PT2246427T - Anticorpos capazes de se ligar especificamente a oligómeros beta amilóides e a sua utilização - Google Patents
Anticorpos capazes de se ligar especificamente a oligómeros beta amilóides e a sua utilizaçãoInfo
- Publication number
- PT2246427T PT2246427T PT97075113T PT09707511T PT2246427T PT 2246427 T PT2246427 T PT 2246427T PT 97075113 T PT97075113 T PT 97075113T PT 09707511 T PT09707511 T PT 09707511T PT 2246427 T PT2246427 T PT 2246427T
- Authority
- PT
- Portugal
- Prior art keywords
- oligomers
- amyloid beta
- antibodies capable
- binding specifically
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008028386 | 2008-02-08 | ||
| US8554508P | 2008-08-01 | 2008-08-01 | |
| JP2008201058 | 2008-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2246427T true PT2246427T (pt) | 2017-03-03 |
Family
ID=40952248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97075113T PT2246427T (pt) | 2008-02-08 | 2009-02-06 | Anticorpos capazes de se ligar especificamente a oligómeros beta amilóides e a sua utilização |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8378081B2 (pt) |
| EP (2) | EP3121277B1 (pt) |
| JP (2) | JP5113853B2 (pt) |
| KR (1) | KR101616136B1 (pt) |
| CN (2) | CN102124105A (pt) |
| AU (2) | AU2009211635B2 (pt) |
| CA (1) | CA2714413C (pt) |
| DK (1) | DK2246427T3 (pt) |
| ES (1) | ES2617604T3 (pt) |
| HK (1) | HK1181789A1 (pt) |
| HU (1) | HUE031944T2 (pt) |
| PL (1) | PL2246427T3 (pt) |
| PT (1) | PT2246427T (pt) |
| SG (1) | SG188116A1 (pt) |
| WO (1) | WO2009099176A1 (pt) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10277519B2 (en) * | 2006-01-31 | 2019-04-30 | Silicon Laboratories Inc. | Response time for a gateway connecting a lower bandwidth network with a higher speed network |
| IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
| HUE033325T2 (en) * | 2007-01-05 | 2017-11-28 | Univ Zuerich | Anti-beta-amyloid binder antibodies and their use |
| JP2010515717A (ja) * | 2007-01-11 | 2010-05-13 | フィリップス−ウニベルジテート・マールブルク | アルツハイマーおよび他の神経性認知症疾患の診断ならびに処置 |
| US20100291071A1 (en) * | 2008-08-01 | 2010-11-18 | Immunas Pharma, Inc. | Antibody Specific Binding to A-Beta Oligomer and the Use |
| AU2008312802A1 (en) * | 2007-10-19 | 2009-04-23 | Immunas Pharma, Inc. | Antibody capable of specifically binding to abeta oligomer, and use thereof |
| PT2246427T (pt) * | 2008-02-08 | 2017-03-03 | Immunas Pharma Inc | Anticorpos capazes de se ligar especificamente a oligómeros beta amilóides e a sua utilização |
| EP2321348A2 (en) * | 2008-07-09 | 2011-05-18 | University of Zürich | Method of promoting neurogenesis |
| US9085614B2 (en) | 2008-08-01 | 2015-07-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to Aβ oligomers and uses thereof |
| ES2641612T3 (es) | 2009-04-17 | 2017-11-10 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a oligómeros de beta A y uso de los mismos |
| CN102574915B (zh) | 2009-08-06 | 2014-10-22 | 伊缪纳斯制药株式会社 | 特异性结合Aβ寡聚体的抗体及其用途 |
| JP5599454B2 (ja) * | 2009-08-06 | 2014-10-01 | イムナス・ファーマ株式会社 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
| JP5692073B2 (ja) * | 2009-08-07 | 2015-04-01 | 協和発酵キリン株式会社 | 抗アミロイドβオリゴマーヒト化抗体 |
| BR112012002819B1 (pt) * | 2009-08-07 | 2022-11-22 | Kyowa Kirin Co., Ltd | Anticorpo humanizado antioligômero de amiloide-b, seus usos, e formulação farmacêutica |
| WO2011151076A2 (en) * | 2010-06-04 | 2011-12-08 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | MONOCLONAL ANTIBODIES TARGETING Αβ OLIGOMERS |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| US9260473B2 (en) | 2010-07-19 | 2016-02-16 | Virginia Commonwealth University | Bivalent multifunctional ligands targeting Aβ oligomers as treatment for Alzheimer's disease |
| US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| US20130273574A1 (en) * | 2012-03-13 | 2013-10-17 | Janssen Alzheimer Immunotherapy | Oligomeric a-beta in the diagnosis, prognosis, and monitoring of alzheimer's disease |
| EP2847217B1 (en) | 2012-05-10 | 2017-10-11 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | CONFORMATIONAL-SPECIFIC ANTIBODIES AGAINST OLIGOMERS of Amyloid beta |
| JP6092049B2 (ja) * | 2013-08-28 | 2017-03-08 | 東芝ライフスタイル株式会社 | 撮像システム及び撮像装置 |
| US10942190B2 (en) | 2014-01-21 | 2021-03-09 | Shimadzu Corporation | Measurement method for amyloid precursor protein cleavage peptides |
| ES2769048T3 (es) | 2014-05-22 | 2020-06-24 | Shimadzu Corp | Biomarcador indirecto para evaluar la acumulación de péptido beta amiloide intracerebral y método para el análisis del mismo |
| CN107074938A (zh) * | 2014-10-16 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 抗‑α‑突触核蛋白抗体和使用方法 |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| GB2541003A (en) * | 2015-08-05 | 2017-02-08 | Kran Life Sciences Llp | Neurodegenerative disorders |
| US11268965B2 (en) | 2015-09-16 | 2022-03-08 | Shimadzu Corporation | Multiplex biomarker for use in evaluation of state of accumulation of amyloid B in brain, and analysis method for said evaluation |
| CN113817060B (zh) * | 2016-01-09 | 2024-03-08 | 嘉立医疗科技(广州)有限公司 | 用于癌症治疗的钙粘蛋白-17特异性抗体和细胞毒性细胞 |
| JP2017132742A (ja) * | 2016-01-29 | 2017-08-03 | 国立大学法人 大分大学 | Ａβオリゴマー特異的抗体の新規薬理用途 |
| CN107118260B (zh) * | 2017-05-12 | 2020-10-16 | 中国科学院过程工程研究所 | 一种多肽及其组成的疫苗和应用 |
| IL272773B2 (en) | 2017-08-22 | 2024-06-01 | Biogen Ma Inc | Pharmaceutical preparations containing anti-amyloid cell antibodies |
| CA3114869C (en) | 2018-10-01 | 2023-10-03 | Toru Miyazaki | Therapeutic agent for neurodegenerative disease |
| CA3146118A1 (en) * | 2019-06-28 | 2020-12-30 | The Regents Of The University Of California | Methods and compositions for treating alzheimer's disease |
| JP7370569B2 (ja) * | 2019-08-07 | 2023-10-30 | 国立大学法人 大分大学 | アミロイドβタンパク質オリゴマーと結合するヒト化抗体 |
| GB201912008D0 (en) * | 2019-08-21 | 2019-10-02 | Cambridge Entpr Ltd | Antibody |
| WO2021067628A2 (en) * | 2019-10-01 | 2021-04-08 | Beth Israel Deaconess Medical Center, Inc. | Conformation-specific antibodies that bind nuclear factor kappa-light-chain-enhancer of activated b cells |
| EP4185612A1 (en) | 2020-07-23 | 2023-05-31 | Othair Prothena Limited | Anti-abeta antibodies |
| EP4373858A1 (en) * | 2021-07-19 | 2024-05-29 | University of Pittsburgh - of the Commonwealth System of Higher Education | Mct11 antibodies to treat t cell functional exhaustion and enhance cancer immunotherapy |
| CN118742565A (zh) * | 2021-11-15 | 2024-10-01 | 先知生物科技股份有限公司 | 逆转treml1诱导的免疫抑制的方法 |
| CN114605532B (zh) * | 2022-05-07 | 2022-08-23 | 北京第一生物化学药业有限公司 | 抗β-淀粉样蛋白抗体及其用途 |
| CN117088984B (zh) * | 2022-05-11 | 2024-05-10 | 东莞市朋志生物科技有限公司 | 抗苯二氮卓抗体、检测苯二氮卓的试剂和试剂盒 |
| CN116789818B (zh) * | 2023-06-25 | 2024-01-26 | 东南大学 | 一种抗β淀粉样蛋白的单链抗体及应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0239102A3 (en) | 1986-03-28 | 1989-07-12 | Tsuji, Kimiyoshi | Process for the formation of human-human hybridoma |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| JPH08509612A (ja) | 1993-04-26 | 1996-10-15 | ジェンファーム インターナショナル インコーポレイテッド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| DE69637481T2 (de) | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US20030068316A1 (en) | 1997-02-05 | 2003-04-10 | Klein William L. | Anti-ADDL antibodies and uses thereof |
| US6218506B1 (en) | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
| AR022952A1 (es) * | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
| AUPR617901A0 (en) | 2001-07-06 | 2001-08-02 | Pacmab Pty Ltd | Method for treating multiple myeloma |
| DE60226036T9 (de) | 2001-08-03 | 2016-09-29 | Medical & Biological Laboratories Co., Ltd. | ANTIKÖRPER, DER DAS GM1-GANGLIOSID-GEBUNDENE AMYLOID-b-PROTEIN ERKENNT, UND DNA, DIE FÜR DIESEN ANTIKÖRPER CODIERT |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| WO2010012004A2 (en) | 2008-07-25 | 2010-01-28 | The Regents Of The University Of California | Monoclonal antibodies specific for pathological amyoid aggregates common to amyloids formed from proteins of differing sequence |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US8394379B2 (en) * | 2003-05-15 | 2013-03-12 | Iogenetics, Llc | Targeted cryptosporidium biocides |
| AU2005269940A1 (en) * | 2004-07-02 | 2006-02-09 | Northwestern University | Monolocal antibodies that target pathological assemblies of amyloid beta (Abeta) |
| US20080044356A1 (en) | 2004-10-22 | 2008-02-21 | Regents Of The University Of Minnesota | Assemblies of Oligomeric Amyloid Beta Protein and Uses Thereof |
| AU2005306997B2 (en) * | 2004-10-25 | 2012-07-05 | Merck Sharp & Dohme Corp. | Anti-ADDL antibodies and uses thereof |
| WO2006066171A1 (en) * | 2004-12-15 | 2006-06-22 | Neuralab Limited | Amyloid βετα antibodies for use in improving cognition |
| EP1853299A4 (en) | 2005-01-14 | 2009-11-11 | Univ California | COMPOSITIONS AND METHODS FOR INHIBITING THE PRESENCE OF DRUGS AND DIAGNOSING OR TREATING DRUG-INDUCED DISEASES |
| CA2589860A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
| US7731962B2 (en) | 2005-02-14 | 2010-06-08 | Merck & Co., Inc. | Anti-ADDL monoclonal antibody and use thereof |
| AU2006222193B2 (en) | 2005-03-05 | 2011-11-17 | AbbVie Deutschland GmbH & Co. KG | Screening method, process for purifying of non-diffusible A-beta oligomers, selective antibodies against said non-diffusible A-beta oligomers and a process for manufacturing of said antibodies |
| EP1921137A4 (en) | 2005-06-21 | 2011-01-26 | Med & Biological Lab Co Ltd | ANTIBODIES WITH INHIBITOR EFFECT ON THE FORMATION OF AMYLOID FIBRILLES |
| EP1749839A1 (en) | 2005-07-22 | 2007-02-07 | Novoplant GmbH | Antigen binding polypeptides against F4(K88) fimbriae |
| RU2429244C2 (ru) * | 2006-03-23 | 2011-09-20 | Байоарктик Ньюросайенс Аб | Улучшенные селективные в отношении протофибрилл антитела и их применение |
| US20090232801A1 (en) | 2007-05-30 | 2009-09-17 | Abbot Laboratories | Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof |
| US20100291071A1 (en) | 2008-08-01 | 2010-11-18 | Immunas Pharma, Inc. | Antibody Specific Binding to A-Beta Oligomer and the Use |
| AU2008312802A1 (en) | 2007-10-19 | 2009-04-23 | Immunas Pharma, Inc. | Antibody capable of specifically binding to abeta oligomer, and use thereof |
| WO2009085200A2 (en) | 2007-12-21 | 2009-07-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
| PT2246427T (pt) | 2008-02-08 | 2017-03-03 | Immunas Pharma Inc | Anticorpos capazes de se ligar especificamente a oligómeros beta amilóides e a sua utilização |
| US9085614B2 (en) | 2008-08-01 | 2015-07-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to Aβ oligomers and uses thereof |
| ES2641612T3 (es) | 2009-04-17 | 2017-11-10 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a oligómeros de beta A y uso de los mismos |
| CN102574915B (zh) | 2009-08-06 | 2014-10-22 | 伊缪纳斯制药株式会社 | 特异性结合Aβ寡聚体的抗体及其用途 |
| JP5599454B2 (ja) | 2009-08-06 | 2014-10-01 | イムナス・ファーマ株式会社 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
-
2009
- 2009-02-06 PT PT97075113T patent/PT2246427T/pt unknown
- 2009-02-06 JP JP2009552533A patent/JP5113853B2/ja active Active
- 2009-02-06 ES ES09707511.3T patent/ES2617604T3/es active Active
- 2009-02-06 HU HUE09707511A patent/HUE031944T2/en unknown
- 2009-02-06 KR KR1020107019827A patent/KR101616136B1/ko active IP Right Grant
- 2009-02-06 PL PL09707511T patent/PL2246427T3/pl unknown
- 2009-02-06 CA CA2714413A patent/CA2714413C/en active Active
- 2009-02-06 CN CN2009801112374A patent/CN102124105A/zh active Pending
- 2009-02-06 WO PCT/JP2009/052039 patent/WO2009099176A1/ja active Application Filing
- 2009-02-06 EP EP16183829.7A patent/EP3121277B1/en active Active
- 2009-02-06 CN CN201210469872.3A patent/CN102936287B/zh active Active
- 2009-02-06 DK DK09707511.3T patent/DK2246427T3/da active
- 2009-02-06 SG SG2013008826A patent/SG188116A1/en unknown
- 2009-02-06 EP EP09707511.3A patent/EP2246427B1/en active Active
- 2009-02-06 AU AU2009211635A patent/AU2009211635B2/en active Active
- 2009-07-31 US US12/533,348 patent/US8378081B2/en active Active
-
2010
- 2010-08-05 US US12/851,233 patent/US20110097319A1/en not_active Abandoned
-
2012
- 2012-10-12 JP JP2012226553A patent/JP5765857B2/ja active Active
-
2013
- 2013-02-06 US US13/760,936 patent/US9090680B2/en active Active
- 2013-08-02 HK HK13109030.8A patent/HK1181789A1/xx unknown
-
2014
- 2014-09-11 AU AU2014224074A patent/AU2014224074A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SG188116A1 (en) | 2013-03-28 |
| ES2617604T3 (es) | 2017-06-19 |
| CA2714413A1 (en) | 2009-08-13 |
| KR101616136B1 (ko) | 2016-04-27 |
| US20130149316A1 (en) | 2013-06-13 |
| JP5113853B2 (ja) | 2013-01-09 |
| EP2246427A4 (en) | 2012-04-25 |
| US8378081B2 (en) | 2013-02-19 |
| US20100028357A1 (en) | 2010-02-04 |
| US9090680B2 (en) | 2015-07-28 |
| CN102124105A (zh) | 2011-07-13 |
| KR20100113623A (ko) | 2010-10-21 |
| JP5765857B2 (ja) | 2015-08-19 |
| HUE031944T2 (en) | 2017-08-28 |
| EP2246427A1 (en) | 2010-11-03 |
| JPWO2009099176A1 (ja) | 2011-05-26 |
| DK2246427T3 (da) | 2017-02-20 |
| WO2009099176A1 (ja) | 2009-08-13 |
| EP2246427B1 (en) | 2016-11-30 |
| AU2009211635B2 (en) | 2014-06-26 |
| CA2714413C (en) | 2017-01-24 |
| HK1181789A1 (en) | 2013-11-15 |
| EP3121277B1 (en) | 2018-04-11 |
| US20110097319A1 (en) | 2011-04-28 |
| JP2013063976A (ja) | 2013-04-11 |
| EP3121277A1 (en) | 2017-01-25 |
| PL2246427T3 (pl) | 2017-06-30 |
| AU2014224074A1 (en) | 2014-10-02 |
| CN102936287A (zh) | 2013-02-20 |
| CN102936287B (zh) | 2015-09-09 |
| AU2009211635A1 (en) | 2009-08-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT2246427T (pt) | Anticorpos capazes de se ligar especificamente a oligómeros beta amilóides e a sua utilização | |
| HK1256622A1 (zh) | Il-6的抗體和其用途 | |
| HK1220706A1 (zh) | 特異性結合蛋白及其用途 | |
| HK1216028A1 (zh) | 定向於 的抗體及其用途 | |
| ZA201003496B (en) | Monoclonal antibody capable of binding to anexelekto,and use thereof | |
| IL230771A (en) | Antibody from a person that binds pcsk9 | |
| IL232276A0 (en) | Antibodies to 6-il and their uses | |
| HUE042940T2 (hu) | Anti-FXI antitestek és alkalmazási eljárások | |
| IL209309A0 (en) | Anti-fn14 antibodies and uses thereof | |
| ZA201100058B (en) | Prostaglandin e2 binding proteins and uses thereof | |
| EP2427479A4 (en) | ANTIBODIES AND METHODS OF USE THEREOF | |
| IL216731A (en) | And antibodies against p95 – her2 and their uses | |
| EP2481754A4 (en) | SPECIFIC BINDING PROTEINS AND USES THEREOF | |
| IL211623A0 (en) | Anti-notch2 antibodies and methods of use | |
| IL215795A0 (en) | Anti-il-17f antibodies and methods of use thereof | |
| EP2185719A4 (en) | RANTES ANTIBODIES AND METHOD FOR THEIR USE | |
| EP2388320A4 (en) | ANTI-HS6ST2 ANTIBODIES AND USE THEREOF |