MA28590B1 - Plasmine a modification par recombinaison - Google Patents

Plasmine a modification par recombinaison

Info

Publication number
MA28590B1
MA28590B1 MA29466A MA29466A MA28590B1 MA 28590 B1 MA28590 B1 MA 28590B1 MA 29466 A MA29466 A MA 29466A MA 29466 A MA29466 A MA 29466A MA 28590 B1 MA28590 B1 MA 28590B1
Authority
MA
Morocco
Prior art keywords
plasmine
domain
terminal
human plasminogen
recombinant modification
Prior art date
Application number
MA29466A
Other languages
English (en)
Inventor
Jennifer Audrey Hunt
Valery Novokhatny
Original Assignee
Talecris Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34982338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28590(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Talecris Biotherapeutics Inc filed Critical Talecris Biotherapeutics Inc
Publication of MA28590B1 publication Critical patent/MA28590B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des polynucléotides et des polypeptides relatifs à une molécule de plasmine (plasminogène) à modification par recombinaison. Ladite molécule comporte une terminaison N de domaine kringle unique sur le site d'activation présent dans la molécule plasminogène humaine d'origine et présente des propriétés de liaison avec la lysine et des caractéristiques enzymatiques importantes associées à l'enzyme d'origine.
MA29466A 2004-04-22 2006-11-20 Plasmine a modification par recombinaison MA28590B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56447204P 2004-04-22 2004-04-22

Publications (1)

Publication Number Publication Date
MA28590B1 true MA28590B1 (fr) 2007-05-02

Family

ID=34982338

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29466A MA28590B1 (fr) 2004-04-22 2006-11-20 Plasmine a modification par recombinaison

Country Status (28)

Country Link
US (2) US8034913B2 (fr)
EP (2) EP1740698B1 (fr)
JP (1) JP5026254B2 (fr)
KR (1) KR101161819B1 (fr)
CN (2) CN102660564B (fr)
AT (1) ATE476502T1 (fr)
AU (1) AU2005238464B2 (fr)
BR (1) BRPI0510063B8 (fr)
CA (1) CA2563675C (fr)
CY (1) CY1111650T1 (fr)
DE (1) DE602005022692D1 (fr)
DK (1) DK1740698T3 (fr)
EA (1) EA010784B1 (fr)
ES (2) ES2534744T3 (fr)
HK (3) HK1099341A1 (fr)
HR (1) HRP20100568T1 (fr)
IL (1) IL178343A (fr)
MA (1) MA28590B1 (fr)
MX (1) MXPA06012236A (fr)
NO (1) NO338542B1 (fr)
NZ (1) NZ550250A (fr)
PL (2) PL1740698T3 (fr)
PT (2) PT2246417E (fr)
RS (1) RS51623B (fr)
SI (1) SI1740698T1 (fr)
TN (1) TNSN06332A1 (fr)
WO (1) WO2005105990A2 (fr)
ZA (1) ZA200608498B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005078109A2 (fr) 2004-02-11 2005-08-25 Biolex, Inc. Expression du plasminogene et du microplasminogene dans une lentille d'eau
SI1740698T1 (sl) 2004-04-22 2010-11-30 Talecris Biotherapeutics Inc Rekombinantno modificiran plazmin
WO2007047874A2 (fr) * 2005-10-20 2007-04-26 Talecris Biotherapeutics, Inc. Plasmine modifiée par recombinaison
KR100888022B1 (ko) * 2006-12-21 2009-03-09 재단법인 목암생명공학연구소 면역글로불린 Ｆｃ와 인간 아포리포단백질（ａ）크링글절편의 융합단백질 ＬＫ8­Ｆｃ
AU2008331545B2 (en) 2007-11-29 2014-01-16 Grifols Therapeutics Inc. Recombinantly modified plasmin
KR20110017903A (ko) 2008-06-04 2011-02-22 테일크리스 바이오쎄러퓨틱스 아이엔씨. 플라스민의 제조를 위한 조성물, 방법 및 키트
PT2403865E (pt) 2009-03-03 2015-11-18 Grifols Therapeutics Inc Métodos de preparação de plasminogénio
WO2011004011A1 (fr) 2009-07-10 2011-01-13 Thrombogenics Nv Variantes du plasminogène et de la plasmine
WO2011023805A1 (fr) 2009-08-28 2011-03-03 Thrombogenics N.V. Utilisation de plasmine pour le traitement d'une insuffisance de filtration après une trabéculectomie
DK2661493T3 (en) 2011-01-05 2016-07-18 Thrombogenics Nv PLASMINOGEN AND PLASMIN VARIANS
AU2012296884B2 (en) 2011-08-12 2015-02-05 Thrombogenics N.V. Plasminogen and plasmin variants
US10709771B2 (en) * 2015-12-18 2020-07-14 Talengen International Limited Method for preventing or treating diabetic retinopathy
CN108210895A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防动脉粥样硬化及其并发症的药物及其用途
CN110121357A (zh) 2016-12-15 2019-08-13 泰伦基国际有限公司 一种治疗糖尿病的新方法
TW201829448A (zh) 2016-12-15 2018-08-16 大陸商深圳瑞健生命科學硏究院有限公司 纖溶酶原在製備預防或治療肥胖症及疾病倂發的肥胖的藥物中的用途
TW201822809A (zh) 2016-12-15 2018-07-01 深圳瑞健生命科學硏究院有限公司 一種預防和治療高脂血症的方法
US11754130B2 (en) 2020-04-13 2023-09-12 Kabushiki Kaisha F.C.C. Power transmission apparatus
CA3182911A1 (fr) * 2020-05-11 2021-11-18 Talengen International Limited Procede et medicament pour le traitement d'une amyotrophie spinale
AR124640A1 (es) 2020-11-25 2023-04-19 Grifols Worldwide Operations Ltd Cicatrización de heridas
US11964004B2 (en) * 2021-03-31 2024-04-23 Shenzhen Bay Laboratory Short in vivo half-life and in vivo unstable recombinant microplasmin, pharmaceutical composition comprising thereof and method of treating thromboembolism related diseases including administration thereof
WO2024018051A1 (fr) 2022-07-22 2024-01-25 Grifols Worldwide Operations Limited Compositions de plasmine stables pour la conservation et le reconditionnement d'organes

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US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US4774087A (en) * 1987-08-14 1988-09-27 Northwestern University Micro-size fibrinolytic plasmin
US7253264B1 (en) 1990-06-28 2007-08-07 Sanofi-Arentideutschland GmbH Immunoglobulin fusion proteins, their production and use
DE59109032D1 (de) 1990-06-28 1998-09-03 Hoechst Ag Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung
DE69739304D1 (de) 1996-01-23 2009-04-23 Operon Biotechnologies Inc Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen
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JPH10158300A (ja) 1996-11-28 1998-06-16 Suzuki Motor Corp 血管新生抑制効果を有するタンパク質とその製造方法及びアンギオスタチンの製造方法
HUP0002518A3 (en) 1997-07-22 2003-01-28 Qiagen Genomics Inc Computer method and system for correlating sequencing data by ms
JP2002520367A (ja) 1998-07-14 2002-07-09 ブリストル−マイヤーズ スクイブ カンパニー アンギオスタチンのリジン結合フラグメント
CN1191856C (zh) 1998-09-29 2005-03-09 勒芬研究与发展公司 可在体内减少α2－抗纤溶酶的化合物在制备用于治疗局部缺血性中风的组合物中的用途
US6355243B1 (en) 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
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DE10390418D2 (de) 2002-02-06 2005-01-13 N Zyme Biotec Gmbh Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen
GB0228409D0 (en) 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
SI1740698T1 (sl) 2004-04-22 2010-11-30 Talecris Biotherapeutics Inc Rekombinantno modificiran plazmin
WO2007047874A2 (fr) 2005-10-20 2007-04-26 Talecris Biotherapeutics, Inc. Plasmine modifiée par recombinaison
AU2008331545B2 (en) 2007-11-29 2014-01-16 Grifols Therapeutics Inc. Recombinantly modified plasmin

Also Published As

Publication number Publication date
HRP20100568T1 (hr) 2010-11-30
US8034913B2 (en) 2011-10-11
CA2563675C (fr) 2012-08-28
EA010784B1 (ru) 2008-10-30
CN102660564A (zh) 2012-09-12
DE602005022692D1 (de) 2010-09-16
US20100304465A1 (en) 2010-12-02
TNSN06332A1 (en) 2008-02-22
ATE476502T1 (de) 2010-08-15
ZA200608498B (en) 2008-07-30
KR101161819B1 (ko) 2012-07-03
DK1740698T3 (da) 2010-10-25
NO20065050L (no) 2006-11-03
WO2005105990A3 (fr) 2006-01-12
AU2005238464A1 (en) 2005-11-10
RS51623B (en) 2011-08-31
EP1740698A2 (fr) 2007-01-10
PT1740698E (pt) 2010-11-02
MXPA06012236A (es) 2007-01-31
SI1740698T1 (sl) 2010-11-30
EA200601950A1 (ru) 2007-02-27
BRPI0510063B1 (pt) 2020-03-17
HK1175812A1 (en) 2013-07-12
AU2005238464B2 (en) 2011-01-27
WO2005105990A2 (fr) 2005-11-10
HK1099341A1 (en) 2007-08-10
EP2246417A1 (fr) 2010-11-03
ES2534744T3 (es) 2015-04-28
IL178343A0 (en) 2007-02-11
JP2007533327A (ja) 2007-11-22
HK1150242A1 (en) 2011-11-11
US20110318812A1 (en) 2011-12-29
JP5026254B2 (ja) 2012-09-12
NO338542B1 (no) 2016-09-05
PT2246417E (pt) 2015-05-05
IL178343A (en) 2010-11-30
BRPI0510063B8 (pt) 2021-05-25
KR20070006918A (ko) 2007-01-11
EP2246417B1 (fr) 2015-01-21
US8420079B2 (en) 2013-04-16
EP1740698B1 (fr) 2010-08-04
PL1740698T3 (pl) 2011-01-31
NZ550250A (en) 2009-05-31
CY1111650T1 (el) 2015-10-07
PL2246417T3 (pl) 2015-06-30
CA2563675A1 (fr) 2005-11-10
CN1961070A (zh) 2007-05-09
BRPI0510063A (pt) 2008-03-11
CN102660564B (zh) 2013-05-08
ES2349555T3 (es) 2011-01-05

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