HK1087700A1 - Triazolopyridazines as protein kinases inhibitors - Google Patents

Triazolopyridazines as protein kinases inhibitors

Info

Publication number
HK1087700A1
HK1087700A1 HK06107864.2A HK06107864A HK1087700A1 HK 1087700 A1 HK1087700 A1 HK 1087700A1 HK 06107864 A HK06107864 A HK 06107864A HK 1087700 A1 HK1087700 A1 HK 1087700A1
Authority
HK
Hong Kong
Prior art keywords
protein kinases
triazolopyridazines
compounds
inhibitors
kinases inhibitors
Prior art date
Application number
HK06107864.2A
Other languages
English (en)
Inventor
Jeremy Green
Ronald Grey Jr
Albert C Pierce
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of HK1087700A1 publication Critical patent/HK1087700A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings

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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
HK06107864.2A 2002-12-18 2006-07-14 Triazolopyridazines as protein kinases inhibitors HK1087700A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43512402P 2002-12-18 2002-12-18
PCT/US2003/039990 WO2004058769A2 (en) 2002-12-18 2003-12-17 Triazolopyridazines as protein kinases inhibitors

Publications (1)

Publication Number Publication Date
HK1087700A1 true HK1087700A1 (en) 2006-10-20

Family

ID=32682164

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06107864.2A HK1087700A1 (en) 2002-12-18 2006-07-14 Triazolopyridazines as protein kinases inhibitors

Country Status (15)

Country Link
US (1) US7268136B2 (ja)
EP (1) EP1575959B1 (ja)
JP (1) JP4817661B2 (ja)
KR (1) KR101075812B1 (ja)
CN (1) CN100567296C (ja)
AT (1) ATE473980T1 (ja)
AU (1) AU2003297161B8 (ja)
CA (1) CA2510534C (ja)
DE (1) DE60333387D1 (ja)
HK (1) HK1087700A1 (ja)
MX (1) MXPA05006478A (ja)
NO (1) NO20053470L (ja)
NZ (1) NZ541151A (ja)
RU (1) RU2005122484A (ja)
WO (1) WO2004058769A2 (ja)

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AU2003297161B8 (en) 2011-03-31
WO2004058769A2 (en) 2004-07-15
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JP4817661B2 (ja) 2011-11-16
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WO2004058769A3 (en) 2004-09-30
CA2510534A1 (en) 2004-07-15
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JP2006513208A (ja) 2006-04-20
DE60333387D1 (de) 2010-08-26
CN100567296C (zh) 2009-12-09
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MXPA05006478A (es) 2005-09-08
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ATE473980T1 (de) 2010-07-15
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