HK1084383A1 - 4-pyrrolidino-phenyl-bezyl ether derivatives - Google Patents

4-pyrrolidino-phenyl-bezyl ether derivatives

Info

Publication number
HK1084383A1
HK1084383A1 HK06103481A HK06103481A HK1084383A1 HK 1084383 A1 HK1084383 A1 HK 1084383A1 HK 06103481 A HK06103481 A HK 06103481A HK 06103481 A HK06103481 A HK 06103481A HK 1084383 A1 HK1084383 A1 HK 1084383A1
Authority
HK
Hong Kong
Prior art keywords
bezyl
pyrrolidino
phenyl
ether derivatives
derivatives
Prior art date
Application number
HK06103481A
Other languages
English (en)
Inventor
Jolidon Synese
Rodriguez-Sarmiento Rosa Maria
Thomas Andrew William
Wostl Wolfgang
Wyler Rene
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1084383A1 publication Critical patent/HK1084383A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK06103481A 2002-09-20 2006-03-20 4-pyrrolidino-phenyl-bezyl ether derivatives HK1084383A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02021319 2002-09-20
PCT/EP2003/010383 WO2004026826A1 (en) 2002-09-20 2003-09-18 4-pyrrolidino-phenyl-benzyl ether derivatives

Publications (1)

Publication Number Publication Date
HK1084383A1 true HK1084383A1 (en) 2006-07-28

Family

ID=32010924

Family Applications (3)

Application Number Title Priority Date Filing Date
HK06103476.1A HK1083499A1 (en) 2002-09-20 2006-03-20 Pyrrolidone derivatives as maob inhibitors
HK06103481A HK1084383A1 (en) 2002-09-20 2006-03-20 4-pyrrolidino-phenyl-bezyl ether derivatives
HK06103475A HK1083498A1 (en) 2002-09-20 2006-03-20 Pyrrolidone derivatives as maob inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK06103476.1A HK1083499A1 (en) 2002-09-20 2006-03-20 Pyrrolidone derivatives as maob inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK06103475A HK1083498A1 (en) 2002-09-20 2006-03-20 Pyrrolidone derivatives as maob inhibitors

Country Status (32)

Country Link
US (4) US7235581B2 (no)
EP (3) EP1542969B1 (no)
JP (3) JP4335141B2 (no)
KR (3) KR100676015B1 (no)
CN (3) CN100503562C (no)
AR (3) AR041299A1 (no)
AT (2) ATE472530T1 (no)
AU (3) AU2003267381B2 (no)
BR (4) BRPI0314631B1 (no)
CA (3) CA2496756C (no)
CY (1) CY1110745T1 (no)
DE (2) DE60333202D1 (no)
DK (1) DK1542970T3 (no)
ES (2) ES2344557T3 (no)
GT (3) GT200300206A (no)
HK (3) HK1083499A1 (no)
HR (3) HRP20050263B1 (no)
JO (2) JO2605B1 (no)
MX (3) MXPA05002880A (no)
MY (3) MY134480A (no)
NO (3) NO329754B1 (no)
NZ (3) NZ538046A (no)
PA (3) PA8583001A1 (no)
PE (3) PE20050077A1 (no)
PL (3) PL376019A1 (no)
PT (1) PT1542970E (no)
RU (3) RU2336267C2 (no)
SI (1) SI1542970T1 (no)
TW (3) TWI286132B (no)
UY (3) UY27990A1 (no)
WO (3) WO2004026827A1 (no)
ZA (3) ZA200501137B (no)

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GB0314373D0 (en) 2003-06-19 2003-07-23 Glaxo Group Ltd Chemical compounds
KR100845366B1 (ko) * 2004-08-02 2008-07-09 에프. 호프만-라 로슈 아게 모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
MX2007001169A (es) 2004-08-02 2007-03-12 Hoffmann La Roche Derivados de benciloxi como inhibidores de la oxidasa de monoamina b.
KR20070094666A (ko) 2005-02-25 2007-09-20 에프. 호프만-라 로슈 아게 약제 물질 분산성이 향상된 정제
KR100915736B1 (ko) * 2005-03-15 2009-09-04 에프. 호프만-라 로슈 아게 에난티오머 순수한 4-피롤리디노페닐, 벤질, 에터 유도체의제조 방법
US7501528B2 (en) 2005-03-15 2009-03-10 Hoffmann-La Roche Inc. Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
EP1943216B1 (en) * 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
TW200730494A (en) * 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
US8372380B2 (en) * 2007-03-30 2013-02-12 The Regents Of The University Of California In vivo imaging of sulfotransferases
KR101220182B1 (ko) * 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) * 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) * 2013-02-28 2019-09-05 삼성디스플레이 주식회사 박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
KR20150127172A (ko) 2013-03-14 2015-11-16 다트 뉴로사이언스 (케이만) 엘티디. Mao 억제제로서 치환된 나프티리딘 및 퀴놀린 화합물
CZ305213B6 (cs) 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
RU2016118748A (ru) * 2013-10-29 2017-12-05 Ф. Хоффманн-Ля Рош Аг Кристаллические формы производного пирролидона, полезные при лечении болезни альцгеймера, и их получение
ES2912881T3 (es) 2014-12-23 2022-05-30 Convergence Pharmaceuticals Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
EP3273946A1 (en) 2015-03-27 2018-01-31 F. Hoffmann-La Roche AG Pharmaceutical formulation comprising sembragiline
JP7169592B2 (ja) 2017-09-27 2022-11-11 国立大学法人 鹿児島大学 Ｐａｃ１受容体拮抗薬を用いた鎮痛薬
JP2020536870A (ja) 2017-10-05 2020-12-17 バイオジェン インコーポレイテッド アルファカルボキサミドピロリジン誘導体の調製方法
CN108299272B (zh) * 2018-01-31 2019-10-18 福州大学 一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
CA3092747A1 (en) * 2018-03-08 2019-09-12 Sunshine Lake Pharma Co., Ltd. Pyrrolidineamide derivatives and uses thereof
EP3932490A4 (en) 2019-02-27 2022-11-16 Kagoshima University ANTIPRURIC AGENT USING PAC1 RECEPTOR ANTAGONISTS
US20230181587A1 (en) 2020-05-08 2023-06-15 Kagoshima University Antidepressant/anxiolytic drug in which pac1 receptor antagonist is used
CN112851561A (zh) * 2021-01-29 2021-05-28 南京艾美斐生物医药科技有限公司 一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de) 2021-06-21 2022-12-29 Bayer Aktiengesellschaft Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

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CA2361848A1 (en) * 1999-04-02 2000-10-12 Dupont Pharmaceuticals Company Novel lactam inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase
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Also Published As

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HRP20050262A2 (en) 2006-06-30
HRP20050263B1 (hr) 2013-09-30
PE20050079A1 (es) 2005-03-01
AR041297A1 (es) 2005-05-11
BRPI0314631B1 (pt) 2018-04-17
PL376019A1 (en) 2005-12-12
NO20050665L (no) 2005-04-18
CN100503562C (zh) 2009-06-24
CA2498785C (en) 2011-07-26
AU2003267381A1 (en) 2004-04-08
GT200300205A (es) 2004-04-29
NZ538048A (en) 2007-05-31
MXPA05002880A (es) 2005-05-27
ATE459601T1 (de) 2010-03-15
AU2003270213A1 (en) 2004-04-08
ZA200501137B (en) 2006-12-27
US7037935B2 (en) 2006-05-02
JO2605B1 (en) 2011-11-01
DE60333202D1 (de) 2010-08-12
NO20050701L (no) 2005-03-02
AU2003273901B2 (en) 2008-07-10
TW200408624A (en) 2004-06-01
JO2604B1 (en) 2011-11-01
MXPA05002881A (es) 2005-05-27
PL216030B1 (pl) 2014-02-28
UY27991A1 (es) 2004-03-31
ZA200501311B (en) 2006-10-25
JP4335142B2 (ja) 2009-09-30
MY133332A (en) 2007-11-30
NO20050652L (no) 2005-03-08
WO2004026826A1 (en) 2004-04-01
NO329754B1 (no) 2010-12-13
NZ538046A (en) 2007-08-31
NZ538049A (en) 2007-05-31
RU2323209C2 (ru) 2008-04-27
RU2336267C2 (ru) 2008-10-20
HK1083499A1 (en) 2006-07-07
SI1542970T1 (sl) 2010-08-31
WO2004026825A1 (en) 2004-04-01
TW200410935A (en) 2004-07-01
MY134480A (en) 2007-12-31
CA2496756A1 (en) 2004-04-01
NO330012B1 (no) 2011-02-07
PA8583001A1 (es) 2004-04-23
AR041299A1 (es) 2005-05-11
TWI286132B (en) 2007-09-01
PL376018A1 (en) 2005-12-12
CN100383118C (zh) 2008-04-23
DE60331559D1 (de) 2010-04-15
PA8583501A1 (es) 2004-04-23
TW200413350A (en) 2004-08-01
US7122562B2 (en) 2006-10-17
US20040106650A1 (en) 2004-06-03
BR0314299A (pt) 2005-12-13
MY135696A (en) 2008-06-30
HK1083498A1 (en) 2006-07-07
KR20050057466A (ko) 2005-06-16
CN1681777A (zh) 2005-10-12
ZA200501557B (en) 2005-09-08
JP4335141B2 (ja) 2009-09-30
PE20050078A1 (es) 2005-02-28
UY27993A1 (es) 2004-03-31
UY27990A1 (es) 2004-03-31
US20040097578A1 (en) 2004-05-20
JP2006503834A (ja) 2006-02-02
MXPA05002878A (es) 2005-05-27
PE20050077A1 (es) 2005-03-01
AU2003270213B8 (en) 2009-03-05
KR100676015B1 (ko) 2007-01-30
RU2005111968A (ru) 2006-11-10
HRP20050261A2 (en) 2006-05-31
CY1110745T1 (el) 2015-06-10
KR20050057450A (ko) 2005-06-16
US7151111B2 (en) 2006-12-19
EP1542971A1 (en) 2005-06-22
RU2336268C2 (ru) 2008-10-20
RU2005111969A (ru) 2006-01-20
RU2005111974A (ru) 2006-01-20
DK1542970T3 (da) 2010-08-02
EP1542969A1 (en) 2005-06-22
KR100681586B1 (ko) 2007-02-09
PL376021A1 (en) 2005-12-12
JP2006503833A (ja) 2006-02-02
AU2003273901A1 (en) 2004-04-08
AR041298A1 (es) 2005-05-11
US20060122235A1 (en) 2006-06-08
ES2344557T3 (es) 2010-08-31
US7235581B2 (en) 2007-06-26
GT200300204A (es) 2004-04-29
KR20050057456A (ko) 2005-06-16
CN1681779A (zh) 2005-10-12
ATE472530T1 (de) 2010-07-15
PT1542970E (pt) 2010-07-19
BR0314631A (pt) 2005-08-02
HRP20050263A2 (en) 2006-12-31
TWI337604B (en) 2011-02-21
GT200300206A (es) 2004-04-29
CN1681778A (zh) 2005-10-12
WO2004026827A1 (en) 2004-04-01
CA2496756C (en) 2012-01-10
KR100676014B1 (ko) 2007-01-30
ES2338646T3 (es) 2010-05-11
CN100400509C (zh) 2008-07-09
TWI331994B (en) 2010-10-21
US20040116707A1 (en) 2004-06-17
EP1542969B1 (en) 2010-03-03
EP1542970A1 (en) 2005-06-22
EP1542970B1 (en) 2010-06-30
JP4335140B2 (ja) 2009-09-30
BR0314314A (pt) 2005-07-26
JP2006510596A (ja) 2006-03-30
CA2498785A1 (en) 2004-04-01
CA2498335A1 (en) 2004-04-01
AU2003267381B2 (en) 2009-08-27
AU2003270213B2 (en) 2009-02-12
PA8583601A1 (es) 2004-09-16

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