HK1059564A1 - Indanylderivatives for treating airway diseases - Google Patents

Indanylderivatives for treating airway diseases

Info

Publication number
HK1059564A1
HK1059564A1 HK04100918A HK04100918A HK1059564A1 HK 1059564 A1 HK1059564 A1 HK 1059564A1 HK 04100918 A HK04100918 A HK 04100918A HK 04100918 A HK04100918 A HK 04100918A HK 1059564 A1 HK1059564 A1 HK 1059564A1
Authority
HK
Hong Kong
Prior art keywords
indanylderivatives
airway diseases
treating airway
treating
corticosteroid
Prior art date
Application number
HK04100918A
Other languages
English (en)
Inventor
Bernard Cuenoud
Robin Alec Fairhurst
Nicholas Lowther
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1059564A1 publication Critical patent/HK1059564A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK04100918A 2000-12-04 2004-02-11 Indanylderivatives for treating airway diseases HK1059564A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0029562.6A GB0029562D0 (en) 2000-12-04 2000-12-04 Organic compounds
PCT/EP2001/014122 WO2002045703A2 (en) 2000-12-04 2001-12-03 Mixtures or organic compounds for the treatmentof airway diseases

Publications (1)

Publication Number Publication Date
HK1059564A1 true HK1059564A1 (en) 2004-07-09

Family

ID=9904414

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04100918A HK1059564A1 (en) 2000-12-04 2004-02-11 Indanylderivatives for treating airway diseases

Country Status (28)

Country Link
US (5) US6800643B2 (ja)
EP (2) EP1341542B1 (ja)
JP (2) JP2004514739A (ja)
KR (1) KR100523541B1 (ja)
CN (1) CN1212119C (ja)
AT (1) ATE361077T1 (ja)
AU (2) AU2002217082B2 (ja)
BR (1) BRPI0115910B8 (ja)
CA (1) CA2427282C (ja)
CY (1) CY1106727T1 (ja)
CZ (1) CZ304294B6 (ja)
DE (1) DE60128258T2 (ja)
DK (1) DK1341542T3 (ja)
EC (1) ECSP034620A (ja)
ES (1) ES2284732T3 (ja)
GB (1) GB0029562D0 (ja)
HK (1) HK1059564A1 (ja)
HU (1) HU229552B1 (ja)
IL (2) IL155709A0 (ja)
MX (1) MXPA03004976A (ja)
NO (1) NO325692B1 (ja)
NZ (1) NZ525731A (ja)
PL (1) PL204002B1 (ja)
PT (1) PT1341542E (ja)
RU (1) RU2292890C2 (ja)
SK (1) SK287331B6 (ja)
WO (1) WO2002045703A2 (ja)
ZA (1) ZA200303399B (ja)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
GB0029562D0 (en) * 2000-12-04 2001-01-17 Novartis Ag Organic compounds
DE60318938T2 (de) 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
US20040146509A1 (en) * 2002-07-25 2004-07-29 Zhihe Li Methods for improvement of lung function using TGF-beta inhibitors
PA8578101A1 (es) 2002-08-13 2004-05-07 Warner Lambert Co Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
US7250426B2 (en) * 2002-11-29 2007-07-31 Boehringer Ingelheim Pharma Gmbh & Co Kg Tiotropium-containing pharmaceutical combination for inhalation
TWI324151B (en) * 2003-04-02 2010-05-01 Novartis Ag Process for the preparation of 5-(haloacetyl)-8-substituted oxy-(1h)-quinolin-2-ones
GB0307856D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
WO2004087142A1 (en) * 2003-04-04 2004-10-14 Novartis Ag Quinoline-2-one-derivatives for the treatment of airways diseases
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
JP4990142B2 (ja) 2004-08-23 2012-08-01 マンカインド コーポレイション 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩
KR100666220B1 (ko) * 2005-01-31 2007-01-09 영남대학교 산학협력단 구내염 치료용 분사제 조성물
JP2008534611A (ja) * 2005-03-30 2008-08-28 シェーリング コーポレイション 抗コリン作用薬、コルチコステロイドおよび長時間作用性βアゴニストを合わせる薬物および方法
GB0511065D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0511066D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
TW200738634A (en) 2005-08-02 2007-10-16 Astrazeneca Ab New salt
TW200744612A (en) * 2005-08-26 2007-12-16 Astrazeneca Ab New combination
HUE028691T2 (en) 2005-09-14 2016-12-28 Mannkind Corp A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients
GB0523656D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
GB0523655D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
JP2009520823A (ja) * 2005-12-20 2009-05-28 ティカ レーケメデル アーベー 薬物動態学的プロフィールの向上を有するコルチコステロイドを送達するための方法およびシステム
AU2007216966C1 (en) 2006-02-22 2014-03-20 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US20070225233A1 (en) * 2006-03-27 2007-09-27 Tsu-Fuh Yeh Reducing the risk of chronic lung disease in infants
EP1878722A1 (en) * 2006-07-13 2008-01-16 Novartis AG Quinolinone derivatives and their pharmaceutical compositions
KR101402398B1 (ko) * 2006-06-30 2014-06-03 노파르티스 아게 퀴놀리논 유도체 및 이의 제약 조성물
PT2230934E (pt) 2007-12-14 2012-11-20 Aerodesigns Inc Distribuir produtos alimentares aerossolizáveis
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2655921T3 (es) 2008-06-13 2018-02-22 Mannkind Corporation Un inhalador de polvo seco y sistema para administración de fármacos
ES2904623T3 (es) 2008-06-20 2022-04-05 Mannkind Corp Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
PL3111926T3 (pl) 2009-05-29 2020-06-29 Pearl Therapeutics, Inc. Kompozycje, sposoby i układy do dostarczania dwóch lub większej liczby środków czynnych do układu oddechowego
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
KR100940388B1 (ko) * 2009-07-01 2010-02-02 유병덕 스크류탈수기 및 이를 포함하는 유기성폐기물 건조장치
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
KR20130117755A (ko) 2010-06-21 2013-10-28 맨카인드 코포레이션 건조 분말 약물 운반 시스템 및 방법
US20130274232A1 (en) * 2010-07-16 2013-10-17 Cipla Limited Pharmaceutical Compositions
BR112013008974A2 (pt) * 2010-10-12 2023-12-19 Cipla Ltd Composição farmacêutica, processo para fabricar uma composição farmacêutica e uso de uma composição farmacêutica
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN102247380A (zh) * 2011-08-19 2011-11-23 北京阜康仁生物制药科技有限公司 一种以布地奈德与茚达特罗为活性成分的复方制剂
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
WO2013132514A2 (en) * 2012-03-09 2013-09-12 Rao Davuluri Ramamohan A novel process for the preparation of (r)-5-[2-[(5, 6-diethyl-2, 3-dihydro-1h-inden-2-yl) amino]-1-hydroxyethyl]-8-hydroxy quinolin-2(1h)-one
WO2014008639A1 (zh) * 2012-07-11 2014-01-16 上海威智医药科技有限公司 制备茚达特罗的方法
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
WO2014044288A1 (en) 2012-09-21 2014-03-27 Crystal Pharma Sa Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
ITUB20153978A1 (it) * 2015-09-28 2017-03-28 Laboratorio Chimico Int S P A Procedimento per la preparazione di derivati di indanammina e di nuovi intermedi di sintesi.
CN107868045A (zh) * 2016-09-28 2018-04-03 四川海思科制药有限公司 一种茚达特罗中间体的制备方法
CN106831445B (zh) * 2016-11-22 2019-01-22 斯芬克司药物研发(天津)股份有限公司 一种茚基胺化合物的制备方法
CN110229078A (zh) * 2019-05-22 2019-09-13 博诺康源(北京)药业科技有限公司 一种茚达特罗起始原料开环杂质的制备
CN114751857A (zh) * 2022-04-29 2022-07-15 梯尔希(南京)药物研发有限公司 一种茚达特罗杂质的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607028A (en) * 1983-08-18 1986-08-19 Ciba-Geigy Corporation Novel carboxylic acid esters
WO1993018007A1 (en) * 1992-03-13 1993-09-16 Tokyo Tanabe Company Limited Novel carbostyril derivative
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
GB9501286D0 (en) * 1995-01-24 1995-03-15 Ciba Geigy Ag Pharmaceutical compositions and preparations thereof
EP0761216B1 (en) * 1995-08-16 2003-11-12 Huntington Medical Research Institutes Rhodamine 123 compositions for treating prostate cancer
GB9603237D0 (en) * 1996-02-16 1996-04-17 Sandoz Ltd Organic compounds
SG72727A1 (en) 1996-02-19 2000-05-23 Kissei Pharmaceutical 3,4-Disubstituted phenylethanolaminotetralincarboxamide derivatives
GB9610122D0 (en) 1996-05-15 1996-07-24 Reckitt & Colmann Prod Ltd Organic compositions
ES2149742T1 (es) 1997-07-03 2000-11-16 Asahi Chemical Ind Nuevos compuestos triciclicos que tienen anillos saturados y composiciones medicinales que contienen los mismos.
GB9902689D0 (en) 1999-02-08 1999-03-31 Novartis Ag Organic compounds
GB9913083D0 (en) * 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US6448239B1 (en) 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
US6664235B1 (en) 1999-08-20 2003-12-16 Riken Medicaments comprising sialic acid derivatives as active ingredients
EP1311294A2 (en) * 2000-08-04 2003-05-21 Longwood Pharmaceutical Research, Inc. Formulations of mometasone and a bronchodilator for pulmonary administration
GB0029562D0 (en) * 2000-12-04 2001-01-17 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
PL362443A1 (en) 2004-11-02
US20040038951A1 (en) 2004-02-26
EP1341542B1 (en) 2007-05-02
AU2002217082B2 (en) 2005-04-07
BR0115910A (pt) 2004-01-20
EP1772142A2 (en) 2007-04-11
KR20030048065A (ko) 2003-06-18
DK1341542T3 (da) 2007-09-03
KR100523541B1 (ko) 2005-10-25
GB0029562D0 (en) 2001-01-17
DE60128258D1 (de) 2007-06-14
HU229552B1 (en) 2014-01-28
PL204002B1 (pl) 2009-12-31
ZA200303399B (en) 2004-04-23
EP1341542A2 (en) 2003-09-10
ES2284732T3 (es) 2007-11-16
WO2002045703A2 (en) 2002-06-13
CY1106727T1 (el) 2012-05-23
HUP0302571A3 (en) 2005-05-30
ATE361077T1 (de) 2007-05-15
CZ20031537A3 (cs) 2003-10-15
CN1477963A (zh) 2004-02-25
DE60128258T2 (de) 2007-12-27
JP2007302684A (ja) 2007-11-22
AU1708202A (en) 2002-06-18
SK6502003A3 (en) 2003-12-02
EP1772142A3 (en) 2011-09-14
RU2003119549A (ru) 2005-02-10
NZ525731A (en) 2004-11-26
NO20032510D0 (no) 2003-06-03
SK287331B6 (sk) 2010-07-07
BRPI0115910B8 (pt) 2021-05-25
BRPI0115910B1 (pt) 2019-12-31
CA2427282A1 (en) 2002-06-13
CA2427282C (en) 2010-10-19
IL155709A (en) 2008-11-26
MXPA03004976A (es) 2003-09-05
US20120108555A1 (en) 2012-05-03
ECSP034620A (es) 2003-06-25
US6800643B2 (en) 2004-10-05
US20050009795A1 (en) 2005-01-13
CZ304294B6 (cs) 2014-02-19
HUP0302571A2 (hu) 2003-11-28
CN1212119C (zh) 2005-07-27
WO2002045703A3 (en) 2003-03-13
JP2004514739A (ja) 2004-05-20
US7008951B2 (en) 2006-03-07
US20100068288A1 (en) 2010-03-18
IL155709A0 (en) 2003-11-23
NO20032510L (no) 2003-06-03
NO325692B1 (no) 2008-07-07
US7622484B2 (en) 2009-11-24
RU2292890C2 (ru) 2007-02-10
US20060052352A1 (en) 2006-03-09
PT1341542E (pt) 2007-08-01

Similar Documents

Publication Publication Date Title
HK1059564A1 (en) Indanylderivatives for treating airway diseases
GB9902689D0 (en) Organic compounds
GB9904919D0 (en) Organic compounds
NZ527113A (en) Rapid-onset medicament for the treatment of sexual dysfunction
ZA200408649B (en) Opthamological use of roflumilast for the treatment of diseases of the eye
EP1431286A3 (en) Prodigiosin derivatives for treating cancer or viral diseases
HK1045464A1 (en) Use of sulfodehydroabietic acid for the treatment of inflammatory bowel disease

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20211202