PL2220221T3 - Rekombinacyjnie zmodyfikowana plazmina - Google Patents

Rekombinacyjnie zmodyfikowana plazmina

Info

Publication number
PL2220221T3
PL2220221T3 PL08857923T PL08857923T PL2220221T3 PL 2220221 T3 PL2220221 T3 PL 2220221T3 PL 08857923 T PL08857923 T PL 08857923T PL 08857923 T PL08857923 T PL 08857923T PL 2220221 T3 PL2220221 T3 PL 2220221T3
Authority
PL
Poland
Prior art keywords
recombinantly modified
modified plasmin
plasmin
recombinantly
modified
Prior art date
Application number
PL08857923T
Other languages
English (en)
Inventor
Valery Novokhatny
Original Assignee
Grifols Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grifols Therapeutics Inc filed Critical Grifols Therapeutics Inc
Publication of PL2220221T3 publication Critical patent/PL2220221T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
PL08857923T 2007-11-29 2008-11-25 Rekombinacyjnie zmodyfikowana plazmina PL2220221T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99114807P 2007-11-29 2007-11-29
PCT/US2008/084645 WO2009073471A1 (en) 2007-11-29 2008-11-25 Recombinantly modified plasmin
EP08857923.0A EP2220221B1 (en) 2007-11-29 2008-11-25 Recombinantly modified plasmin

Publications (1)

Publication Number Publication Date
PL2220221T3 true PL2220221T3 (pl) 2015-07-31

Family

ID=40379999

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08857923T PL2220221T3 (pl) 2007-11-29 2008-11-25 Rekombinacyjnie zmodyfikowana plazmina

Country Status (18)

Country Link
US (3) US8101394B2 (pl)
EP (1) EP2220221B1 (pl)
JP (1) JP5539896B2 (pl)
KR (1) KR101529743B1 (pl)
CN (1) CN101918548B (pl)
AU (1) AU2008331545B2 (pl)
BR (1) BRPI0819780B1 (pl)
CA (1) CA2707266C (pl)
ES (1) ES2534040T3 (pl)
HK (1) HK1146089A1 (pl)
HU (1) HUE024916T2 (pl)
IL (1) IL205936A (pl)
MX (1) MX2010005947A (pl)
NZ (2) NZ585715A (pl)
PL (1) PL2220221T3 (pl)
PT (1) PT2220221E (pl)
WO (1) WO2009073471A1 (pl)
ZA (1) ZA201003730B (pl)

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AU2010270146B9 (en) 2009-07-10 2015-04-02 Thrombogenics Nv Variants of plasminogen and plasmin
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KR20140015289A (ko) 2011-01-05 2014-02-06 쓰롬보제닉스 엔.브이. 플라스미노겐 및 플라스민 변이체
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CN103205410B (zh) * 2012-01-13 2018-03-06 蔺莹莹 重组微纤维蛋白溶酶及其制备方法和应用
CA2916421A1 (en) 2013-03-14 2014-09-25 Bayer Healthcare Llc Monoclonal antibodies against antithrombin beta complexed with heparin
DE102014112212A1 (de) * 2014-08-26 2016-03-03 Akesion Gmbh Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen
FR3035120B1 (fr) * 2015-04-15 2020-02-07 Arcadophta Composition de plasminogenase immobilisee, procede de preparation, utilisation et dispositif comprenant une telle composition
WO2017101867A1 (zh) 2015-12-18 2017-06-22 深圳瑞健生命科学研究院有限公司 一种预防或治疗糖尿病性神经损伤及其相关病症的方法
JP6783870B2 (ja) 2015-12-18 2020-11-11 タレンゲン インターナショナル リミテッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 心血管病を予防及び治療するための新しい方法
JP2019500426A (ja) 2015-12-18 2019-01-10 タレンゲン インターナショナル リミティッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 糖尿病網膜症を予防または治療するための方法
JP6682008B2 (ja) 2015-12-18 2020-04-15 タレンゲン インターナショナル リミテッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 糖尿病性腎症を予防及び治療するための方法
WO2018107708A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种促进胰岛素受体底物-2表达的方法
TWI657823B (zh) 2016-12-15 2019-05-01 大陸商深圳瑞健生命科學研究院有限公司 一種預防和治療系統性硬化症的方法
EP3556379A4 (en) 2016-12-15 2020-08-19 Talengen International Limited METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY
CN108210910A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗系统性硬化症的药物及其用途
TW202123963A (zh) 2016-12-15 2021-07-01 大陸商深圳瑞健生命科學研究院有限公司 一種治療冠狀動脈粥樣硬化及其併發症的方法
JP7194440B2 (ja) 2016-12-15 2022-12-22 タレンゲン インターナショナル リミテッド 心臓病変を改善するための方法
CA3067890A1 (en) 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
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US20220096608A1 (en) * 2019-01-25 2022-03-31 Council Of Scientific And Industrial Research Fibrinolytic composition and method of its preparation
CN115697385A (zh) * 2020-05-11 2023-02-03 泰伦基国际有限公司 一种治疗脊髓性肌萎缩症的方法和药物

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US8231869B2 (en) * 2005-10-20 2012-07-31 Grifols Therapeutics Inc. Recombinant plasmin for opthalmic indications
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Also Published As

Publication number Publication date
JP5539896B2 (ja) 2014-07-02
NZ585715A (en) 2011-11-25
US20120093799A1 (en) 2012-04-19
CN101918548A (zh) 2010-12-15
US20110003332A1 (en) 2011-01-06
US8512980B2 (en) 2013-08-20
AU2008331545A1 (en) 2009-06-11
US8182808B2 (en) 2012-05-22
EP2220221B1 (en) 2014-12-31
CA2707266A1 (en) 2009-06-11
BRPI0819780B1 (pt) 2023-01-24
US20120276611A1 (en) 2012-11-01
IL205936A0 (en) 2010-11-30
US8101394B2 (en) 2012-01-24
MX2010005947A (es) 2010-09-10
KR20100102135A (ko) 2010-09-20
IL205936A (en) 2015-04-30
ZA201003730B (en) 2012-11-28
NZ593837A (en) 2013-01-25
BRPI0819780A2 (pt) 2015-08-11
PT2220221E (pt) 2015-04-16
HUE024916T2 (en) 2016-02-29
WO2009073471A1 (en) 2009-06-11
AU2008331545B2 (en) 2014-01-16
ES2534040T3 (es) 2015-04-16
EP2220221A1 (en) 2010-08-25
CA2707266C (en) 2013-12-31
CN101918548B (zh) 2013-10-16
KR101529743B1 (ko) 2015-06-17
HK1146089A1 (en) 2011-05-13
JP2011505140A (ja) 2011-02-24

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