HK1157010A1 - 朊病毒蛋白配體及其使用方法 - Google Patents

朊病毒蛋白配體及其使用方法

Info

Publication number
HK1157010A1
HK1157010A1 HK11111172.4A HK11111172A HK1157010A1 HK 1157010 A1 HK1157010 A1 HK 1157010A1 HK 11111172 A HK11111172 A HK 11111172A HK 1157010 A1 HK1157010 A1 HK 1157010A1
Authority
HK
Hong Kong
Prior art keywords
prion protein
ligands
prion
methods
protein ligands
Prior art date
Application number
HK11111172.4A
Other languages
English (en)
Inventor
David J Hammond
Julia T Lathrop
Larisa Cervenakova
Ruben G Carbonell
Original Assignee
Univ North Carolina State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina State filed Critical Univ North Carolina State
Publication of HK1157010A1 publication Critical patent/HK1157010A1/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK11111172.4A 2002-12-03 2011-10-19 朊病毒蛋白配體及其使用方法 HK1157010A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43042302P 2002-12-03 2002-12-03

Publications (1)

Publication Number Publication Date
HK1157010A1 true HK1157010A1 (zh) 2012-06-22

Family

ID=32469468

Family Applications (4)

Application Number Title Priority Date Filing Date
HK06109265.3A HK1088948A1 (en) 2002-12-03 2006-08-22 Prion protein ligands and methods of use
HK09101031A HK1124388A1 (zh) 2002-12-03 2009-02-05 朊病毒蛋白配體及其使用方法
HK11111159.1A HK1157009A1 (zh) 2002-12-03 2011-10-19 朊病毒蛋白配體及其使用方法
HK11111172.4A HK1157010A1 (zh) 2002-12-03 2011-10-19 朊病毒蛋白配體及其使用方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HK06109265.3A HK1088948A1 (en) 2002-12-03 2006-08-22 Prion protein ligands and methods of use
HK09101031A HK1124388A1 (zh) 2002-12-03 2009-02-05 朊病毒蛋白配體及其使用方法
HK11111159.1A HK1157009A1 (zh) 2002-12-03 2011-10-19 朊病毒蛋白配體及其使用方法

Country Status (15)

Country Link
US (3) US7863411B2 (zh)
EP (4) EP2312318B1 (zh)
JP (1) JP4485367B2 (zh)
CN (3) CN1739029B (zh)
AT (1) ATE529744T1 (zh)
AU (2) AU2003302500B2 (zh)
CA (2) CA2507936C (zh)
DK (4) DK2317317T3 (zh)
ES (4) ES2527408T3 (zh)
HK (4) HK1088948A1 (zh)
IL (3) IL168904A (zh)
MX (2) MXPA05005920A (zh)
NZ (3) NZ572892A (zh)
PT (4) PT2312318E (zh)
WO (1) WO2004050851A2 (zh)

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DK2317317T3 (en) 2015-03-02
DK1573323T3 (da) 2012-01-23
JP2006509013A (ja) 2006-03-16
AU2010201499B2 (en) 2013-02-07
IL200468A (en) 2012-06-28
CA2836951C (en) 2017-01-10
IL200468A0 (en) 2011-07-31
US20140206021A1 (en) 2014-07-24
US8604161B2 (en) 2013-12-10
NZ560410A (en) 2008-12-24
CA2507936A1 (en) 2004-06-17
WO2004050851A2 (en) 2004-06-17
ATE529744T1 (de) 2011-11-15
EP2312318B1 (en) 2014-10-08
CA2507936C (en) 2014-02-25
IL206129A0 (en) 2010-11-30
CN1739029A (zh) 2006-02-22
HK1088948A1 (en) 2006-11-17
EP2317317A1 (en) 2011-05-04
PT2312318E (pt) 2015-01-14
EP1573323B1 (en) 2011-10-19
IL206129A (en) 2013-11-28
NZ572892A (en) 2010-03-26
DK2312318T3 (en) 2015-01-12
PT1953551E (pt) 2014-05-06
ES2375958T3 (es) 2012-03-07
EP1573323A2 (en) 2005-09-14
US9678085B2 (en) 2017-06-13
EP1573323A4 (en) 2007-04-04
CN102241741A (zh) 2011-11-16
IL168904A (en) 2010-11-30
DK1953551T3 (da) 2014-05-12
NZ540417A (en) 2008-04-30
PT1573323E (pt) 2012-01-10
US7863411B2 (en) 2011-01-04
EP1953551B1 (en) 2014-02-19
CN1739029B (zh) 2011-06-22
WO2004050851A3 (en) 2005-01-27
ES2460641T3 (es) 2014-05-14
US20040229280A1 (en) 2004-11-18
JP4485367B2 (ja) 2010-06-23
PT2317317E (pt) 2015-03-02
HK1124388A1 (zh) 2009-07-10
CN102297798A (zh) 2011-12-28
EP2312318A1 (en) 2011-04-20
AU2003302500B2 (en) 2010-04-29
CN102297798B (zh) 2015-11-18
AU2003302500A1 (en) 2004-06-23
MX337569B (es) 2016-03-09
ES2531926T3 (es) 2015-03-20
HK1157009A1 (zh) 2012-06-22
ES2527408T3 (es) 2015-01-23
MXPA05005920A (es) 2006-03-17
CN102241741B (zh) 2013-11-13
AU2010201499A1 (en) 2010-05-06
EP1953551A2 (en) 2008-08-06
EP2317317B1 (en) 2014-11-26
EP1953551A3 (en) 2009-03-18
US20080268474A1 (en) 2008-10-30
CA2836951A1 (en) 2004-06-17

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