HK1164869A1 - 氮雜二環式化合物或其鹽 - Google Patents

氮雜二環式化合物或其鹽

Info

Publication number
HK1164869A1
HK1164869A1 HK12105624.9A HK12105624A HK1164869A1 HK 1164869 A1 HK1164869 A1 HK 1164869A1 HK 12105624 A HK12105624 A HK 12105624A HK 1164869 A1 HK1164869 A1 HK 1164869A1
Authority
HK
Hong Kong
Prior art keywords
salt
azabicyclo compound
azabicyclo
compound
Prior art date
Application number
HK12105624.9A
Other languages
English (en)
Inventor
Makoto Kitade
Shuichi Ohkubo
Chihoko Yoshimura
Satoshi Yamashita
Hiromi Oshiumi
Takao Uno
Yuichi Kawai
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of HK1164869A1 publication Critical patent/HK1164869A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK12105624.9A 2009-07-10 2012-06-08 氮雜二環式化合物或其鹽 HK1164869A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009164196 2009-07-10
PCT/JP2010/004466 WO2011004610A1 (ja) 2009-07-10 2010-07-09 アザ二環式化合物又はその塩

Publications (1)

Publication Number Publication Date
HK1164869A1 true HK1164869A1 (zh) 2012-09-28

Family

ID=43429037

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12105624.9A HK1164869A1 (zh) 2009-07-10 2012-06-08 氮雜二環式化合物或其鹽

Country Status (19)

Country Link
US (2) US8779142B2 (zh)
EP (1) EP2452940B1 (zh)
JP (1) JP5227456B2 (zh)
KR (1) KR101609412B1 (zh)
CN (2) CN102471335B (zh)
AU (1) AU2010269674B2 (zh)
BR (1) BRPI1013999B1 (zh)
CA (1) CA2767556C (zh)
DK (1) DK2452940T3 (zh)
ES (1) ES2527222T3 (zh)
HK (1) HK1164869A1 (zh)
MX (1) MX2012000487A (zh)
MY (1) MY152972A (zh)
PL (1) PL2452940T3 (zh)
PT (1) PT2452940E (zh)
RU (1) RU2565078C2 (zh)
SG (1) SG177306A1 (zh)
TW (1) TWI460177B (zh)
WO (1) WO2011004610A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103140490A (zh) 2010-07-15 2013-06-05 百时美施贵宝公司 氮杂吲唑化合物
US9266880B2 (en) 2010-11-12 2016-02-23 Bristol-Myers Squibb Company Substituted azaindazole compounds
JP5792201B2 (ja) * 2011-01-07 2015-10-07 大鵬薬品工業株式会社 新規二環式化合物又はその塩
MX2013007937A (es) 2011-01-07 2013-11-01 Taiho Pharmaceutical Co Ltd Nuevo derivado de indol o indazol o sal del mismo.
US8969586B2 (en) 2011-09-27 2015-03-03 Bristol-Myers Squibb Company Substituted bicyclic heteroaryl compounds
JP6242885B2 (ja) 2012-06-27 2017-12-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ５−アザインダゾール化合物及び使用方法
BR112016003247B1 (pt) 2013-08-22 2022-05-10 Taiho Pharmaceutical Co., Ltd Composto substituído por quinolina, composição farmacêutica compreendendo o referido composto e seu uso
RU2657783C2 (ru) * 2013-09-30 2018-06-15 Тайхо Фармасьютикал Ко., Лтд. Комбинированная терапия с использованием азабициклосоединения для ракового заболевания
JP6479669B2 (ja) * 2013-10-02 2019-03-06 大鵬薬品工業株式会社 耐性変異型９０ｋＤａ熱ショックタンパク質
KR102412146B1 (ko) 2015-02-11 2022-06-22 주식회사 아이엔테라퓨틱스 소디움 채널 차단제
AU2016260279B2 (en) * 2015-05-12 2019-03-14 Taiho Pharmaceutical Co., Ltd. Crystals of azabicyclic compound
JOP20190073A1 (ar) 2016-10-31 2019-04-07 Taiho Pharmaceutical Co Ltd مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20
CN108976150B (zh) * 2017-06-05 2022-11-18 重庆博腾制药科技股份有限公司 一种3-乙基-4-氟苯腈的制备方法
CN110831594A (zh) * 2017-06-30 2020-02-21 大鹏药品工业株式会社 使用氮杂双环式化合物的癌症化学疗法
DK3677266T5 (da) 2017-09-01 2024-08-26 Taiho Pharmaceutical Co Ltd Exon-18- og/eller exon-21-mutant egfr-selektiv hæmmer
WO2019054465A1 (ja) 2017-09-15 2019-03-21 大鵬薬品工業株式会社 Ｉｄｏの発現が関与する疾患の予防及び／又は治療剤
WO2019220512A1 (ja) 2018-05-14 2019-11-21 大鵬薬品工業株式会社 アザ二環式化合物による悪性腫瘍の治療法
EP4229053A1 (en) * 2020-10-14 2023-08-23 Ranok Therapeutics (Hangzhou) Co. Ltd. Methods and compositions for targeted protein degradation
CN114685492A (zh) * 2020-12-31 2022-07-01 杭州领业医药科技有限公司 Tas-116的晶型及其制备方法、药物组合物和用途
TW202245774A (zh) * 2021-02-05 2022-12-01 大陸商上海齊魯製藥研究中心有限公司 嘧啶或吡啶並雜環類腺苷受體抑制劑及其製備方法和用途
CN117003754A (zh) * 2022-04-28 2023-11-07 腾讯科技（深圳）有限公司 吡咯并[2,3-d]嘧啶或吡唑并[3,4-d]嘧啶衍生物及其用途
CN115960100B (zh) * 2022-12-28 2023-08-18 北京康立生医药技术开发有限公司 一种治疗胃肠道间质瘤药物皮咪特昔布的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
CN101906106A (zh) * 2003-09-18 2010-12-08 康福玛医药公司 作为hsp90-抑制剂的新的杂环化合物
CA2557004A1 (en) * 2003-12-19 2005-06-30 Glaxo Group Limited Pyrazolo [3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors
GB0425035D0 (en) 2004-11-12 2004-12-15 Novartis Ag Organic compounds
MX2007014327A (es) * 2005-05-16 2008-02-11 Irm Llc Derivados de pirrolopiridina como inhibidores de cinasa de proteina.
WO2007021966A1 (en) 2005-08-12 2007-02-22 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate hsp90 activity
US20070185184A1 (en) 2005-09-16 2007-08-09 Serenex, Inc. Carbazole derivatives
US20080119457A1 (en) 2006-08-24 2008-05-22 Serenex, Inc. Benzene, Pyridine, and Pyridazine Derivatives
GB0617161D0 (en) 2006-08-31 2006-10-11 Vernalis R&D Ltd Enzyme inhibitors
EA019103B1 (ru) 2007-03-20 2014-01-30 Кьюрис, Инк. Конденсированный аминопиридин в качестве ингибиторов hsp90
JP5529004B2 (ja) * 2007-03-27 2014-06-25 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０阻害剤として有用なトリアジノンおよびジアジノン誘導体
AR075874A1 (es) 2009-03-19 2011-05-04 Sanofi Aventis Derivados de indazol inhibidores de hsp90 composiciones que los contienen y utilizacion
MX2013007937A (es) 2011-01-07 2013-11-01 Taiho Pharmaceutical Co Ltd Nuevo derivado de indol o indazol o sal del mismo.
JP5792201B2 (ja) 2011-01-07 2015-10-07 大鵬薬品工業株式会社 新規二環式化合物又はその塩

Also Published As

Publication number Publication date
US20120108589A1 (en) 2012-05-03
MX2012000487A (es) 2012-01-27
TWI460177B (zh) 2014-11-11
AU2010269674B2 (en) 2014-01-16
US9273045B2 (en) 2016-03-01
PT2452940E (pt) 2015-02-27
AU2010269674A1 (en) 2012-01-19
ES2527222T3 (es) 2015-01-21
US20140303162A1 (en) 2014-10-09
EP2452940A4 (en) 2012-12-12
BRPI1013999B1 (pt) 2020-06-02
CA2767556A1 (en) 2011-01-13
WO2011004610A1 (ja) 2011-01-13
EP2452940B1 (en) 2014-12-17
PL2452940T3 (pl) 2015-05-29
CN102471335B (zh) 2015-09-30
RU2565078C2 (ru) 2015-10-20
KR101609412B1 (ko) 2016-04-05
US8779142B2 (en) 2014-07-15
JPWO2011004610A1 (ja) 2012-12-20
RU2012104700A (ru) 2013-08-20
CN102471335A (zh) 2012-05-23
DK2452940T3 (en) 2015-01-12
BRPI1013999A2 (pt) 2016-04-05
AU2010269674A2 (en) 2012-02-16
JP5227456B2 (ja) 2013-07-03
EP2452940A1 (en) 2012-05-16
TW201105670A (en) 2011-02-16
SG177306A1 (en) 2012-02-28
KR20120035181A (ko) 2012-04-13
CN104710420A (zh) 2015-06-17
MY152972A (en) 2014-12-15
CN104710420B (zh) 2016-07-27
CA2767556C (en) 2017-11-28

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