HK1087711A1 - Thiadiazoles as cxc and cc- chemokine receptor ligands - Google Patents
Thiadiazoles as cxc and cc- chemokine receptor ligandsInfo
- Publication number
- HK1087711A1 HK1087711A1 HK06109781A HK06109781A HK1087711A1 HK 1087711 A1 HK1087711 A1 HK 1087711A1 HK 06109781 A HK06109781 A HK 06109781A HK 06109781 A HK06109781 A HK 06109781A HK 1087711 A1 HK1087711 A1 HK 1087711A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cxc
- thiadiazoles
- chemokine receptor
- receptor ligands
- ligands
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53131103P | 2003-12-19 | 2003-12-19 | |
US53171303P | 2003-12-22 | 2003-12-22 | |
PCT/US2004/042060 WO2005066147A1 (fr) | 2003-12-19 | 2004-12-16 | Utilisation de thiadiazoles comme ligands des recepteurs aux chimiokines cxc et cc |
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JP (2) | JP4939229B2 (fr) |
CN (1) | CN1918138B (fr) |
AR (1) | AR046791A1 (fr) |
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CA (1) | CA2550189A1 (fr) |
DE (1) | DE602004016211D1 (fr) |
ES (1) | ES2308299T3 (fr) |
HK (1) | HK1087711A1 (fr) |
MX (1) | MXPA06007076A (fr) |
MY (1) | MY139808A (fr) |
TW (1) | TW200528450A (fr) |
WO (1) | WO2005066147A1 (fr) |
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CN101253165A (zh) * | 2005-06-29 | 2008-08-27 | 先灵公司 | 作为cxc-化学活素受体配体的二取代的二唑 |
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SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
JP5535931B2 (ja) * | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
TW201100429A (en) | 2009-05-22 | 2011-01-01 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
UA106078C2 (uk) | 2009-05-22 | 2014-07-25 | Інсайт Корпорейшн | 3-[4-(7H-ПІРОЛО[2,3-d]ПІРИМІДИН-4-ІЛ)-1H-ПІРАЗОЛ-1-ІЛ]ОКТАН- АБО ГЕПТАННІТРИЛ ЯК JAK-ІНГІБІТОРИ |
WO2011028685A1 (fr) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Dérivés hétérocycliques de pyrazol-4-yl-pyrrolo[2,3-d] pyrimidines en tant qu'inhibiteurs de janus kinase |
WO2011071995A2 (fr) | 2009-12-08 | 2011-06-16 | Case Western Reserve University | Composés et procédés de traitement de troubles oculaires |
US20130085133A1 (en) * | 2010-02-08 | 2013-04-04 | Sourthern Research Institute Office of Commercialization and Intellectual Prop. | Anti-viral treatment and assay to screenfor anti-viral agent |
TWI643857B (zh) | 2010-03-10 | 2018-12-11 | 英塞特公司 | 作為jak1抑制劑之哌啶-4-基三亞甲亞胺衍生物 |
PE20130216A1 (es) | 2010-05-21 | 2013-02-27 | Incyte Corp | Formulacion topica para un inhibidor de jak |
WO2012068440A1 (fr) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Pyrrolopyridines et pyrrolopyrimidines à substitution hétérocyclique utilisées en tant qu'inhibiteurs des jak |
JP5917545B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体 |
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TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
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US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
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TWI634121B (zh) | 2013-03-06 | 2018-09-01 | 英塞特控股公司 | 用於製備jak抑制劑之方法及中間物 |
KR20220103810A (ko) | 2013-08-07 | 2022-07-22 | 인사이트 코포레이션 | Jak1 억제제용 지속 방출 복용 형태 |
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- 2004-12-16 MY MYPI20045183A patent/MY139808A/en unknown
- 2004-12-16 EP EP04814266A patent/EP1694659B8/fr active Active
- 2004-12-16 AT AT04814266T patent/ATE406356T1/de not_active IP Right Cessation
- 2004-12-16 CN CN2004800416952A patent/CN1918138B/zh not_active Expired - Fee Related
- 2004-12-16 US US11/013,753 patent/US7338968B2/en not_active Expired - Fee Related
- 2004-12-16 WO PCT/US2004/042060 patent/WO2005066147A1/fr active Application Filing
- 2004-12-16 CA CA002550189A patent/CA2550189A1/fr not_active Abandoned
- 2004-12-16 TW TW093139212A patent/TW200528450A/zh unknown
- 2004-12-16 DE DE602004016211T patent/DE602004016211D1/de active Active
- 2004-12-16 JP JP2006545364A patent/JP4939229B2/ja not_active Expired - Fee Related
- 2004-12-16 ES ES04814266T patent/ES2308299T3/es active Active
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- 2004-12-17 AR ARP040104753A patent/AR046791A1/es not_active Application Discontinuation
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- 2007-09-26 US US11/861,870 patent/US7786149B2/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
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DE602004016211D1 (en) | 2008-10-09 |
JP4939229B2 (ja) | 2012-05-23 |
CA2550189A1 (fr) | 2005-07-21 |
US20060223864A1 (en) | 2006-10-05 |
EP1694659B8 (fr) | 2008-10-08 |
US7338968B2 (en) | 2008-03-04 |
US7786149B2 (en) | 2010-08-31 |
AR046791A1 (es) | 2005-12-21 |
MY139808A (en) | 2009-10-30 |
EP1694659B1 (fr) | 2008-08-27 |
CN1918138B (zh) | 2011-05-04 |
TW200528450A (en) | 2005-09-01 |
ES2308299T3 (es) | 2008-12-01 |
EP1694659A1 (fr) | 2006-08-30 |
MXPA06007076A (es) | 2006-08-31 |
US20080090823A1 (en) | 2008-04-17 |
ATE406356T1 (de) | 2008-09-15 |
JP2011093943A (ja) | 2011-05-12 |
WO2005066147A1 (fr) | 2005-07-21 |
CN1918138A (zh) | 2007-02-21 |
JP2007514746A (ja) | 2007-06-07 |
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