ATE529744T1 - Prionproteinliganden und verfahren zu ihrer verwendung - Google Patents
Prionproteinliganden und verfahren zu ihrer verwendungInfo
- Publication number
- ATE529744T1 ATE529744T1 AT03808431T AT03808431T ATE529744T1 AT E529744 T1 ATE529744 T1 AT E529744T1 AT 03808431 T AT03808431 T AT 03808431T AT 03808431 T AT03808431 T AT 03808431T AT E529744 T1 ATE529744 T1 AT E529744T1
- Authority
- AT
- Austria
- Prior art keywords
- prion protein
- ligands
- prion
- methods
- protein ligands
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43042302P | 2002-12-03 | 2002-12-03 | |
| PCT/US2003/038343 WO2004050851A2 (en) | 2002-12-03 | 2003-12-03 | Prion protein ligands and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE529744T1 true ATE529744T1 (de) | 2011-11-15 |
Family
ID=32469468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03808431T ATE529744T1 (de) | 2002-12-03 | 2003-12-03 | Prionproteinliganden und verfahren zu ihrer verwendung |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7863411B2 (de) |
| EP (4) | EP1953551B1 (de) |
| JP (1) | JP4485367B2 (de) |
| CN (3) | CN102297798B (de) |
| AT (1) | ATE529744T1 (de) |
| AU (2) | AU2003302500B2 (de) |
| CA (2) | CA2507936C (de) |
| DK (4) | DK2317317T3 (de) |
| ES (4) | ES2531926T3 (de) |
| HK (4) | HK1088948A1 (de) |
| IL (3) | IL168904A (de) |
| MX (2) | MXPA05005920A (de) |
| NZ (3) | NZ540417A (de) |
| PT (4) | PT1953551E (de) |
| WO (1) | WO2004050851A2 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050026165A1 (en) | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
| US7166471B2 (en) * | 2001-05-31 | 2007-01-23 | Arete Associates | Misfolded protein sensor method in body fluids |
| EP1953551B1 (de) | 2002-12-03 | 2014-02-19 | Pathogen Removal and Diagnostic Technologies, Inc. | Prionen-Protein-Liganden und Verfahren zu deren Verwendung |
| MXPA05011159A (es) * | 2003-04-14 | 2006-05-25 | Pathogen Removal And Diagnosti | Metodo para identificar ligandos especificos para isoformas estructurales de proteinas. |
| US7439041B2 (en) | 2003-08-13 | 2008-10-21 | Novartis Vaccines And Diagnostics, Inc. | Prion-specific peptide reagents |
| US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
| US20060057671A1 (en) * | 2004-09-10 | 2006-03-16 | Orser Cindy S | Immobilized probes and methods of detecting conformationally altered prion proteins |
| US8372593B2 (en) * | 2005-02-15 | 2013-02-12 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
| WO2007030804A1 (en) * | 2005-09-09 | 2007-03-15 | Novartis Ag | Prion-specific peptoid reagents |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| CA2638823A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
| WO2008005960A2 (en) * | 2006-07-07 | 2008-01-10 | Pall Corporation | Prion processing |
| JP5097206B2 (ja) * | 2006-07-28 | 2012-12-12 | エイディーライフ インコーポレイティッド | 診断および治療のためのペプチドプローブ |
| JP2010515879A (ja) * | 2007-01-12 | 2010-05-13 | オールプリオン・アーゲー | プリオンタンパク質を取り出すための方法 |
| AU2009243060A1 (en) * | 2008-04-30 | 2009-11-05 | Novartis Ag. | Assay for pathogenic conformers |
| ME03596B (de) * | 2009-04-15 | 2020-07-20 | Abraxis Bioscience Llc | Prionenfreie nanopartikelzusammensetzungen und verfahren |
| WO2010134970A1 (en) | 2009-05-21 | 2010-11-25 | American National Red Cross | Inhibition of prion protein propagation by receptor associated protein (rap). its derivatives, mimetics and syntentic peptides |
| US8841429B2 (en) * | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
| EP2496947A1 (de) * | 2009-11-04 | 2012-09-12 | Novartis AG | Positiv geladene gattung als bindereagenzien bei der trennung von proteinaggregaten von monomeren |
| US9162223B2 (en) | 2011-12-21 | 2015-10-20 | North Carolina State University | Alkaline-stable chromatographic resins |
| CA2928851A1 (en) | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| CN103336124B (zh) * | 2012-12-11 | 2015-07-15 | 武汉工业学院 | 一种检测朊病毒蛋白(PrPSC)的方法和试剂盒 |
| EP2995621A1 (de) | 2014-09-10 | 2016-03-16 | Previpharma AG | Liganden und Verfahren zur Isolierung oder Beseitigung von Proteinen |
| CN113376364A (zh) | 2015-08-10 | 2021-09-10 | Essenlix 公司 | 步骤简化、小样品、快速、易使用的生物/化学分析装置和方法 |
| AU2016323062A1 (en) | 2015-09-14 | 2018-04-12 | Essenlix Corp. | Device and system for analyzing a sample, particularly blood, as well as methods of using the same |
| AU2016323072B2 (en) | 2015-09-14 | 2019-09-19 | Essenlix Corporation | Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same |
| JP6667052B1 (ja) | 2016-12-21 | 2020-03-18 | エッセンリックス コーポレーション | 試料を認証するためのデバイスおよび方法ならびにその使用 |
| EP3579981A4 (de) | 2017-02-07 | 2021-03-31 | Essenlix Corporation | Komprimierter open-flow-test und verwendung |
| US11927560B2 (en) | 2017-02-08 | 2024-03-12 | Essenlix Corporation | Bio/chemical material extraction and assay |
| WO2018148470A1 (en) | 2017-02-08 | 2018-08-16 | Essenlix Corporation | Sample collection and handling for delayed analysis |
| EP3580565B1 (de) | 2017-02-09 | 2024-05-29 | Essenlix Corporation | Assay mit verschiedenen abstandshöhen |
| CA3053120A1 (en) | 2017-02-09 | 2018-08-16 | Essenlix Corporation | Colorimetric assays |
| US11940382B2 (en) | 2017-02-09 | 2024-03-26 | Essenlix Corporation | Assay with amplification |
| US10966634B2 (en) | 2017-02-16 | 2021-04-06 | Essenlix Corporation | Assay with textured surface |
| EP3406632A1 (de) | 2017-05-23 | 2018-11-28 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | An prionprotein bindende liganden zur verwendung bei der behandlung von synukleinopathien |
| CN111492222A (zh) | 2017-08-01 | 2020-08-04 | Essenlix公司 | 样品收集、保持和测定 |
| US11280706B2 (en) | 2017-08-01 | 2022-03-22 | Essenlix Corporation | Dilution calibration |
| CN112689758A (zh) | 2017-08-01 | 2021-04-20 | Essenlix公司 | 检查药物对微生物影响的装置和方法 |
| US11393561B2 (en) | 2017-10-13 | 2022-07-19 | Essenlix Corporation | Devices and methods for authenticating a medical test and use of the same |
| US10807095B2 (en) | 2017-10-26 | 2020-10-20 | Essenlix Corporation | Making and tracking assay card |
| US11237113B2 (en) | 2017-10-26 | 2022-02-01 | Essenlix Corporation | Rapid pH measurement |
| US11609224B2 (en) | 2017-10-26 | 2023-03-21 | Essenlix Corporation | Devices and methods for white blood cell analyses |
| WO2019118652A1 (en) | 2017-12-12 | 2019-06-20 | Essenlix Corporation | Sample manipulation and assay with rapid temperature change |
| CN112534259A (zh) | 2017-12-14 | 2021-03-19 | Essenlix公司 | 监测毛发的装置，系统和方法 |
| US11156606B2 (en) | 2018-01-11 | 2021-10-26 | Essenlix Corporation | Homogeneous assay (II) |
| US11885952B2 (en) | 2018-07-30 | 2024-01-30 | Essenlix Corporation | Optics, device, and system for assaying and imaging |
| JP7376040B2 (ja) * | 2019-09-03 | 2023-11-08 | 国立大学法人京都工芸繊維大学 | 神経変性疾患におけるバイオマーカー分子の検出方法 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3601398A1 (de) * | 1986-01-18 | 1987-07-23 | Fresenius Ag | Verwendung von oligopeptiden zur behandlung von cerebralen stoerungen |
| US5133866A (en) | 1988-03-24 | 1992-07-28 | Terrapin Technologies, Inc. | Method to identify analyte-bending ligands |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| EP0347890B1 (de) | 1988-06-22 | 1993-03-17 | Roussel Morishita Co., Ltd. | Aminosäure-Nahrungsmittelzusammensetzungen |
| WO1991005262A1 (en) | 1989-10-02 | 1991-04-18 | University Of Michigan | Bioanalytical detection system |
| US5498538A (en) | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| WO1991013904A1 (en) | 1990-03-05 | 1991-09-19 | Cephalon, Inc. | Chymotrypsin-like proteases and their inhibitors |
| US5416013A (en) * | 1990-04-04 | 1995-05-16 | Sterling Winthrop Inc. | Interleukin 1β protease and interleukin 1β protease inhibitors |
| US6995141B1 (en) | 1990-04-04 | 2006-02-07 | Vertex Pharmaceuticals Incorporated | Interleukin 1β protease and interleukin 1β protease inhibitors |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| GB9024005D0 (en) * | 1990-11-05 | 1990-12-19 | British Bio Technology | Process for amplifying nucleic acid |
| DE69228701T2 (de) * | 1991-12-03 | 1999-07-29 | Proteus Molecular Design Ltd., Macclesfield, Cheshire | Fragmente von Prion Proteinen. |
| US5312730A (en) | 1992-05-27 | 1994-05-17 | Ciba Corning Diagnostics Corp. | Immune complex transfer with lypophilic bridge |
| CA2109646C (en) * | 1992-11-24 | 2000-03-07 | Gaston O. Daumy | Para-nitroanilide peptides |
| JPH08178926A (ja) | 1994-10-25 | 1996-07-12 | Sumitomo Pharmaceut Co Ltd | イムノアッセイプレートおよびその用途 |
| US5834318A (en) | 1995-05-10 | 1998-11-10 | Bayer Corporation | Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins |
| US5948763A (en) * | 1995-06-07 | 1999-09-07 | New York University | Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits |
| WO1997012992A2 (en) | 1995-10-02 | 1997-04-10 | Royal Netherlands Academy Of Arts And Sciences | Diagnosis method for a disease caused by a frameshift mutation in a gene and reagents therefore |
| US5750361A (en) | 1995-11-02 | 1998-05-12 | The Regents Of The University Of California | Formation and use of prion protein (PRP) complexes |
| DE69724619T2 (de) | 1996-05-14 | 2004-07-01 | Winnacker, Ernst-Ludwig, Prof. | Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können |
| JP2000512131A (ja) * | 1996-05-29 | 2000-09-19 | マクギル ユニバーシティー | プリオン蛋白結合蛋白およびその使用法 |
| US5808011A (en) | 1996-07-01 | 1998-09-15 | Biopure Corporation | Method for chromatographic removal of prions |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| JPH10182695A (ja) * | 1996-12-27 | 1998-07-07 | Teikoku Seiyaku Co Ltd | ｇｐ１２０に対して親和性を有するペプチド |
| US6221614B1 (en) | 1997-02-21 | 2001-04-24 | The Regents Of The University Of California | Removal of prions from blood, plasma and other liquids |
| GB9710582D0 (en) | 1997-05-22 | 1997-07-16 | Oxford Glycosciences Uk Ltd | A method for de novo peptide sequence determination |
| US6211149B1 (en) * | 1998-08-03 | 2001-04-03 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors of formation of protease resistant prion protein |
| US6750025B1 (en) | 1998-07-09 | 2004-06-15 | V.I. Technologies, Inc. | Method of detecting and isolating prion protein and variants thereof |
| DE19917838A1 (de) * | 1999-01-12 | 2000-07-13 | Bundesrepublik Deutschland Let | Arzneimittel zur prophylaktischen oder therapeutischen Behandlung von transmissiblen spongiformen Enzephalopathien, Morbus Alzheimer und Corea Huntington und anderen neurodegenerativen Erkrankungen sowie diagnostische Mittel |
| EP1181058A2 (de) * | 1999-05-27 | 2002-02-27 | Max-Delbrück-Centrum Für Molekulare Medizin | Vakzine gegen konformationsabhängige antigene sowie gegen antigene, die keine oder nicht ausschliesslich proteine oder peptide sind |
| DE60032486T2 (de) * | 1999-06-23 | 2007-08-16 | Idexx Laboratories, Inc. | Prion protein peptide und deren verwendung |
| JP2003531356A (ja) * | 1999-06-29 | 2003-10-21 | マクギル ユニバーシティー | プリオンタンパク質結合タンパク質及びそれらの使用 |
| US6261790B1 (en) * | 1999-07-15 | 2001-07-17 | The United States Of America As Represented By The Secretary Of Agriculture | Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies |
| CA2378953A1 (en) * | 1999-07-27 | 2001-02-01 | Abgenix, Inc. | Methods and compositions for inhibiting polypeptide accumulation associated with neurological disorders |
| WO2001019867A1 (de) * | 1999-09-14 | 2001-03-22 | Memorec Stoffel Gmbh | Prionen-verwandtes protein |
| US6437102B1 (en) | 1999-11-24 | 2002-08-20 | Bayer Corporation | Method of separating prions from biological materials |
| WO2001071042A2 (en) * | 2000-03-23 | 2001-09-27 | Pe Corporation (Ny) | Detection kits, such as nucleic acid arrays, for detecting the expression of 10,000 or more drosophila genes and uses thereof |
| EP1272509A2 (de) | 2000-04-05 | 2003-01-08 | V.I. Technologies, Inc. | Peptidische bindstoffe für prione und verfahren zu deren verwendung |
| US20020155808A1 (en) * | 2000-04-12 | 2002-10-24 | Harumi Kawamura | Data transmission method and data transmission apparatus |
| GB0009918D0 (en) * | 2000-04-20 | 2000-06-07 | Rose Keith | Covalent capture facilitating purification of polypeptides |
| US20020155106A1 (en) * | 2000-12-01 | 2002-10-24 | Hammond David J. | Method of identifying a ligand for a target molecule |
| US7022486B2 (en) | 2001-08-13 | 2006-04-04 | Douglas A. Campbell | Peptide sequence tags and method of using same |
| DE10152677A1 (de) | 2001-10-19 | 2003-05-08 | Aventis Behring Gmbh | Antikörper zum spezifischen Nachweis von pathogenen Prionen humanen Ursprungs und damit durchgeführten Nachweisverfahren |
| JP2003149461A (ja) * | 2001-11-12 | 2003-05-21 | Allied Tereshisu Kk | 収納装置 |
| EP1953551B1 (de) * | 2002-12-03 | 2014-02-19 | Pathogen Removal and Diagnostic Technologies, Inc. | Prionen-Protein-Liganden und Verfahren zu deren Verwendung |
| US7510848B2 (en) | 2003-04-04 | 2009-03-31 | North Carolina State University | Prion protein binding materials and methods of use |
| SG187269A1 (en) | 2003-04-04 | 2013-02-28 | Univ North Carolina State | Prion protein binding materials and methods of use |
| WO2006102099A2 (en) | 2005-03-18 | 2006-09-28 | The Regents Of The University Of California | ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP |
-
2003
- 2003-12-03 EP EP20080150151 patent/EP1953551B1/de not_active Expired - Lifetime
- 2003-12-03 ES ES10176707.7T patent/ES2531926T3/es not_active Expired - Lifetime
- 2003-12-03 MX MXPA05005920A patent/MXPA05005920A/es active IP Right Grant
- 2003-12-03 PT PT08150151T patent/PT1953551E/pt unknown
- 2003-12-03 DK DK10176707T patent/DK2317317T3/en active
- 2003-12-03 EP EP20100176708 patent/EP2312318B1/de not_active Expired - Lifetime
- 2003-12-03 CA CA2507936A patent/CA2507936C/en not_active Expired - Lifetime
- 2003-12-03 NZ NZ540417A patent/NZ540417A/en not_active IP Right Cessation
- 2003-12-03 ES ES03808431T patent/ES2375958T3/es not_active Expired - Lifetime
- 2003-12-03 DK DK10176708T patent/DK2312318T3/en active
- 2003-12-03 CN CN201110113280.3A patent/CN102297798B/zh not_active Expired - Lifetime
- 2003-12-03 NZ NZ560410A patent/NZ560410A/en not_active IP Right Cessation
- 2003-12-03 PT PT101767085T patent/PT2312318E/pt unknown
- 2003-12-03 AT AT03808431T patent/ATE529744T1/de active
- 2003-12-03 WO PCT/US2003/038343 patent/WO2004050851A2/en active Application Filing
- 2003-12-03 EP EP03808431A patent/EP1573323B1/de not_active Expired - Lifetime
- 2003-12-03 US US10/727,335 patent/US7863411B2/en active Active
- 2003-12-03 CN CN2011101132413A patent/CN102241741B/zh not_active Expired - Lifetime
- 2003-12-03 PT PT03808431T patent/PT1573323E/pt unknown
- 2003-12-03 DK DK08150151T patent/DK1953551T3/da active
- 2003-12-03 PT PT10176707T patent/PT2317317E/pt unknown
- 2003-12-03 DK DK03808431.5T patent/DK1573323T3/da active
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