HK1083188A1 - Diaryl ethers as opioid receptor antagonists - Google Patents

Diaryl ethers as opioid receptor antagonists

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Publication number
HK1083188A1
HK1083188A1 HK06102045A HK06102045A HK1083188A1 HK 1083188 A1 HK1083188 A1 HK 1083188A1 HK 06102045 A HK06102045 A HK 06102045A HK 06102045 A HK06102045 A HK 06102045A HK 1083188 A1 HK1083188 A1 HK 1083188A1
Authority
HK
Hong Kong
Prior art keywords
receptor antagonists
opioid receptor
diaryl ethers
diaryl
ethers
Prior art date
Application number
HK06102045A
Other languages
English (en)
Inventor
Blanco-Pillado Maria-Jesus
Chappel Mark Donald
La Garcia Torre Marta De
Diaz Buezo Nuria
Fritz James Erwin
Holloway William Glen
Matt James Edward Jr
Mitch Charles Howard
Pedregal-Tercero Concepcion
Quimby Steven James
Siegel Miles Goodman
Smith Dana Rae
Stucky Russel Dean
Takeuchi Kumiko
Thomas Elizabeth Marie
Wolfe Chad Nolan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1083188A1 publication Critical patent/HK1083188A1/xx

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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