HK1119090A1 - Coated lipid complexes and their use - Google Patents

Coated lipid complexes and their use

Info

Publication number
HK1119090A1
HK1119090A1 HK08113257.3A HK08113257A HK1119090A1 HK 1119090 A1 HK1119090 A1 HK 1119090A1 HK 08113257 A HK08113257 A HK 08113257A HK 1119090 A1 HK1119090 A1 HK 1119090A1
Authority
HK
Hong Kong
Prior art keywords
lipid complexes
coated lipid
coated
complexes
lipid
Prior art date
Application number
HK08113257.3A
Other languages
English (en)
Inventor
Oliver Keil
Joerg Kaufmann
Original Assignee
Silence Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Silence Therapeutics Ag filed Critical Silence Therapeutics Ag
Publication of HK1119090A1 publication Critical patent/HK1119090A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery
    • Y10S977/907Liposome
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
HK08113257.3A 2004-12-27 2008-12-05 Coated lipid complexes and their use HK1119090A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04030846 2004-12-27
PCT/EP2005/014074 WO2006069782A2 (fr) 2004-12-27 2005-12-27 Complexes lipidiques revetus et leur utilisation

Publications (1)

Publication Number Publication Date
HK1119090A1 true HK1119090A1 (en) 2009-02-27

Family

ID=36540272

Family Applications (2)

Application Number Title Priority Date Filing Date
HK08113257.3A HK1119090A1 (en) 2004-12-27 2008-12-05 Coated lipid complexes and their use
HK16110655.7A HK1222541A1 (zh) 2004-12-27 2016-09-07 塗層脂質複合體和它們的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK16110655.7A HK1222541A1 (zh) 2004-12-27 2016-09-07 塗層脂質複合體和它們的用途

Country Status (17)

Country Link
US (2) US8852472B2 (fr)
EP (2) EP1830888B1 (fr)
JP (1) JP5292572B2 (fr)
KR (1) KR101366482B1 (fr)
CN (1) CN101287497B (fr)
AU (1) AU2005321469B2 (fr)
BR (1) BRPI0519468A2 (fr)
CA (1) CA2593032C (fr)
DK (1) DK1830888T3 (fr)
ES (1) ES2548515T3 (fr)
HK (2) HK1119090A1 (fr)
IL (1) IL183775A (fr)
MX (1) MX2007007913A (fr)
PL (1) PL1830888T3 (fr)
SG (1) SG158175A1 (fr)
WO (1) WO2006069782A2 (fr)
ZA (1) ZA200704168B (fr)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05001355A (es) 2002-08-05 2005-09-30 Atugen Ag Formas nuevas adicionales de moleculas de arn de interferencia.
HUE036916T2 (hu) 2004-05-05 2018-08-28 Silence Therapeutics Gmbh Lipidek, lipid komplexek és ezek alkalmazása
JP5292572B2 (ja) * 2004-12-27 2013-09-18 サイレンス・セラピューティクス・アーゲー コーティングされた脂質複合体およびそれらの使用
JP2008540363A (ja) * 2005-05-04 2008-11-20 ノクソン・フアルマ・アクチエンゲゼルシヤフト シュピーゲルマーの新規な使用
JP2009534342A (ja) * 2006-04-20 2009-09-24 サイレンス・セラピューティクス・アーゲー 血管内皮に特異的に送達するためのリポプレックス処方剤
JP2009544281A (ja) * 2006-07-21 2009-12-17 サイレンス・セラピューティクス・アーゲー プロテインキナーゼ3の発現を阻害するための手段
JP2010513354A (ja) 2006-12-19 2010-04-30 ノヴォソム アクチェンゲゼルシャフト トランスフェクションエンハンサー要素を含む脂質および脂質集合体
WO2010021718A1 (fr) 2008-08-19 2010-02-25 Nektar Therapeutics Complexes d'acides nucléiques interférents courts
EP2398903A1 (fr) 2009-02-18 2011-12-28 Silence Therapeutics Aktiengesellschaft Moyen d'inhibition de l'expression de ang2
WO2011035065A1 (fr) 2009-09-17 2011-03-24 Nektar Therapeutics Chitosanes monoconjugués en tant qu'agents de distribution pour de petits acides nucléiques interférents
US8359883B2 (en) * 2009-11-13 2013-01-29 Hasmukh Dholakiya Gemstone setting
JP2013528665A (ja) 2010-03-26 2013-07-11 メルサナ セラピューティックス, インコーポレイテッド ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法
WO2011133658A1 (fr) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions et procédés de ciblage et d'administration d'agents thérapeutiques dans des cellules
WO2012113413A1 (fr) * 2011-02-21 2012-08-30 Curevac Gmbh Composition de vaccin comprenant des acides nucléiques immunostimulateurs complexés et des antigènes emballés avec des conjugués de polyéthylèneglycol/peptide à liaison disulfure
TW201726599A (zh) 2012-07-06 2017-08-01 協和醱酵麒麟有限公司 陽離子性脂質
WO2014018375A1 (fr) 2012-07-23 2014-01-30 Xenon Pharmaceuticals Inc. Cyp8b1 et ses utilisations dans des méthodes thérapeutiques et diagnostiques
CA2915728A1 (fr) 2013-08-21 2015-02-26 Thomas Kramps Vaccin contre le virus respiratoire syncytial
JP2016540769A (ja) * 2013-12-05 2016-12-28 サイレンス・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 肺特異的送達用手段
US10611664B2 (en) 2014-07-31 2020-04-07 Corning Incorporated Thermally strengthened architectural glass and related systems and methods
US11097974B2 (en) 2014-07-31 2021-08-24 Corning Incorporated Thermally strengthened consumer electronic glass and related systems and methods
WO2016083623A1 (fr) * 2014-11-28 2016-06-02 Silence Therapeutics Gmbh Moyens pour le traitement de la prééclampsie
EP3402762B1 (fr) 2016-01-12 2023-11-08 Corning Incorporated Articles à base de verre fin renforcé chimiquement et thermiquement
US11795102B2 (en) 2016-01-26 2023-10-24 Corning Incorporated Non-contact coated glass and related coating system and method
CN105832709A (zh) * 2016-03-14 2016-08-10 苏州博创康源生物技术有限公司 一种核酸药物载药组织粘贴膜及其制备方法
CN105687165A (zh) * 2016-03-14 2016-06-22 苏州博创康源生物技术有限公司 一种蛋白或多肽药物载药组织粘贴膜及其制备方法
CN106038517A (zh) * 2016-03-14 2016-10-26 苏州博创康源生物技术有限公司 一种多糖药物载药组织粘贴膜及其制备方法
CN106038516A (zh) * 2016-03-14 2016-10-26 苏州博创康源生物技术有限公司 一种化合物药物载药组织粘贴膜及其制备方法
CN105902523A (zh) * 2016-03-14 2016-08-31 苏州博创康源生物技术有限公司 一种载药组织粘贴膜及其制备方法
US11352647B2 (en) 2016-08-17 2022-06-07 The Broad Institute, Inc. Crispr enzymes and systems
CN110312799A (zh) 2016-08-17 2019-10-08 博德研究所 新型crispr酶和系统
WO2019040818A2 (fr) 2017-08-24 2019-02-28 Corning Incorporated Verres présentant des capacités de trempe améliorées
CN111511388A (zh) 2017-09-21 2020-08-07 博德研究所 用于靶向核酸编辑的系统、方法和组合物
US20210363260A1 (en) 2017-11-13 2021-11-25 The Broad Institute, Inc. Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
TWI785156B (zh) 2017-11-30 2022-12-01 美商康寧公司 具有高熱膨脹係數及對於熱回火之優先破裂行為的非離子交換玻璃
US10968257B2 (en) 2018-04-03 2021-04-06 The Broad Institute, Inc. Target recognition motifs and uses thereof
CA3106035A1 (fr) 2018-08-07 2020-02-13 The Broad Institute, Inc. Enzymes cas12b et systemes
WO2020191102A1 (fr) 2019-03-18 2020-09-24 The Broad Institute, Inc. Systèmes et protéines crispr de type vii
WO2020236972A2 (fr) 2019-05-20 2020-11-26 The Broad Institute, Inc. Systèmes de ciblage d'acides nucléiques à constituants multiples autres que de classe i
JP2022542839A (ja) 2019-07-19 2022-10-07 フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー リコンビナーゼ組成物及び使用方法
KR20220044538A (ko) 2019-08-06 2022-04-08 코닝 인코포레이티드 균열을 저지하기 위한 매장된 응력 스파이크를 갖는 유리 적층물 및 이를 제조하는 방법
CA3172591A1 (fr) 2020-03-24 2021-09-30 Douglas Anthony KERR Vecteurs d'adn non viraux et leurs utilisations pour exprimer des agents therapeutiques de la maladie de gaucher
US20230138409A1 (en) 2020-03-24 2023-05-04 Generation Bio Co. Non-viral dna vectors and uses thereof for expressing factor ix therapeutics
AU2021275213A1 (en) 2020-05-20 2023-02-02 Flagship Pioneering Innovations Vi, Llc Immunogenic compositions and uses thereof
JP2023526422A (ja) 2020-05-20 2023-06-21 フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー コロナウイルス抗原組成物及びそれらの使用
AU2021281453A1 (en) 2020-05-29 2022-11-17 Flagship Pioneering Innovations Vi, Llc. Trem compositions and methods relating thereto
CN116018405A (zh) 2020-05-29 2023-04-25 旗舰先锋创新Vi有限责任公司 Trem组合物及其相关方法
WO2022023284A1 (fr) 2020-07-27 2022-02-03 Anjarium Biosciences Ag Compositions de molécules d'adn, leurs procédés de fabrication et leurs procédés d'utilisation
CN116157148A (zh) 2020-09-03 2023-05-23 旗舰创业创新第六有限责任公司 免疫原性组合物及其用途
KR20230135585A (ko) 2020-12-23 2023-09-25 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 변형된 trem의 조성물 및 이의 용도
EP4313109A1 (fr) 2021-03-31 2024-02-07 Flagship Pioneering Innovations V, Inc. Polypeptides de thanotransmission et leur utilisation dans le traitement du cancer
CA3214538A1 (fr) 2021-04-20 2022-10-27 Joel DE BEER Compositions de molecules d'adn codant pour la beta-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase, leurs procedes de fabrication et leurs procedes d'utilisation
KR20240011714A (ko) 2021-04-27 2024-01-26 제너레이션 바이오 컴퍼니 치료용 항체를 발현하는 비바이러스성 dna 벡터 및 이의 용도
WO2022232286A1 (fr) 2021-04-27 2022-11-03 Generation Bio Co. Vecteurs d'adn non viraux exprimant des anticorps anti-coronavirus et leurs utilisations
CN113372226B (zh) * 2021-06-08 2023-05-26 深圳市人民医院 一种脂质分子、脂质纳米粒及其制备方法和应用
EP4377457A1 (fr) 2021-07-26 2024-06-05 Flagship Pioneering Innovations VI, LLC Compositions de trem et leurs utilisations
AR127073A1 (es) 2021-09-17 2023-12-13 Flagship Pioneering Innovations Vi Llc Composiciones y métodos para producir polirribonucleótidos circulares
CA3235625A1 (fr) 2021-10-18 2023-04-27 Flagship Pioneering Innovations Vi, Llc Compositions et procedes de purification de polyribonucleotides
WO2023081526A1 (fr) 2021-11-08 2023-05-11 Orna Therapeutics, Inc. Compositions de nanoparticules lipidiques pour l'administration de polynucléotides circulaires
AU2022397292A1 (en) 2021-11-24 2024-05-30 Flagship Pioneering Innovations Vi, Llc Varicella-zoster virus immunogen compositions and their uses
WO2023097003A2 (fr) 2021-11-24 2023-06-01 Flagship Pioneering Innovations Vi, Llc Compositions immunogènes et leurs utilisations
WO2023096990A1 (fr) 2021-11-24 2023-06-01 Flagship Pioneering Innovation Vi, Llc Compositions immunogènes de coronavirus et leurs utilisations
TW202340460A (zh) 2021-12-17 2023-10-16 美商旗艦先鋒創新有限責任公司 用於在變性條件下富集環狀rna之方法
WO2023122745A1 (fr) 2021-12-22 2023-06-29 Flagship Pioneering Innovations Vi, Llc Compositions et procédés de purification de polyribonucléotides
TW202342064A (zh) 2021-12-23 2023-11-01 美商旗艦先鋒創新有限責任公司 編碼抗融合多肽之環狀多核糖核苷酸
WO2023135273A2 (fr) 2022-01-14 2023-07-20 Anjarium Biosciences Ag Compositions de molécules d'adn codant pour le facteur viii, leurs procédés de préparation et leurs méthodes d'utilisation
WO2023177655A1 (fr) 2022-03-14 2023-09-21 Generation Bio Co. Compositions vaccinales prime-boost hétérologues et méthodes d'utilisation
WO2023183616A1 (fr) 2022-03-25 2023-09-28 Senda Biosciences, Inc. Nouveaux lipides et nanoparticules lipidiques ionisables et leurs procédés d'utilisation
WO2023196818A1 (fr) 2022-04-04 2023-10-12 The Regents Of The University Of California Compositions et procédés de complémentation génétique
WO2023196634A2 (fr) 2022-04-08 2023-10-12 Flagship Pioneering Innovations Vii, Llc Vaccins et procédés associés
WO2023220083A1 (fr) 2022-05-09 2023-11-16 Flagship Pioneering Innovations Vi, Llc Compositions de trem et procédés d'utilisation pour traiter des troubles prolifératifs
WO2023220729A2 (fr) 2022-05-13 2023-11-16 Flagship Pioneering Innovations Vii, Llc Compositions d'adn à double brin et procédés associés
WO2023239756A1 (fr) 2022-06-07 2023-12-14 Generation Bio Co. Compositions de nanoparticules lipidiques et leurs utilisations
WO2023250112A1 (fr) 2022-06-22 2023-12-28 Flagship Pioneering Innovations Vi, Llc Compositions de trem modifiées et leurs utilisations
WO2024030856A2 (fr) 2022-08-01 2024-02-08 Flagship Pioneering Innovations Vii, Llc Protéines immunomodulatrices et méthodes associées
WO2024035952A1 (fr) 2022-08-12 2024-02-15 Remix Therapeutics Inc. Procédés et compositions pour moduler l'épissage au niveau de sites d'épissage alternatifs
WO2024040222A1 (fr) 2022-08-19 2024-02-22 Generation Bio Co. Adn à extrémités fermées clivable (adnce) et ses procédés d'utilisation
WO2024049979A2 (fr) 2022-08-31 2024-03-07 Senda Biosciences, Inc. Nouveaux lipides ionisables et nanoparticules lipidiques, ainsi que procédés d'utilisation associés
WO2024077191A1 (fr) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Molécules d'acide nucléique codant pour des trif et des polypeptides supplémentaires et leur utilisation dans le traitement du cancer
WO2024097664A1 (fr) 2022-10-31 2024-05-10 Flagship Pioneering Innovations Vi, Llc Compositions et procédés de purification de polyribonucléotides
WO2024102799A1 (fr) 2022-11-08 2024-05-16 Flagship Pioneering Innovations Vi, Llc Compositions et procédés de production de polyribonucléotides circulaires
WO2024102730A1 (fr) 2022-11-08 2024-05-16 Orna Therapeutics, Inc. Lipides et compositions de nanoparticules pour l'administration de polynucléotides
WO2024102762A1 (fr) 2022-11-08 2024-05-16 Orna Therapeutics, Inc. Lipides et compositions de nanoparticules lipidiques pour administration de polynucléotides
WO2024102677A1 (fr) 2022-11-08 2024-05-16 Orna Therapeutics, Inc. Compositions d'arn circulaire

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1695978A1 (fr) 1990-06-11 2006-08-30 Gilead Sciences, Inc. Ligands constitués par des acides nucléiques
GB2270920B (en) 1992-09-25 1997-04-02 Univ Keele Alginate-bioactive agent conjugates
FR2698628B1 (fr) 1992-12-02 1995-02-17 Fournier Ind & Sante Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5777153A (en) 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5820873A (en) * 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US7422902B1 (en) * 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
DE69634084T2 (de) 1995-06-07 2005-12-08 Inex Pharmaceuticals Corp. Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
WO1997003939A1 (fr) 1995-07-21 1997-02-06 Genta Incorporated Nouveaux lipides cationiques a base d'amides
EP0934331B1 (fr) 1996-08-30 2002-11-27 Jens Peter Fürste Selection et evolution speculaires d'acides nucleiques
US5989912A (en) 1996-11-21 1999-11-23 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
CA2217550A1 (fr) 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Lipides cationiques pour therapie genique
US6358523B1 (en) 1996-12-06 2002-03-19 The Regents Of The University Of California Macromolecule-lipid complexes and methods for making and regulating
WO1998044909A1 (fr) 1997-04-04 1998-10-15 Valentis Inc. Methodes ameliorees de transport utilisant des lipides cationiques et des lipides assistants
WO1998051285A2 (fr) 1997-05-15 1998-11-19 Genzyme Corporation Formulations amphiphiles cationiques
AR012894A1 (es) 1997-06-13 2000-11-22 Lilly Co Eli Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
US20030073640A1 (en) * 1997-07-23 2003-04-17 Ribozyme Pharmaceuticals, Inc. Novel compositions for the delivery of negatively charged molecules
CA2301166A1 (fr) * 1997-07-24 1999-02-04 Yuan-Peng Zhang Compositions de liposomes pour la distribution des catalyseurs de l'acide nucleique
US6150345A (en) 1998-08-10 2000-11-21 Regents Of The University Of California Methods for promoting survival of myelin producing cells
FR2788275B1 (fr) 1999-01-11 2002-06-14 Lipha ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US7015040B2 (en) * 1999-02-26 2006-03-21 Mirus Bio Corporation Intravascular delivery of nucleic acid
CA2383244A1 (fr) 1999-05-28 2000-12-07 Sugen, Inc. Proteines kinases
EP1064944A1 (fr) 1999-06-25 2001-01-03 Schering Aktiengesellschaft Inhibiteur de la protéine kinase N contenant du Fasudil
IL147089A0 (en) * 1999-07-15 2002-08-14 Inex Pharmaceuticals Corp Methods of preparing lipid-encapsulated therapeutic agents
US6133032A (en) 1999-09-09 2000-10-17 Isis Pharmaceutical Inc. Antisense modulation of PI3 kinase p110 beta expression
KR20080023768A (ko) 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Rna 간섭의 rna 서열 특이적인 매개체
US7282219B2 (en) 2000-03-31 2007-10-16 Kirin Beer Kabushiki Kaisha Powdery preparation for transmucosal administration containing a polymeric form of drug and exhibiting improved storage stability
AU2001254548B2 (en) * 2000-04-20 2006-09-28 The University Of British Columbia Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane
WO2002034236A2 (fr) 2000-10-25 2002-05-02 The University Of British Columbia Formulations de lipides pour une administration ciblee
CZ302719B6 (cs) 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
US20030135033A1 (en) 2002-01-04 2003-07-17 Anke Klippel-Giese Compounds and methods for the identification and/ or validation of a target
AU2003207708A1 (en) 2002-02-20 2003-09-09 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes
US20040156816A1 (en) 2002-08-06 2004-08-12 David Anderson Lipid-drug complexes in reversed liquid and liquid crystalline phases
EP1393742A1 (fr) 2002-08-14 2004-03-03 atugen AG Utilisation de la protéine kinase N bêta
MXPA05001766A (es) 2002-08-14 2005-08-19 Atugen Ag Uso de proteina quinasa n beta.
US7635770B2 (en) 2002-11-14 2009-12-22 Dharmacon, Inc. siRNA targeting protein kinase N-3 (PKN-3)
AU2003299818A1 (en) 2002-12-20 2004-07-22 Applera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
WO2005019258A2 (fr) 2003-08-11 2005-03-03 Genentech, Inc. Compositions et methodes de traitement de maladies relatives au systeme immunitaire
EP1663171B9 (fr) * 2003-08-26 2009-08-19 SmithKline Beecham Corporation Copolymeres heterofonctionnels de glycerol et de polyethylene glycol, conjugues et compositions associes
HUE036916T2 (hu) 2004-05-05 2018-08-28 Silence Therapeutics Gmbh Lipidek, lipid komplexek és ezek alkalmazása
EP1799258A4 (fr) 2004-08-20 2009-07-22 Univ Johns Hopkins Methodes pour un traitement d'angiogenese
AU2005306075A1 (en) 2004-11-19 2006-05-26 Novosom Ag Improvements in or relating to pharmaceutical compositions for local administration
JP5292572B2 (ja) * 2004-12-27 2013-09-18 サイレンス・セラピューティクス・アーゲー コーティングされた脂質複合体およびそれらの使用
WO2006074546A1 (fr) 2005-01-13 2006-07-20 Protiva Biotherapeutics, Inc. Arn interferant encapsule dans des lipides
AU2007241369A1 (en) 2006-04-20 2007-11-01 Silence Therapeutics Ag Means for inhibiting the expression of CD31
JP2009534342A (ja) 2006-04-20 2009-09-24 サイレンス・セラピューティクス・アーゲー 血管内皮に特異的に送達するためのリポプレックス処方剤
JP2009544281A (ja) 2006-07-21 2009-12-17 サイレンス・セラピューティクス・アーゲー プロテインキナーゼ3の発現を阻害するための手段

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US8852472B2 (en) 2014-10-07
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MX2007007913A (es) 2007-08-14
WO2006069782A9 (fr) 2009-04-30
AU2005321469A1 (en) 2006-07-06
US20100062967A1 (en) 2010-03-11
PL1830888T3 (pl) 2015-12-31
ES2548515T3 (es) 2015-10-19
KR101366482B1 (ko) 2014-02-21
JP2008525514A (ja) 2008-07-17
EP1830888B1 (fr) 2015-08-05
HK1222541A1 (zh) 2017-07-07
WO2006069782A2 (fr) 2006-07-06
EP1830888A2 (fr) 2007-09-12
EP2992902A1 (fr) 2016-03-09
KR20070090956A (ko) 2007-09-06
US20150031752A1 (en) 2015-01-29
BRPI0519468A2 (pt) 2009-01-27
CN101287497B (zh) 2013-03-06
CA2593032C (fr) 2015-12-22
WO2006069782A3 (fr) 2007-04-12
JP5292572B2 (ja) 2013-09-18
DK1830888T3 (en) 2015-10-19
US9387262B2 (en) 2016-07-12
IL183775A0 (en) 2007-09-20
AU2005321469B2 (en) 2012-04-05
CA2593032A1 (fr) 2006-07-06
CN101287497A (zh) 2008-10-15
ZA200704168B (en) 2008-05-28

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