PL2246417T3 - Rekombinacyjnie zmodyfikowana plazmina - Google Patents
Rekombinacyjnie zmodyfikowana plazminaInfo
- Publication number
- PL2246417T3 PL2246417T3 PL10166134T PL10166134T PL2246417T3 PL 2246417 T3 PL2246417 T3 PL 2246417T3 PL 10166134 T PL10166134 T PL 10166134T PL 10166134 T PL10166134 T PL 10166134T PL 2246417 T3 PL2246417 T3 PL 2246417T3
- Authority
- PL
- Poland
- Prior art keywords
- domain
- recombinantly modified
- terminal
- human plasminogen
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56447204P | 2004-04-22 | 2004-04-22 | |
| EP10166134.6A EP2246417B1 (en) | 2004-04-22 | 2005-04-21 | Recombinantly modified plasmin |
| EP05737862A EP1740698B1 (en) | 2004-04-22 | 2005-04-21 | Recombinantly modified plasmin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2246417T3 true PL2246417T3 (pl) | 2015-06-30 |
Family
ID=34982338
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05737862T PL1740698T3 (pl) | 2004-04-22 | 2005-04-21 | Rekombinacyjnie zmodyfikowana plazmina |
| PL10166134T PL2246417T3 (pl) | 2004-04-22 | 2005-04-21 | Rekombinacyjnie zmodyfikowana plazmina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05737862T PL1740698T3 (pl) | 2004-04-22 | 2005-04-21 | Rekombinacyjnie zmodyfikowana plazmina |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8034913B2 (pl) |
| EP (2) | EP1740698B1 (pl) |
| JP (1) | JP5026254B2 (pl) |
| KR (1) | KR101161819B1 (pl) |
| CN (2) | CN102660564B (pl) |
| AT (1) | ATE476502T1 (pl) |
| AU (1) | AU2005238464B2 (pl) |
| BR (1) | BRPI0510063B8 (pl) |
| CA (1) | CA2563675C (pl) |
| CY (1) | CY1111650T1 (pl) |
| DE (1) | DE602005022692D1 (pl) |
| DK (1) | DK1740698T3 (pl) |
| EA (1) | EA010784B1 (pl) |
| ES (2) | ES2534744T3 (pl) |
| HK (3) | HK1099341A1 (pl) |
| HR (1) | HRP20100568T1 (pl) |
| IL (1) | IL178343A (pl) |
| MA (1) | MA28590B1 (pl) |
| MX (1) | MXPA06012236A (pl) |
| NO (1) | NO338542B1 (pl) |
| NZ (1) | NZ550250A (pl) |
| PL (2) | PL1740698T3 (pl) |
| PT (2) | PT2246417E (pl) |
| RS (1) | RS51623B (pl) |
| SI (1) | SI1740698T1 (pl) |
| TN (1) | TNSN06332A1 (pl) |
| WO (1) | WO2005105990A2 (pl) |
| ZA (1) | ZA200608498B (pl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007521834A (ja) | 2004-02-11 | 2007-08-09 | バイオレックス インク | ウキクサ中でのプラスミノ−ゲン及びミクロプラスミノ−ゲンの発現 |
| PT2246417E (pt) | 2004-04-22 | 2015-05-05 | Grifols Therapeutics Inc | Plasmina modificada por recombinação |
| WO2007047874A2 (en) * | 2005-10-20 | 2007-04-26 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
| KR100888022B1 (ko) * | 2006-12-21 | 2009-03-09 | 재단법인 목암생명공학연구소 | 면역글로불린 Ｆｃ와 인간 아포리포단백질（ａ）크링글절편의 융합단백질 ＬＫ8Ｆｃ |
| HUE024916T2 (en) | 2007-11-29 | 2016-02-29 | Grifols Therapeutics Inc | Recombinantly modified plasmin |
| US8617863B2 (en) | 2008-06-04 | 2013-12-31 | Grifols Therapeutics Inc. | Composition, method, and kit for preparing plasmin |
| ES2552337T3 (es) | 2009-03-03 | 2015-11-27 | Grifols Therapeutics Inc. | Procedimientos para la preparación de plasminógeno |
| AU2010270146B9 (en) | 2009-07-10 | 2015-04-02 | Thrombogenics Nv | Variants of plasminogen and plasmin |
| WO2011023805A1 (en) | 2009-08-28 | 2011-03-03 | Thrombogenics N.V. | Use of plasmin for the treatment of filtration failure after trabeculectomy |
| MX337248B (es) | 2011-01-05 | 2016-02-19 | Thrombogenics Nv | Variantes de plasminogeno y plasmina. |
| JP6000353B2 (ja) | 2011-08-12 | 2016-09-28 | スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ | プラスミノーゲンおよびプラスミンの変異体 |
| WO2017101870A1 (zh) * | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性视网膜病变的方法 |
| CN108210902A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗脂肪肝的药物及其用途 |
| WO2018107685A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种治疗冠状动脉粥样硬化及其并发症的方法 |
| EP3556390B1 (en) | 2016-12-15 | 2024-04-03 | Talengen International Limited | Plasminogen for use in treating diabetes |
| EP3556379A4 (en) | 2016-12-15 | 2020-08-19 | Talengen International Limited | METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY |
| JP7391192B2 (ja) | 2020-04-13 | 2023-12-04 | 株式会社エフ・シー・シー | 動力伝達装置 |
| CA3182911A1 (en) * | 2020-05-11 | 2021-11-18 | Talengen International Limited | Method and drug for treating spinal muscular atrophy |
| JP2023550301A (ja) | 2020-11-25 | 2023-12-01 | グリフォルス・ワールドワイド・オペレーションズ・リミテッド | 創傷治癒 |
| US11964004B2 (en) * | 2021-03-31 | 2024-04-23 | Shenzhen Bay Laboratory | Short in vivo half-life and in vivo unstable recombinant microplasmin, pharmaceutical composition comprising thereof and method of treating thromboembolism related diseases including administration thereof |
| WO2024018051A1 (en) | 2022-07-22 | 2024-01-25 | Grifols Worldwide Operations Limited | Stable plasmin compositions for organ preservation and reconditioning |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4652639A (en) | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
| US4774087A (en) * | 1987-08-14 | 1988-09-27 | Northwestern University | Micro-size fibrinolytic plasmin |
| US7253264B1 (en) | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
| ES2251009T3 (es) | 1990-06-28 | 2006-04-16 | Sanofi-Aventis Deutschland Gmbh | Proteinas de fusion con partes de inmunoglobulinas, su preparacion y uso. |
| US6613508B1 (en) | 1996-01-23 | 2003-09-02 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
| HUP9901321A3 (en) | 1996-01-23 | 2001-10-29 | Rapigene Inc Bothell | Methods and compositions for determining the sequence of nucleic acid molecules |
| US6312893B1 (en) | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
| JPH10158300A (ja) | 1996-11-28 | 1998-06-16 | Suzuki Motor Corp | 血管新生抑制効果を有するタンパク質とその製造方法及びアンギオスタチンの製造方法 |
| CN1249252C (zh) | 1997-07-22 | 2006-04-05 | 佳根基因组学公司 | 通过ms使序列数据相关的计算机方法和系统 |
| AU751283B2 (en) | 1998-07-14 | 2002-08-08 | Bristol-Myers Squibb Company | Lysine binding fragments of angiostatin |
| EP1117437B1 (en) | 1998-09-29 | 2006-12-27 | Leuven Research & Development vzw | Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke |
| US6964764B2 (en) | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| US6355243B1 (en) | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
| US6969515B2 (en) | 1999-11-13 | 2005-11-29 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| CA2410440A1 (en) | 2000-06-02 | 2001-12-13 | Blue Heron Biotechnology, Inc. | Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides |
| US7445775B2 (en) | 2000-12-21 | 2008-11-04 | Thromb-X Nv | Yeast expression vector and a method of making a recombinant protein by expression in a yeast cell |
| WO2003054232A2 (en) | 2001-12-13 | 2003-07-03 | Blue Heron Biotechnology, Inc. | Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins |
| US7776026B2 (en) | 2002-02-06 | 2010-08-17 | Nuvue Technologies, Inc. | Method for vitreous liquefaction |
| DE10390418D2 (de) | 2002-02-06 | 2005-01-13 | N Zyme Biotec Gmbh | Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen |
| GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
| PT2246417E (pt) | 2004-04-22 | 2015-05-05 | Grifols Therapeutics Inc | Plasmina modificada por recombinação |
| WO2007047874A2 (en) | 2005-10-20 | 2007-04-26 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
| HUE024916T2 (en) | 2007-11-29 | 2016-02-29 | Grifols Therapeutics Inc | Recombinantly modified plasmin |
-
2005
- 2005-04-21 PT PT101661346T patent/PT2246417E/pt unknown
- 2005-04-21 ES ES10166134.6T patent/ES2534744T3/es active Active
- 2005-04-21 MX MXPA06012236A patent/MXPA06012236A/es active IP Right Grant
- 2005-04-21 SI SI200531131T patent/SI1740698T1/sl unknown
- 2005-04-21 AU AU2005238464A patent/AU2005238464B2/en not_active Ceased
- 2005-04-21 KR KR1020067024427A patent/KR101161819B1/ko active IP Right Grant
- 2005-04-21 WO PCT/US2005/013562 patent/WO2005105990A2/en active Application Filing
- 2005-04-21 CN CN2012101142890A patent/CN102660564B/zh not_active Expired - Fee Related
- 2005-04-21 JP JP2007509616A patent/JP5026254B2/ja not_active Expired - Fee Related
- 2005-04-21 ES ES05737862T patent/ES2349555T3/es active Active
- 2005-04-21 DE DE602005022692T patent/DE602005022692D1/de active Active
- 2005-04-21 BR BRPI0510063A patent/BRPI0510063B8/pt not_active IP Right Cessation
- 2005-04-21 RS RS20100473A patent/RS51623B/en unknown
- 2005-04-21 EA EA200601950A patent/EA010784B1/ru not_active IP Right Cessation
- 2005-04-21 PL PL05737862T patent/PL1740698T3/pl unknown
- 2005-04-21 US US11/568,023 patent/US8034913B2/en not_active Expired - Fee Related
- 2005-04-21 NZ NZ550250A patent/NZ550250A/en not_active IP Right Cessation
- 2005-04-21 CN CNA2005800155389A patent/CN1961070A/zh active Pending
- 2005-04-21 EP EP05737862A patent/EP1740698B1/en active Active
- 2005-04-21 DK DK05737862.2T patent/DK1740698T3/da active
- 2005-04-21 AT AT05737862T patent/ATE476502T1/de active
- 2005-04-21 EP EP10166134.6A patent/EP2246417B1/en active Active
- 2005-04-21 PT PT05737862T patent/PT1740698E/pt unknown
- 2005-04-21 PL PL10166134T patent/PL2246417T3/pl unknown
- 2005-04-21 CA CA2563675A patent/CA2563675C/en active Active
-
2006
- 2006-09-27 IL IL178343A patent/IL178343A/en active IP Right Grant
- 2006-10-11 ZA ZA200608498A patent/ZA200608498B/en unknown
- 2006-10-13 TN TNP2006000332A patent/TNSN06332A1/en unknown
- 2006-11-03 NO NO20065050A patent/NO338542B1/no not_active IP Right Cessation
- 2006-11-20 MA MA29466A patent/MA28590B1/fr unknown
-
2007
- 2007-06-15 HK HK07106503.0A patent/HK1099341A1/xx not_active IP Right Cessation
-
2010
- 2010-10-18 CY CY20101100930T patent/CY1111650T1/el unknown
- 2010-10-19 HR HR20100568T patent/HRP20100568T1/hr unknown
-
2011
- 2011-04-28 HK HK11104278.2A patent/HK1150242A1/xx not_active IP Right Cessation
- 2011-09-01 US US13/223,373 patent/US8420079B2/en active Active
-
2013
- 2013-03-12 HK HK13103040.9A patent/HK1175812A1/xx not_active IP Right Cessation
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