HK1085368A1 - Methods of diagnosing pre-eclampsia - Google Patents

Methods of diagnosing pre-eclampsia

Info

Publication number
HK1085368A1
HK1085368A1 HK06103543A HK06103543A HK1085368A1 HK 1085368 A1 HK1085368 A1 HK 1085368A1 HK 06103543 A HK06103543 A HK 06103543A HK 06103543 A HK06103543 A HK 06103543A HK 1085368 A1 HK1085368 A1 HK 1085368A1
Authority
HK
Hong Kong
Prior art keywords
eclampsia
methods
diagnosing pre
diagnosing
Prior art date
Application number
HK06103543A
Other languages
English (en)
Inventor
S Ananth Karumanchi
Sharon Maynard
Vikas P Sukhatme
Original Assignee
Beth Israel Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital filed Critical Beth Israel Hospital
Publication of HK1085368A1 publication Critical patent/HK1085368A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1891—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
HK06103543A 2002-07-19 2006-03-20 Methods of diagnosing pre-eclampsia HK1085368A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39748102P 2002-07-19 2002-07-19
US45179603P 2003-03-03 2003-03-03
US46739003P 2003-05-02 2003-05-02
PCT/US2003/022892 WO2004008946A2 (en) 2002-07-19 2003-07-21 Methods of diagnosing and treating pre-eclampsia or clamp

Publications (1)

Publication Number Publication Date
HK1085368A1 true HK1085368A1 (en) 2006-08-25

Family

ID=30773520

Family Applications (3)

Application Number Title Priority Date Filing Date
HK06103543A HK1085368A1 (en) 2002-07-19 2006-03-20 Methods of diagnosing pre-eclampsia
HK11110529.6A HK1156233A1 (en) 2002-07-19 2011-10-06 Methods of treating pre-eclampsia
HK11110874.7A HK1156521A1 (en) 2002-07-19 2011-10-13 Methods of treating pre-eclampsia

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK11110529.6A HK1156233A1 (en) 2002-07-19 2011-10-06 Methods of treating pre-eclampsia
HK11110874.7A HK1156521A1 (en) 2002-07-19 2011-10-13 Methods of treating pre-eclampsia

Country Status (19)

Country Link
US (2) US7407659B2 (ja)
EP (3) EP2308507B1 (ja)
JP (2) JP5650876B2 (ja)
KR (1) KR101215701B1 (ja)
CN (1) CN1777443B (ja)
AP (1) AP2005003230A0 (ja)
AU (2) AU2003265294B8 (ja)
BR (1) BRPI0312818B8 (ja)
CA (2) CA2922031C (ja)
DK (3) DK1575416T3 (ja)
EA (1) EA200500232A1 (ja)
EC (1) ECSP055608A (ja)
ES (3) ES2534926T3 (ja)
HK (3) HK1085368A1 (ja)
IL (2) IL166393A (ja)
MX (1) MXPA05000832A (ja)
OA (1) OA12890A (ja)
PT (3) PT2305301E (ja)
WO (1) WO2004008946A2 (ja)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2305301E (pt) * 2002-07-19 2015-04-21 Beth Israel Hospital Métodos de tratamento de pré-eclâmpsia
US7435419B2 (en) * 2002-07-19 2008-10-14 Beth Israel Deaconess Medical Center Methods of diagnosing and treating pre-eclampsia or eclampsia
US7335362B2 (en) * 2002-07-19 2008-02-26 Beth Israel Deaconess Medical Center Methods of treating pre-eclampsia or eclampsia
US7794716B2 (en) 2002-07-25 2010-09-14 Glenveigh Pharmaceuticals, Llc Antibody composition and passive immunization against pregnancy-induced hypertension
EP1962096B1 (de) * 2002-11-16 2012-07-18 Siemens Healthcare Diagnostics Products GmbH SCD40L, PAPP-A und plazentaler-Wachstumsfaktor (PIGF) als biochemische Markerkombination bei kardiovaskulären Erkrankungen
US7323346B2 (en) * 2003-08-14 2008-01-29 The General Hospital Corporation Screening for gestational disorders
JP2007536251A (ja) * 2004-05-04 2007-12-13 チルドレンズ メディカル センター コーポレーション 子癇前症の処置のための方法および組成物
DE602005024850D1 (de) * 2004-09-24 2010-12-30 Beth Israel Hospital Verfahren zur diagnose und behandlung von schwangerschaftsskomplikationen
US7740849B2 (en) * 2004-09-24 2010-06-22 Beth Israel Deaconess Medical Center Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
DE102004051847B4 (de) * 2004-10-25 2008-09-18 Dade Behring Marburg Gmbh Verhältnis von PIGF und Flt-1 als prognostischer Parameter bei kardio-vaskulären Erkrankungen
JP2008523816A (ja) 2004-12-15 2008-07-10 ベス イスラエル ディーコネス メディカル センター 妊娠合併症の診断および処置に有用な核酸およびポリペプチド
ATE519109T1 (de) 2004-12-21 2011-08-15 Univ Yale Präeklampsie-diagnose
US20060153835A1 (en) * 2005-01-12 2006-07-13 Smith Henry J Treatment of pre-eclampsia in pregnant women using targeted apheresis
JP2008537776A (ja) * 2005-03-24 2008-09-25 ベス イスラエル デアコネス メディカル センター 妊娠期間中に胎児１３トリソミーまたは胎児１３トリソミーのリスクを診断する方法
DE102005022047A1 (de) 2005-05-09 2006-11-30 Dade Behring Marburg Gmbh Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung
JP2009501521A (ja) * 2005-07-13 2009-01-22 ベス イスラエル ディーコネス メディカル センター 炎症応答を診断および処置する方法
WO2007024752A2 (en) * 2005-08-26 2007-03-01 Beth Israel Deaconess Medical Center Methods and compositions for the treatment and diagnosis of endothelial cell disorders and angiogenic disorders
US20070111326A1 (en) * 2005-11-14 2007-05-17 Abbott Laboratories Diagnostic method for proteinaceous binding pairs, cardiovascular conditions and preeclampsia
US20090286271A1 (en) * 2006-05-31 2009-11-19 Karumanchi Ananth S Methods of Diagnosing and Treating Complications of Pregnancy
US20080071151A1 (en) * 2006-06-30 2008-03-20 Sogin David C Method and Apparatus for Diagnosing Pre-eclampsia
AU2007269714A1 (en) 2006-07-03 2008-01-10 Charles David Adair Composition for modulating the expression of cell adhesion molecules
DE602006015964D1 (de) * 2006-09-20 2010-09-16 Roche Diagnostics Gmbh Natriurethische Peptide und Plazenta-Wachstumfaktor/löslicher VEGF-Rezeptor unterscheiden zwischen mit der Plazenta verbundener Herzdysfunktion und mit Herzerkrankung verbundener Herzdysfunktion
US8592166B2 (en) * 2006-11-21 2013-11-26 Beth Israel Deaconess Medical Center, Inc. Hypoxia related genes and proteins for the treatment and diagnosis of pregnancy related complications
JP2010512781A (ja) * 2006-12-20 2010-04-30 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド Ｖｅｇｆｒの変化体ならびに妊娠関連の医学的状態の診断および処置におけるその使用
GB0703683D0 (en) * 2007-02-26 2007-04-04 Ark Therapeutics Ltd The treatment of complications in pregnancy
EP2235529B1 (en) * 2008-01-07 2016-12-14 Ortho-Clinical Diagnostics, Inc. Determination of sflt-1:angiogenic factor complex
EP2245180B1 (en) * 2008-01-25 2014-06-18 PerkinElmer Health Sciences, Inc. Methods for determining the risk of prenatal complications
CN107677830A (zh) 2008-10-31 2018-02-09 耶鲁大学 子痫前期检测和治疗的方法和组合物
EP2370092A1 (en) 2008-12-03 2011-10-05 Research Development Foundation Modulation of olfml-3 mediated angiogenesis
US8349325B2 (en) * 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
US20100247650A1 (en) * 2009-03-31 2010-09-30 Smith Henry J Treatment for pre-eclampsia in pregnant women using targeted apheresis
US8530150B2 (en) * 2009-09-25 2013-09-10 The University Of Bristol Detection of risk of pre-eclampsia
WO2011036429A1 (en) * 2009-09-25 2011-03-31 The University Of Bristol Detection of risk of pre-eclampsia
EP2543729B1 (en) 2010-03-04 2017-11-01 Masaru Okabe Model animal for pregnancy-induced hypertension syndrome, and treatment method therefor
DE102010013555A1 (de) 2010-03-31 2011-10-06 Christian Hamm Verwendung der Biomarker sFlt und PIGF in der Diagnose und Therapie der pulmonalen Hypertonie
EP2569253A4 (en) 2010-05-14 2013-10-02 Beth Israel Hospital EXTRACORPOREAL DEVICES AND METHODS FOR TREATING PREGNANCY COMPLICATIONS
BR112012033423A2 (pt) * 2010-07-19 2016-10-25 Hoffmann La Roche métodos para melhorar a eficácia do tratamento de um regime de quimioterapia e in vitro, usos de bevacizumab e de sondas específicas, kit e uso de um polipeptídeo
RU2013106938A (ru) * 2010-07-19 2014-08-27 Ф.Хоффманн-Ля Рош Аг Биомаркеры в плазме крови, предназначенные для комбинированных терапий с использованием бевацизумаба при лечении рака молочной железы
CA2826563C (en) * 2011-02-07 2020-10-20 Paul Kussie Methods and systems for treating eclampsia and pre-eclampsia
EP2490027A1 (en) * 2011-02-15 2012-08-22 Roche Diagnostics GmbH Means and methods for diagnosing pregnancy complications based on GDF-15 and PlGF/sFlt1
RU2466462C1 (ru) * 2011-04-25 2012-11-10 Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации Способ коррекции нарушения микроциркуляции в плаценте рекомбинантным эритропоэтином при adma-подобной модели гестоза
RU2462765C1 (ru) * 2011-04-25 2012-09-27 Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации Способ коррекции эндотелиальной дисфункции дистантным прекондиционированием при adma-подобной модели гестоза
RU2460148C1 (ru) * 2011-04-25 2012-08-27 Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации Способ коррекции нарушения микроциркуляции в плаценте при adma-подобной модели гестоза
RU2462766C1 (ru) * 2011-04-25 2012-09-27 Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации Способ коррекции эндотелиальной дисфункции рекомбинантным эритропоэтином при adma-подобной модели гестоза
DK2739310T3 (en) 2011-08-05 2018-07-16 Res Found Dev Improved methods and compositions for modulating OLFML3-mediated angiogenesis
WO2013068475A1 (en) 2011-11-09 2013-05-16 Roche Diagnostics Gmbh Dynamic of sflt-1 or endoglin/plgf ratio as an indicator for imminent preeclampsia and/or hellp syndrome
IN2014CN04326A (ja) * 2011-12-15 2015-09-04 Pronota Nv
RU2507595C2 (ru) * 2012-03-07 2014-02-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Способ коррекции эндотелиальной дисфункции азитромицином при adma-подобной модели гестоза в эксперименте
RU2507594C2 (ru) * 2012-03-07 2014-02-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Способ коррекции эндотелиальной дисфункции при adma-подобной модели гестоза в эксперименте
RU2483311C1 (ru) * 2012-06-15 2013-05-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразви Способ диагностики преэклампсии у беременных с хронической артериальной гипертензией
EP2867670B1 (en) 2012-06-27 2018-05-30 Roche Diagnostics GmbH MEANS AND METHODS APPLYING sFlt-1/PlGF OR ENDOGLIN/PlGF RATIO TO RULE-OUT ONSET OF PREECLAMPSIA WITHIN A CERTAIN TIME PERIOD
EP2706359A1 (en) 2012-09-07 2014-03-12 Roche Diagniostics GmbH Means and methods applying sFlt-1/PlGF or Endoglin/PlGF ratio to rule-out onset of preeclampsia within a certain time period
KR101297886B1 (ko) * 2012-10-02 2013-08-19 인제대학교 산학협력단 자간전증의 조기 진단 및 예후 평가 방법
CA2888345C (en) 2012-10-24 2020-04-21 Research Development Foundation Jam-c antibodies and methods for treatment of cancer
CN114621346A (zh) 2013-08-21 2022-06-14 德克萨斯州大学系统董事会 用于靶向连接蛋白半通道的组合物和方法
CN105917233B (zh) 2014-01-24 2018-07-03 豪夫迈·罗氏有限公司 产后hellp综合征、产后子痫或产后子痫前期的预测
RU2543359C1 (ru) * 2014-03-11 2015-02-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ коррекции эндотелиальной дисфункуии фармакологическим прекондиционированием никорандилом при adma-подобной модели гестоза в эксперименте
JP6697394B2 (ja) 2014-04-10 2020-05-20 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ 異常折り畳みタンパク質を検出するための方法および組成物
WO2016132136A1 (en) * 2015-02-18 2016-08-25 Aston University Diagnostic assay and treatment for preeclampsia
GB201504772D0 (en) 2015-03-20 2015-05-06 Univ Aston Preeclampsia
WO2016161378A1 (en) 2015-04-03 2016-10-06 University Of Massachusetts Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
LT3277814T (lt) 2015-04-03 2020-10-26 University Of Massachusetts Oligonukleotidų junginiai, skirti nukreipimui į hantingtino mrnr
BR112017021416A2 (pt) * 2015-04-07 2018-07-03 Shire Human Genetic Therapies anticorpos anti-flt-1 no tratamento de displasia broncopulmonar.
MA41908A (fr) * 2015-04-07 2021-03-31 Shire Human Genetic Therapies Anticorps anti-flt-1 utilisés dans le traitement de la dysplasie bronchopulmonaire
WO2016194708A1 (ja) * 2015-05-29 2016-12-08 国立大学法人名古屋大学 尿中ＶＥＧＦ－Ａ１６５ｂを指標とした腎機能の検査方法及び検査装置、腎機能の検査装置として機能させるためのプログラム及び記録媒体
FR3037657B1 (fr) * 2015-06-22 2017-06-23 Univ Rouen Centre Hospitalier Methode de diagnostic des troubles causes par l'alcoolisation foetale
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US11253590B2 (en) 2015-12-02 2022-02-22 Stsciences, Inc. Antibodies specific to glycosylated BTLA (B- and T- lymphocyte attenuator)
WO2017096051A1 (en) 2015-12-02 2017-06-08 Stcube & Co., Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
US10511462B2 (en) * 2016-01-06 2019-12-17 Apple Inc. DC offset cancelation for wireless communications
JP2019503394A (ja) 2016-01-31 2019-02-07 ユニバーシティ・オブ・マサチューセッツＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ 分岐オリゴヌクレオチド
AU2017224122B2 (en) 2016-02-26 2024-04-11 The Board Of Regents Of The University Of Texas System Connexin (Cx) 43 hemichannel-binding antibodies and uses thereof
BR112018015532A2 (pt) 2016-02-29 2018-12-26 Hoffmann La Roche métodos para o diagnóstico de pré-eclâmpsia, para avaliar a gravidade da pré-eclâmpsia, e para o monitoramento pré-eclâmpsia, usos de biomarcador, kit adaptado para a realização do método e dispositivo adaptado para diagnosticar se uma paciente sofre de pré-eclâmpsia
KR102418372B1 (ko) 2016-03-29 2022-07-08 주식회사 에스티큐브 글리코실화된 pd-l1에 특이적인 이중 기능 항체 및 이의 사용 방법
EP3436480A4 (en) 2016-03-30 2019-11-27 Musc Foundation for Research Development METHOD FOR THE TREATMENT AND DIAGNOSIS OF CANCER BY TARGETING GLYCOPROTEIN A REPETITION PREDOMINANT (GARP) AND FOR EFFECTIVE IMMUNOTHERAPY ALONE OR IN COMBINATION
KR101916652B1 (ko) * 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
WO2018017673A1 (en) 2016-07-20 2018-01-25 Stcube, Inc. Methods of cancer treatment and therapy using a combination of antibodies that bind glycosylated pd-l1
US11753638B2 (en) 2016-08-12 2023-09-12 University Of Massachusetts Conjugated oligonucleotides
CN107884570A (zh) * 2016-09-29 2018-04-06 韦彦余 一种孕妇先兆子痫检测试剂盒
KR20200015602A (ko) 2017-05-31 2020-02-12 주식회사 에스티큐브앤컴퍼니 Btn1a1에 면역특이적으로 결합하는 항체 및 분자 및 이의 치료적 용도
EP3630834A1 (en) 2017-05-31 2020-04-08 STCube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1
CN110997724A (zh) 2017-06-06 2020-04-10 斯特库伯株式会社 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法
EP3642341A4 (en) 2017-06-23 2021-06-16 University Of Massachusetts TWO-DAY SELF-RELEASING SIRNA AND RELATED PROCEDURES
EP3682250A4 (en) 2017-09-13 2021-03-03 Progenity, Inc. PRECLAMPSY BIOMARKERS AND RELATED SYSTEMS AND PROCEDURES
WO2019055825A1 (en) 2017-09-15 2019-03-21 The Regents Of The University Of California INHIBITION OF AMINOACYLASE 3 (AA3) IN THE TREATMENT OF CANCER
BR112020017626A2 (pt) * 2018-02-28 2020-12-22 Pharming Intellectual Property B.V. Tratamento e prevenção de pré-eclâmpsia
SG11202101288TA (en) 2018-08-10 2021-03-30 Univ Massachusetts Modified oligonucleotides targeting snps
AU2020329155A1 (en) 2019-08-09 2022-03-10 University Of Massachusetts Chemically modified oligonucleotides targeting SNPs
EP4041767A1 (en) 2019-09-26 2022-08-17 StCube & Co. Antibodies specific to glycosylated ctla-4 and methods of use thereof
WO2021072277A1 (en) 2019-10-09 2021-04-15 Stcube & Co. Antibodies specific to glycosylated lag3 and methods of use thereof
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS
EP4107173A1 (en) 2020-02-17 2022-12-28 Board of Regents, The University of Texas System Methods for expansion of tumor infiltrating lymphocytes and use thereof
KR102435297B1 (ko) * 2020-07-21 2022-08-22 부산대학교 산학협력단 임신중독증 조기진단용 바이오마커 조성물 및 이를 이용한 진단방법
CN117677699A (zh) 2021-06-23 2024-03-08 马萨诸塞大学 用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物
WO2023104975A1 (en) 2021-12-08 2023-06-15 B.R.A.H.M.S Gmbh Biomarkers for prognosis of early onset preeclampsia
WO2024121392A1 (en) 2022-12-08 2024-06-13 B.R.A.H.M.S Gmbh Multiple sflt-1 measurements for prognosis of early onset preeclampsia

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
IL89489A0 (en) 1988-03-09 1989-09-10 Hybritech Inc Chimeric antibodies directed against human carcinoembryonic antigen
KR900700134A (ko) 1988-04-15 1990-08-11 원본미기재 Il-2 수용체-특이적 키메릭 항체
WO1989009825A1 (en) 1988-04-16 1989-10-19 Celltech Limited Method for producing recombinant dna proteins
US5240848A (en) 1988-11-21 1993-08-31 Monsanto Company Dna sequences encoding human vascular permeability factor having 189 amino acids
US5238819A (en) 1988-12-14 1993-08-24 The Regents Of The University Of California Diagnostic assay for the detection of preeclampsia
US5332671A (en) 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
US5194596A (en) 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5219739A (en) 1989-07-27 1993-06-15 Scios Nova Inc. DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
LU91067I2 (fr) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1993021319A1 (en) 1992-04-08 1993-10-28 Cetus Oncology Corporation HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES
US5712395A (en) 1992-11-13 1998-01-27 Yissum Research Development Corp. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5763441A (en) 1992-11-13 1998-06-09 Sugen, Inc. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US6410322B1 (en) 1993-07-27 2002-06-25 Hybridon Inc Antisense oligonucleotide inhibition of vascular endothelial growth factor expression
US5861499A (en) 1994-02-10 1999-01-19 Imclone Systems Incorporated Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
WO1995022618A1 (en) 1994-02-22 1995-08-24 Dana-Farber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof
US5543138A (en) 1994-03-10 1996-08-06 Genetics Institute, Inc. Methods of diagnosing and treating preeclampsia
GB9512994D0 (en) 1995-06-26 1995-08-30 Brf International Method for quantitative measurement of an enzyme linked immunosorbent assay
US5830879A (en) 1995-10-02 1998-11-03 St. Elizabeth's Medical Center Of Boston, Inc. Treatment of vascular injury using vascular endothelial growth factor
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US6399585B1 (en) 1996-05-15 2002-06-04 Janet E. Larson In Utero treatment of CFTR-related deficiencies
CA2275708A1 (en) * 1996-12-23 1998-07-02 Cambridge University Technical Services Limited Diagnosis and treatment of pathological pregnancies
US20030114407A1 (en) 2001-12-06 2003-06-19 Monia Brett P. Antisense modulation of G protein-coupled receptor ETBR-LP-2 expression
EP1417971A3 (en) 1998-09-09 2004-06-30 Scios Inc. Use of an angiogenic factor for the treatment of microvascular angiopathies
US7030083B2 (en) 1998-09-09 2006-04-18 University Of Washington Treatment of eclampsia and preeclampsia
US6677300B1 (en) 1998-09-09 2004-01-13 Scios, Inc. Treatment of microvascular angiopathies
US6245577B1 (en) 1998-09-11 2001-06-12 Midland Bioproducts Corporation IgG antibody testing method
EP1016726A1 (en) 1998-12-30 2000-07-05 Introgene B.V. Gene therapy to promote angiogenesis
KR20080023768A (ko) 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
GB0008269D0 (en) 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
US6667300B2 (en) * 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
GB0026823D0 (en) 2000-11-02 2000-12-20 King S College London Diagnosis of pre-eclampsia
WO2002070535A1 (en) 2001-03-01 2002-09-12 Isis Pharmaceuticals, Inc. Antisense modulation of recql5 expression
US7335362B2 (en) 2002-07-19 2008-02-26 Beth Israel Deaconess Medical Center Methods of treating pre-eclampsia or eclampsia
PT2305301E (pt) 2002-07-19 2015-04-21 Beth Israel Hospital Métodos de tratamento de pré-eclâmpsia
US7435419B2 (en) 2002-07-19 2008-10-14 Beth Israel Deaconess Medical Center Methods of diagnosing and treating pre-eclampsia or eclampsia
US7323346B2 (en) 2003-08-14 2008-01-29 The General Hospital Corporation Screening for gestational disorders
AU2004276791B2 (en) 2003-09-23 2010-07-01 Beth Israel Deaconess Medical Center Screening for gestational disorders
ATE519109T1 (de) 2004-12-21 2011-08-15 Univ Yale Präeklampsie-diagnose
US7335562B2 (en) * 2005-10-24 2008-02-26 Kabushiki Kaisha Toshiba Method of manufacturing semiconductor device

Also Published As

Publication number Publication date
EP2305301B1 (en) 2015-01-07
EP2305301A2 (en) 2011-04-06
IL166393A0 (en) 2006-01-15
DK2305301T3 (en) 2015-04-13
EP1575416A2 (en) 2005-09-21
EP2305301A3 (en) 2011-06-22
HK1156521A1 (en) 2012-06-15
IL166393A (en) 2015-06-30
CA2922031C (en) 2020-12-15
EP2308507A2 (en) 2011-04-13
US7407659B2 (en) 2008-08-05
AU2003265294B2 (en) 2009-06-04
PT2308507E (pt) 2015-05-11
US20040126828A1 (en) 2004-07-01
WO2004008946A2 (en) 2004-01-29
ECSP055608A (es) 2006-03-01
IL233205A0 (en) 2014-07-31
ES2534926T3 (es) 2015-04-30
AU2003265294B8 (en) 2009-06-25
EP2308507A3 (en) 2011-06-22
PT2305301E (pt) 2015-04-21
JP5650876B2 (ja) 2015-01-07
KR101215701B1 (ko) 2012-12-26
CA2496253A1 (en) 2004-01-29
BR0312818A (pt) 2007-06-26
EP1575416A4 (en) 2007-09-05
JP2006511615A (ja) 2006-04-06
AU2009202176B2 (en) 2012-12-06
BRPI0312818B8 (pt) 2021-05-25
DK1575416T3 (da) 2014-01-13
HK1156233A1 (en) 2012-06-08
CA2922031A1 (en) 2004-01-29
JP2014193920A (ja) 2014-10-09
OA12890A (en) 2006-10-13
ES2534294T3 (es) 2015-04-21
ES2440651T3 (es) 2014-01-29
US7947449B2 (en) 2011-05-24
PT1575416E (pt) 2014-01-08
WO2004008946A3 (en) 2006-01-05
EP2308507B1 (en) 2015-01-14
KR20060002008A (ko) 2006-01-06
MXPA05000832A (es) 2005-10-19
US20090004669A1 (en) 2009-01-01
IL233205B (en) 2020-04-30
CN1777443A (zh) 2006-05-24
DK2308507T3 (da) 2015-04-20
AU2009202176A1 (en) 2009-06-18
CN1777443B (zh) 2010-06-23
JP5973496B2 (ja) 2016-08-23
EA200500232A1 (ru) 2005-12-29
AU2003265294A1 (en) 2004-02-09
EP1575416B1 (en) 2013-10-02
BRPI0312818B1 (pt) 2019-08-20
CA2496253C (en) 2016-05-10
AP2005003230A0 (en) 2005-03-31

Similar Documents

Publication Publication Date Title
HK1085368A1 (en) Methods of diagnosing pre-eclampsia
DE60223721D1 (en) Docking-informationssystem für schiffe
GB0311467D0 (en) Lexical stress prediction
IL150189A0 (en) Acoustic diagnosis of sinusitis
AU2003236991A8 (en) Representations of processes
EP1577280A4 (en) DEUTERATION PROCESS
AU2003228920A8 (en) Improved first aid kit instructions
EP1488046A4 (en) CONSTRUCTION METHODS
PL1634082T3 (pl) Rozpoznawanie stanu przedrzucawkowego
AU2003294206A8 (en) Methods for diagnosing htlv-i-mediated diseases
IL150906A0 (en) Diagnostic microspheres
GB0229444D0 (en) Diagnostic method and assay kit
AU2003264722A8 (en) Methods
GB2393207B (en) Means of assembly
GB0214842D0 (en) Diagnostic method
AU2003222004A8 (en) Methods of diagnosing the presence of trail
GB0209723D0 (en) Diagnostic kit
GB0200526D0 (en) Methods
GB0217632D0 (en) Diagnostic method
GB0217620D0 (en) Diagnostic method
GB0201854D0 (en) Diagnostic method
GB0202308D0 (en) Diagnostic method
GB0223616D0 (en) Diagnostic method
GB0209776D0 (en) Diagnostic method
GB0217628D0 (en) Diagnostic method

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220721