HK1065316A1 - Anthranilic acid amides with a heteroarylsulfonyl side chain, and use thereof as antiarrhythmic active substances - Google Patents
Anthranilic acid amides with a heteroarylsulfonyl side chain, and use thereof as antiarrhythmic active substancesInfo
- Publication number
- HK1065316A1 HK1065316A1 HK04108195A HK04108195A HK1065316A1 HK 1065316 A1 HK1065316 A1 HK 1065316A1 HK 04108195 A HK04108195 A HK 04108195A HK 04108195 A HK04108195 A HK 04108195A HK 1065316 A1 HK1065316 A1 HK 1065316A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- side chain
- active substances
- acid amides
- anthranilic acid
- antiarrhythmic active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10128331A DE10128331A1 (de) | 2001-06-12 | 2001-06-12 | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| PCT/EP2002/005956 WO2002100825A2 (de) | 2001-06-12 | 2002-05-31 | Anthranilsäureamide mit heteroarylsulfonyl-seitenkette und ihre verwendung als antiarrhythmische wirkstoffe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1065316A1 true HK1065316A1 (en) | 2005-02-18 |
Family
ID=7687941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK04108195A HK1065316A1 (en) | 2001-06-12 | 2004-10-20 | Anthranilic acid amides with a heteroarylsulfonyl side chain, and use thereof as antiarrhythmic active substances |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US6903216B2 (es) |
| EP (1) | EP1399423B9 (es) |
| JP (1) | JP4422477B2 (es) |
| KR (1) | KR100863924B1 (es) |
| CN (1) | CN1247544C (es) |
| AR (1) | AR036045A1 (es) |
| AT (1) | ATE378318T1 (es) |
| AU (1) | AU2002316939B2 (es) |
| BG (1) | BG108415A (es) |
| BR (1) | BR0210374A (es) |
| CA (1) | CA2450076C (es) |
| CO (1) | CO5540283A2 (es) |
| CR (1) | CR7140A (es) |
| CY (1) | CY1107427T1 (es) |
| CZ (1) | CZ20033361A3 (es) |
| DE (2) | DE10128331A1 (es) |
| DK (1) | DK1399423T3 (es) |
| EC (1) | ECSP034883A (es) |
| EE (1) | EE05196B1 (es) |
| ES (1) | ES2295360T3 (es) |
| HK (1) | HK1065316A1 (es) |
| HR (1) | HRP20031028A2 (es) |
| HU (1) | HUP0400159A3 (es) |
| IL (2) | IL159247A0 (es) |
| MA (1) | MA27037A1 (es) |
| MX (1) | MXPA03010875A (es) |
| MY (1) | MY138341A (es) |
| NO (1) | NO20035450D0 (es) |
| NZ (1) | NZ530081A (es) |
| OA (1) | OA12631A (es) |
| PE (1) | PE20021066A1 (es) |
| PL (1) | PL364371A1 (es) |
| PT (1) | PT1399423E (es) |
| RS (1) | RS97703A (es) |
| RU (1) | RU2293727C2 (es) |
| SK (1) | SK15222003A3 (es) |
| TN (1) | TNSN03134A1 (es) |
| TW (1) | TWI304400B (es) |
| UA (1) | UA75412C2 (es) |
| WO (1) | WO2002100825A2 (es) |
| ZA (1) | ZA200308520B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10128331A1 (de) * | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| US7119112B2 (en) * | 2002-02-28 | 2006-10-10 | Icagen, Inc. | Sulfonamides as potassium channel blockers |
| EP1500650A4 (en) * | 2002-04-26 | 2006-08-23 | Ishihara Sangyo Kaisha | PYRIDINE COMPOUNDS OR SALTS THEREOF AND HERBICIDES CONTAINING SAME |
| EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| DE10312061A1 (de) * | 2003-03-18 | 2004-09-30 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit Blockern des IK-Kanals und deren Verwendung zur Behandlung von Vorhofarrhythmien |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| EP1489071A1 (en) * | 2003-06-18 | 2004-12-22 | 4Sc Ag | N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators |
| PT1651621E (pt) | 2003-08-08 | 2008-09-30 | Janssen Pharmaceutica Nv | Compostos de 2-(quinoxalin-5-ilsulfonilamino)-benzamida como moduladores de cck2 |
| DE10341233A1 (de) * | 2003-09-08 | 2005-03-24 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien |
| DE102004009931A1 (de) * | 2004-02-26 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| BRPI0516027A (pt) * | 2004-09-24 | 2008-08-19 | Janssen Pharmaceutica Nv | compostos de sulfonamida |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| NZ572231A (en) * | 2006-04-27 | 2010-12-24 | Sanofi Aventis Deutschland | Inhibitors of the task-1 and task-3 ion channel |
| WO2008124524A2 (en) * | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Aryl sulfonamide compounds as modulators of the cck2 receptor |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| WO2011000541A1 (en) * | 2009-06-29 | 2011-01-06 | Merz Pharma Gmbh & Co Kgaa | Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane |
| ES2632954T3 (es) | 2009-06-29 | 2017-09-18 | Agios Pharmaceuticals, Inc. | Derivados de quinolina-8-sulfonamida que tienen una actividad anticancerosa |
| WO2011010132A1 (en) * | 2009-07-21 | 2011-01-27 | Astrazeneca Ab | Sustained-release composition comprising compound 600 |
| FR2967674B1 (fr) * | 2010-11-23 | 2012-12-14 | Pf Medicament | Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
| WO2013112932A1 (en) | 2012-01-27 | 2013-08-01 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| US9701627B2 (en) * | 2014-06-16 | 2017-07-11 | University Of Maryland, Baltimore | LRRK2 GTP binding inhibitors for treatment of Parkinson's disease and neuroinflammatory disorders |
| CN111183129A (zh) * | 2017-08-07 | 2020-05-19 | 国立大学法人广岛大学 | 新型邻氨基苯甲酸系化合物、使用了该化合物的Pin1抑制剂、炎症性疾病及癌症的治疗剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2155662A1 (en) | 1993-12-27 | 1995-07-06 | Fumihiro Ozaki | Anthranilic acid derivative |
| US5670504A (en) | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
| US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| DK173062B1 (da) | 1996-10-11 | 1999-12-13 | Krueger As I | Fremgangsmåde til fjernelse af opløste metaller og/eller metalloider fra et vandigt medium indeholdende samme og med et sto |
| US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| TW523506B (en) | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
| CA2336807C (en) | 1998-07-08 | 2010-04-13 | Aventis Pharma Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
| AU754204B2 (en) | 1998-09-01 | 2002-11-07 | Bristol-Myers Squibb Company | Potassium channel inhibitors and method |
| IL146513A0 (en) * | 1999-06-24 | 2002-07-25 | Smithkline Beecham Corp | Macrophage scavenger receptor antagonists |
| DE19947457A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| US6531495B1 (en) * | 1999-10-02 | 2003-03-11 | Aventis Pharma Deutschland Gmbh | 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them |
| DE10128331A1 (de) * | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
-
2001
- 2001-06-12 DE DE10128331A patent/DE10128331A1/de not_active Withdrawn
-
2002
- 2002-05-17 PE PE2002000419A patent/PE20021066A1/es not_active Application Discontinuation
- 2002-05-21 OA OA1200300333A patent/OA12631A/fr unknown
- 2002-05-31 CN CNB028118502A patent/CN1247544C/zh not_active Expired - Fee Related
- 2002-05-31 RS YU97703A patent/RS97703A/sr unknown
- 2002-05-31 EP EP02745333A patent/EP1399423B9/de not_active Expired - Lifetime
- 2002-05-31 NZ NZ530081A patent/NZ530081A/en unknown
- 2002-05-31 CZ CZ20033361A patent/CZ20033361A3/cs unknown
- 2002-05-31 UA UA2004010206A patent/UA75412C2/uk unknown
- 2002-05-31 KR KR1020037016206A patent/KR100863924B1/ko not_active IP Right Cessation
- 2002-05-31 HU HU0400159A patent/HUP0400159A3/hu unknown
- 2002-05-31 ES ES02745333T patent/ES2295360T3/es not_active Expired - Lifetime
- 2002-05-31 PL PL02364371A patent/PL364371A1/xx not_active IP Right Cessation
- 2002-05-31 DK DK02745333T patent/DK1399423T3/da active
- 2002-05-31 IL IL15924702A patent/IL159247A0/xx unknown
- 2002-05-31 CA CA2450076A patent/CA2450076C/en not_active Expired - Fee Related
- 2002-05-31 DE DE50211213T patent/DE50211213D1/de not_active Expired - Lifetime
- 2002-05-31 PT PT02745333T patent/PT1399423E/pt unknown
- 2002-05-31 BR BR0210374-5A patent/BR0210374A/pt not_active Application Discontinuation
- 2002-05-31 SK SK1522-2003A patent/SK15222003A3/sk unknown
- 2002-05-31 EE EEP200300558A patent/EE05196B1/xx not_active IP Right Cessation
- 2002-05-31 JP JP2003503594A patent/JP4422477B2/ja not_active Expired - Fee Related
- 2002-05-31 AT AT02745333T patent/ATE378318T1/de active
- 2002-05-31 RU RU2004100302/04A patent/RU2293727C2/ru not_active IP Right Cessation
- 2002-05-31 WO PCT/EP2002/005956 patent/WO2002100825A2/de active IP Right Grant
- 2002-05-31 MX MXPA03010875A patent/MXPA03010875A/es active IP Right Grant
- 2002-05-31 AU AU2002316939A patent/AU2002316939B2/en not_active Ceased
- 2002-06-10 AR ARP020102178A patent/AR036045A1/es active IP Right Grant
- 2002-06-10 TW TW091112464A patent/TWI304400B/zh not_active IP Right Cessation
- 2002-06-11 MY MYPI20022165A patent/MY138341A/en unknown
- 2002-06-12 US US10/166,595 patent/US6903216B2/en not_active Expired - Lifetime
-
2003
- 2003-07-08 TN TNPCT/EP2002/005956A patent/TNSN03134A1/en unknown
- 2003-10-31 ZA ZA200308520A patent/ZA200308520B/en unknown
- 2003-11-04 CR CR7140A patent/CR7140A/es not_active Application Discontinuation
- 2003-12-03 EC EC2003004883A patent/ECSP034883A/es unknown
- 2003-12-04 BG BG108415A patent/BG108415A/xx unknown
- 2003-12-08 NO NO20035450A patent/NO20035450D0/no not_active Application Discontinuation
- 2003-12-08 IL IL159247A patent/IL159247A/en not_active IP Right Cessation
- 2003-12-10 MA MA27434A patent/MA27037A1/fr unknown
- 2003-12-11 HR HR20031028A patent/HRP20031028A2/hr not_active Application Discontinuation
- 2003-12-11 CO CO03108701A patent/CO5540283A2/es not_active Application Discontinuation
-
2004
- 2004-10-20 HK HK04108195A patent/HK1065316A1/xx not_active IP Right Cessation
-
2005
- 2005-02-08 US US11/052,959 patent/US7235664B2/en not_active Expired - Lifetime
-
2008
- 2008-02-04 CY CY20081100143T patent/CY1107427T1/el unknown
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Effective date: 20100531 |