HK1158989A1 - Methods of use for cyclopamine analogs (cyclopamine) - Google Patents
Methods of use for cyclopamine analogs (cyclopamine)Info
- Publication number
- HK1158989A1 HK1158989A1 HK11113839.5A HK11113839A HK1158989A1 HK 1158989 A1 HK1158989 A1 HK 1158989A1 HK 11113839 A HK11113839 A HK 11113839A HK 1158989 A1 HK1158989 A1 HK 1158989A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cyclopamine
- methods
- analogs
- cyclopamine analogs
- Prior art date
Links
- QASFUMOKHFSJGL-LAFRSMQTSA-N Cyclopamine Chemical class C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H](CC2=C3C)[C@@H]1[C@@H]2CC[C@@]13O[C@@H]2C[C@H](C)CN[C@H]2[C@H]1C QASFUMOKHFSJGL-LAFRSMQTSA-N 0.000 title 2
- QASFUMOKHFSJGL-UHFFFAOYSA-N cyclopamine Natural products C1C=C2CC(O)CCC2(C)C(CC2=C3C)C1C2CCC13OC2CC(C)CNC2C1C QASFUMOKHFSJGL-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4747—Quinolines; Isoquinolines spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87801806P | 2006-12-28 | 2006-12-28 | |
US94159607P | 2007-06-01 | 2007-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1158989A1 true HK1158989A1 (en) | 2012-07-27 |
Family
ID=39589207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11113839.5A HK1158989A1 (en) | 2006-12-28 | 2011-12-22 | Methods of use for cyclopamine analogs (cyclopamine) |
Country Status (26)
Country | Link |
---|---|
US (18) | US7812164B2 (es) |
EP (4) | EP2368551B1 (es) |
JP (2) | JP5542448B2 (es) |
KR (2) | KR101489394B1 (es) |
CN (2) | CN101677551B (es) |
AR (1) | AR081107A1 (es) |
AU (2) | AU2007339786B2 (es) |
BR (2) | BRPI0720993B8 (es) |
CA (2) | CA2673995C (es) |
CL (1) | CL2007003854A1 (es) |
DK (1) | DK2096917T3 (es) |
ES (2) | ES2612746T3 (es) |
HK (1) | HK1158989A1 (es) |
IL (1) | IL199554B (es) |
JO (1) | JO2947B1 (es) |
MX (3) | MX2009007075A (es) |
NO (3) | NO347310B1 (es) |
NZ (2) | NZ578053A (es) |
PE (1) | PE20090042A1 (es) |
PL (1) | PL2096917T3 (es) |
PT (1) | PT2096917E (es) |
RU (2) | RU2492859C2 (es) |
SG (2) | SG177930A1 (es) |
TW (1) | TWI433674B (es) |
WO (2) | WO2008083248A2 (es) |
ZA (2) | ZA200904445B (es) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005280112B2 (en) | 2004-08-27 | 2012-07-19 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
JP2010520295A (ja) * | 2007-03-07 | 2010-06-10 | インフィニティ・ディスカバリー・インコーポレイテッド | へテロ環状シクロパミン類似体及びその使用方法 |
NZ579356A (en) | 2007-03-07 | 2012-04-27 | Infinity Pharmaceuticals Inc | Cyclopamine lactam analogs and methods of use thereof |
CN104059124A (zh) * | 2007-12-27 | 2014-09-24 | 无限药品股份有限公司 | 立体选择性还原的方法 |
US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
US20090181997A1 (en) * | 2007-12-27 | 2009-07-16 | Grayzel David | Therapeutic cancer treatments |
US20100222287A1 (en) * | 2007-12-27 | 2010-09-02 | Mcgovern Karen J | Therapeutic Cancer Treatments |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
CN101990542A (zh) * | 2008-02-08 | 2011-03-23 | 德克萨斯大学董事会 | 环巴胺酒石酸盐及其用途 |
WO2010080817A2 (en) * | 2009-01-06 | 2010-07-15 | Utah State University | Carbohydrate-cyclopamine conjugates as anticancer agents |
CA2750639A1 (en) * | 2009-01-23 | 2010-07-29 | Cancer Research Technology Limited | Hedgehog pathway inhibitors |
WO2011017551A1 (en) * | 2009-08-05 | 2011-02-10 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
US20110065645A1 (en) * | 2009-09-10 | 2011-03-17 | The Regents Of The University Of California | Compositions and Methods for Modulating Neuron Degeneration and Neuron Guidance |
CA2779424A1 (en) * | 2009-11-06 | 2011-05-12 | Infinity Pharmaceuticals, Inc. | Oral formulations of a hedgehog pathway inhibitor |
WO2011063309A1 (en) * | 2009-11-20 | 2011-05-26 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
WO2011088404A1 (en) * | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
CN103002738A (zh) | 2010-05-21 | 2013-03-27 | 英特利凯恩有限责任公司 | 用于激酶调节的化学化合物、组合物和方法 |
WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
AU2011326427B2 (en) | 2010-11-10 | 2016-01-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
BR112013017670B1 (pt) | 2011-01-10 | 2022-07-19 | Infinity Pharmaceuticals, Inc | Processos de preparação de isoquinolinonas e formas sólidas de isoquinolinonas |
WO2013012915A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
CA2846431A1 (en) | 2011-08-29 | 2013-03-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
CA2752008A1 (en) * | 2011-09-13 | 2013-03-13 | Universite De Montreal | Combination therapy using ribavirin as elf4e inhibitor |
US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9399035B2 (en) | 2012-03-06 | 2016-07-26 | The Board Of Trustees Of The University Of Illinois | Procaspase 3 activation by combination therapy |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
MX355261B (es) | 2012-06-21 | 2018-04-12 | Eisai R&D Man Co Ltd | Derivado de indanosulfamida novedoso. |
TR201812261T4 (tr) | 2012-11-01 | 2018-11-21 | Infinity Pharmaceuticals Inc | Pi3 ki̇naz i̇zoform modülatörleri̇ i̇le kanser tedavi̇si̇ |
EP2925363A4 (en) | 2012-11-29 | 2016-11-09 | Strasspharma Llc | METHOD FOR MODULATING FOLLICLE-STIMULATING HORMONACTIVITY |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
NZ629037A (en) | 2013-03-15 | 2017-04-28 | Infinity Pharmaceuticals Inc | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
SG11201509842SA (en) | 2013-05-30 | 2015-12-30 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
MY175778A (en) | 2013-10-04 | 2020-07-08 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
US20160244452A1 (en) | 2013-10-21 | 2016-08-25 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2932529C (en) | 2013-12-19 | 2022-03-22 | Eisai R&D Management Co., Ltd. | Therapeutic and/or preventive agent comprising 1-indansulfamide derivative for pain |
CN106456628A (zh) | 2014-03-19 | 2017-02-22 | 无限药品股份有限公司 | 用于治疗PI3K‑γ介导的障碍的杂环化合物 |
WO2015160986A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
CN105232562B (zh) * | 2014-07-07 | 2019-06-28 | 中国科学院上海巴斯德研究所 | 一种人呼吸道合胞病毒的抑制剂和抗病毒药物设计靶点 |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP3302428A1 (en) | 2015-06-04 | 2018-04-11 | Pellepharm Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
WO2017139497A1 (en) * | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
CN105622708B (zh) | 2016-02-14 | 2017-10-10 | 山东大学 | 治疗呼吸道合胞病毒感染的化合物及其制备方法与用途 |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
BR112018070199A2 (pt) | 2016-04-01 | 2019-01-29 | Therapeuticsmd Inc | composição farmacêutica de hormônio esteroide |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
MX2018016227A (es) | 2016-06-24 | 2019-07-08 | Infinity Pharmaceuticals Inc | Terapias de combinacion. |
KR20240023684A (ko) | 2016-09-13 | 2024-02-22 | 알레간 인코포레이티드 | 안정화된 비단백질 클로스트리듐 독소 조성물 |
SG11202004384YA (en) | 2017-11-17 | 2020-06-29 | Univ Illinois | Cancer therapy by degrading dual mek signaling |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
CN113461771B (zh) * | 2020-03-31 | 2022-09-30 | 南方科技大学 | 钠钾atp酶抑制剂的制备方法 |
Family Cites Families (146)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6333341A (ja) | 1986-07-28 | 1988-02-13 | Seitetsu Kagaku Co Ltd | 配糖体の処理方法 |
US4843071A (en) | 1986-12-05 | 1989-06-27 | Serotonin Industries Of Charleston | Method and composition for treating obesity, drug abuse, and narcolepsy |
JP2851054B2 (ja) | 1989-03-15 | 1999-01-27 | サントリー株式会社 | ベンズオキセピン誘導体 |
US5169780A (en) | 1989-06-22 | 1992-12-08 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
FR2656310B1 (fr) | 1989-12-22 | 1992-05-07 | Roussel Uclaf | Nouveaux produits sterouides comportant en position 10, un radical thioethyle substitue, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
CA2157594A1 (en) | 1993-03-10 | 1994-09-15 | Leah L. Frye | Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants |
IT1265001B1 (it) | 1993-12-16 | 1996-10-17 | Zambon Spa | Composizione farmaceutica per uso topico contenente acido (s)-2-(4- isobutilfenil) propionico |
CA2179029C (en) | 1993-12-30 | 2009-02-24 | Philip W. Ingham | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
EP0897300A4 (en) | 1995-10-10 | 2000-07-05 | Marilyn Strube | TREATMENT OF PRURITUS WITH VITAMIN D AND ITS ANALOGS |
US6887820B1 (en) | 1995-12-06 | 2005-05-03 | Japan Science And Technology Corporation | Method for producing optically active compounds |
EP1300381B1 (en) | 1995-12-06 | 2006-03-08 | Japan Science and Technology Agency | Process for preparing optically active alcohols |
GB9706321D0 (en) | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Catalytic hydrogenation |
US7709454B2 (en) | 1997-06-20 | 2010-05-04 | New York University | Methods and compositions for inhibiting tumorigenesis |
US6238876B1 (en) | 1997-06-20 | 2001-05-29 | New York University | Methods and materials for the diagnosis and treatment of sporadic basal cell carcinoma |
US7741298B2 (en) | 1997-06-20 | 2010-06-22 | New York University | Method and compositions for inhibiting tumorigenesis |
US7361336B1 (en) | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
US6231875B1 (en) | 1998-03-31 | 2001-05-15 | Johnson & Johnson Consumer Companies, Inc. | Acidified composition for topical treatment of nail and skin conditions |
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
US6867216B1 (en) | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
EP1105149A1 (en) * | 1998-08-13 | 2001-06-13 | University Of Southern California | Methods to increase blood flow to ischemic tissue |
GB9821067D0 (en) | 1998-09-29 | 1998-11-18 | Zeneca Ltd | Transfer hydrogenation process |
US6291516B1 (en) | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
FR2796938B1 (fr) | 1999-07-29 | 2004-04-02 | Ppg Sipsy | Nouveaux derives chiraux n-substitues de la norephedrine, leur preparation et leur utilisation pour la synthese de composes fonctionnalises optiquement actifs par transfert d'hydrogene |
US6545005B1 (en) | 1999-09-16 | 2003-04-08 | Curtis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
US20070021493A1 (en) | 1999-09-16 | 2007-01-25 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
US6993456B2 (en) | 1999-09-30 | 2006-01-31 | Rockwell Automation Technologies, Inc. | Mechanical-electrical template based method and apparatus |
DE60028411T2 (de) * | 1999-10-13 | 2007-01-04 | Johns Hopkins University School Of Medicine | Verbindungen zur regulierung des hedgehog-signalwegs, zusammensetzungen und verwendungen davon |
US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
CA2388468C (en) | 1999-10-14 | 2011-01-25 | Curis, Inc. | Mediators of hedgehog signalling pathways, compositions and uses related thereto |
US6893637B1 (en) | 1999-10-21 | 2005-05-17 | Zymogenetics, Inc. | Method of treating fibrosis |
IL133809A0 (en) | 1999-12-30 | 2001-04-30 | Yeda Res & Dev | Steroidal alkaloids and pharmaceutical compositions comprising them |
KR20010077591A (ko) | 2000-02-03 | 2001-08-20 | 복성해 | 아라니콜라 프로테오리티쿠스에서 분리한 신규 금속성단백질 분해효소 및 그의 유전자 |
US6613798B1 (en) | 2000-03-30 | 2003-09-02 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
DE60113823T3 (de) | 2000-03-30 | 2010-07-01 | Curis, Inc., Cambridge | Kleine organische moleküle als regulatoren der zellproliferation |
AU2001264595A1 (en) | 2000-05-19 | 2001-12-03 | Guilford Pharmaceuticals Inc. | Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses |
WO2002030462A2 (en) | 2000-10-13 | 2002-04-18 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
GB0029356D0 (en) | 2000-12-01 | 2001-01-17 | Avecia Ltd | Transfer hydrogenation |
US6456928B1 (en) | 2000-12-29 | 2002-09-24 | Honeywell International Inc. | Prognostics monitor for systems that are subject to failure |
RU2708563C2 (ru) | 2001-03-16 | 2019-12-10 | Алза Корпорейшн | Трансдермальный пластырь для введения фентанила |
EP1401469A2 (en) | 2001-04-09 | 2004-03-31 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
AUPR602401A0 (en) | 2001-06-29 | 2001-07-26 | Smart Drug Systems Inc | Sustained release delivery system |
EP2216022B1 (en) | 2001-07-02 | 2015-01-07 | Sinan Tas | Use of cyclopamine in the treatment of basal cell carcinoma and other tumors |
RU2308948C2 (ru) * | 2001-07-02 | 2007-10-27 | ТАШ Шинан | Применение циклопамина для лечения базально-клеточной эпителиомы (карциномы) и других опухолей |
CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
CN1638765A (zh) | 2001-07-27 | 2005-07-13 | 柯里斯公司 | Hedgehog信号转导途径介质、其相关组合物以及应用 |
JP2003192919A (ja) | 2001-10-17 | 2003-07-09 | Asahi Denka Kogyo Kk | 難燃性合成樹脂組成物 |
WO2003040150A1 (en) | 2001-11-09 | 2003-05-15 | Yun Chi | Volatile noble metal organometallic complexes |
US7105637B2 (en) | 2002-02-15 | 2006-09-12 | William Marsh Rice University | Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), methods of their synthesis |
EP1490031A1 (en) * | 2002-03-07 | 2004-12-29 | Vectura Limited | Fast melt multiparticulate formulations for oral delivery |
ATE370952T1 (de) | 2002-04-19 | 2007-09-15 | Smithkline Beecham Corp | Neue verbindungen |
DE60322869D1 (de) | 2002-04-22 | 2008-09-25 | Univ Johns Hopkins | Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen |
GB0210234D0 (en) | 2002-05-03 | 2002-06-12 | Novartis Ag | Process for the manufacture of organic compounds |
CN1671724A (zh) | 2002-06-20 | 2005-09-21 | 日本水产株式会社 | 前药、其作为医药的应用及其制法 |
WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
GB0221539D0 (en) | 2002-09-17 | 2002-10-23 | Medical Res Council | Methods of treatment |
GB0230217D0 (en) | 2002-12-27 | 2003-02-05 | Biotica Tech Ltd | Borrelidin-producing polyketide synthase and its uses |
FR2850022B1 (fr) | 2003-01-22 | 2006-09-08 | Centre Nat Rech Scient | Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications |
EP1639097B1 (en) | 2003-06-25 | 2013-08-07 | Ottawa Health Research Institute | Methods and compositions for modulating stem cell growth and differentiation |
WO2005013800A2 (en) | 2003-07-15 | 2005-02-17 | The Johns Hopkins University | Elevated hedgehog pathway activity in digestive system tumors, and methods of treating digestive system tumors having elevated hedgehog pathway activity |
WO2005033288A2 (en) | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
US20080095761A1 (en) | 2003-10-01 | 2008-04-24 | The Johns Hopkins University | Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis |
US20070231828A1 (en) | 2003-10-01 | 2007-10-04 | Johns Hopkins University | Methods of predicting behavior of cancers |
EP1673437A4 (en) | 2003-10-01 | 2007-07-11 | Invitrogen Corp | COMPOSITIONS AND METHODS FOR SYNTHESIS, PURIFICATION AND DETECTION OF BIOMOLECULES |
US20080057071A1 (en) | 2003-10-20 | 2008-03-06 | Watkins David N | Use Of Hedgehog Pathway Inhibitors In Small-Cell Lung Cancer |
US20070219250A1 (en) | 2003-11-28 | 2007-09-20 | Romi Singh | Pharmaceutical Compositions of Nateglinide |
DK1745041T3 (da) | 2004-04-30 | 2012-09-24 | Genentech Inc | Quinoxalin-inhibitorer af hedgehog-signaleringsvejen |
AU2005280112B2 (en) | 2004-08-27 | 2012-07-19 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
CN102964294A (zh) | 2004-09-02 | 2013-03-13 | 遗传技术研究公司 | Hedgehog信号转导的吡啶基抑制剂 |
WO2006039569A1 (en) | 2004-09-30 | 2006-04-13 | The University Of Chicago | Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents |
BRPI0517253A (pt) | 2004-10-28 | 2008-10-07 | Irm Llc | compostos e composições como moduladores de trajetória de ouriço |
US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
US20060252073A1 (en) | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
AU2006249199A1 (en) | 2005-05-12 | 2006-11-23 | Introgen Therapeutics, Inc. | P53 vaccines for the treatment of cancers |
JP5435946B2 (ja) | 2005-08-22 | 2014-03-05 | ジョンズ ホプキンス ユニバーシティ | 疾患を処置するためのヘッジホッグ経路アンタゴニスト |
JP4712524B2 (ja) | 2005-10-28 | 2011-06-29 | 富士通コンポーネント株式会社 | 入力デバイス及び電子機器 |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20070197473A1 (en) | 2005-11-04 | 2007-08-23 | Frankel Stanley R | Methods of using SAHA and Bortezomib for treating cancer |
EP1945202A2 (en) | 2005-11-11 | 2008-07-23 | Licentia OY | Mammalian hedgehog signaling inhiabitors |
DK1957461T3 (en) | 2005-11-14 | 2016-12-19 | Genentech Inc | Bisamidhæmmere the hedgehog-signalling |
WO2007076294A2 (en) | 2005-12-15 | 2007-07-05 | Wei Chen | Method of screening the activity of the smoothened receptor to identify theraputic modulation agents or diagnose disease |
EP1978973B1 (en) | 2005-12-27 | 2011-11-16 | Genentech, Inc. | Use hedgehog kinase antagonists to inhibit hedgehog signaling and to treat cancer |
EP1818411A1 (en) | 2006-02-13 | 2007-08-15 | Lonza AG | Process for the preparation of optically active chiral amines |
EP1998785A4 (en) | 2006-02-21 | 2009-06-17 | Univ Michigan | CANCER TREATMENT USING A HEDGEHOG SIGNALING PATH |
US20110034498A1 (en) | 2006-03-24 | 2011-02-10 | Mcgovern Karen J | Dosing regimens for the treatment of cancer |
EP2010170A2 (en) | 2006-04-14 | 2009-01-07 | Novartis AG | Use of biarylcarboxamides in the treatment of hedgehog pathway-related disorders |
UA93548C2 (uk) | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
DE102006031358A1 (de) * | 2006-07-05 | 2008-01-17 | Schott Ag | Verfahren zur Gehäusung optischer oder optoelektronischer Bauteile, sowie verfahrensgemäß herstellbares optisches oder optoelektronisches Gehäuseelement |
WO2008011071A2 (en) | 2006-07-19 | 2008-01-24 | The Regents Of The University Of California | Interactions of hedgehog and liver x receptor signaling pathways |
PE20080948A1 (es) | 2006-07-25 | 2008-09-10 | Irm Llc | Derivados de imidazol como moduladores de la senda de hedgehog |
US20090305338A1 (en) | 2006-09-29 | 2009-12-10 | Anneli Ritala-Nurmi | Plant cell lines established from the medicinal plant veratrum californicum |
CN101583379B (zh) | 2006-10-05 | 2013-04-03 | 约翰斯霍普金斯大学 | 使用优良聚合物纳米粒子的水溶性差药物的水可分散性口服,肠胃外和局部制剂 |
JP5399255B2 (ja) | 2006-10-31 | 2014-01-29 | アメリカ合衆国 | スムースンドポリペプチドおよび使用方法 |
US20080103116A1 (en) | 2006-11-01 | 2008-05-01 | Jennings-Spring Barbara L | Method of treatment and compositions of D-chiro inositol and phosphates thereof |
US20080182859A1 (en) | 2006-11-02 | 2008-07-31 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
AU2006350960B2 (en) | 2006-11-20 | 2013-09-12 | Satori Pharmaceuticals, Inc. | Compounds useful for treating neurodegenerative disorders |
WO2008063166A1 (en) | 2006-11-20 | 2008-05-29 | Thomson Licensing | Method for eliminating redundant connections |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
WO2008089123A2 (en) | 2007-01-12 | 2008-07-24 | Infinity Discovery, Inc. | Methods for analysis of hedgehog pathway inhibitors |
FI123481B (fi) | 2007-02-05 | 2013-05-31 | Upm Kymmene Corp | Menetelmä painopaperin valmistamiseksi ja seoskoostumus |
NZ579356A (en) * | 2007-03-07 | 2012-04-27 | Infinity Pharmaceuticals Inc | Cyclopamine lactam analogs and methods of use thereof |
JP2010520295A (ja) * | 2007-03-07 | 2010-06-10 | インフィニティ・ディスカバリー・インコーポレイテッド | へテロ環状シクロパミン類似体及びその使用方法 |
NZ579480A (en) | 2007-03-14 | 2012-03-30 | Exelixis Patent Co Llc | 2-Arylamino-quinazoline derivatives |
DK2137162T3 (en) | 2007-03-15 | 2018-11-26 | Novartis Ag | Organic compounds and their applications |
US9095589B2 (en) | 2007-04-05 | 2015-08-04 | Johns Hopkins University | Chirally pure isomers of itraconazole for use as angiogenesis inhibitors |
EP2136803B1 (en) | 2007-04-18 | 2012-05-02 | Merck Sharp & Dohme Corp. | Triazole derivatives which are smo antagonists |
US20090054517A1 (en) | 2007-04-20 | 2009-02-26 | Lubahn Dennis B | Phytoestrogens As Regulators Of Hedgehog Signaling And Methods Of Their Use In Cancer Treatment |
US9296776B2 (en) | 2007-07-09 | 2016-03-29 | Eastern Virginia Medical School | Substituted nucleoside derivatives with antiviral and antimicrobial properties |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
WO2009049258A1 (en) * | 2007-10-12 | 2009-04-16 | The Johns Hopkins University | Compounds for hedgehog pathway blockade in proliferative disorders, including hematopoietic malignancies |
BRPI0820856A2 (pt) | 2007-12-13 | 2019-05-14 | Siena Bhiotech.S.P.A. | anatagonista da série de reação de hedgehog e aplicações terapêuticas dos mesmos |
US20100297118A1 (en) | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
CN104059124A (zh) | 2007-12-27 | 2014-09-24 | 无限药品股份有限公司 | 立体选择性还原的方法 |
US20090181997A1 (en) | 2007-12-27 | 2009-07-16 | Grayzel David | Therapeutic cancer treatments |
US20100222287A1 (en) | 2007-12-27 | 2010-09-02 | Mcgovern Karen J | Therapeutic Cancer Treatments |
CN101990542A (zh) | 2008-02-08 | 2011-03-23 | 德克萨斯大学董事会 | 环巴胺酒石酸盐及其用途 |
US20090246841A1 (en) | 2008-03-26 | 2009-10-01 | Jamieson Andrew C | Methods and compositions for production of acetaldehyde |
US20110217294A1 (en) | 2008-04-11 | 2011-09-08 | Daniel Fults | Combination of hgf inhibitor and hedgehog inhibitor to treat cancer |
CL2009001479A1 (es) | 2008-07-02 | 2010-01-04 | Infinity Pharmaceuticals Inc | Metodo para aislar un alcaloide del veratrum desglicosilado que comprende proporcionar un material de planta veratrum, poner en contacto con una solucion acuosa y extraer el material de la planta veratrum con un solvente para proporcionar un extracto que comprende dicho alcaloide. |
CA2636807A1 (en) | 2008-07-04 | 2010-01-04 | Steven Splinter | Methods for obtaining cyclopamine |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
NZ591420A (en) | 2008-09-17 | 2012-07-27 | Novartis Ag | Salts of n-[6-cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide |
EP3492492A1 (en) | 2008-09-22 | 2019-06-05 | Aileron Therapeutics, Inc. | Methods for preparing purified polypeptide compositions |
US20100081637A1 (en) | 2008-10-01 | 2010-04-01 | Innovia Skincare Corp. | Eczema treatment with vitamin D and analogs thereof method, composition and cream |
CA2750639A1 (en) | 2009-01-23 | 2010-07-29 | Cancer Research Technology Limited | Hedgehog pathway inhibitors |
AR077490A1 (es) | 2009-07-21 | 2011-08-31 | Novartis Ag | Composiciones farmaceuticas topicas para el tratamiento de una condicion hiperproliferativa de la piel |
WO2011017551A1 (en) | 2009-08-05 | 2011-02-10 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
CA2779424A1 (en) | 2009-11-06 | 2011-05-12 | Infinity Pharmaceuticals, Inc. | Oral formulations of a hedgehog pathway inhibitor |
WO2011063309A1 (en) | 2009-11-20 | 2011-05-26 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
WO2011088404A1 (en) | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
GB201010954D0 (en) | 2010-06-29 | 2010-08-11 | Edko Pazarlama Tanitim Ticaret | Compositions |
US20120010229A1 (en) | 2010-07-08 | 2012-01-12 | Macdougall John R | Therapeutic regimens for hedgehog-associated cancers |
US20120010230A1 (en) | 2010-07-08 | 2012-01-12 | Macdougall John R | Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling |
WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
CN102085176A (zh) | 2010-12-31 | 2011-06-08 | 江苏中丹制药有限公司 | 一种纳米级伊曲康唑外用制剂、其制备方法及其用途 |
US8865765B2 (en) | 2011-01-12 | 2014-10-21 | The William M. Yarbrough Foundation | Method for treating eczema |
EP2753179A4 (en) | 2011-09-09 | 2015-03-04 | Univ Leland Stanford Junior | TOPICAL FORMULATIONS OF ITRACONAZOLE AND USES THEREOF |
US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
MX2015007518A (es) | 2012-12-14 | 2016-03-01 | Trevi Therapeutics Inc | Metodos para tratar el prurito. |
US9452139B2 (en) | 2013-03-14 | 2016-09-27 | Novartis Ag | Respirable agglomerates of porous carrier particles and micronized drug |
PE20170331A1 (es) | 2014-03-24 | 2017-04-28 | Guangdong Zhongsheng Pharmaceutical Co Ltd | Derivados quinolina como inhibidores smo |
EP3302428A1 (en) | 2015-06-04 | 2018-04-11 | Pellepharm Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
WO2017139497A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
-
2007
- 2007-12-24 TW TW096149773A patent/TWI433674B/zh active
- 2007-12-27 EP EP11165825.8A patent/EP2368551B1/en active Active
- 2007-12-27 NZ NZ578053A patent/NZ578053A/xx unknown
- 2007-12-27 RU RU2009129000/15A patent/RU2492859C2/ru active
- 2007-12-27 SG SG2011096674A patent/SG177930A1/en unknown
- 2007-12-27 CN CN200780051112.8A patent/CN101677551B/zh active Active
- 2007-12-27 KR KR1020097015913A patent/KR101489394B1/ko active IP Right Grant
- 2007-12-27 MX MX2009007075A patent/MX2009007075A/es active IP Right Grant
- 2007-12-27 JP JP2009544277A patent/JP5542448B2/ja active Active
- 2007-12-27 JP JP2009544276A patent/JP5412292B2/ja active Active
- 2007-12-27 BR BRPI0720993A patent/BRPI0720993B8/pt active IP Right Grant
- 2007-12-27 RU RU2009128997/04A patent/RU2486194C2/ru active
- 2007-12-27 CA CA2673995A patent/CA2673995C/en active Active
- 2007-12-27 AU AU2007339786A patent/AU2007339786B2/en active Active
- 2007-12-27 EP EP11189894A patent/EP2443926A3/en not_active Withdrawn
- 2007-12-27 DK DK07870001.0T patent/DK2096917T3/da active
- 2007-12-27 ES ES07870006.9T patent/ES2612746T3/es active Active
- 2007-12-27 EP EP07870006.9A patent/EP2101580B1/en active Active
- 2007-12-27 BR BRPI0720972A patent/BRPI0720972B8/pt active IP Right Grant
- 2007-12-27 PL PL07870001T patent/PL2096917T3/pl unknown
- 2007-12-27 KR KR1020097015914A patent/KR101482693B1/ko active IP Right Grant
- 2007-12-27 SG SG2011096666A patent/SG177929A1/en unknown
- 2007-12-27 PT PT78700010T patent/PT2096917E/pt unknown
- 2007-12-27 CA CA2674302A patent/CA2674302C/en active Active
- 2007-12-27 MX MX2012007856A patent/MX342683B/es unknown
- 2007-12-27 US US11/965,688 patent/US7812164B2/en active Active
- 2007-12-27 ES ES07870001.0T patent/ES2488466T3/es active Active
- 2007-12-27 CN CN200780051114.7A patent/CN101631463B/zh active Active
- 2007-12-27 JO JO2007564A patent/JO2947B1/en active
- 2007-12-27 EP EP07870001.0A patent/EP2096917B1/en active Active
- 2007-12-27 AU AU2007339782A patent/AU2007339782B2/en active Active
- 2007-12-27 NO NO20190059A patent/NO347310B1/no unknown
- 2007-12-27 MX MX2009007077A patent/MX2009007077A/es active IP Right Grant
- 2007-12-27 NZ NZ577916A patent/NZ577916A/xx unknown
- 2007-12-27 US US11/965,675 patent/US8017648B2/en active Active
- 2007-12-27 WO PCT/US2007/088990 patent/WO2008083248A2/en active Application Filing
- 2007-12-27 WO PCT/US2007/088995 patent/WO2008083252A2/en active Application Filing
- 2007-12-28 CL CL200703854A patent/CL2007003854A1/es unknown
- 2007-12-28 AR ARP070105973A patent/AR081107A1/es active IP Right Grant
-
2008
- 2008-01-02 PE PE2008000074A patent/PE20090042A1/es active IP Right Grant
- 2008-08-27 US US12/199,689 patent/US8785635B2/en active Active
- 2008-08-27 US US12/199,722 patent/US8669365B2/en active Active
-
2009
- 2009-06-25 ZA ZA2009/04445A patent/ZA200904445B/en unknown
- 2009-06-25 IL IL199554A patent/IL199554B/en active IP Right Grant
- 2009-06-25 ZA ZA2009/04446A patent/ZA200904446B/en unknown
- 2009-07-20 NO NO20092711A patent/NO344315B1/no not_active IP Right Cessation
- 2009-07-20 NO NO20092710A patent/NO343748B1/no unknown
-
2011
- 2011-04-20 US US13/090,694 patent/US20110230509A1/en not_active Abandoned
- 2011-07-27 US US13/191,545 patent/US8227509B2/en active Active
- 2011-12-22 HK HK11113839.5A patent/HK1158989A1/xx unknown
-
2012
- 2012-05-18 US US13/475,352 patent/US8895576B2/en active Active
- 2012-05-18 US US13/475,510 patent/US20130108583A1/en not_active Abandoned
-
2013
- 2013-10-15 US US14/054,350 patent/US9145422B2/en active Active
-
2014
- 2014-03-10 US US14/203,297 patent/US9492435B2/en active Active
-
2015
- 2015-08-31 US US14/841,001 patent/US9669011B2/en active Active
-
2016
- 2016-10-10 US US15/289,887 patent/US9951083B2/en active Active
-
2017
- 2017-05-02 US US15/585,038 patent/US10045970B2/en active Active
-
2018
- 2018-03-27 US US15/936,919 patent/US10406139B2/en active Active
- 2018-07-27 US US16/047,008 patent/US10314827B2/en active Active
-
2019
- 2019-04-26 US US16/396,565 patent/US10821102B2/en active Active
- 2019-07-24 US US16/521,447 patent/US11007181B2/en active Active
-
2020
- 2020-09-28 US US17/035,611 patent/US11602527B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1158989A1 (en) | Methods of use for cyclopamine analogs (cyclopamine) | |
HK1139657A1 (en) | Heterocyclic cyclopamine analogs and methods of use thereof (cyclopamine) | |
ZA200906083B (en) | Cyclopamine lactam analogs and methods of use thereof | |
HK1112580A1 (en) | Analogs of ghrelin (ghrelin) | |
GB0621607D0 (en) | Inhibitors of c-Met | |
IL196706A0 (en) | Crystalline forms of rapamycin analogs | |
IL197006A0 (en) | Crystal forms of 9-hydroxy-risperidone (paliperidone) | |
ZA200900336B (en) | Process for the preparation of diesters | |
EP1888618A4 (en) | GLYCYL-PROLYL-GLUTAMATE ANALOGS | |
HK1110219A1 (en) | Use of prodrugs for ocular intravitreous administration | |
GB0907684D0 (en) | Process for preparation of alkoxysilanes | |
HK1119708A1 (en) | Methods of preparing quinolone analogs | |
TWM300818U (en) | Structure for accessory of eyeglasses set | |
EP2023720A4 (en) | TETRACYCLIC IMIDAZOLE ANALOGS | |
PL2102174T3 (pl) | Sposób wytwarzania pochodnych podstawionych cyjanofenoksy-pirymidynyloksyfenyloakrylanów | |
IL196320A0 (en) | Derivatives and analogs of n-ethylquinolones and n-ethylazaquinolones | |
EP2037916A4 (en) | PURE TRITOQUALINE ISOMERS | |
GB0700179D0 (en) | Use of epoxidised compounds | |
GB0722482D0 (en) | Apparatus of supplying organome compound | |
ZA200900740B (en) | Crystalline forms of rapamycin analogs | |
TWM298442U (en) | Improved structure of sprinkle-nozzle for fire-extinguisher | |
IL198836A0 (en) | Processes for preparation of 9-haloacetamidomidominocyclines | |
TWM298723U (en) | Structure of projecting apparatus | |
ZA200810632B (en) | Derivativs and analogs of N-ethylquinolones and N-ethylazaquinolones | |
SI1864667T1 (sl) | Uporaba predzdravil za okularno intravitrealno administracijo |