WO2006056438A3 - Protein-biochip zur validierung von bindern - Google Patents

Protein-biochip zur validierung von bindern Download PDF

Info

Publication number
WO2006056438A3
WO2006056438A3 PCT/EP2005/012567 EP2005012567W WO2006056438A3 WO 2006056438 A3 WO2006056438 A3 WO 2006056438A3 EP 2005012567 W EP2005012567 W EP 2005012567W WO 2006056438 A3 WO2006056438 A3 WO 2006056438A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
binding agents
biochip
validating
validating binding
Prior art date
Application number
PCT/EP2005/012567
Other languages
English (en)
French (fr)
Other versions
WO2006056438A2 (de
Inventor
Petra Weingarten
Angelika Lueking
Verena Gruss
Original Assignee
Protagen Ag
Petra Weingarten
Angelika Lueking
Verena Gruss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protagen Ag, Petra Weingarten, Angelika Lueking, Verena Gruss filed Critical Protagen Ag
Priority to US11/791,562 priority Critical patent/US20090124509A1/en
Priority to EP05809098A priority patent/EP1817586A2/de
Priority to CA002588992A priority patent/CA2588992A1/en
Priority to AU2005308967A priority patent/AU2005308967A1/en
Publication of WO2006056438A2 publication Critical patent/WO2006056438A2/de
Publication of WO2006056438A3 publication Critical patent/WO2006056438A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die vorliegende Erfindung betrifft eine Anordnung von Proteinen enthaltend mindestens eine cDNA-Expressionsbibliothek und dessen Verwendung als Protein-Biochip, insbesondere zur Validierung von Bindern sowie Protein-Bindern und Verfahren zur simultanen Bestimmung quantitativer Größen.
PCT/EP2005/012567 2004-11-24 2005-11-24 Protein-biochip zur validierung von bindern WO2006056438A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/791,562 US20090124509A1 (en) 2004-11-24 2005-11-24 Protein-biochip for validating binding agents
EP05809098A EP1817586A2 (de) 2004-11-24 2005-11-24 Protein-biochip zur validierung von bindern
CA002588992A CA2588992A1 (en) 2004-11-24 2005-11-24 Protein biochip for validating binding agents
AU2005308967A AU2005308967A1 (en) 2004-11-24 2005-11-24 Protein-biochip for validating binding agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004056794A DE102004056794B4 (de) 2004-11-24 2004-11-24 Verwendung einer Anordnung und Verfahren zur Validierung von Bindern
DE102004056794.8 2004-11-24

Publications (2)

Publication Number Publication Date
WO2006056438A2 WO2006056438A2 (de) 2006-06-01
WO2006056438A3 true WO2006056438A3 (de) 2006-08-03

Family

ID=35840256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/012567 WO2006056438A2 (de) 2004-11-24 2005-11-24 Protein-biochip zur validierung von bindern

Country Status (6)

Country Link
US (1) US20090124509A1 (de)
EP (1) EP1817586A2 (de)
AU (1) AU2005308967A1 (de)
CA (1) CA2588992A1 (de)
DE (1) DE102004056794B4 (de)
WO (1) WO2006056438A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006003782A1 (de) * 2006-01-25 2007-08-02 Protagen Ag Immunadsorptionstherapie mittels Autoantigenen
DE102006027259A1 (de) * 2006-06-09 2007-12-13 Protagen Ag Protein-Biochip zum differentiellen Screenen von Protein-Protein-Wechselwirkungen
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
AU2008276251B2 (en) 2007-07-13 2014-04-24 Nestec S.A. Drug selection for lung cancer therapy using antibody-based arrays
NZ600339A (en) 2008-02-25 2013-12-20 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
JP5795311B2 (ja) 2009-07-15 2015-10-14 ネステク ソシエテ アノニム 抗体ベースのアレイを使用する胃癌療法のための薬物選択
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
WO2013033623A1 (en) 2011-09-02 2013-03-07 Nestec S.A. Profiling of signal pathway proteins to determine therapeutic efficacy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1073770T1 (de) * 1998-04-30 2002-07-04 Max Planck Gesellschaft Neuartiges Verfahren zur Identifizierung von Klonen mit einer gewünschten Biologischen Eigenschaft, ausgehend von einer Expressionsgenbank (2001/06)
DE10041809A1 (de) * 2000-08-25 2002-03-07 Giesing Michael Arrays immobilisierter Biomoleküle, deren Herstellung und Verwendung

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LUEKING A ET AL: "PROTEIN MICROARRAYS FOR GENE EXPRESSION AND ANTIBODY SCREENING", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 270, no. 1, May 1999 (1999-05-01), pages 103 - 111, XP000949937, ISSN: 0003-2697 *
LUEKING ANGELIKA ET AL: "A nonredundant human protein chip for antibody screening and serum profiling.", MOLECULAR & CELLULAR PROTEOMICS, vol. 2, no. 12, December 2003 (2003-12-01), pages 1342 - 1349, XP002377917, ISSN: 1535-9476 *
MICHAUD GREGORY A ET AL: "Analyzing antibody specificity with whole proteome microarrays.", NATURE BIOTECHNOLOGY. DEC 2003, vol. 21, no. 12, December 2003 (2003-12-01), pages 1509 - 1512, XP002377918, ISSN: 1087-0156 *
PREDKI PAUL F: "Functional protein microarrays: ripe for discovery.", CURRENT OPINION IN CHEMICAL BIOLOGY. FEB 2004, vol. 8, no. 1, February 2004 (2004-02-01), pages 8 - 13, XP002377919, ISSN: 1367-5931 *
See also references of EP1817586A2 *

Also Published As

Publication number Publication date
WO2006056438A2 (de) 2006-06-01
AU2005308967A1 (en) 2006-06-01
DE102004056794B4 (de) 2010-08-26
US20090124509A1 (en) 2009-05-14
DE102004056794A1 (de) 2006-06-14
EP1817586A2 (de) 2007-08-15
CA2588992A1 (en) 2006-06-01

Similar Documents

Publication Publication Date Title
WO2006056438A3 (de) Protein-biochip zur validierung von bindern
ZA200800844B (en) Methods and compositions for treating ophthalmic conditions via serum retinol, serum retinol binding protein (RBP), and/or serum retinol-RBP modulation
EP1693448A4 (de) Doppelt spezifische antikörper als ersatz für funktionelles protein
WO2007007192A8 (en) Use of ionic matrices for maldi mass spectrometry analysis of tissue sections
IL174794A0 (en) Bispecific antibody substituting for functional proteins
WO2005118857A3 (en) Methods and agents for screening for compounds capable of modulating vegf expression
EP1789451A4 (de) Tie-komplex-bindende proteine
EP1793359A4 (de) Inhaltskaufsverarbeitungsendgerät, verfahren dafür und programm
WO2007071692A3 (en) Immunogenic composition
EA200702193A1 (ru) Гликозилирование белков
WO2004053497A3 (en) Method for predicting the response to her2-directed therapy
WO2004035742A3 (en) Sets of digital antibodies directed against short epitopes, and methods using same
WO2006053251A3 (en) Method of measuring amyloid-beta peptides
WO2005028497A3 (en) Receptor binding peptides derived from the sars s protein
WO2006079334A3 (de) Verfahren zu nachweis und quantifizierung von proteinen unter verwendung von farbstoffen auf der basis von polymethinen
SI1951395T1 (sl) Postopek za kvantitativno doloäśitev poloksamerjev
WO2006094185A3 (en) Quantification of proteins
WO2005018552A3 (en) Heparin binding proteins: sensors for heparin detection
EP1845376A4 (de) Quantitatives messverfahren für rekombinantes protein
WO2004069860A3 (en) Isg15-conjugated proteins
WO2003087051A3 (en) Methods for identifying allosteric sites
WO2006060739A3 (en) Ubiquitin ligase assays and related reagents
WO2005034840A8 (en) Identification of kinase inhibitors
EP1696230A4 (de) Proteinanalyseverfahren
EP1780531A4 (de) Peptid- oder proteinphosphorylierungsanalysegerät, phosphorylierungsdiskriminierungsprogramm sowie aufzeichungsmedium für das programm

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2588992

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005308967

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2005809098

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2005308967

Country of ref document: AU

Date of ref document: 20051124

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005308967

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2005809098

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 11791562

Country of ref document: US