) HK1200438A1 (zh)
IL (1) IL202405A (zh)
MX (1) MX2009012685A (zh)
NZ (1) NZ580429A (zh)
RU (1) RU2470011C2 (zh)
WO (1) WO2008151156A1 (zh)
ZA (1) ZA200907171B (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2006427A3 (cs) 2003-12-29 2006-11-15 Sepracor Inc. Pyrrolové a pyrazolové inhibitory DAAO
JP2009500425A (ja) 2005-07-06 2009-01-08 セプラコア インコーポレーテッド エスゾピクロン及びトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミン又はトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
US20070203111A1 (en) 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
EP2816024B8 (en) 2006-03-31 2018-04-04 Sunovion Pharmaceuticals Inc. Chiral amines
AU2007260836B2 (en) 2006-06-23 2012-11-15 Abbvie Bahamas Ltd. Cyclopropyl amine derivatives as histamin H3 receptor modulators
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP5420534B2 (ja) 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
WO2014018563A2 (en) * 2012-07-23 2014-01-30 The Board Of Trustees Of The Leland Stanford Junior University Methods for the treatment of cancer
US9283196B1 (en) * 2013-01-30 2016-03-15 MediSynergics, LLC Cycloalkyl-diamines for CNS disorders
US9381170B2 (en) * 2013-01-30 2016-07-05 MediSynergics, LLC Cycloalkyl-diamines for neurodegenerative disorders
US9126891B2 (en) * 2014-01-29 2015-09-08 MediSynergics, LLC Cycloalkyl-diamines
WO2016008862A1 (de) * 2014-07-18 2016-01-21 Bayer Cropscience Aktiengesellschaft Substituierte vinyl- und alkinyl-cyanocycloalkanole sowie vinyl- und alkinyl-cyanoheterocyclylalkanole als wirkstoffe gegen abiotischen pflanzenstress
JP7073272B2 (ja) * 2016-05-12 2022-05-23 リサーチ トライアングル インスティテュート 神経伝達物質放出剤としてのビニローグフェネチルアミン
US20230212144A1 (en) 2020-05-29 2023-07-06 Daegu-Gyeongbuk Medical Innovation Foundation 5-membered heteroaryl derivative containing at least one n, and pharmaceutical composition for preventing or treating mental disorders, containing same as active ingredient
WO2021241875A1 (ko) 2020-05-29 2021-12-02 재단법인 대구경북첨단의료산업진흥재단 설폰아미드 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
EP4159725A4 (en) 2020-05-29 2023-12-20 Daegu-Gyeongbuk Medical Innovation Foundation CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF AS AN ACTIVE SUBSTANCE FOR THE PREVENTION OR TREATMENT OF MENTAL DISEASES

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE616646A (zh)
DE1124485B (de) 1960-02-12 1962-03-01 Hoechst Ag Verfahren zur Herstellung von analeptisch wirksamen Phenylcycloalkylmethylaminen
US3496181A (en) 1966-10-24 1970-02-17 Upjohn Co 2 - aminocycloalkyl hydroquinones,esters,ethers and n-oxides thereof,and a process for preparing the same
GB1207731A (en) 1968-05-14 1970-10-07 Reckitt & Sons Ltd Derivatives of pyrrolidine
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3974157A (en) 1974-03-04 1976-08-10 Pennwalt Corporation 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4287212A (en) * 1976-04-30 1981-09-01 American Hoechst Corporation 2-Aryl-1,2-dialkylcycloalkylamines
JPS6033106B2 (ja) 1977-10-07 1985-08-01 住友化学工業株式会社 カルボン酸エステル、その製造法およびそれを有効成分とする殺虫、殺ダニ剤
ZA817261B (en) 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
ZA829562B (en) * 1982-02-09 1983-10-26 Upjohn Co 2-(phenylmethylene)cycloalkylamines and-azetidines
US4540690A (en) * 1982-02-09 1985-09-10 The Upjohn Company 2-(Phenylmethylene)cycloalkylamines and -azetidines
JPS58177915A (ja) 1982-04-12 1983-10-18 Green Cross Corp:The 抗血栓剤
JPS60172970A (ja) * 1984-02-15 1985-09-06 Shionogi & Co Ltd シス−アゾリルシクロアルカノ−ル誘導体およびその製造法ならびに農業用殺菌剤
EP0152032B1 (en) 1984-02-03 1988-10-26 Olympus Optical Co., Ltd. Calculus crushing apparatus
WO1986000896A1 (en) 1984-07-30 1986-02-13 Schering Corporation NOVEL PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA ADb BDPYRROLE-2-CARBOXYLATE
DE3431541A1 (de) 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4738709A (en) 1985-01-10 1988-04-19 Ppg Industries, Inc. Herbicidally active substituted benzisoxazoles
US4751231A (en) 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
JPH01172388A (ja) 1987-12-25 1989-07-07 Sumitomo Chem Co Ltd チエノ〔３，２−ｂ〕ピロロ〔２，３−ｄ〕ピロール類およびその製法
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US4981870A (en) 1989-03-07 1991-01-01 Pfizer Inc. Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
JPH0347123A (ja) 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
JP2785879B2 (ja) 1989-05-31 1998-08-13 ジ・アップジョン・カンパニー 治療学的に有用な２―アミノテトラリン誘導体
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
WO1991011437A1 (en) 1990-02-02 1991-08-08 Schering Corporation 4,5-cycloalkano-3-benzazepin-7-ol-derivatives and their use
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
JPH0477476A (ja) 1990-07-19 1992-03-11 Sankyo Co Ltd 抗潰瘍剤
US5086054A (en) 1990-07-31 1992-02-04 Sri International Novel arylcycloalkanepolyalkylamines
JP3007138B2 (ja) 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
GB9208492D0 (en) 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
WO1994010158A1 (en) 1992-10-28 1994-05-11 Toyama Chemical Co., Ltd. Novel 1,2-benzisoxazole derivative or salt thereof, and brain protective agent comprising the same
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
GB9304500D0 (en) 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
ES2081747B1 (es) 1993-09-07 1997-01-16 Esteve Labor Dr Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.
GB9321221D0 (en) 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
GB9326284D0 (en) 1993-12-23 1994-02-23 Erba Carlo Spa Pyrrolydenemethyl-derivatives and process for their preparation
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
CN1047384C (zh) 1994-07-28 1999-12-15 北京大学 雷米普利的合成方法
CN1098843C (zh) 1994-08-30 2003-01-15 三共株式会社 异噁唑衍生物
US5484763A (en) 1995-02-10 1996-01-16 American Cyanamid Company Substituted benzisoxazole and benzisothiazole herbicidal agents
US5620997A (en) 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
US5859042A (en) 1995-09-27 1999-01-12 Ono Pharmaceutical Co., Ltd. Five membered heterocyclic compounds
JP3926390B2 (ja) 1995-10-26 2007-06-06 三菱ウェルファーマ株式会社 β３作業薬として有用なフェニルエタノールアミン化合物、その製法およびその製造における中間体
SI0882021T1 (en) 1996-01-31 2003-10-31 Altana Pharma Ag New phenanthridines
DE19711785A1 (de) 1997-03-21 1998-09-24 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US6503582B1 (en) 1997-08-19 2003-01-07 Mattel, Inc. Fluid-swellable composition, device and method for using the same
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
WO1999018065A1 (en) 1997-10-03 1999-04-15 Chirotech Technology Limited Chiral amines
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9803228D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
JP2002507598A (ja) 1998-03-26 2002-03-12 スージェン・インコーポレーテッド チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー
US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6632836B1 (en) 1998-10-30 2003-10-14 Merck & Co., Inc. Carbocyclic potassium channel inhibitors
AU1400100A (en) * 1998-12-02 2000-06-19 Darwin Discovery Limited Therapeutic product and its use
US6828460B2 (en) * 1999-03-22 2004-12-07 Pfizer Inc. Resorcinol derivatives
DE19915601A1 (de) * 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung
FR2795733B1 (fr) 1999-06-30 2001-09-07 Aventis Pharma Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
EP1391460A1 (en) 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors
ES2211454T3 (es) 1999-09-30 2004-07-16 Pfizer Products Inc. Pirrolilamidas como inhibidores de la colageno fosforilasa.
JP4803935B2 (ja) 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
EP1246797B1 (en) 1999-12-08 2008-07-23 Eli Lilly And Company Cyclopentyl sulfonamide derivatives
DE19960917A1 (de) 1999-12-17 2001-06-21 Bayer Ag Neue 3-Oxo-2,1-benzisoxazol-1(3H)-carboxamide zur Behandlung von ZNS-Erkrankungen
DE10000312A1 (de) 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
JP2001247462A (ja) 2000-03-07 2001-09-11 Otsuka Pharmaceut Co Ltd ウレアーゼ阻害剤
US6632417B2 (en) 2000-03-07 2003-10-14 Chevron U.S.A. Inc. Process for preparing zeolites
EP1136071A3 (en) 2000-03-22 2003-03-26 Pfizer Products Inc. Use of glycogen phosphorylase inhibitors
EP1188756B1 (en) 2000-04-19 2004-06-23 Kaneka Corporation Novel azetidine derivative and process for preparation thereof
GB0012214D0 (en) 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
AU2001280461A1 (en) 2000-08-04 2002-02-18 Eli Lilly And Company Substituted pyrrole compounds and their use as spla2 inhibitors
GB0021831D0 (en) 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
AU2000277557A1 (en) 2000-10-06 2002-04-22 Smith Kline Beecham Corporation Methods of agonizing and antagonizing fabk
EP1334087A1 (en) * 2000-10-13 2003-08-13 Eli Lilly And Company Cycloalkylfluorosulfonamide derivatives
SE0003810D0 (sv) 2000-10-20 2000-10-20 Pharmacia Ab Novel compounds their use and preparations
TWI283575B (en) 2000-10-31 2007-07-11 Eisai Co Ltd Medicinal compositions for concomitant use as anticancer agent
DE10063992A1 (de) 2000-12-21 2002-07-04 Max Planck Gesellschaft Tryptophan-Analoga in Proteinen, Peptiden und peptidischen Leitstrukturen
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US20020123490A1 (en) 2001-03-01 2002-09-05 Pfizer Inc. Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
GB0115602D0 (en) 2001-06-26 2001-08-15 Syngenta Participations Ag Organic compounds
DE10132747A1 (de) 2001-07-05 2003-01-23 Gruenenthal Gmbh Substituierte 1-Aryl-but-3-enylamin- und 1-Aryl-but-2-enylaminverbindungen
US6603000B2 (en) 2001-07-11 2003-08-05 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis for heteroarylamine compounds
CN100545160C (zh) 2001-08-09 2009-09-30 第一制药株式会社 二胺衍生物
US7045543B2 (en) 2001-11-05 2006-05-16 Enzrel Inc. Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites
US20030162825A1 (en) 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
AU2002364517A1 (en) * 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
DE10164581A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Substituierte Aminoalkohole
DE10161809A1 (de) 2001-12-14 2003-06-26 Gruenenthal Gmbh Arzneimittel enthaltend N,N'-disubstituierte Piperazin-Verbindungen
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
AU2003210236A1 (en) * 2002-02-11 2003-09-04 Rhodia Chimie Detergent composition comprising a block copolymer
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
US6995144B2 (en) 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
AU2003227360A1 (en) 2002-04-25 2003-11-10 Yamanouchi Pharmaceutical Co., Ltd. Novel amide derivatives or salts thereof
AU2003236247A1 (en) 2002-05-03 2003-11-17 Warner-Lambert Company Llc Bombesin antagonists
FR2841487B1 (fr) 2002-06-26 2004-08-20 Solystic Procede de detection de plis simples et de plis en prise multiple dans une installation de tri postal
US20050182131A1 (en) * 2002-07-19 2005-08-18 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl cyclohexane compounds and therapies for depressive symptoms, pain and incontinence
DE10233048A1 (de) 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
EP1541570A4 (en) 2002-07-31 2008-05-21 Mercian Corp NEW PHYSIOLOGICALLY ACTIVE SUBSTANCE
US7537891B2 (en) 2002-08-27 2009-05-26 Bristol-Myers Squibb Company Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
AU2003272285A1 (en) 2002-09-06 2004-03-29 Janssen Pharmaceutica, N.V. Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands
US20040087661A1 (en) 2002-09-16 2004-05-06 Sepracor, Inc. Treatment of CNS disorders with trans 4-3(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine
JP4610336B2 (ja) 2002-09-16 2011-01-12 セプラコール インク． トランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミン及びそのホルムアミドによる中枢神経系障害の治療
TW200418838A (en) * 2002-09-18 2004-10-01 Bristol Myers Squibb Co Compounds for the treatment of premature ejaculation
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0222912D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
CA2500662A1 (en) 2002-10-03 2004-04-15 Cypress Bioscience, Inc. Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders
US20040097554A1 (en) 2002-10-30 2004-05-20 Pfizer Inc Heteroaryl-hexanoic acid amide derivatives as immonomodulatory agents
CA2503727A1 (en) 2002-11-07 2004-05-21 Pfizer Products Inc. Anti-diabetic agents
KR100998796B1 (ko) 2003-01-31 2010-12-06 가부시키가이샤산와카가쿠켄큐쇼 디펩티딜 펩티다아제 ｉｖ를 저해하는 화합물
WO2004089470A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S New amide derivatives and pharmaceutical use thereof
MXPA05011702A (es) 2003-04-30 2006-01-23 Pfizer Prod Inc Agentes antidiabeticos.
WO2004113345A1 (ja) 2003-06-20 2004-12-29 Japan Tobacco Inc. 縮合ピロール化合物及びその医薬用途
PT1362864E (pt) 2003-06-30 2007-07-23 Servier Lab Novo processo de síntese do perindopril e dos seus sais aceitáveis do ponto de vista farmacêutico
AU2004255863A1 (en) 2003-07-07 2005-01-20 Ciba Specialty Chemicals Holding Inc. Process for the preparation of furopyrroles
NZ601780A (en) 2003-07-29 2012-10-26 Signature R & D Holdings Llc Amino Acid Prodrugs
GB0318463D0 (en) 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0319759D0 (en) 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
WO2005020986A1 (en) 2003-08-29 2005-03-10 Astrazeneca Ab Heterocyclic amide derivatives which posses glycogen phosphorylase inhibitory activity
GB0320422D0 (en) 2003-08-30 2003-10-01 Astrazeneca Ab Chemical compounds
US7396940B2 (en) 2003-10-23 2008-07-08 Hoffmann-La Roche Inc. Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid
ES2297502T3 (es) 2003-10-23 2008-05-01 F. Hoffmann-La Roche Ag Derivados de triaza-espiropiperidinas para uso como inhibidores de glyt-1 en el tratamiento de trastornos neurologicos y neuropsiquiatricos.
DK1420028T3 (da) 2003-11-19 2007-06-18 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
CZ2006427A3 (cs) 2003-12-29 2006-11-15 Sepracor Inc. Pyrrolové a pyrazolové inhibitory DAAO
CN1922157B (zh) 2003-12-29 2011-01-12 塞普拉科公司 苯并[d]异噁唑-3-醇DAAO抑制剂
CA2559105A1 (en) 2004-03-16 2005-09-29 Janssen Pharmaceutica N.V. Benzisoxazoles
RS51403B (en) 2004-05-07 2011-02-28 Warner-Lambert Company Llc DERIVATIVES OF 3-OR 4-MONOSUBSTITIZED PHENOLS AND THIOPHENOLS USEFUL AS H3 LIGANDS
US7244866B2 (en) * 2004-05-14 2007-07-17 Janssen Pharmaceutical N.V. Carboxamido opioid compounds
AU2005257859A1 (en) * 2004-05-21 2006-01-05 Merck & Co., Inc. Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
WO2005115990A1 (ja) 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. シンナミド化合物
WO2005123677A1 (en) 2004-06-16 2005-12-29 Actelion Pharmaceuticals Ltd 4-carbonyl substituted 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa'a!pentalene derivatives as agonists for the g-protein-coupled receptor s1p1/edg1 and immunosuppressive agents
CA2569530C (en) 2004-07-01 2013-07-30 Daiichi Asubio Pharma Co.,Ltd. Thienopyrazole derivative having pde 7 inhibitory activity
US7276631B2 (en) 2004-07-20 2007-10-02 Bristol-Myers Squibb Company Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists
JO2629B1 (en) 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
US7411093B2 (en) 2004-12-20 2008-08-12 Hoffman-La Roche Inc. Aminocycloalkanes as DPP-IV inhibitors
JP2008527032A (ja) 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なチエノピロール
CN100391945C (zh) 2005-05-31 2008-06-04 浙江大学 一种s-(-)-吲哚啉-2-羧酸的合成方法
US20090306169A1 (en) 2005-10-06 2009-12-10 Brandish Philip E Use of Fused Pyrrole Carboxylic Acids for the Treatment of Neurodegenerative and Psychiatric Diseases and D-Amino Acid Oxidase Inhibitors
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
US20070203111A1 (en) 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
EP2816024B8 (en) 2006-03-31 2018-04-04 Sunovion Pharmaceuticals Inc. Chiral amines
US20080058395A1 (en) 2006-06-30 2008-03-06 Sepracor Inc. Fused heterocyclic inhibitors of D-amino acid oxidase
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
CA2659060A1 (en) 2006-06-30 2008-01-10 Sepracor Inc. Fused heterocyclic inhibitors of d-amino acid oxidase
CN1962656A (zh) 2006-11-29 2007-05-16 沈阳药科大学 吲哚美辛5－氟尿嘧啶甲酯药用化合物及其制剂和制备方法
RU2009128062A (ru) 2006-12-21 2011-01-27 Эбботт Лэборетриз (Us) Соединения агонисты и антагонисты рецептора сфингозин-1-фосфата
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP2010516697A (ja) 2007-01-18 2010-05-20 セプラコール インク． Ｄ−アミノ酸オキシダーゼ阻害剤
JP5420534B2 (ja) * 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
US20100120740A1 (en) 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase

Also Published As

Publication number Publication date
EP2154962A1 (en) 2010-02-24
RU2470011C2 (ru) 2012-12-20
MX2009012685A (es) 2009-12-14
JP2014062108A (ja) 2014-04-10
US20170204050A1 (en) 2017-07-20
EP2617704B1 (en) 2017-06-28
IL202405A (en) 2014-05-28
JP2010529045A (ja) 2010-08-26
US20140121282A1 (en) 2014-05-01
US9586888B2 (en) 2017-03-07
NZ580429A (en) 2012-04-27
CA2688493C (en) 2016-04-19
RU2009149292A (ru) 2011-07-10
US8669291B2 (en) 2014-03-11
BRPI0811639A2 (pt) 2014-09-30
EP2617704A1 (en) 2013-07-24
CA2688493A1 (en) 2008-12-11
KR20100019982A (ko) 2010-02-19
JP2016065085A (ja) 2016-04-28
EP3296289A2 (en) 2018-03-21
WO2008151156A1 (en) 2008-12-11
JP5420534B2 (ja) 2014-02-19
AU2008259841A1 (en) 2008-12-11
US20090005456A1 (en) 2009-01-01
CN108178733A (zh) 2018-06-19
EP3296289A3 (en) 2018-06-20
AU2008259841B2 (en) 2015-02-05
KR101581289B1 (ko) 2015-12-31
CN103936605A (zh) 2014-07-23
IL202405A0 (en) 2010-06-30
CN101686672A (zh) 2010-03-31
CN103936605B (zh) 2017-09-01
ZA200907171B (en) 2010-12-29
EP2154962A4 (en) 2012-08-15

Similar Documents

Publication Publication Date Title
HK1200438A1 (zh) 苯基取代的環烷胺作為元胺再攝取抑制劑
IL192613A0 (en) Cycloalkylamines as monoamine reuptake inhibitors
EP1978961A4 (en) MONOAMINE RECORDING INHIBITORS ON TETRALON BASIS
PL2860212T3 (pl) Nowa kompozycja aminowa
HRP20130698T1 (en) Novel phenylpyrazinones as kinase inhibitors
EP2200439A4 (en) HDAC INHIBITORS
EP2345636A4 (en) AGONIST OF THE CASR
ZA201100898B (en) Novel inhibitors
PL2128199T3 (pl) Nowa kompozycja
IL200383A0 (en) Neurogenic compounds
IL195014A0 (en) Benzazepine derivatives as monoamine reuptake inhibitors
GB0801836D0 (en) Novel composition
ZA201102329B (en) Novel composition
ZA201002504B (en) Novel taxoid-based compositions
HK1137985A1 (en) Improved raf inhibitors
HRP20150021T1 (en) Phenanthrenone compounds, compositions and methods
EP2259934A4 (en) NEW MIKTOPOLYMERIC COMPOSITIONS
TWI369343B (en) 4-trimethylammonio-butyrates as cpt2 inhibitors
GB0707488D0 (en) Novel inhibitors
GB0707495D0 (en) Novel inhibitors
GB0707493D0 (en) Novel inhibitors
GB0707632D0 (en) Novel inhibitors
GB0707497D0 (en) Novel inhibitors
GB0704589D0 (en) Novel inhibitors
GB0707498D0 (en) Novel inhibitors

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230602