MX337569B - Ligandos de proteina prion y metodos de uso. - Google Patents
Ligandos de proteina prion y metodos de uso.Info
- Publication number
- MX337569B MX337569B MX2013012129A MX2013012129A MX337569B MX 337569 B MX337569 B MX 337569B MX 2013012129 A MX2013012129 A MX 2013012129A MX 2013012129 A MX2013012129 A MX 2013012129A MX 337569 B MX337569 B MX 337569B
- Authority
- MX
- Mexico
- Prior art keywords
- prion protein
- ligands
- prion
- methods
- protein ligands
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a un ligando que se enlaza a un prión, en donde el ligando es un péptido que consiste de la secuencia de aminoácidos SEQ ID NO: 63.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43042302P | 2002-12-03 | 2002-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX337569B true MX337569B (es) | 2016-03-09 |
Family
ID=32469468
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05005920A MXPA05005920A (es) | 2002-12-03 | 2003-12-03 | Ligandos de proteina prion y metodos de uso. |
MX2013012129A MX337569B (es) | 2002-12-03 | 2005-06-02 | Ligandos de proteina prion y metodos de uso. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05005920A MXPA05005920A (es) | 2002-12-03 | 2003-12-03 | Ligandos de proteina prion y metodos de uso. |
Country Status (15)
Country | Link |
---|---|
US (3) | US7863411B2 (es) |
EP (4) | EP2317317B1 (es) |
JP (1) | JP4485367B2 (es) |
CN (3) | CN1739029B (es) |
AT (1) | ATE529744T1 (es) |
AU (2) | AU2003302500B2 (es) |
CA (2) | CA2836951C (es) |
DK (4) | DK1953551T3 (es) |
ES (4) | ES2460641T3 (es) |
HK (4) | HK1088948A1 (es) |
IL (3) | IL168904A (es) |
MX (2) | MXPA05005920A (es) |
NZ (3) | NZ540417A (es) |
PT (4) | PT2317317E (es) |
WO (1) | WO2004050851A2 (es) |
Families Citing this family (47)
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US20050026165A1 (en) * | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
MXPA03011000A (es) * | 2001-05-31 | 2004-02-27 | Arete Associates | Metodo de sensor de proteinas deformadas. |
EP2317317B1 (en) * | 2002-12-03 | 2014-11-26 | North Carolina State University | Prion protein ligands and methods of use |
EP1616036A4 (en) * | 2003-04-14 | 2007-03-21 | Pathogen Removal And Diagnosti | PROCESS FOR IDENTIFYING LIGANDS SPECIFIC TO STRUCTURAL FORMS OF PROTEINS |
AU2004264953B2 (en) | 2003-08-13 | 2009-07-23 | Novartis Vaccines And Diagnostics, Inc. | Prion-specific peptide reagents |
US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
US20060057671A1 (en) * | 2004-09-10 | 2006-03-16 | Orser Cindy S | Immobilized probes and methods of detecting conformationally altered prion proteins |
AU2006214463B2 (en) * | 2005-02-15 | 2012-08-30 | Presympto, Inc. | Method for detecting misfolded proteins and prions |
JP5209477B2 (ja) | 2005-09-09 | 2013-06-12 | ノバルティス アーゲー | プリオンに特異的なペプトイド試薬 |
US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
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HUE047376T2 (hu) | 2009-04-15 | 2020-04-28 | Abraxis Bioscience Llc | Prionmentes nanorészecske-készítmények és elõállításuk |
JP5862560B2 (ja) | 2009-05-21 | 2016-02-16 | アメリカン ナショナル レッド クロス | レセプター随伴タンパク質(rap)、前記の誘導体、模倣体および合成ペプチドによるプリオン増殖の阻害 |
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AU2010315133B2 (en) * | 2009-11-04 | 2015-09-10 | Novartis Ag | Positively charged species as binding reagents in the separation of protein aggregates from monomers |
US9162223B2 (en) | 2011-12-21 | 2015-10-20 | North Carolina State University | Alkaline-stable chromatographic resins |
JP6268173B2 (ja) | 2012-07-19 | 2018-01-24 | 第一三共株式会社 | 抗Siglec−15抗体 |
CN103336124B (zh) * | 2012-12-11 | 2015-07-15 | 武汉工业学院 | 一种检测朊病毒蛋白(PrPSC)的方法和试剂盒 |
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CA2995204A1 (en) | 2015-08-10 | 2017-02-16 | Essenlix Corp. | Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use |
EP3341724B1 (en) | 2015-09-14 | 2023-10-04 | Essenlix Corporation | Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same |
AU2016323062A1 (en) | 2015-09-14 | 2018-04-12 | Essenlix Corp. | Device and system for analyzing a sample, particularly blood, as well as methods of using the same |
JP6667052B1 (ja) | 2016-12-21 | 2020-03-18 | エッセンリックス コーポレーション | 試料を認証するためのデバイスおよび方法ならびにその使用 |
CN111246945A (zh) | 2017-02-07 | 2020-06-05 | Essenlix公司 | 压缩开放流测定和使用 |
CA3053002A1 (en) | 2017-02-08 | 2018-08-16 | Essenlix Corp. | Bio/chemical material extraction and assay |
CN111656155B (zh) | 2017-02-08 | 2024-05-31 | 上海宜晟生物科技有限公司 | 用于延迟分析的样品采集和操作 |
WO2018148461A1 (en) | 2017-02-09 | 2018-08-16 | Essenlix Corp. | Assay with amplification |
WO2018148607A1 (en) | 2017-02-09 | 2018-08-16 | Essenlix Corporation | Assay using different spacing heights |
WO2018148609A2 (en) | 2017-02-09 | 2018-08-16 | Essenlix Corporation | Colorimetric assays |
JP7107953B2 (ja) | 2017-02-16 | 2022-07-27 | エッセンリックス コーポレーション | テクスチャ表面を用いたアッセイ |
EP3406632A1 (en) | 2017-05-23 | 2018-11-28 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | Ligands binding to prion protein for use in the treatment of synucleinopathies |
US11280706B2 (en) | 2017-08-01 | 2022-03-22 | Essenlix Corporation | Dilution calibration |
CN112689758A (zh) | 2017-08-01 | 2021-04-20 | Essenlix公司 | 检查药物对微生物影响的装置和方法 |
CN111492222A (zh) | 2017-08-01 | 2020-08-04 | Essenlix公司 | 样品收集、保持和测定 |
WO2019075415A1 (en) | 2017-10-13 | 2019-04-18 | Essenlix Corporation | DEVICES AND METHODS FOR AUTHENTICATING MEDICAL ANALYSIS AND USES THEREOF |
US11237113B2 (en) | 2017-10-26 | 2022-02-01 | Essenlix Corporation | Rapid pH measurement |
US11609224B2 (en) | 2017-10-26 | 2023-03-21 | Essenlix Corporation | Devices and methods for white blood cell analyses |
US10807095B2 (en) | 2017-10-26 | 2020-10-20 | Essenlix Corporation | Making and tracking assay card |
US11648551B2 (en) | 2017-12-12 | 2023-05-16 | Essenlix Corporation | Sample manipulation and assay with rapid temperature change |
US11510608B2 (en) | 2017-12-14 | 2022-11-29 | Essenlix Corporation | Devices, systems, and methods for monitoring hair |
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-
2003
- 2003-12-03 EP EP20100176707 patent/EP2317317B1/en not_active Expired - Lifetime
- 2003-12-03 PT PT10176707T patent/PT2317317E/pt unknown
- 2003-12-03 PT PT03808431T patent/PT1573323E/pt unknown
- 2003-12-03 PT PT101767085T patent/PT2312318E/pt unknown
- 2003-12-03 EP EP20100176708 patent/EP2312318B1/en not_active Expired - Lifetime
- 2003-12-03 DK DK08150151T patent/DK1953551T3/da active
- 2003-12-03 DK DK10176708T patent/DK2312318T3/en active
- 2003-12-03 EP EP03808431A patent/EP1573323B1/en not_active Expired - Lifetime
- 2003-12-03 NZ NZ540417A patent/NZ540417A/en not_active IP Right Cessation
- 2003-12-03 CN CN2003801090433A patent/CN1739029B/zh not_active Expired - Lifetime
- 2003-12-03 NZ NZ560410A patent/NZ560410A/en not_active IP Right Cessation
- 2003-12-03 DK DK03808431.5T patent/DK1573323T3/da active
- 2003-12-03 JP JP2004557512A patent/JP4485367B2/ja not_active Expired - Lifetime
- 2003-12-03 US US10/727,335 patent/US7863411B2/en active Active
- 2003-12-03 AT AT03808431T patent/ATE529744T1/de active
- 2003-12-03 ES ES08150151T patent/ES2460641T3/es not_active Expired - Lifetime
- 2003-12-03 MX MXPA05005920A patent/MXPA05005920A/es active IP Right Grant
- 2003-12-03 ES ES10176707.7T patent/ES2531926T3/es not_active Expired - Lifetime
- 2003-12-03 DK DK10176707T patent/DK2317317T3/en active
- 2003-12-03 WO PCT/US2003/038343 patent/WO2004050851A2/en active Application Filing
- 2003-12-03 NZ NZ572892A patent/NZ572892A/en not_active IP Right Cessation
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