HUP0400159A2 - Heteroarilszulfonil-oldalláncot hordozó antranilsavamid-származékok, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Heteroarilszulfonil-oldalláncot hordozó antranilsavamid-származékok, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400159A2 HUP0400159A2 HU0400159A HUP0400159A HUP0400159A2 HU P0400159 A2 HUP0400159 A2 HU P0400159A2 HU 0400159 A HU0400159 A HU 0400159A HU P0400159 A HUP0400159 A HU P0400159A HU P0400159 A2 HUP0400159 A2 HU P0400159A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- naphthyl
- phenyl
- heteroaryl
- Prior art date
Links
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 title 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000001424 substituent group Chemical group 0.000 abstract 8
- 125000001624 naphthyl group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- -1 methylsulfonylamino group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 4
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 3
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 abstract 2
- 125000001041 indolyl group Chemical group 0.000 abstract 2
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000005493 quinolyl group Chemical group 0.000 abstract 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
A találmány szerinti vegyületek (I) általános képletében R(I)jelentése (a), (b), (c) vagy (d) általános képletű csoport, ahol Ajelentése -CnH2n- képletű csoport, ahol n értéke 0, 1, 2, 3, 4 vagy 5,D jelentése közvetlen kötés vagy oxigénatom, E jelentése -CmH2m-képletű csoport, ahol m értéke 0, 1, 2, 3, 4 vagy 5, R(8) jelentésehidrogénatom, alkilcsoport vagy CpH2p-R(14) általános képletű csoport,ahol p értéke 0, 1, 2, 3, 4 vagy 5, R(14) jelentése fenilcsoport,naftilcsoport vagy heteroarilcsoport, amelyek adott esetben 1, 2 vagy3 szubsztituenssel szubsztituálva lehetnek, ahol a szubsztituens F,CL, Br; I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH;alkilcsoport, alkoxicsoport, dimetilaminocsoport, szulfamoilcsoport,metilszulfonilcsoport vagy metilszulfonilaminocsoport, R(9) jelentésehidrogénatom vagy alkiIcsoport, R(10) jelentése hidrogénatom,alkilcsoport, fenilcsoport, naftilcsoport vagy heteroarilcsoport, ahola fenilcsoport, naftilcsoport és heteroarilcsoport adott esetben 1, 2vagy 3 szubsztituenssel szubsztituálva lehet, ahol a szubsztituens F,CI, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH,alkilcsoport, alkoxicsoport, dimetilaminocsoport, szulfamoilcsoport,metilszulfonilcsoport vagy metilszulfonilaminocsoport, R(11) jelentésecikloalkilcsoport, fenilcsoport, naftilcsoport, tienilcsoport,furilcsoport, piridilcsoport, pirazinilcsoport, pirimidinilcsoport,piridazinilcsoport, indolilcsoport, indazolilcsoport, kinolilcsoport,izokinolilcsoport, ftalazinilcsoport; kinoxalinilcsoport,kinazolinilcsoport vagy cinnolinilcsoport, ahol fenilcsoport,naftilcsaport, tienilcsoport, furilcsoport, piridilcsoport,pirazinilcsoport, pirimidinilcsoport, piridazinilcsoport,indolilcsoport, indazolilcsoport, kinolilcsoport, izokinoilcsoport,ftalazinilcsoport, kinoxalinilcsoport, kinazolinilcsoport éscinnolinilcsoport adott esetben 1, 2 vagy 3 szubsztituensselszubsztituálva lehet, ahol a szubsztituens F, Cl, Br, I, CF3, OCF3,NO2, CN, COMe, NH2, OH, alkilcsoport, alkoxicsopart,dimetilaminocsoport, szulfamoilcsoport, metilszulfonilcsoport vagymetilszulfonilaminocsoport, R(12) jelentése alkilcsoport,alkinilcsoport, cikloalkilcsoport, fenilcsoport, naftilcsoport vagyheteroarilcsoport, ahol a fenilcsoport, naftilcsoport ésheteroarilcsoport adott esetben 1, 2 vagy 3 szubsztituensselszubsztituálva lehet, ahol a szubsztituens F, Cl, Br, I, CF3, OCF3,NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkilcsoport, alkoxicsoport,dimetilaminocsoport, szulfamoilcsoport, metilszulfonilcsoport vagymetilszulfanilaminocsoport, R(13) jelentése CpH2p-R(14) általánosképletű csoport, ahol p értéke 0, I, 2, 3, 4 vagy 5, R(15) jelentésecikloalkilcsoport, R(2) jelentése hidrogénatom vagy alkilcsoport, R(3)jelentése heteroarilcsoport, amely adott esetben 1,
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10128331A DE10128331A1 (de) | 2001-06-12 | 2001-06-12 | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| PCT/EP2002/005956 WO2002100825A2 (de) | 2001-06-12 | 2002-05-31 | Anthranilsäureamide mit heteroarylsulfonyl-seitenkette und ihre verwendung als antiarrhythmische wirkstoffe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0400159A2 true HUP0400159A2 (hu) | 2004-07-28 |
| HUP0400159A3 HUP0400159A3 (en) | 2008-10-28 |
Family
ID=7687941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400159A HUP0400159A3 (en) | 2001-06-12 | 2002-05-31 | Anthranilic acid amides with a heteroarylsulfonyl side chain, method for the production thereof, use thereof and pharmaceutical compositions containing them |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US6903216B2 (hu) |
| EP (1) | EP1399423B9 (hu) |
| JP (1) | JP4422477B2 (hu) |
| KR (1) | KR100863924B1 (hu) |
| CN (1) | CN1247544C (hu) |
| AR (1) | AR036045A1 (hu) |
| AT (1) | ATE378318T1 (hu) |
| AU (1) | AU2002316939B2 (hu) |
| BG (1) | BG108415A (hu) |
| BR (1) | BR0210374A (hu) |
| CA (1) | CA2450076C (hu) |
| CO (1) | CO5540283A2 (hu) |
| CR (1) | CR7140A (hu) |
| CY (1) | CY1107427T1 (hu) |
| CZ (1) | CZ20033361A3 (hu) |
| DE (2) | DE10128331A1 (hu) |
| DK (1) | DK1399423T3 (hu) |
| EC (1) | ECSP034883A (hu) |
| EE (1) | EE05196B1 (hu) |
| ES (1) | ES2295360T3 (hu) |
| HK (1) | HK1065316A1 (hu) |
| HR (1) | HRP20031028A2 (hu) |
| HU (1) | HUP0400159A3 (hu) |
| IL (2) | IL159247A0 (hu) |
| MA (1) | MA27037A1 (hu) |
| MX (1) | MXPA03010875A (hu) |
| MY (1) | MY138341A (hu) |
| NO (1) | NO20035450D0 (hu) |
| NZ (1) | NZ530081A (hu) |
| OA (1) | OA12631A (hu) |
| PE (1) | PE20021066A1 (hu) |
| PL (1) | PL364371A1 (hu) |
| PT (1) | PT1399423E (hu) |
| RS (1) | RS97703A (hu) |
| RU (1) | RU2293727C2 (hu) |
| SK (1) | SK15222003A3 (hu) |
| TN (1) | TNSN03134A1 (hu) |
| TW (1) | TWI304400B (hu) |
| UA (1) | UA75412C2 (hu) |
| WO (1) | WO2002100825A2 (hu) |
| ZA (1) | ZA200308520B (hu) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10128331A1 (de) * | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| US7119112B2 (en) * | 2002-02-28 | 2006-10-10 | Icagen, Inc. | Sulfonamides as potassium channel blockers |
| KR20040104643A (ko) * | 2002-04-26 | 2004-12-10 | 이시하라 산교 가부시끼가이샤 | 피리딘계 화합물 또는 이의 염 및 이들을 함유하는 제초제 |
| EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| DE10312061A1 (de) * | 2003-03-18 | 2004-09-30 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit Blockern des IK-Kanals und deren Verwendung zur Behandlung von Vorhofarrhythmien |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| EP1489071A1 (en) * | 2003-06-18 | 2004-12-22 | 4Sc Ag | N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators |
| PT1651621E (pt) | 2003-08-08 | 2008-09-30 | Janssen Pharmaceutica Nv | Compostos de 2-(quinoxalin-5-ilsulfonilamino)-benzamida como moduladores de cck2 |
| DE10341233A1 (de) * | 2003-09-08 | 2005-03-24 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien |
| DE102004009931A1 (de) * | 2004-02-26 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| CN101061116A (zh) | 2004-09-24 | 2007-10-24 | 詹森药业有限公司 | 磺酰胺化合物 |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| WO2007124849A2 (en) * | 2006-04-27 | 2007-11-08 | Sanofi-Aventis Deutschland Gmbh | Inhibitors of the task-1 and task-3 ion channel |
| WO2008124524A2 (en) * | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Aryl sulfonamide compounds as modulators of the cck2 receptor |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| SG10201403696UA (en) | 2009-06-29 | 2014-10-30 | Agios Pharmaceuticals Inc | Therapeutic compounds and compositions |
| DK2448909T3 (da) * | 2009-06-29 | 2013-07-15 | Merz Pharma Gmbh & Co Kgaa | Fremgangsmåde til fremstilling af 1-amino-1,3,3,5,5-pentamethylcyclohexan |
| WO2011010132A1 (en) * | 2009-07-21 | 2011-01-27 | Astrazeneca Ab | Sustained-release composition comprising compound 600 |
| FR2967674B1 (fr) | 2010-11-23 | 2012-12-14 | Pf Medicament | Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (hu) | 2011-07-01 | 2018-04-28 | ||
| NZ627942A (en) | 2012-01-27 | 2016-03-31 | Gilead Sciences Inc | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| US9701627B2 (en) * | 2014-06-16 | 2017-07-11 | University Of Maryland, Baltimore | LRRK2 GTP binding inhibitors for treatment of Parkinson's disease and neuroinflammatory disorders |
| EP3680232A4 (en) * | 2017-08-07 | 2021-08-11 | Hiroshima University | NEW COMBINATION BASED ON ANTHRANIC ACID AND PIN1 INHIBITOR, THERAPEUTIC FOR INFLAMMATORY DISEASES AND THERAPEUTIC FOR CANCER WITH IT |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716993A (en) | 1993-12-27 | 1998-02-10 | Eisai Co., Ltd. | Anthranilic acid derivatives |
| US5670504A (en) | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
| US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| DK173062B1 (da) | 1996-10-11 | 1999-12-13 | Krueger As I | Fremgangsmåde til fjernelse af opløste metaller og/eller metalloider fra et vandigt medium indeholdende samme og med et sto |
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| TW523506B (en) | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
| DE69928260T2 (de) * | 1998-07-08 | 2006-07-20 | Sanofi-Aventis Deutschland Gmbh | Schwefel-substituierte sulfonylaminocarbonsäure n-arylamide, ihre herstellung, ihre anwendung und diese enthaltende pharmazeutische zusammensetzungen |
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| BR0011571A (pt) * | 1999-06-24 | 2002-03-05 | Smithkline Beecham Corp | Antagonistas do receptor de limpeza de macrófago |
| US6531495B1 (en) * | 1999-10-02 | 2003-03-11 | Aventis Pharma Deutschland Gmbh | 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them |
| DE19947457A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
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2001
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2002
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2004
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