HK1151694A1 - 作為極光激酶抑制劑的稠合雙環嘧啶化合物 - Google Patents

作為極光激酶抑制劑的稠合雙環嘧啶化合物

Info

Publication number
HK1151694A1
HK1151694A1 HK11105941.6A HK11105941A HK1151694A1 HK 1151694 A1 HK1151694 A1 HK 1151694A1 HK 11105941 A HK11105941 A HK 11105941A HK 1151694 A1 HK1151694 A1 HK 1151694A1
Authority
HK
Hong Kong
Prior art keywords
kinase inhibitors
fused bicyclic
aurora kinase
pyrimidine compounds
bicyclic pyrimidine
Prior art date
Application number
HK11105941.6A
Other languages
English (en)
Inventor
謝興邦
‧考瑪
徐祖安
伍素螢
趙宇生
Original Assignee
國家衛生研究院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 國家衛生研究院 filed Critical 國家衛生研究院
Publication of HK1151694A1 publication Critical patent/HK1151694A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK11105941.6A 2008-04-30 2011-06-13 作為極光激酶抑制劑的稠合雙環嘧啶化合物 HK1151694A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4906308P 2008-04-30 2008-04-30
PCT/US2009/041382 WO2009134658A2 (en) 2008-04-30 2009-04-22 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors

Publications (1)

Publication Number Publication Date
HK1151694A1 true HK1151694A1 (zh) 2012-02-10

Family

ID=41255689

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11105941.6A HK1151694A1 (zh) 2008-04-30 2011-06-13 作為極光激酶抑制劑的稠合雙環嘧啶化合物

Country Status (13)

Country Link
US (1) US8138194B2 (zh)
EP (1) EP2276346B1 (zh)
JP (1) JP5502072B2 (zh)
KR (1) KR101667822B1 (zh)
CN (1) CN102014627B (zh)
AU (1) AU2009241469B2 (zh)
CA (1) CA2722220C (zh)
DK (1) DK2276346T3 (zh)
ES (1) ES2616255T3 (zh)
HK (1) HK1151694A1 (zh)
PL (1) PL2276346T3 (zh)
TW (1) TWI363627B (zh)
WO (1) WO2009134658A2 (zh)

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EP2831073B1 (en) * 2012-03-30 2020-12-09 Rhizen Pharmaceuticals S.A. Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of c-met protein kinases
CN104470926A (zh) 2012-05-21 2015-03-25 拜耳医药股份有限公司 取代的吡咯并嘧啶
JP6234444B2 (ja) 2012-05-21 2017-11-22 バイエル ファーマ アクチエンゲゼルシャフト チエノピリミジン類
WO2013174735A1 (en) 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Substituted benzothienopyrimidines
BR112014032913A2 (pt) 2012-06-29 2017-06-27 Pfizer novas 4-(amino-substituídas)-7h-pirrolo[2,3-d]pirimidinas como inibidores de lrrk2
TW201412740A (zh) 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
CN103664993B (zh) * 2012-09-25 2016-05-25 韩冰 一类治疗缺血性脑损伤的化合物及其用途
CN103012428A (zh) 2013-01-08 2013-04-03 中国药科大学 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
CN105189518A (zh) 2013-02-01 2015-12-23 拜耳制药股份公司 取代的噻吩并吡啶和其药物用途
WO2014135480A1 (en) 2013-03-06 2014-09-12 Bayer Pharma Aktiengesellschaft Substituted thiazolopyrimidines
US9695171B2 (en) 2013-12-17 2017-07-04 Pfizer Inc. 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors
KR20160142401A (ko) 2014-04-25 2016-12-12 화이자 인코포레이티드 도파민 d1 리간드로서 헤테로방향족 화합물 및 이의 용도
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN105061460B (zh) * 2015-08-18 2017-06-30 沈阳药科大学 含有硫醚结构的四氢苯并[4,5]噻吩并[2,3‑d]嘧啶类化合物及其应用
CN105061461B (zh) * 2015-08-18 2017-06-30 沈阳药科大学 含有苄胺结构的四氢苯并[4,5]噻吩并[2,3‑d]嘧啶类化合物及其应用
EP3350178B1 (en) 2015-09-14 2021-10-20 Pfizer Inc. Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106243124B (zh) * 2016-07-29 2018-03-09 湖北民族学院 一种噻吩并嘧啶脲类化合物及其制备方法和应用
CN109890821A (zh) 2016-08-24 2019-06-14 艾科尔公司 氨基-吡咯并嘧啶酮化合物及其使用方法
CN106810512B (zh) * 2017-01-18 2019-09-10 江苏省中医药研究院 Idh2突变体抑制剂及其用途
BR112020003130A2 (pt) * 2017-08-15 2020-10-13 AbbVie Deutschland GmbH & Co. KG inibidores macrocíclicos de mcl-1 e métodos de uso
US10676485B2 (en) * 2017-08-15 2020-06-09 Abbvie Inc. Macrocyclic MCL-1 inhibitors and methods of use
WO2019035927A1 (en) * 2017-08-15 2019-02-21 Abbvie Inc. MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
WO2021041392A1 (en) * 2019-08-26 2021-03-04 Chemwerth, Inc. Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors
CN112500421B (zh) * 2020-12-15 2021-08-24 河南科技大学第一附属医院 一种可用于杀菌消毒的苯并吡喃脲类化合物的制备方法及应用
TW202413367A (zh) * 2022-08-19 2024-04-01 財團法人國家衛生研究院 Ｔａｍ受體抑制劑

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BRPI0511139B8 (pt) 2004-05-14 2021-05-25 Millennium Pharm Inc compostos que inibem quinase aurora e composição farmacêutica contendo os mesmos
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Also Published As

Publication number Publication date
EP2276346A2 (en) 2011-01-26
EP2276346A4 (en) 2011-08-24
WO2009134658A2 (en) 2009-11-05
CN102014627B (zh) 2014-10-29
JP5502072B2 (ja) 2014-05-28
AU2009241469B2 (en) 2015-05-07
KR20100132067A (ko) 2010-12-16
KR101667822B1 (ko) 2016-10-19
CA2722220C (en) 2016-06-07
PL2276346T3 (pl) 2017-07-31
TW200948365A (en) 2009-12-01
JP2011522789A (ja) 2011-08-04
US8138194B2 (en) 2012-03-20
EP2276346B1 (en) 2016-11-23
CN102014627A (zh) 2011-04-13
AU2009241469A1 (en) 2009-11-05
ES2616255T3 (es) 2017-06-12
TWI363627B (en) 2012-05-11
DK2276346T3 (en) 2017-02-27
CA2722220A1 (en) 2009-11-05
WO2009134658A3 (en) 2009-12-30
US20090275533A1 (en) 2009-11-05

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