DE60336265D1 - Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen - Google Patents
Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungenInfo
- Publication number
- DE60336265D1 DE60336265D1 DE60336265T DE60336265T DE60336265D1 DE 60336265 D1 DE60336265 D1 DE 60336265D1 DE 60336265 T DE60336265 T DE 60336265T DE 60336265 T DE60336265 T DE 60336265T DE 60336265 D1 DE60336265 D1 DE 60336265D1
- Authority
- DE
- Germany
- Prior art keywords
- eopa
- inhibitors
- activity
- heopa
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 108010073106 thimet oligopeptidase Proteins 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 241000282414 Homo sapiens Species 0.000 abstract 2
- 101150006989 NDEL1 gene Proteins 0.000 abstract 2
- 102100023312 Nuclear distribution protein nudE-like 1 Human genes 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- HLXHCNWEVQNNKA-UHFFFAOYSA-N 5-methoxy-2,3-dihydro-1h-inden-2-amine Chemical compound COC1=CC=C2CC(N)CC2=C1 HLXHCNWEVQNNKA-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 241000206602 Eukaryota Species 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000006741 behavioral dysfunction Effects 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000009918 complex formation Effects 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 102000014187 peptide receptors Human genes 0.000 abstract 1
- 108010011903 peptide receptors Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR0205000 | 2002-12-09 | ||
| BR0305688A BR0305688A (pt) | 2003-12-05 | 2003-12-05 | Processo para a determinação da estrutura primária do rna mensageiro codificante para a endooligopeptidase a humana (heopa) [genbank acc n°af217798] e da sua sequência protéica [genbank acc n° aaf24516], para a determinação do gene da eopa humana, e para a produção da eopa humana recombinante; processo de geração de anticorpos anti-heopa; processo de padronização e utilização de substratos sintéticos para a determinação das propriedades bioquìmicas e proteolìticas da heopa; processo de identificação e produção de inibidores da eopa, obtenção de anticorpos com atividade inibitória sobre a atividade catalìtica e sobre a interação com oligopeptìdeos; método de identificação dessa proteìna em patologias congênitas, infecciosas e degenerativas do sistema nervoso central, e método de determinação do papel da eopa em processos imunológicos; método de diagnóstico imuno-quìmico e/ou enzimático, para a prevenção, evolução de patologias, prognóstico ou tratamento de doenças congênitas, infecciosas e degenerativas do sistema nervoso central; uso das propriedades de interação de ligantes com o centro ativo da eopa atuando quer como inibidores da sua ação enzimática e/ou alterando a sua associação com outras proteìnas intracelulares, úteis no tratamento de patologias neurológicas, psiquiátricas e degenerativas |
| PCT/BR2003/000189 WO2004053052A2 (en) | 2002-12-09 | 2003-12-08 | HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60336265D1 true DE60336265D1 (de) | 2011-04-14 |
Family
ID=37719837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60336265T Expired - Lifetime DE60336265D1 (de) | 2002-12-09 | 2003-12-08 | Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20070031830A1 (de) |
| EP (1) | EP1578953B1 (de) |
| JP (1) | JP5272114B2 (de) |
| AT (1) | ATE500324T1 (de) |
| AU (1) | AU2003302901A1 (de) |
| CA (1) | CA2507811C (de) |
| DE (1) | DE60336265D1 (de) |
| WO (1) | WO2004053052A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7985555B2 (en) | 2004-06-25 | 2011-07-26 | Washington University | Markers for brain damage |
| CA2715080C (en) | 2007-09-28 | 2021-09-28 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
| BRPI1004231A2 (pt) * | 2010-11-09 | 2013-03-12 | Universidade Federal De São Paulo- Unifesp | mÉtodo e kit para diagnàstico de condiÇÕes neuropsiquiÁtricas, mÉtodo para avaliaÇço de tratamentos de condiÇÕes neuropsiquiÁtricas e mÉtodo de identificaÇço de fÁrmacos potencialmente éteis no tratamento de condiÇÕes neuropsiquiÁtricas |
| US10115661B2 (en) | 2013-02-08 | 2018-10-30 | Qualcomm Incorporated | Substrate-less discrete coupled inductor structure |
| KR102453739B1 (ko) * | 2013-03-29 | 2022-10-11 | 애플 인크. | 셀 방식 네트워크에서의 인터넷에의 연결 확립 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171790B1 (en) * | 1998-05-01 | 2001-01-09 | Incyte Pharmaceuticals, Inc. | Human protease associated proteins |
| US6406891B1 (en) * | 1998-09-28 | 2002-06-18 | Board Of Regents, The University Of Texas System | Dual RT procedure for cDNA synthesis |
| JP5058403B2 (ja) * | 2000-06-27 | 2012-10-24 | シスメックス株式会社 | Ｃｋ−ｍｂ活性測定法およびｃｋ−ｍｂ活性測定試薬 |
| JP2002065266A (ja) * | 2000-08-28 | 2002-03-05 | Teijin Ltd | 気道特異的トリプシン様酵素およびその利用法 |
-
2003
- 2003-12-08 WO PCT/BR2003/000189 patent/WO2004053052A2/en active Application Filing
- 2003-12-08 AT AT03812536T patent/ATE500324T1/de not_active IP Right Cessation
- 2003-12-08 EP EP03812536A patent/EP1578953B1/de not_active Expired - Lifetime
- 2003-12-08 DE DE60336265T patent/DE60336265D1/de not_active Expired - Lifetime
- 2003-12-08 CA CA2507811A patent/CA2507811C/en not_active Expired - Fee Related
- 2003-12-08 AU AU2003302901A patent/AU2003302901A1/en not_active Abandoned
- 2003-12-08 US US10/538,071 patent/US20070031830A1/en not_active Abandoned
- 2003-12-08 JP JP2004557687A patent/JP5272114B2/ja not_active Expired - Fee Related
-
2008
- 2008-04-14 US US12/102,821 patent/US20090017042A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2507811C (en) | 2013-11-05 |
| JP5272114B2 (ja) | 2013-08-28 |
| WO2004053052A3 (en) | 2006-08-03 |
| EP1578953B1 (de) | 2011-03-02 |
| US20070031830A1 (en) | 2007-02-08 |
| EP1578953A4 (de) | 2007-08-08 |
| CA2507811A1 (en) | 2004-06-24 |
| AU2003302901A8 (en) | 2004-06-30 |
| WO2004053052A2 (en) | 2004-06-24 |
| ATE500324T1 (de) | 2011-03-15 |
| EP1578953A2 (de) | 2005-09-28 |
| JP2006524983A (ja) | 2006-11-09 |
| AU2003302901A1 (en) | 2004-06-30 |
| US20090017042A1 (en) | 2009-01-15 |
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