AR036045A1 - Amidas de acidos antranilicos con cadena lateral de heteroarilsulfonilo, su empleo para la preparacion de un medicamento, asi como composiciones farmaceuticas que las contienen - Google Patents
Amidas de acidos antranilicos con cadena lateral de heteroarilsulfonilo, su empleo para la preparacion de un medicamento, asi como composiciones farmaceuticas que las contienenInfo
- Publication number
- AR036045A1 AR036045A1 ARP020102178A ARP020102178A AR036045A1 AR 036045 A1 AR036045 A1 AR 036045A1 AR P020102178 A ARP020102178 A AR P020102178A AR P020102178 A ARP020102178 A AR P020102178A AR 036045 A1 AR036045 A1 AR 036045A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- alkyl
- naphthyl
- phenyl
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Amidas de ácidos antranílicos con cadena lateral de heteroarilsulfonilo, de la fórmula (1) en donde, R1 significa fórmulas (2), (3), (4) o (5); A es -CnH2n-; n = 0, 1, 2, 3, 4 ó 5; D es un enlace u -O-; E es -CmH2m-; m = 0, 1, 2, 3, 4 ó 5; R8 es hidrógeno, alquilo con 1, 2, 3 ó 4 átomos de C o CpH2p-R14; p = 0, 1, 2, 3, 4 ó 5; R14 es fenilo, naftilo o heteroarilo, estando fenilo, naftilo y heteroarilo no sustituidos o estando sustituidos con 1, 2 o 3 sustituyentes elegidos del grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo con 1, 2, 3 o 4 átomos de C, alcoxi con 1, 2, 3 ó 4 átomos de C, dimetilamino, sulfamoílo, metilsulfonilo y metilsulfonilamino; R9 es hidrógeno o alquilo con 1, 2, 3, 4, 5 ó 6 átomos de C; R10 es hidrógeno, alquilo con 1, 2, 3, ó 4 átomos de C, fenilo, naftilo o heteroarilo, estando fenilo, naftilo y heteroarilo no sustituidos o estando sustituidos con 1, 2, o 3 sustituyentes elegidos del grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo con 1, 2, 3 o 4 átomos de C, alcoxi con 1, 2, 3 ó 4 átomos de C, dimetilamino, sulfamoílo, metilsulfonilo y metilsulfonilamino; R11 es cicloalquilo con 3, 4, 5 ó 6 átomos de C, fenilo, naftilo, tienilo, furilo, piridilo, pirazinilo, pirimidinilo, piridazinilo, indolilo, indazolilo, quinolilo, isoquinolilo, ftalazinilo, quinoxalinilo, quinazolinilo o cinolinilo, estando fenilo, naftilo, tienilo, furilo, piridilo, pirazinilo, pirimidinilo, piridazinilo, indolilo, indazolilo, quinolilo, isoquinolilo, ftalazinilo, quinoxalinilo, quinazolinilo o cinolinilo no sustituidos o estando sustituidos con 1, 2 o 3 sustituyentes elegidos del grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COMe, NH2, OH, alquilo con 1, 2, 3 ó 4 átomos de C, alcoxi con 1, 2, 3 ó 4 átomos de C, dimetilamino, sulfamoílo, metilsulfonilo y metilsulfonilamino; R12 es alquilo con 1, 2, 3 ó 4 átomos de C, alquinilo con 1, 2, 3 ó 4 átomos de C, cicloalquilo con 3, 4, 5 ó 6 átomos de C, fenilo, naftilo o heteroarilo, estando fenilo, naftilo y heteroarilo no sustituidos o estando sustituidos con 1, 2, o 3 sustituyentes elegidos del grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo con 1, 2, 3 ó 4 átomos de C, alcoxi con 1, 2, 3 ó 4 átomos de C, dimetilamino, sulfamoílo, metilsulfonilo y metilsulfonilamino; R13 es CpH2p-R14; p = 0, 1, 2, 3, 4 ó 5; R15 es cicloalquilo con 3, 4, 5, 6, 7 u 8 átomos de C; R2 es hidrógeno o alquilo con 1, 2, 3 ó 4 átomos de C; R3 es heteroarilo, estando heteroarilo no sustituido o estando sustituido con 1, 2, o 3 sustituyentes elegidos del grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo con 1, 2, 3 ó 4 átomos de C, alcoxi con 1, 2, 3 ó 4 átomos de C, dimetilamino, sulfamoílo, metilsulfonilo y metilsulfonilamino; R4, R5, R6 y R7, son, independientemente uno de otro, hidrógeno, F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo con 1, 2, 3 ó 4 átomos de C, alcoxi con 1, 2, 3 ó 4 átomos de C, dimetilamino, sulfamoílo, metilsulfonilo y metilsulfonilamino; así como sus sales farmacéuticamente aceptables; su empleo para la preparación de un medicamento, así como composiciones farmacéuticas que las contienen, que actúan sobre el canal de potasio Kv1.5 e inhiben en la aurícula humana una corriente de potasio denominada ''rectificador retardado de activación ultra-rápida''. Por lo tanto, los compuestos son muy particularmente adecuados como nuevos principios activos antiarrítmicos, en particular para el tratamiento y la profilaxia de arritmias auriculares, por ejemplo la fibrilación auricular (fibrilación atrial, FA), o la tremulación auricular (tremulación atrial).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10128331A DE10128331A1 (de) | 2001-06-12 | 2001-06-12 | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036045A1 true AR036045A1 (es) | 2004-08-04 |
Family
ID=7687941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102178A AR036045A1 (es) | 2001-06-12 | 2002-06-10 | Amidas de acidos antranilicos con cadena lateral de heteroarilsulfonilo, su empleo para la preparacion de un medicamento, asi como composiciones farmaceuticas que las contienen |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US6903216B2 (es) |
| EP (1) | EP1399423B9 (es) |
| JP (1) | JP4422477B2 (es) |
| KR (1) | KR100863924B1 (es) |
| CN (1) | CN1247544C (es) |
| AR (1) | AR036045A1 (es) |
| AT (1) | ATE378318T1 (es) |
| AU (1) | AU2002316939B2 (es) |
| BG (1) | BG108415A (es) |
| BR (1) | BR0210374A (es) |
| CA (1) | CA2450076C (es) |
| CO (1) | CO5540283A2 (es) |
| CR (1) | CR7140A (es) |
| CY (1) | CY1107427T1 (es) |
| CZ (1) | CZ20033361A3 (es) |
| DE (2) | DE10128331A1 (es) |
| DK (1) | DK1399423T3 (es) |
| EC (1) | ECSP034883A (es) |
| EE (1) | EE05196B1 (es) |
| ES (1) | ES2295360T3 (es) |
| HK (1) | HK1065316A1 (es) |
| HR (1) | HRP20031028A2 (es) |
| HU (1) | HUP0400159A3 (es) |
| IL (2) | IL159247A0 (es) |
| MA (1) | MA27037A1 (es) |
| MX (1) | MXPA03010875A (es) |
| MY (1) | MY138341A (es) |
| NO (1) | NO20035450D0 (es) |
| NZ (1) | NZ530081A (es) |
| OA (1) | OA12631A (es) |
| PE (1) | PE20021066A1 (es) |
| PL (1) | PL364371A1 (es) |
| PT (1) | PT1399423E (es) |
| RS (1) | RS97703A (es) |
| RU (1) | RU2293727C2 (es) |
| SK (1) | SK15222003A3 (es) |
| TN (1) | TNSN03134A1 (es) |
| TW (1) | TWI304400B (es) |
| UA (1) | UA75412C2 (es) |
| WO (1) | WO2002100825A2 (es) |
| ZA (1) | ZA200308520B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10128331A1 (de) * | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| US7119112B2 (en) * | 2002-02-28 | 2006-10-10 | Icagen, Inc. | Sulfonamides as potassium channel blockers |
| BR0309522A (pt) * | 2002-04-26 | 2005-02-09 | Ishihara Sangyo Kaisha | Compostos piridina ou sais destes e herbicidas contendo os mesmos |
| EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| DE10312061A1 (de) * | 2003-03-18 | 2004-09-30 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit Blockern des IK-Kanals und deren Verwendung zur Behandlung von Vorhofarrhythmien |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| EP1489071A1 (en) * | 2003-06-18 | 2004-12-22 | 4Sc Ag | N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators |
| DK1651621T3 (da) | 2003-08-08 | 2008-11-10 | Janssen Pharmaceutica Nv | 2-(Quinoxalin-5-ylsulfonylamino)benzamidforbindelser som CCK2-modulatorer |
| DE10341233A1 (de) * | 2003-09-08 | 2005-03-24 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien |
| DE102004009931A1 (de) * | 2004-02-26 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| CN101061116A (zh) * | 2004-09-24 | 2007-10-24 | 詹森药业有限公司 | 磺酰胺化合物 |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| NZ572231A (en) * | 2006-04-27 | 2010-12-24 | Sanofi Aventis Deutschland | Inhibitors of the task-1 and task-3 ion channel |
| WO2008124524A2 (en) * | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Aryl sulfonamide compounds as modulators of the cck2 receptor |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| UA107667C2 (uk) * | 2009-06-29 | 2015-02-10 | Аджиос Фармасьютікалз, Інк. | Лікарські сполуки, що модулюють активність піруваткінази-м2, композиції на їх основі та застосування при лікуванні раку |
| ES2416071T3 (es) * | 2009-06-29 | 2013-07-30 | Merz Pharma Gmbh & Co. Kgaa | Método para preparar 1-amino-1,3,3,5,5-pentametilciclohexano |
| WO2011010132A1 (en) * | 2009-07-21 | 2011-01-27 | Astrazeneca Ab | Sustained-release composition comprising compound 600 |
| FR2967674B1 (fr) | 2010-11-23 | 2012-12-14 | Pf Medicament | Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
| EP2806865A1 (en) | 2012-01-27 | 2014-12-03 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| US9701627B2 (en) * | 2014-06-16 | 2017-07-11 | University Of Maryland, Baltimore | LRRK2 GTP binding inhibitors for treatment of Parkinson's disease and neuroinflammatory disorders |
| JP7205830B2 (ja) * | 2017-08-07 | 2023-01-17 | 国立大学法人広島大学 | 新規アントラニル酸系化合物、並びにそれを用いたＰｉｎ１阻害剤、炎症性疾患の治療剤及び癌の治療剤 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU694465B2 (en) | 1993-12-27 | 1998-07-23 | Eisai Co. Ltd. | Anthranilic acid derivative |
| US5670504A (en) | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
| US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| DK173062B1 (da) | 1996-10-11 | 1999-12-13 | Krueger As I | Fremgangsmåde til fjernelse af opløste metaller og/eller metalloider fra et vandigt medium indeholdende samme og med et sto |
| US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| TW523506B (en) | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
| CZ302691B6 (cs) * | 1998-07-08 | 2011-09-07 | Sanofi - Aventis Deutschland GmbH | N-Arylamidová sloucenina, zpusob její prípravy, farmaceutický prostredek tuto slouceninu obsahující, tato sloucenina pro použití jako aktivátor a pro použití k terapii nebo profylaxi |
| AU754204B2 (en) | 1998-09-01 | 2002-11-07 | Bristol-Myers Squibb Company | Potassium channel inhibitors and method |
| JP2003502347A (ja) * | 1999-06-24 | 2003-01-21 | スミスクライン・ビーチャム・コーポレイション | マクロファ−ジスカベンジャ−受容体アンタゴニスト |
| DE19947457A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| US6531495B1 (en) | 1999-10-02 | 2003-03-11 | Aventis Pharma Deutschland Gmbh | 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them |
| DE10128331A1 (de) * | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
-
2001
- 2001-06-12 DE DE10128331A patent/DE10128331A1/de not_active Withdrawn
-
2002
- 2002-05-17 PE PE2002000419A patent/PE20021066A1/es not_active Application Discontinuation
- 2002-05-21 OA OA1200300333A patent/OA12631A/fr unknown
- 2002-05-31 IL IL15924702A patent/IL159247A0/xx unknown
- 2002-05-31 CN CNB028118502A patent/CN1247544C/zh not_active Expired - Fee Related
- 2002-05-31 MX MXPA03010875A patent/MXPA03010875A/es active IP Right Grant
- 2002-05-31 CZ CZ20033361A patent/CZ20033361A3/cs unknown
- 2002-05-31 UA UA2004010206A patent/UA75412C2/uk unknown
- 2002-05-31 PL PL02364371A patent/PL364371A1/xx not_active IP Right Cessation
- 2002-05-31 DK DK02745333T patent/DK1399423T3/da active
- 2002-05-31 JP JP2003503594A patent/JP4422477B2/ja not_active Expired - Fee Related
- 2002-05-31 ES ES02745333T patent/ES2295360T3/es not_active Expired - Lifetime
- 2002-05-31 RU RU2004100302/04A patent/RU2293727C2/ru not_active IP Right Cessation
- 2002-05-31 DE DE50211213T patent/DE50211213D1/de not_active Expired - Lifetime
- 2002-05-31 PT PT02745333T patent/PT1399423E/pt unknown
- 2002-05-31 WO PCT/EP2002/005956 patent/WO2002100825A2/de active IP Right Grant
- 2002-05-31 AU AU2002316939A patent/AU2002316939B2/en not_active Ceased
- 2002-05-31 EP EP02745333A patent/EP1399423B9/de not_active Expired - Lifetime
- 2002-05-31 AT AT02745333T patent/ATE378318T1/de active
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- 2002-05-31 KR KR1020037016206A patent/KR100863924B1/ko not_active IP Right Cessation
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- 2002-06-10 AR ARP020102178A patent/AR036045A1/es active IP Right Grant
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2003
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2004
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