BR0210374A - Amidas de ácido antranìlico com cadeia lateral de heteroarilsulfonila, processos para produção das mesmas, uso das mesmas como medicamento ou agente de diagnóstico, bem como preparações farmacêuticas que contêm as mesmas - Google Patents

Amidas de ácido antranìlico com cadeia lateral de heteroarilsulfonila, processos para produção das mesmas, uso das mesmas como medicamento ou agente de diagnóstico, bem como preparações farmacêuticas que contêm as mesmas

Info

Publication number
BR0210374A
BR0210374A BR0210374-5A BR0210374A BR0210374A BR 0210374 A BR0210374 A BR 0210374A BR 0210374 A BR0210374 A BR 0210374A BR 0210374 A BR0210374 A BR 0210374A
Authority
BR
Brazil
Prior art keywords
processes
side chain
pharmaceutical preparations
diagnostic agent
preparations containing
Prior art date
Application number
BR0210374-5A
Other languages
English (en)
Inventor
Joachim Brendel
Thomas Boehme
Stefan Peukert
Heinz-Werner Kleemann
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0210374A publication Critical patent/BR0210374A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"AMIDAS DE áCIDO ANTRANìLICO COM CADEIA LATERAL DE HETEROARILSULFONILA, PROCESSOS PARA PRODUçãO DAS MESMAS, USO DAS MESMAS COMO MEDICAMENTO OU AGENTE DE DIAGNóSTICO, BEM COMO PREPARAçõES FARMACêUTICAS QUE CONTêM AS MESMAS". A invenção refere-se a compostos da fórmula (I), nos quais R(1) - R(7) têm os significados indicados nas reivindicações. Os referidos compostos atuam sobre o canal de potássio de Kv1,5 e inibem uma corrente de potássio no átrio do coração humano, designada por "ultra-rapidly activating delayed rectifier" (retificador retardado de ativação ultra-rápida). Por esse motivo, eles são particularmente apropriados para o uso como substâncias ativas antiarrítmicas novas, particularmente no tratamento e profilaxia de arritmia atrial, por exemplo, fibrilação atrial (AF) ou palpitação atrial.
BR0210374-5A 2001-06-12 2002-05-31 Amidas de ácido antranìlico com cadeia lateral de heteroarilsulfonila, processos para produção das mesmas, uso das mesmas como medicamento ou agente de diagnóstico, bem como preparações farmacêuticas que contêm as mesmas BR0210374A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10128331A DE10128331A1 (de) 2001-06-12 2001-06-12 Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2002/005956 WO2002100825A2 (de) 2001-06-12 2002-05-31 Anthranilsäureamide mit heteroarylsulfonyl-seitenkette und ihre verwendung als antiarrhythmische wirkstoffe

Publications (1)

Publication Number Publication Date
BR0210374A true BR0210374A (pt) 2004-07-13

Family

ID=7687941

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210374-5A BR0210374A (pt) 2001-06-12 2002-05-31 Amidas de ácido antranìlico com cadeia lateral de heteroarilsulfonila, processos para produção das mesmas, uso das mesmas como medicamento ou agente de diagnóstico, bem como preparações farmacêuticas que contêm as mesmas

Country Status (41)

Country Link
US (2) US6903216B2 (pt)
EP (1) EP1399423B9 (pt)
JP (1) JP4422477B2 (pt)
KR (1) KR100863924B1 (pt)
CN (1) CN1247544C (pt)
AR (1) AR036045A1 (pt)
AT (1) ATE378318T1 (pt)
AU (1) AU2002316939B2 (pt)
BG (1) BG108415A (pt)
BR (1) BR0210374A (pt)
CA (1) CA2450076C (pt)
CO (1) CO5540283A2 (pt)
CR (1) CR7140A (pt)
CY (1) CY1107427T1 (pt)
CZ (1) CZ20033361A3 (pt)
DE (2) DE10128331A1 (pt)
DK (1) DK1399423T3 (pt)
EC (1) ECSP034883A (pt)
EE (1) EE05196B1 (pt)
ES (1) ES2295360T3 (pt)
HK (1) HK1065316A1 (pt)
HR (1) HRP20031028A2 (pt)
HU (1) HUP0400159A3 (pt)
IL (2) IL159247A0 (pt)
MA (1) MA27037A1 (pt)
MX (1) MXPA03010875A (pt)
MY (1) MY138341A (pt)
NO (1) NO20035450D0 (pt)
NZ (1) NZ530081A (pt)
OA (1) OA12631A (pt)
PE (1) PE20021066A1 (pt)
PL (1) PL364371A1 (pt)
PT (1) PT1399423E (pt)
RS (1) RS97703A (pt)
RU (1) RU2293727C2 (pt)
SK (1) SK15222003A3 (pt)
TN (1) TNSN03134A1 (pt)
TW (1) TWI304400B (pt)
UA (1) UA75412C2 (pt)
WO (1) WO2002100825A2 (pt)
ZA (1) ZA200308520B (pt)

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EP1500650A4 (en) * 2002-04-26 2006-08-23 Ishihara Sangyo Kaisha PYRIDINE COMPOUNDS OR SALTS THEREOF AND HERBICIDES CONTAINING SAME
EP1388535A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated arylcycloalkylamines and their use as pharmaceuticals
DE10312061A1 (de) * 2003-03-18 2004-09-30 Aventis Pharma Deutschland Gmbh Kombination von Phenylcarbonsäureamiden mit Blockern des IK-Kanals und deren Verwendung zur Behandlung von Vorhofarrhythmien
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
EP1489071A1 (en) * 2003-06-18 2004-12-22 4Sc Ag N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators
PT1651621E (pt) 2003-08-08 2008-09-30 Janssen Pharmaceutica Nv Compostos de 2-(quinoxalin-5-ilsulfonilamino)-benzamida como moduladores de cck2
DE10341233A1 (de) * 2003-09-08 2005-03-24 Aventis Pharma Deutschland Gmbh Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
DE102004009931A1 (de) * 2004-02-26 2005-09-15 Aventis Pharma Deutschland Gmbh Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
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BRPI0516027A (pt) * 2004-09-24 2008-08-19 Janssen Pharmaceutica Nv compostos de sulfonamida
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NZ572231A (en) * 2006-04-27 2010-12-24 Sanofi Aventis Deutschland Inhibitors of the task-1 and task-3 ion channel
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GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
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NO3175985T3 (pt) 2011-07-01 2018-04-28
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Also Published As

Publication number Publication date
US20030114499A1 (en) 2003-06-19
PL364371A1 (en) 2004-12-13
CY1107427T1 (el) 2012-12-19
OA12631A (fr) 2006-06-14
KR100863924B1 (ko) 2008-10-17
HUP0400159A3 (en) 2008-10-28
NO20035450D0 (no) 2003-12-08
HUP0400159A2 (hu) 2004-07-28
UA75412C2 (en) 2006-04-17
DK1399423T3 (da) 2008-03-17
MXPA03010875A (es) 2004-02-17
ECSP034883A (es) 2004-01-28
HRP20031028A2 (en) 2005-10-31
ES2295360T3 (es) 2008-04-16
CO5540283A2 (es) 2005-07-29
PE20021066A1 (es) 2003-01-21
IL159247A0 (en) 2004-06-01
RU2293727C2 (ru) 2007-02-20
EP1399423A2 (de) 2004-03-24
CR7140A (es) 2004-04-15
PT1399423E (pt) 2008-02-07
CN1247544C (zh) 2006-03-29
TWI304400B (en) 2008-12-21
NZ530081A (en) 2005-07-29
JP4422477B2 (ja) 2010-02-24
RS97703A (en) 2006-12-15
CZ20033361A3 (cs) 2004-05-12
CA2450076C (en) 2010-11-30
SK15222003A3 (sk) 2004-06-08
TNSN03134A1 (en) 2005-12-23
BG108415A (en) 2004-07-30
MA27037A1 (fr) 2004-12-20
ZA200308520B (en) 2004-09-06
KR20040030668A (ko) 2004-04-09
RU2004100302A (ru) 2005-04-10
AR036045A1 (es) 2004-08-04
CN1529695A (zh) 2004-09-15
EE200300558A (et) 2004-02-16
HK1065316A1 (en) 2005-02-18
WO2002100825A3 (de) 2003-12-11
IL159247A (en) 2010-06-16
EP1399423B1 (de) 2007-11-14
JP2004533464A (ja) 2004-11-04
CA2450076A1 (en) 2002-12-19
US6903216B2 (en) 2005-06-07
DE50211213D1 (de) 2007-12-27
EP1399423B9 (de) 2008-02-27
US7235664B2 (en) 2007-06-26
ATE378318T1 (de) 2007-11-15
MY138341A (en) 2009-05-29
US20050137200A1 (en) 2005-06-23
AU2002316939B2 (en) 2006-11-23
WO2002100825A2 (de) 2002-12-19
DE10128331A1 (de) 2002-12-19
EE05196B1 (et) 2009-08-17

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B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements