BRPI0819780A2 - Plasmina modificada de forma recombinante. - Google Patents

Plasmina modificada de forma recombinante.

Info

Publication number
BRPI0819780A2
BRPI0819780A2 BRPI0819780-6A BRPI0819780A BRPI0819780A2 BR PI0819780 A2 BRPI0819780 A2 BR PI0819780A2 BR PI0819780 A BRPI0819780 A BR PI0819780A BR PI0819780 A2 BRPI0819780 A2 BR PI0819780A2
Authority
BR
Brazil
Prior art keywords
recombinantly modified
modified plasma
plasma
recombinantly
modified
Prior art date
Application number
BRPI0819780-6A
Other languages
English (en)
Inventor
Valery Novokhatny
Original Assignee
Talecris Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Talecris Biotherapeutics Inc filed Critical Talecris Biotherapeutics Inc
Publication of BRPI0819780A2 publication Critical patent/BRPI0819780A2/pt
Publication of BRPI0819780B1 publication Critical patent/BRPI0819780B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
BRPI0819780-6A 2007-11-29 2008-11-25 Polinucleotídeo e método para produzir um ou mais polipeptídeos de plasmina recombinante BRPI0819780B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99114807P 2007-11-29 2007-11-29
US60/991,148 2007-11-29
PCT/US2008/084645 WO2009073471A1 (en) 2007-11-29 2008-11-25 Recombinantly modified plasmin

Publications (2)

Publication Number Publication Date
BRPI0819780A2 true BRPI0819780A2 (pt) 2015-08-11
BRPI0819780B1 BRPI0819780B1 (pt) 2023-01-24

Family

ID=40379999

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819780-6A BRPI0819780B1 (pt) 2007-11-29 2008-11-25 Polinucleotídeo e método para produzir um ou mais polipeptídeos de plasmina recombinante

Country Status (18)

Country Link
US (3) US8101394B2 (pt)
EP (1) EP2220221B1 (pt)
JP (1) JP5539896B2 (pt)
KR (1) KR101529743B1 (pt)
CN (1) CN101918548B (pt)
AU (1) AU2008331545B2 (pt)
BR (1) BRPI0819780B1 (pt)
CA (1) CA2707266C (pt)
ES (1) ES2534040T3 (pt)
HK (1) HK1146089A1 (pt)
HU (1) HUE024916T2 (pt)
IL (1) IL205936A (pt)
MX (1) MX2010005947A (pt)
NZ (2) NZ585715A (pt)
PL (1) PL2220221T3 (pt)
PT (1) PT2220221E (pt)
WO (1) WO2009073471A1 (pt)
ZA (1) ZA201003730B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034913B2 (en) 2004-04-22 2011-10-11 Grifols Therapeutics Inc. Recombinantly modified plasmin
NZ585715A (en) 2007-11-29 2011-11-25 Talecris Biotherapeutics Inc Recombinantly modified plasmin
AU2009256168B2 (en) 2008-06-04 2014-06-05 Grifols Therapeutics Inc. Composition, method and kit for preparing plasmin
US9206410B2 (en) * 2009-03-03 2015-12-08 Grifols Therapeutics Inc. Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom
KR20120050442A (ko) 2009-07-10 2012-05-18 쓰롬보제닉스 엔.브이. 플라스미노겐 및 플라스민의 변이체
EP2480249B1 (en) 2009-08-28 2015-01-28 ThromboGenics N.V. Plasmin for the treatment of filtration failure after trabeculectomy
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
JP6085568B2 (ja) 2011-01-05 2017-02-22 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
AU2012296884B2 (en) 2011-08-12 2015-02-05 Thrombogenics N.V. Plasminogen and plasmin variants
CN103205410B (zh) * 2012-01-13 2018-03-06 蔺莹莹 重组微纤维蛋白溶酶及其制备方法和应用
UY35457A (es) 2013-03-14 2014-10-31 Bayer Healthcare Llc ANTICUERPOS MONOCLONALES CONTRA ANTITROMBINA ß
DE102014112212A1 (de) * 2014-08-26 2016-03-03 Akesion Gmbh Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen
FR3035120B1 (fr) * 2015-04-15 2020-02-07 Arcadophta Composition de plasminogenase immobilisee, procede de preparation, utilisation et dispositif comprenant une telle composition
TWI653981B (zh) 2015-12-18 2019-03-21 深圳瑞健生命科學硏究院有限公司 Use of plasminogen for the preparation of a medicament for preventing or treating a condition associated with diabetic nerve injury
US10709771B2 (en) 2015-12-18 2020-07-14 Talengen International Limited Method for preventing or treating diabetic retinopathy
CA3008686C (en) 2015-12-18 2023-03-14 Talengen International Limited Method for preventing and treating diabetic nephropathy
CA3008186A1 (en) 2015-12-18 2017-06-22 Talengen International Limited Novel method for preventing and treating angiocardiopathy
CA3047175A1 (en) 2016-12-15 2018-06-21 Talengen International Limited Method for mitigating heart disease
TWI644682B (zh) * 2016-12-15 2018-12-21 深圳瑞健生命科學硏究院有限公司 一種纖溶酶原在製備促進胰島細胞損傷修復的藥物上的用途
CN110191718A (zh) 2016-12-15 2019-08-30 泰伦基国际有限公司 一种预防和治疗组织器官纤维化的方法
JP7214225B2 (ja) * 2016-12-15 2023-01-30 タレンゲン インターナショナル リミテッド 脂肪肝を予防および治療するための方法
CN108210905A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗皮肤纤维化的药物及其用途
WO2018108161A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗肥胖症的方法和药物
CN111344004A (zh) 2017-06-19 2020-06-26 泰伦基国际有限公司 一种调控glp-1/glp-1r 的方法和药物
US11140020B1 (en) 2018-03-01 2021-10-05 Amazon Technologies, Inc. Availability-enhancing gateways for network traffic in virtualized computing environments
WO2020152713A1 (en) * 2019-01-25 2020-07-30 Council Of Scientific & Industrial Research Fibrinolytic composition and method of its preparation
KR20230005298A (ko) * 2020-05-11 2023-01-09 탈렌젠 인터내셔널 리미티드 척수성 근위축증의 치료 방법 및 약물

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652639A (en) 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4774087A (en) 1987-08-14 1988-09-27 Northwestern University Micro-size fibrinolytic plasmin
US7253264B1 (en) 1990-06-28 2007-08-07 Sanofi-Arentideutschland GmbH Immunoglobulin fusion proteins, their production and use
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
KR100482917B1 (ko) 1996-01-23 2005-11-11 퀴아진 지노믹스, 인코포레이티드 핵산분자의서열을결정하는방법및이를위한조성물
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
JPH10158300A (ja) 1996-11-28 1998-06-16 Suzuki Motor Corp 血管新生抑制効果を有するタンパク質とその製造方法及びアンギオスタチンの製造方法
NZ501774A (en) 1997-07-22 2002-02-01 Qiagen Genomics Inc Computer method and system for correlating known characteristics of biomolecules to molecular tags with unique molecular weights that are associated with the biomolecule
JP2002520367A (ja) 1998-07-14 2002-07-09 ブリストル−マイヤーズ スクイブ カンパニー アンギオスタチンのリジン結合フラグメント
EP1117437B1 (en) 1998-09-29 2006-12-27 Leuven Research & Development vzw Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke
US6969515B2 (en) 1999-11-13 2005-11-29 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6355243B1 (en) 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US6664112B2 (en) 2000-06-02 2003-12-16 Blue Heron Biotechnology, Inc. Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides
WO2002050290A1 (en) * 2000-12-21 2002-06-27 Thromb-X Nv A yeast expression vector and a method of making a recombinant protein by expression in a yeast cell
AU2002357249A1 (en) 2001-12-13 2003-07-09 Blue Heron Biotechnology, Inc. Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins
DE10390418D2 (de) 2002-02-06 2005-01-13 N Zyme Biotec Gmbh Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen
US7776026B2 (en) 2002-02-06 2010-08-17 Nuvue Technologies, Inc. Method for vitreous liquefaction
GB0228409D0 (en) * 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
US8034913B2 (en) * 2004-04-22 2011-10-11 Grifols Therapeutics Inc. Recombinantly modified plasmin
WO2007047874A2 (en) * 2005-10-20 2007-04-26 Talecris Biotherapeutics, Inc. Recombinantly modified plasmin
NZ585715A (en) 2007-11-29 2011-11-25 Talecris Biotherapeutics Inc Recombinantly modified plasmin

Also Published As

Publication number Publication date
US8101394B2 (en) 2012-01-24
US20120093799A1 (en) 2012-04-19
BRPI0819780B1 (pt) 2023-01-24
CN101918548A (zh) 2010-12-15
PL2220221T3 (pl) 2015-07-31
ZA201003730B (en) 2012-11-28
KR20100102135A (ko) 2010-09-20
IL205936A (en) 2015-04-30
HK1146089A1 (en) 2011-05-13
JP5539896B2 (ja) 2014-07-02
IL205936A0 (en) 2010-11-30
AU2008331545B2 (en) 2014-01-16
CN101918548B (zh) 2013-10-16
KR101529743B1 (ko) 2015-06-17
MX2010005947A (es) 2010-09-10
JP2011505140A (ja) 2011-02-24
CA2707266C (en) 2013-12-31
ES2534040T3 (es) 2015-04-16
US8182808B2 (en) 2012-05-22
EP2220221B1 (en) 2014-12-31
HUE024916T2 (en) 2016-02-29
WO2009073471A1 (en) 2009-06-11
PT2220221E (pt) 2015-04-16
EP2220221A1 (en) 2010-08-25
US20110003332A1 (en) 2011-01-06
US20120276611A1 (en) 2012-11-01
NZ593837A (en) 2013-01-25
AU2008331545A1 (en) 2009-06-11
US8512980B2 (en) 2013-08-20
NZ585715A (en) 2011-11-25
CA2707266A1 (en) 2009-06-11

Similar Documents

Publication Publication Date Title
BRPI0819780A2 (pt) Plasmina modificada de forma recombinante.
BRPI0813235A2 (pt) Combinação anti-helmíntica.
FR2909857B1 (fr) Endovalve.
BRPI0815717A2 (pt) Compostos de imidazopirazina.
SE0801651L (sv) Granuleringskvarn
IT1391534B1 (it) Barriera.
IT1396642B1 (it) Statore.
FR2935945B1 (fr) Installation de telepherique.
ITME20080002A1 (it) Filcomplex - potabilizzatore di acque.
FR2914486B1 (fr) Magnetrons.
ITCE20060002A1 (it) Patok.
FI20075421A (fi) Tukiranka
FR2898787B1 (fr) Equerre.
DE602007012006D1 (de) htung
ITPA20070017A1 (it) Ciottola.
ES1065423Y (es) Conjunto chaleco-mochila.
ITGE20060082A1 (it) Fattoria pet - therapyazienda agrituristica socioterapeutica e didattica.
ES1062074Y (es) Autorefrigerante solar-ecologico.
ES1061980Y (es) Contenedor-palet.
ITPA20060034A1 (it) Kapot forbir.
ITAV20060001A1 (it) Generafiume.
ITPA20060004U1 (it) Contenitore-dispencer-raccoglitore.
ITPI20060037A1 (it) Carsy.
ITPA20060035A1 (it) Levita.
ITSS20060011A1 (it) Posablocchi.

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: GRIFOLS THERAPEUTICS INC. (US)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/11/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.