PL1740698T3 - Rekombinacyjnie zmodyfikowana plazmina - Google Patents

Rekombinacyjnie zmodyfikowana plazmina

Info

Publication number
PL1740698T3
PL1740698T3 PL05737862T PL05737862T PL1740698T3 PL 1740698 T3 PL1740698 T3 PL 1740698T3 PL 05737862 T PL05737862 T PL 05737862T PL 05737862 T PL05737862 T PL 05737862T PL 1740698 T3 PL1740698 T3 PL 1740698T3
Authority
PL
Poland
Prior art keywords
domain
recombinantly modified
terminal
human plasminogen
polypeptide
Prior art date
Application number
PL05737862T
Other languages
English (en)
Inventor
Jennifer Audrey Hunt
Valery Novokhatny
Original Assignee
Grifols Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34982338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1740698(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grifols Therapeutics Inc filed Critical Grifols Therapeutics Inc
Publication of PL1740698T3 publication Critical patent/PL1740698T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL05737862T 2004-04-22 2005-04-21 Rekombinacyjnie zmodyfikowana plazmina PL1740698T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56447204P 2004-04-22 2004-04-22
PCT/US2005/013562 WO2005105990A2 (en) 2004-04-22 2005-04-21 Recombinantly modified plasmin
EP05737862A EP1740698B1 (en) 2004-04-22 2005-04-21 Recombinantly modified plasmin

Publications (1)

Publication Number Publication Date
PL1740698T3 true PL1740698T3 (pl) 2011-01-31

Family

ID=34982338

Family Applications (2)

Application Number Title Priority Date Filing Date
PL10166134T PL2246417T3 (pl) 2004-04-22 2005-04-21 Rekombinacyjnie zmodyfikowana plazmina
PL05737862T PL1740698T3 (pl) 2004-04-22 2005-04-21 Rekombinacyjnie zmodyfikowana plazmina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL10166134T PL2246417T3 (pl) 2004-04-22 2005-04-21 Rekombinacyjnie zmodyfikowana plazmina

Country Status (28)

Country Link
US (2) US8034913B2 (pl)
EP (2) EP1740698B1 (pl)
JP (1) JP5026254B2 (pl)
KR (1) KR101161819B1 (pl)
CN (2) CN1961070A (pl)
AT (1) ATE476502T1 (pl)
AU (1) AU2005238464B2 (pl)
BR (1) BRPI0510063B8 (pl)
CA (1) CA2563675C (pl)
CY (1) CY1111650T1 (pl)
DE (1) DE602005022692D1 (pl)
DK (1) DK1740698T3 (pl)
EA (1) EA010784B1 (pl)
ES (2) ES2534744T3 (pl)
HK (3) HK1099341A1 (pl)
HR (1) HRP20100568T1 (pl)
IL (1) IL178343A (pl)
MA (1) MA28590B1 (pl)
MX (1) MXPA06012236A (pl)
NO (1) NO338542B1 (pl)
NZ (1) NZ550250A (pl)
PL (2) PL2246417T3 (pl)
PT (2) PT1740698E (pl)
RS (1) RS51623B (pl)
SI (1) SI1740698T1 (pl)
TN (1) TNSN06332A1 (pl)
WO (1) WO2005105990A2 (pl)
ZA (1) ZA200608498B (pl)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
AU2005212431B2 (en) 2004-02-11 2010-07-15 Synthon Biopharmaceuticals B.V. Expression of plasminogen and microplasminogen in duckweed
ATE476502T1 (de) 2004-04-22 2010-08-15 Talecris Biotherapeutics Inc Recombinant modifiziertes plasmin
WO2007047874A2 (en) * 2005-10-20 2007-04-26 Talecris Biotherapeutics, Inc. Recombinantly modified plasmin
KR100888022B1 (ko) * 2006-12-21 2009-03-09 재단법인 목암생명공학연구소 면역글로불린 Ｆｃ와 인간 아포리포단백질（ａ）크링글절편의 융합단백질 ＬＫ8­Ｆｃ
BRPI0819780B1 (pt) * 2007-11-29 2023-01-24 Grifols Therapeutics Inc Polinucleotídeo e método para produzir um ou mais polipeptídeos de plasmina recombinante
MX2010013282A (es) 2008-06-04 2010-12-21 Talecris Biotherapeutics Inc Composicion, metodo y kit para la preparacion de plasmina.
PL2403865T3 (pl) 2009-03-03 2016-01-29 Grifols Therapeutics Inc Sposoby wytwarzania plazminogenu
US9226953B2 (en) 2009-07-10 2016-01-05 Thrombogenics Nv Variants of plasminogen and plasmin
WO2011023805A1 (en) 2009-08-28 2011-03-03 Thrombogenics N.V. Use of plasmin for the treatment of filtration failure after trabeculectomy
DK2661493T3 (en) 2011-01-05 2016-07-18 Thrombogenics Nv PLASMINOGEN AND PLASMIN VARIANS
KR20140064841A (ko) 2011-08-12 2014-05-28 쓰롬보제닉스 엔.브이. 플라스미노겐 변이체 및 플라스민 변이체
CN108463240A (zh) * 2015-12-18 2018-08-28 泰伦基国际有限公司 一种预防或治疗糖尿病性视网膜病变的方法
CN108210914A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗脂肪代谢紊乱及其相关病症的药物及其用途
EP3556379A4 (en) 2016-12-15 2020-08-19 Talengen International Limited METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY
JP7158740B2 (ja) 2016-12-15 2022-10-24 タレンゲン インターナショナル リミテッド 冠状動脈アテローム性硬化症およびその合併症を治療するための方法
EP3556392B1 (en) 2016-12-15 2024-04-17 Talengen International Limited Plasminogen for use in treating diabetes
CN115427703A (zh) 2020-04-13 2022-12-02 株式会社F.C.C. 动力传递装置
US20230181699A1 (en) * 2020-05-11 2023-06-15 Talengen International Limited Method and drug for treating spinal muscular atrophy
WO2022112251A1 (en) 2020-11-25 2022-06-02 Grifols Worldwide Operations Limited Wound healing
US11964004B2 (en) * 2021-03-31 2024-04-23 Shenzhen Bay Laboratory Short in vivo half-life and in vivo unstable recombinant microplasmin, pharmaceutical composition comprising thereof and method of treating thromboembolism related diseases including administration thereof
WO2024018051A1 (en) 2022-07-22 2024-01-25 Grifols Worldwide Operations Limited Stable plasmin compositions for organ preservation and reconditioning

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US4652639A (en) 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US4774087A (en) * 1987-08-14 1988-09-27 Northwestern University Micro-size fibrinolytic plasmin
EP1586635A1 (de) 1990-06-28 2005-10-19 Hoechst Aktiengesellschaft Fusionsproteine mit Immunglobulinanteilen, ihre Herstellung und Verwendung
US7253264B1 (en) 1990-06-28 2007-08-07 Sanofi-Arentideutschland GmbH Immunoglobulin fusion proteins, their production and use
CZ218498A3 (cs) 1996-01-23 1998-12-16 Rapigene, Inc. Způsoby a kompozice pro stanovení sekvence molekul nukleových kyselin
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
JPH10158300A (ja) 1996-11-28 1998-06-16 Suzuki Motor Corp 血管新生抑制効果を有するタンパク質とその製造方法及びアンギオスタチンの製造方法
CA2298117A1 (en) 1997-07-22 1999-02-04 Rapigene Inc. Computer method and system for correlating sequencing data by ms
CA2337231A1 (en) 1998-07-14 2000-01-27 Bristol-Myers Squibb Company Lysine binding fragments of angiostatin
CN1191856C (zh) 1998-09-29 2005-03-09 勒芬研究与发展公司 可在体内减少α2－抗纤溶酶的化合物在制备用于治疗局部缺血性中风的组合物中的用途
US6969515B2 (en) 1999-11-13 2005-11-29 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6355243B1 (en) 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
WO2001094366A1 (en) 2000-06-02 2001-12-13 Blue Heron Biotechnology, Inc. Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides
AU2002218890A1 (en) * 2000-12-21 2002-07-01 Thromb-X N.V. A yeast expression vector and a method of making a recombinant protein by expression in a yeast cell
AU2002357249A1 (en) 2001-12-13 2003-07-09 Blue Heron Biotechnology, Inc. Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins
DE10390418D2 (de) 2002-02-06 2005-01-13 N Zyme Biotec Gmbh Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen
US7776026B2 (en) 2002-02-06 2010-08-17 Nuvue Technologies, Inc. Method for vitreous liquefaction
GB0228409D0 (en) 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
ATE476502T1 (de) 2004-04-22 2010-08-15 Talecris Biotherapeutics Inc Recombinant modifiziertes plasmin
WO2007047874A2 (en) 2005-10-20 2007-04-26 Talecris Biotherapeutics, Inc. Recombinantly modified plasmin
BRPI0819780B1 (pt) * 2007-11-29 2023-01-24 Grifols Therapeutics Inc Polinucleotídeo e método para produzir um ou mais polipeptídeos de plasmina recombinante

Also Published As

Publication number Publication date
CA2563675A1 (en) 2005-11-10
EA010784B1 (ru) 2008-10-30
ES2534744T3 (es) 2015-04-28
HRP20100568T1 (hr) 2010-11-30
IL178343A0 (en) 2007-02-11
EA200601950A1 (ru) 2007-02-27
BRPI0510063B1 (pt) 2020-03-17
WO2005105990A3 (en) 2006-01-12
DE602005022692D1 (de) 2010-09-16
KR20070006918A (ko) 2007-01-11
ZA200608498B (en) 2008-07-30
BRPI0510063B8 (pt) 2021-05-25
HK1099341A1 (en) 2007-08-10
PT2246417E (pt) 2015-05-05
NO338542B1 (no) 2016-09-05
US20100304465A1 (en) 2010-12-02
BRPI0510063A (pt) 2008-03-11
EP2246417B1 (en) 2015-01-21
US20110318812A1 (en) 2011-12-29
AU2005238464A1 (en) 2005-11-10
ES2349555T3 (es) 2011-01-05
CY1111650T1 (el) 2015-10-07
WO2005105990A2 (en) 2005-11-10
CA2563675C (en) 2012-08-28
RS51623B (en) 2011-08-31
CN1961070A (zh) 2007-05-09
MXPA06012236A (es) 2007-01-31
PL2246417T3 (pl) 2015-06-30
HK1150242A1 (en) 2011-11-11
DK1740698T3 (da) 2010-10-25
EP2246417A1 (en) 2010-11-03
AU2005238464B2 (en) 2011-01-27
MA28590B1 (fr) 2007-05-02
US8420079B2 (en) 2013-04-16
IL178343A (en) 2010-11-30
CN102660564B (zh) 2013-05-08
PT1740698E (pt) 2010-11-02
ATE476502T1 (de) 2010-08-15
EP1740698A2 (en) 2007-01-10
KR101161819B1 (ko) 2012-07-03
TNSN06332A1 (en) 2008-02-22
SI1740698T1 (sl) 2010-11-30
NO20065050L (no) 2006-11-03
CN102660564A (zh) 2012-09-12
EP1740698B1 (en) 2010-08-04
HK1175812A1 (en) 2013-07-12
US8034913B2 (en) 2011-10-11
JP2007533327A (ja) 2007-11-22
NZ550250A (en) 2009-05-31
JP5026254B2 (ja) 2012-09-12

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