HK1181789A1 - β- 能夠特異性結合 β寡聚體的抗體及其應用 - Google Patents

β- 能夠特異性結合 β寡聚體的抗體及其應用

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Publication number
HK1181789A1
HK1181789A1 HK13109030.8A HK13109030A HK1181789A1 HK 1181789 A1 HK1181789 A1 HK 1181789A1 HK 13109030 A HK13109030 A HK 13109030A HK 1181789 A1 HK1181789 A1 HK 1181789A1
Authority
HK
Hong Kong
Prior art keywords
ntibody
oligomer
binding specifically
binding
specifically
Prior art date
Application number
HK13109030.8A
Other languages
English (en)
Inventor
松原悦朗柴田昌夫横関達己
Original Assignee
伊繆納斯製藥株式會社
獨立行政法人國立長壽醫療研究中心
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 伊繆納斯製藥株式會社, 獨立行政法人國立長壽醫療研究中心 filed Critical 伊繆納斯製藥株式會社
Publication of HK1181789A1 publication Critical patent/HK1181789A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK13109030.8A 2008-02-08 2013-08-02 β- 能夠特異性結合 β寡聚體的抗體及其應用 HK1181789A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008028386 2008-02-08
US8554508P 2008-08-01 2008-08-01
JP2008201058 2008-08-04

Publications (1)

Publication Number Publication Date
HK1181789A1 true HK1181789A1 (zh) 2013-11-15

Family

ID=40952248

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13109030.8A HK1181789A1 (zh) 2008-02-08 2013-08-02 β- 能夠特異性結合 β寡聚體的抗體及其應用

Country Status (15)

Country Link
US (3) US8378081B2 (zh)
EP (2) EP2246427B1 (zh)
JP (2) JP5113853B2 (zh)
KR (1) KR101616136B1 (zh)
CN (2) CN102936287B (zh)
AU (2) AU2009211635B2 (zh)
CA (1) CA2714413C (zh)
DK (1) DK2246427T3 (zh)
ES (1) ES2617604T3 (zh)
HK (1) HK1181789A1 (zh)
HU (1) HUE031944T2 (zh)
PL (1) PL2246427T3 (zh)
PT (1) PT2246427T (zh)
SG (1) SG188116A1 (zh)
WO (1) WO2009099176A1 (zh)

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JP5765857B2 (ja) 2015-08-19
EP2246427B1 (en) 2016-11-30
KR20100113623A (ko) 2010-10-21
US20110097319A1 (en) 2011-04-28
EP3121277B1 (en) 2018-04-11
US20130149316A1 (en) 2013-06-13
ES2617604T3 (es) 2017-06-19
CN102936287A (zh) 2013-02-20
AU2014224074A1 (en) 2014-10-02
CN102936287B (zh) 2015-09-09
AU2009211635A1 (en) 2009-08-13
CN102124105A (zh) 2011-07-13
DK2246427T3 (da) 2017-02-20
KR101616136B1 (ko) 2016-04-27
AU2009211635B2 (en) 2014-06-26
JP5113853B2 (ja) 2013-01-09
PL2246427T3 (pl) 2017-06-30
EP2246427A4 (en) 2012-04-25
US8378081B2 (en) 2013-02-19
CA2714413A1 (en) 2009-08-13
WO2009099176A1 (ja) 2009-08-13
SG188116A1 (en) 2013-03-28
JPWO2009099176A1 (ja) 2011-05-26
EP3121277A1 (en) 2017-01-25
EP2246427A1 (en) 2010-11-03
US20100028357A1 (en) 2010-02-04
CA2714413C (en) 2017-01-24
PT2246427T (pt) 2017-03-03
JP2013063976A (ja) 2013-04-11
US9090680B2 (en) 2015-07-28
HUE031944T2 (en) 2017-08-28

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