HK1189910A1 - 具有含氮脂環式骨架的單鏈核酸分子 - Google Patents

具有含氮脂環式骨架的單鏈核酸分子

Info

Publication number
HK1189910A1
HK1189910A1 HK14102959.9A HK14102959A HK1189910A1 HK 1189910 A1 HK1189910 A1 HK 1189910A1 HK 14102959 A HK14102959 A HK 14102959A HK 1189910 A1 HK1189910 A1 HK 1189910A1
Authority
HK
Hong Kong
Prior art keywords
nitrogen
rna molecule
stranded rna
alicyclic skeleton
containing alicyclic
Prior art date
Application number
HK14102959.9A
Other languages
English (en)
Inventor
Tadaaki Ohgi
Hirotake Hayashi
Hisao Shirohzu
Tomohiro Hamasaki
Akihiro Itoh
Hiroshi Suzuki
Original Assignee
Bonac Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonac Corp filed Critical Bonac Corp
Publication of HK1189910A1 publication Critical patent/HK1189910A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK14102959.9A 2010-08-03 2014-03-26 具有含氮脂環式骨架的單鏈核酸分子 HK1189910A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010174915 2010-08-03
JP2010230806 2010-10-13
JP2010269823 2010-12-02
JP2011152381 2011-07-08

Publications (1)

Publication Number Publication Date
HK1189910A1 true HK1189910A1 (zh) 2014-06-20

Family

ID=45559420

Family Applications (2)

Application Number Title Priority Date Filing Date
HK14102959.9A HK1189910A1 (zh) 2010-08-03 2014-03-26 具有含氮脂環式骨架的單鏈核酸分子
HK15100974.3A HK1200460A1 (zh) 2010-08-03 2015-01-28 具有含氮脂環式骨架的單鏈核酸分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15100974.3A HK1200460A1 (zh) 2010-08-03 2015-01-28 具有含氮脂環式骨架的單鏈核酸分子

Country Status (10)

Country Link
EP (4) EP2628801B1 (zh)
JP (3) JP4965745B2 (zh)
KR (3) KR101849801B1 (zh)
CN (3) CN103052711B (zh)
DK (1) DK2674494T3 (zh)
ES (4) ES2527660T3 (zh)
HK (2) HK1189910A1 (zh)
PT (1) PT2674494E (zh)
TW (2) TWI515294B (zh)
WO (1) WO2012017919A1 (zh)

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Also Published As

Publication number Publication date
EP2674494B1 (en) 2014-12-17
KR101894702B1 (ko) 2018-09-04
JP5261677B2 (ja) 2013-08-14
JP2013138681A (ja) 2013-07-18
KR20180040728A (ko) 2018-04-20
TW201219570A (en) 2012-05-16
KR101894701B1 (ko) 2018-09-04
TWI572716B (zh) 2017-03-01
ES2528285T3 (es) 2015-02-06
KR101849801B1 (ko) 2018-04-17
JPWO2012017919A1 (ja) 2013-10-03
EP2436767A1 (en) 2012-04-04
EP2639307A8 (en) 2014-04-30
KR20130095738A (ko) 2013-08-28
ES2443346T3 (es) 2014-02-19
PT2674494E (pt) 2015-02-27
DK2674494T3 (en) 2015-02-23
HK1200460A1 (zh) 2015-08-07
EP2436767A4 (en) 2012-05-09
CN103052711A (zh) 2013-04-17
ES2533129T3 (es) 2015-04-07
JP5555346B2 (ja) 2014-07-23
JP2013034470A (ja) 2013-02-21
EP2628801B1 (en) 2015-01-07
TW201615835A (zh) 2016-05-01
KR20180040727A (ko) 2018-04-20
EP2639307B1 (en) 2015-03-04
JP4965745B2 (ja) 2012-07-04
ES2527660T3 (es) 2015-01-28
CN103052711B (zh) 2016-08-03
EP2639307A3 (en) 2014-02-05
WO2012017919A1 (ja) 2012-02-09
EP2436767B1 (en) 2013-11-20
EP2628801A1 (en) 2013-08-21
CN104004018A (zh) 2014-08-27
CN104059911B (zh) 2017-01-04
TWI515294B (zh) 2016-01-01
CN104004018B (zh) 2017-01-04
EP2639307A2 (en) 2013-09-18
EP2674494A1 (en) 2013-12-18
CN104059911A (zh) 2014-09-24

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Effective date: 20230730