HK1057328A1 - Non-neurotoxic plasminogen activating factors for treating stroke - Google Patents

Non-neurotoxic plasminogen activating factors for treating stroke

Info

Publication number
HK1057328A1
HK1057328A1 HK03108108.9A HK03108108A HK1057328A1 HK 1057328 A1 HK1057328 A1 HK 1057328A1 HK 03108108 A HK03108108 A HK 03108108A HK 1057328 A1 HK1057328 A1 HK 1057328A1
Authority
HK
Hong Kong
Prior art keywords
plasminogen activating
treating stroke
activating factors
activity
neurotoxic plasminogen
Prior art date
Application number
HK03108108.9A
Other languages
English (en)
Inventor
Wolf-Dieter Schleuning
Robert Medcalf
Mariola Soehngen
Wolfgang Soehngen
Original Assignee
Paion Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Deutschland Gmbh filed Critical Paion Deutschland Gmbh
Publication of HK1057328A1 publication Critical patent/HK1057328A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
HK03108108.9A 2001-11-02 2003-11-07 Non-neurotoxic plasminogen activating factors for treating stroke HK1057328A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10153601A DE10153601A1 (de) 2001-11-02 2001-11-02 DSPA zur Behandlung von Schlaganfall

Publications (1)

Publication Number Publication Date
HK1057328A1 true HK1057328A1 (en) 2004-04-02

Family

ID=7704253

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03108108.9A HK1057328A1 (en) 2001-11-02 2003-11-07 Non-neurotoxic plasminogen activating factors for treating stroke

Country Status (27)

Country Link
US (7) US20050048027A1 (fr)
EP (4) EP1308166B1 (fr)
JP (2) JP5004407B2 (fr)
KR (3) KR20090128583A (fr)
CN (2) CN100446810C (fr)
AT (3) ATE440614T1 (fr)
AU (1) AU2002350660C1 (fr)
BR (1) BR0213856A (fr)
CA (1) CA2465792C (fr)
CY (3) CY1108446T1 (fr)
DE (3) DE10153601A1 (fr)
DK (3) DK1308166T3 (fr)
EA (3) EA010858B1 (fr)
ES (3) ES2332576T3 (fr)
HK (1) HK1057328A1 (fr)
HR (1) HRP20040383B1 (fr)
HU (1) HU230163B1 (fr)
IL (1) IL205695A0 (fr)
MX (1) MXPA04004155A (fr)
NO (1) NO329789B1 (fr)
NZ (2) NZ545414A (fr)
PL (1) PL208343B1 (fr)
PT (3) PT1308166E (fr)
SG (1) SG148034A1 (fr)
SI (2) SI1441757T1 (fr)
WO (1) WO2003037363A2 (fr)
ZA (1) ZA200403285B (fr)

Families Citing this family (14)

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DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
WO2004096267A1 (fr) * 2003-05-02 2004-11-11 Paion Gmbh Injection intraveineuse d'activateurs du plasminogene non neurotoxiques pour le traitement de l'accident vasculaire cerebral
EP1622639B1 (fr) * 2003-05-02 2013-01-16 Lundbeck, H., A/S Injection intraveineuse d'activateurs de plasminogene non neurotoxiques pour le traitement de l'attaque cerebrale
US20080057050A1 (en) * 2003-05-02 2008-03-06 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
US20060135425A1 (en) * 2003-05-02 2006-06-22 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
US20080213244A1 (en) * 2003-05-05 2008-09-04 Wolfgang Sohngen Glutamate Receptor Antagonists as Neuroprotectives
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
JP2006241109A (ja) * 2005-03-04 2006-09-14 Paion Deutschland Gmbh ヒトＰセレクチンおよびＤＳＰＡα１に対する抗体を含む融合タンパク質
TWI482628B (zh) * 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群
WO2011107299A2 (fr) 2010-04-16 2011-09-09 Paion Deutschland Gmbh Procédé de préparation de dspa alpha1 recombiné
EP2661493B1 (fr) * 2011-01-05 2016-03-30 ThromboGenics N.V. Variantes de plasminogène et de plasmine
JP6000353B2 (ja) 2011-08-12 2016-09-28 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
CA3123872A1 (fr) 2018-12-28 2020-07-02 Catalyst Biosciences, Inc. Polypeptides activateurs de plasminogene de type urokinase modifies et leurs procedes d'utilisation

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DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
US20060135425A1 (en) 2003-05-02 2006-06-22 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
EP1622639B1 (fr) 2003-05-02 2013-01-16 Lundbeck, H., A/S Injection intraveineuse d'activateurs de plasminogene non neurotoxiques pour le traitement de l'attaque cerebrale
US20080057050A1 (en) 2003-05-02 2008-03-06 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
WO2004096267A1 (fr) 2003-05-02 2004-11-11 Paion Gmbh Injection intraveineuse d'activateurs du plasminogene non neurotoxiques pour le traitement de l'accident vasculaire cerebral
US20080213244A1 (en) 2003-05-05 2008-09-04 Wolfgang Sohngen Glutamate Receptor Antagonists as Neuroprotectives
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DE10342518A1 (de) 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
TWI482628B (zh) 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群

Also Published As

Publication number Publication date
PT1308166E (pt) 2009-11-27
SI1441757T1 (sl) 2009-02-28
US8119597B2 (en) 2012-02-21
US20130039902A1 (en) 2013-02-14
EA200801714A1 (ru) 2008-12-30
HUP0402165A3 (en) 2010-01-28
EP1997510A1 (fr) 2008-12-03
EA010858B1 (ru) 2008-12-30
ATE440614T1 (de) 2009-09-15
DK1308166T3 (da) 2009-12-14
SG148034A1 (en) 2008-12-31
CN100446810C (zh) 2008-12-31
AU2002350660B2 (en) 2008-04-10
US20090263373A1 (en) 2009-10-22
PT1997510E (pt) 2012-05-21
NZ545414A (en) 2008-09-26
JP2005519025A (ja) 2005-06-30
CY1108446T1 (el) 2014-04-09
CY1109648T1 (el) 2014-08-13
JP2009137983A (ja) 2009-06-25
US8071091B2 (en) 2011-12-06
ATE401910T1 (de) 2008-08-15
DK1997510T3 (da) 2012-05-21
PL208343B1 (pl) 2011-04-29
ES2311070T3 (es) 2009-02-01
EP2368567A1 (fr) 2011-09-28
KR100816221B1 (ko) 2008-03-24
ES2382224T3 (es) 2012-06-06
CA2465792A1 (fr) 2003-05-08
NO20042262D0 (no) 2004-06-01
US20090004176A1 (en) 2009-01-01
EP1308166A1 (fr) 2003-05-07
HUP0402165A2 (hu) 2005-01-28
NO329789B1 (no) 2010-12-20
US20050048027A1 (en) 2005-03-03
EP1441757A2 (fr) 2004-08-04
WO2003037363A3 (fr) 2003-09-18
KR20090128583A (ko) 2009-12-15
NZ532903A (en) 2006-10-27
EA013707B1 (ru) 2010-06-30
MXPA04004155A (es) 2005-03-31
JP5004407B2 (ja) 2012-08-22
EA200400624A1 (ru) 2004-10-28
US20060142195A1 (en) 2006-06-29
HRP20040383A2 (en) 2005-08-31
NO20042262L (no) 2004-06-01
HU230163B1 (hu) 2015-09-28
HRP20040383B1 (en) 2012-08-31
PT1441757E (pt) 2008-11-03
KR20070087248A (ko) 2007-08-27
SI1997510T1 (sl) 2012-06-29
WO2003037363A2 (fr) 2003-05-08
CN1592634A (zh) 2005-03-09
EA201000386A1 (ru) 2011-06-30
PL369872A1 (en) 2005-05-02
DE50115077D1 (de) 2009-10-08
EP1997510B1 (fr) 2012-02-29
CA2465792C (fr) 2014-04-01
DE50212548D1 (de) 2008-09-04
KR20050042234A (ko) 2005-05-06
ES2332576T3 (es) 2010-02-09
US20170051268A1 (en) 2017-02-23
DK1441757T3 (da) 2008-11-17
IL205695A0 (en) 2010-11-30
CY1112957T1 (el) 2016-04-13
DE10153601A1 (de) 2003-05-22
US20140199287A1 (en) 2014-07-17
EP1441757B1 (fr) 2008-07-23
ATE547115T1 (de) 2012-03-15
AU2002350660C1 (en) 2008-10-09
EP1997510A8 (fr) 2011-04-13
CN101156948A (zh) 2008-04-09
ZA200403285B (en) 2005-07-27
BR0213856A (pt) 2004-08-31
EP1308166B1 (fr) 2009-08-26

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