HK1083511A1 - Antibacterial amide macrocycles - Google Patents

Antibacterial amide macrocycles

Info

Publication number
HK1083511A1
HK1083511A1 HK06103632A HK06103632A HK1083511A1 HK 1083511 A1 HK1083511 A1 HK 1083511A1 HK 06103632 A HK06103632 A HK 06103632A HK 06103632 A HK06103632 A HK 06103632A HK 1083511 A1 HK1083511 A1 HK 1083511A1
Authority
HK
Hong Kong
Prior art keywords
antibacterial amide
amide macrocycles
macrocycles
antibacterial
prophylaxis
Prior art date
Application number
HK06103632A
Other languages
English (en)
Inventor
Thomas Lampe
Isabelle Adelt
Dieter Beyer
Nina Brunner
Rainer Endermann
Kerstin Ehlert
Hein-Peter Kroll
Franz Von Nussbaum
Siegfried Raddatz
Joachim Rudolph
Guido Schiffer
Andreas Schumacher
Yolanda Concho-Grande
Martin Michels
Stefan Weigand
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of HK1083511A1 publication Critical patent/HK1083511A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK06103632A 2002-06-17 2006-03-22 Antibacterial amide macrocycles HK1083511A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10226921A DE10226921A1 (de) 2002-06-17 2002-06-17 Antibakterielle Amid-Makrozyklen
PCT/EP2003/006078 WO2003106480A1 (de) 2002-06-17 2003-06-10 Antibakterielle amid-makrozyklen

Publications (1)

Publication Number Publication Date
HK1083511A1 true HK1083511A1 (en) 2006-07-07

Family

ID=29594575

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06103632A HK1083511A1 (en) 2002-06-17 2006-03-22 Antibacterial amide macrocycles

Country Status (22)

Country Link
US (1) US20070129288A1 (ja)
EP (1) EP1515983B1 (ja)
JP (1) JP4437078B2 (ja)
KR (1) KR20050010060A (ja)
CN (1) CN1326870C (ja)
AT (1) ATE354585T1 (ja)
AU (1) AU2003245928B2 (ja)
BR (1) BR0311948A (ja)
CA (1) CA2489454A1 (ja)
DE (2) DE10226921A1 (ja)
EC (1) ECSP045499A (ja)
ES (1) ES2282643T3 (ja)
HK (1) HK1083511A1 (ja)
HR (1) HRP20050043A2 (ja)
MA (1) MA28613B1 (ja)
MX (1) MXPA04012438A (ja)
NO (1) NO20050210L (ja)
PL (1) PL374554A1 (ja)
PT (1) PT1515983E (ja)
RU (1) RU2005100954A (ja)
WO (1) WO2003106480A1 (ja)
ZA (1) ZA200410006B (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2338789T3 (es) 2003-06-18 2010-05-12 Tranzyme Pharma Inc. Antagonistas macrociclicos del receptor de motilina.
WO2005033129A1 (de) * 2003-10-01 2005-04-14 Bayer Healthcare Ag Antibakterielle amid-makrozyklen
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102004018405A1 (de) * 2004-04-16 2005-11-03 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen II
DE102004025731A1 (de) * 2004-05-26 2005-12-15 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen III
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV
DE102005014245A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
PT1984344E (pt) * 2005-12-29 2012-12-21 Lexicon Pharmaceuticals Inc Derivados de aminoácidos multicíclicos e métodos para a sua utilização
JP2012510958A (ja) * 2008-12-04 2012-05-17 バイエル ファーマ アクチエンゲゼルシャフト 放射性同位体で標識されたリジン及びオルニチン誘導体、それらの使用及び製造方法
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
CN104903302B (zh) * 2012-11-21 2019-03-29 阿奇克斯制药公司 大环广谱抗生素
JP5437525B1 (ja) * 2012-12-28 2014-03-12 株式会社ナード研究所 チロシン誘導体およびチロシン誘導体の製造方法
CA2949681A1 (en) 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
MY193014A (en) 2015-10-27 2022-09-22 Hoffmann La Roche Peptide macrocycles against acinetobacter baumannii
BR112018010267A2 (pt) 2015-11-20 2018-11-27 Genentech Inc antibióticos macrocíclicos de amplo espectro
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
AR119019A1 (es) 2019-05-28 2021-11-17 Hoffmann La Roche Antibióticos macrocíclicos de amplio espectro

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
WO2005033129A1 (de) * 2003-10-01 2005-04-14 Bayer Healthcare Ag Antibakterielle amid-makrozyklen
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
EP1515983B1 (de) 2007-02-21
NO20050210L (no) 2005-03-01
DE50306587D1 (de) 2007-04-05
JP4437078B2 (ja) 2010-03-24
DE10226921A1 (de) 2003-12-24
ZA200410006B (en) 2006-02-22
ATE354585T1 (de) 2007-03-15
WO2003106480A1 (de) 2003-12-24
AU2003245928B2 (en) 2009-03-05
CN1675236A (zh) 2005-09-28
AU2003245928A1 (en) 2003-12-31
US20070129288A1 (en) 2007-06-07
HRP20050043A2 (hr) 2006-04-30
CN1326870C (zh) 2007-07-18
ECSP045499A (es) 2005-03-10
RU2005100954A (ru) 2005-07-10
KR20050010060A (ko) 2005-01-26
BR0311948A (pt) 2005-03-29
MA28613B1 (fr) 2007-06-01
MXPA04012438A (es) 2005-04-19
EP1515983A1 (de) 2005-03-23
PL374554A1 (en) 2005-10-31
PT1515983E (pt) 2007-03-30
ES2282643T3 (es) 2007-10-16
CA2489454A1 (en) 2004-12-14
JP2006511446A (ja) 2006-04-06

Similar Documents

Publication Publication Date Title
HK1083511A1 (en) Antibacterial amide macrocycles
YU91603A (sh) Kristalni oblici azitromicina
EP1560488A4 (en) ANTIBACTERIAL AGENTS
TW200507841A (en) Antibacterial agents
WO2004058144A3 (en) Antibacterial agents
TW200630367A (en) Substituted adenines and the uses thereof
MY138285A (en) Fab i inhibitors
WO2003099217A3 (en) Methods of treating bacterial infections and diseases associated therewith
WO2004096982A3 (en) Antibacterial agents
YU102503A (sh) Kondenzovani pirimidinski dhfr inhibitori kao antibakterijska sredstva
WO2005118613A3 (de) Antibakterielle amid-makrozyklen
ATE495186T1 (de) Antibakterielle amid-makrozyklen iv
TW200621799A (en) Acylated nonadepsipeptides II
ATE510845T1 (de) Antibakterielle makrozyklen mit substituiertem biphenyl
DE50305587D1 (en) 2-heteroarylcarbonsäureamide
HK1106253A1 (en) Desoxo-nonadepsipeptides
TW200504402A (en) Antimicrobial lenses, processes to prepare them and methods of their use
AU2003294565A8 (en) Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
UY28542A1 (es) Amidas macrocíclicas antibacterianas
UA95630C2 (ru) Лизобактинамиды, способ их получения (варианты) и применение их как антибактериального средства
WO2004098500A3 (en) CARBACEPHEM ss-LACTAM ANTIBIOTICS
WO2005011611A3 (en) Bicyclic compounds and compositions as pdf inhibitors
WO2005108563A3 (en) Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4
UA85187C2 (en) 2-aminobenzoyl derivatives
WO2005121160A3 (en) 11, 12 cyclic thiocarbamate macrolide antibacterial agents

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110610