HK1099341A1 - Recombinantly modified plasmin - Google Patents
Recombinantly modified plasminInfo
- Publication number
- HK1099341A1 HK1099341A1 HK07106503.0A HK07106503A HK1099341A1 HK 1099341 A1 HK1099341 A1 HK 1099341A1 HK 07106503 A HK07106503 A HK 07106503A HK 1099341 A1 HK1099341 A1 HK 1099341A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- domain
- recombinantly modified
- terminal
- human plasminogen
- polypeptide
- Prior art date
Links
- 229940012957 plasmin Drugs 0.000 title 1
- 101000605403 Homo sapiens Plasminogen Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56447204P | 2004-04-22 | 2004-04-22 | |
PCT/US2005/013562 WO2005105990A2 (en) | 2004-04-22 | 2005-04-21 | Recombinantly modified plasmin |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1099341A1 true HK1099341A1 (en) | 2007-08-10 |
Family
ID=34982338
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07106503.0A HK1099341A1 (en) | 2004-04-22 | 2007-06-15 | Recombinantly modified plasmin |
HK11104278.2A HK1150242A1 (en) | 2004-04-22 | 2011-04-28 | Recombinantly modified plasmin |
HK13103040.9A HK1175812A1 (en) | 2004-04-22 | 2013-03-12 | Recombinantly modified plasmin |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11104278.2A HK1150242A1 (en) | 2004-04-22 | 2011-04-28 | Recombinantly modified plasmin |
HK13103040.9A HK1175812A1 (en) | 2004-04-22 | 2013-03-12 | Recombinantly modified plasmin |
Country Status (28)
Country | Link |
---|---|
US (2) | US8034913B2 (sl) |
EP (2) | EP2246417B1 (sl) |
JP (1) | JP5026254B2 (sl) |
KR (1) | KR101161819B1 (sl) |
CN (2) | CN102660564B (sl) |
AT (1) | ATE476502T1 (sl) |
AU (1) | AU2005238464B2 (sl) |
BR (1) | BRPI0510063B8 (sl) |
CA (1) | CA2563675C (sl) |
CY (1) | CY1111650T1 (sl) |
DE (1) | DE602005022692D1 (sl) |
DK (1) | DK1740698T3 (sl) |
EA (1) | EA010784B1 (sl) |
ES (2) | ES2534744T3 (sl) |
HK (3) | HK1099341A1 (sl) |
HR (1) | HRP20100568T1 (sl) |
IL (1) | IL178343A (sl) |
MA (1) | MA28590B1 (sl) |
MX (1) | MXPA06012236A (sl) |
NO (1) | NO338542B1 (sl) |
NZ (1) | NZ550250A (sl) |
PL (2) | PL2246417T3 (sl) |
PT (2) | PT1740698E (sl) |
RS (1) | RS51623B (sl) |
SI (1) | SI1740698T1 (sl) |
TN (1) | TNSN06332A1 (sl) |
WO (1) | WO2005105990A2 (sl) |
ZA (1) | ZA200608498B (sl) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070004706A (ko) | 2004-02-11 | 2007-01-09 | 바이오렉스 인코포레이티드 | 개구리밥에서의 플라스미노겐 및 마이크로플라스미노겐의발현 방법 |
ES2534744T3 (es) | 2004-04-22 | 2015-04-28 | Grifols Therapeutics Inc. | Plasmina modificada de forma recombinante |
WO2007047874A2 (en) * | 2005-10-20 | 2007-04-26 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
KR100888022B1 (ko) * | 2006-12-21 | 2009-03-09 | 재단법인 목암생명공학연구소 | 면역글로불린 Fc와 인간 아포리포단백질(a)크링글절편의 융합단백질 LK8Fc |
US8101394B2 (en) * | 2007-11-29 | 2012-01-24 | Grifols Therapeutics Inc. | Recombinantly modified plasmin |
MX2010013282A (es) | 2008-06-04 | 2010-12-21 | Talecris Biotherapeutics Inc | Composicion, metodo y kit para la preparacion de plasmina. |
EP2403865B9 (en) | 2009-03-03 | 2015-12-09 | Grifols Therapeutics Inc. | Methods for preparing plasminogen |
NZ597452A (en) | 2009-07-10 | 2013-10-25 | Thrombogenics Nv | Variants of plasminogen and plasmin |
US20120189609A1 (en) | 2009-08-28 | 2012-07-26 | Thrombogenics Nv | Improvement to trabeculectomy |
EP2661493B1 (en) | 2011-01-05 | 2016-03-30 | ThromboGenics N.V. | Plasminogen and plasmin variants |
US9644196B2 (en) | 2011-08-12 | 2017-05-09 | Thrombogenics Nv | Plasminogen and plasmin variants |
TWI624267B (zh) * | 2015-12-18 | 2018-05-21 | Talengen Institute Of Life Sciences Co Ltd | 纖溶酶原在製備預防或治療糖尿病性視網膜病變的藥劑上的用途及包括纖溶酶原用於預防或治療糖尿病性視網膜病變之藥劑 |
CN108210896A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗高脂血症的药物及其用途 |
CN110139667A (zh) | 2016-12-15 | 2019-08-16 | 泰伦基国际有限公司 | 一种使胰高血糖素、胰岛素恢复正常平衡的方法 |
JP7158740B2 (ja) | 2016-12-15 | 2022-10-24 | タレンゲン インターナショナル リミテッド | 冠状動脈アテローム性硬化症およびその合併症を治療するための方法 |
CA3047181A1 (en) | 2016-12-15 | 2018-06-21 | Talengen International Limited | Method and drug for preventing and treating obesity |
CN115427703A (zh) | 2020-04-13 | 2022-12-02 | 株式会社F.C.C. | 动力传递装置 |
KR20230005298A (ko) * | 2020-05-11 | 2023-01-09 | 탈렌젠 인터내셔널 리미티드 | 척수성 근위축증의 치료 방법 및 약물 |
WO2022112251A1 (en) | 2020-11-25 | 2022-06-02 | Grifols Worldwide Operations Limited | Wound healing |
US11964004B2 (en) * | 2021-03-31 | 2024-04-23 | Shenzhen Bay Laboratory | Short in vivo half-life and in vivo unstable recombinant microplasmin, pharmaceutical composition comprising thereof and method of treating thromboembolism related diseases including administration thereof |
WO2024018051A1 (en) | 2022-07-22 | 2024-01-25 | Grifols Worldwide Operations Limited | Stable plasmin compositions for organ preservation and reconditioning |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4652639A (en) * | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
US4631211A (en) * | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
US4774087A (en) * | 1987-08-14 | 1988-09-27 | Northwestern University | Micro-size fibrinolytic plasmin |
US7253264B1 (en) * | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
DE59109032D1 (de) | 1990-06-28 | 1998-09-03 | Hoechst Ag | Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung |
US6312893B1 (en) * | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
US6613508B1 (en) * | 1996-01-23 | 2003-09-02 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
CN1163619C (zh) | 1996-01-23 | 2004-08-25 | 佳根基因组学公司 | 测定核酸分子序列的方法和组合物 |
JPH10158300A (ja) | 1996-11-28 | 1998-06-16 | Suzuki Motor Corp | 血管新生抑制効果を有するタンパク質とその製造方法及びアンギオスタチンの製造方法 |
HUP0002518A3 (en) | 1997-07-22 | 2003-01-28 | Qiagen Genomics Inc | Computer method and system for correlating sequencing data by ms |
EP1096945A4 (en) | 1998-07-14 | 2003-01-02 | Bristol Myers Squibb Co | ANGIOSTATIN FRAGMENTS BINDING LYSINE |
CN1191856C (zh) * | 1998-09-29 | 2005-03-09 | 勒芬研究与发展公司 | 可在体内减少α2-抗纤溶酶的化合物在制备用于治疗局部缺血性中风的组合物中的用途 |
US6355243B1 (en) | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
US6969515B2 (en) | 1999-11-13 | 2005-11-29 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
US6964764B2 (en) | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
CA2410440A1 (en) | 2000-06-02 | 2001-12-13 | Blue Heron Biotechnology, Inc. | Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides |
AU2002218890A1 (en) | 2000-12-21 | 2002-07-01 | Thromb-X N.V. | A yeast expression vector and a method of making a recombinant protein by expression in a yeast cell |
AU2002357249A1 (en) | 2001-12-13 | 2003-07-09 | Blue Heron Biotechnology, Inc. | Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins |
US7776026B2 (en) * | 2002-02-06 | 2010-08-17 | Nuvue Technologies, Inc. | Method for vitreous liquefaction |
US20050124036A1 (en) * | 2002-02-06 | 2005-06-09 | Rudy Susilo | Method for producing recombinant proteins in micro-organisms |
GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
ES2534744T3 (es) | 2004-04-22 | 2015-04-28 | Grifols Therapeutics Inc. | Plasmina modificada de forma recombinante |
WO2007047874A2 (en) | 2005-10-20 | 2007-04-26 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
US8101394B2 (en) * | 2007-11-29 | 2012-01-24 | Grifols Therapeutics Inc. | Recombinantly modified plasmin |
-
2005
- 2005-04-21 ES ES10166134.6T patent/ES2534744T3/es active Active
- 2005-04-21 NZ NZ550250A patent/NZ550250A/en not_active IP Right Cessation
- 2005-04-21 PT PT05737862T patent/PT1740698E/pt unknown
- 2005-04-21 SI SI200531131T patent/SI1740698T1/sl unknown
- 2005-04-21 CN CN2012101142890A patent/CN102660564B/zh not_active Expired - Fee Related
- 2005-04-21 WO PCT/US2005/013562 patent/WO2005105990A2/en active Application Filing
- 2005-04-21 AU AU2005238464A patent/AU2005238464B2/en not_active Ceased
- 2005-04-21 AT AT05737862T patent/ATE476502T1/de active
- 2005-04-21 US US11/568,023 patent/US8034913B2/en not_active Expired - Fee Related
- 2005-04-21 PL PL10166134T patent/PL2246417T3/pl unknown
- 2005-04-21 CN CNA2005800155389A patent/CN1961070A/zh active Pending
- 2005-04-21 RS RS20100473A patent/RS51623B/en unknown
- 2005-04-21 DE DE602005022692T patent/DE602005022692D1/de active Active
- 2005-04-21 MX MXPA06012236A patent/MXPA06012236A/es active IP Right Grant
- 2005-04-21 CA CA2563675A patent/CA2563675C/en active Active
- 2005-04-21 ES ES05737862T patent/ES2349555T3/es active Active
- 2005-04-21 DK DK05737862.2T patent/DK1740698T3/da active
- 2005-04-21 EP EP10166134.6A patent/EP2246417B1/en active Active
- 2005-04-21 EA EA200601950A patent/EA010784B1/ru not_active IP Right Cessation
- 2005-04-21 BR BRPI0510063A patent/BRPI0510063B8/pt not_active IP Right Cessation
- 2005-04-21 PL PL05737862T patent/PL1740698T3/pl unknown
- 2005-04-21 EP EP05737862A patent/EP1740698B1/en active Active
- 2005-04-21 PT PT101661346T patent/PT2246417E/pt unknown
- 2005-04-21 KR KR1020067024427A patent/KR101161819B1/ko active IP Right Grant
- 2005-04-21 JP JP2007509616A patent/JP5026254B2/ja not_active Expired - Fee Related
-
2006
- 2006-09-27 IL IL178343A patent/IL178343A/en active IP Right Grant
- 2006-10-11 ZA ZA200608498A patent/ZA200608498B/en unknown
- 2006-10-13 TN TNP2006000332A patent/TNSN06332A1/en unknown
- 2006-11-03 NO NO20065050A patent/NO338542B1/no not_active IP Right Cessation
- 2006-11-20 MA MA29466A patent/MA28590B1/fr unknown
-
2007
- 2007-06-15 HK HK07106503.0A patent/HK1099341A1/xx not_active IP Right Cessation
-
2010
- 2010-10-18 CY CY20101100930T patent/CY1111650T1/el unknown
- 2010-10-19 HR HR20100568T patent/HRP20100568T1/hr unknown
-
2011
- 2011-04-28 HK HK11104278.2A patent/HK1150242A1/xx not_active IP Right Cessation
- 2011-09-01 US US13/223,373 patent/US8420079B2/en active Active
-
2013
- 2013-03-12 HK HK13103040.9A patent/HK1175812A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230423 |