HUP0402165A2 - Nem neurotoxikus plazminogén aktiváló faktorok a szélhűdés kezelésére - Google Patents
Nem neurotoxikus plazminogén aktiváló faktorok a szélhűdés kezeléséreInfo
- Publication number
- HUP0402165A2 HUP0402165A2 HU0402165A HUP0402165A HUP0402165A2 HU P0402165 A2 HUP0402165 A2 HU P0402165A2 HU 0402165 A HU0402165 A HU 0402165A HU P0402165 A HUP0402165 A HU P0402165A HU P0402165 A2 HUP0402165 A2 HU P0402165A2
- Authority
- HU
- Hungary
- Prior art keywords
- treating stroke
- activating factors
- plasminogen activating
- neurotoxic plasminogen
- neurotoxic
- Prior art date
Links
- 231100000501 nonneurotoxic Toxicity 0.000 title abstract 2
- 102000013566 Plasminogen Human genes 0.000 title 1
- 108010051456 Plasminogen Proteins 0.000 title 1
- 230000003213 activating effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241000288900 Desmodus rotundus Species 0.000 abstract 1
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 1
- 229940127126 plasminogen activator Drugs 0.000 abstract 1
- ALPWRKFXEOAUDR-GKEJWYBXSA-M sodium;[(2r)-2,3-di(octadecanoyloxy)propyl] hydrogen phosphate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)([O-])=O)OC(=O)CCCCCCCCCCCCCCCCC ALPWRKFXEOAUDR-GKEJWYBXSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
Abstract
A találmány nem-neurotoxikus plazminogén aktiváló faktor használatáraés előállítására vonatkozik, például melyet a Desmodus rotundus-ból(DSPA) izolálhatnak, embereknél a szélhűdés terápiás kezeléséhez,valamint emberek részére új terápiás kezelési lehetőség biztosításáraszélhűdésnél. Ó
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10153601.1 | 2001-11-02 | ||
DE10153601A DE10153601A1 (de) | 2001-11-02 | 2001-11-02 | DSPA zur Behandlung von Schlaganfall |
EP01130006A EP1308166B1 (de) | 2001-11-02 | 2001-12-17 | Nicht-neurotoxische Plasminogen Aktivierende Faktoren zur Behandlung von Schlaganfällen |
EP01130006.8 | 2001-12-17 | ||
PCT/EP2002/012204 WO2003037363A2 (de) | 2001-11-02 | 2002-10-31 | Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0402165A2 true HUP0402165A2 (hu) | 2005-01-28 |
HUP0402165A3 HUP0402165A3 (en) | 2010-01-28 |
HU230163B1 HU230163B1 (hu) | 2015-09-28 |
Family
ID=7704253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0402165A HU230163B1 (hu) | 2001-11-02 | 2002-10-31 | Nem neurotoxikus plazminogén aktiváló faktorok a szélhűdés kezelésére |
Country Status (27)
Country | Link |
---|---|
US (7) | US20050048027A1 (hu) |
EP (4) | EP1308166B1 (hu) |
JP (2) | JP5004407B2 (hu) |
KR (3) | KR100816221B1 (hu) |
CN (2) | CN101156948A (hu) |
AT (3) | ATE440614T1 (hu) |
AU (1) | AU2002350660C1 (hu) |
BR (1) | BR0213856A (hu) |
CA (1) | CA2465792C (hu) |
CY (3) | CY1108446T1 (hu) |
DE (3) | DE10153601A1 (hu) |
DK (3) | DK1308166T3 (hu) |
EA (3) | EA201000386A1 (hu) |
ES (3) | ES2332576T3 (hu) |
HK (1) | HK1057328A1 (hu) |
HR (1) | HRP20040383B1 (hu) |
HU (1) | HU230163B1 (hu) |
IL (1) | IL205695A0 (hu) |
MX (1) | MXPA04004155A (hu) |
NO (1) | NO329789B1 (hu) |
NZ (2) | NZ532903A (hu) |
PL (1) | PL208343B1 (hu) |
PT (3) | PT1308166E (hu) |
SG (1) | SG148034A1 (hu) |
SI (2) | SI1997510T1 (hu) |
WO (1) | WO2003037363A2 (hu) |
ZA (1) | ZA200403285B (hu) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10153601A1 (de) * | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA zur Behandlung von Schlaganfall |
CA2524573A1 (en) * | 2003-05-02 | 2004-11-11 | Paion Deutschland Gmbh | Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke |
US20060135425A1 (en) * | 2003-05-02 | 2006-06-22 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
AU2003227721A1 (en) * | 2003-05-02 | 2004-11-23 | Paion Gmbh | Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke |
US20080057050A1 (en) * | 2003-05-02 | 2008-03-06 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
MXPA05011762A (es) * | 2003-05-05 | 2006-03-30 | Paion Deutschland Gmbh | Antagonistas de receptor de glutamato como neuroprotectores. |
DE10342518A1 (de) * | 2003-09-12 | 2005-05-12 | Paion Gmbh | Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität |
JP2006241109A (ja) * | 2005-03-04 | 2006-09-14 | Paion Deutschland Gmbh | ヒトPセレクチンおよびDSPAα1に対する抗体を含む融合タンパク質 |
AR068914A1 (es) * | 2007-10-18 | 2009-12-16 | Paion Deutschland Gmbh | Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia |
WO2011107299A2 (en) | 2010-04-16 | 2011-09-09 | Paion Deutschland Gmbh | Method for the manufacture of recombinant dspa alpha1 |
CA2823491A1 (en) * | 2011-01-05 | 2012-07-12 | Thrombogenics Nv | Plasminogen and plasmin variants |
US9644196B2 (en) | 2011-08-12 | 2017-05-09 | Thrombogenics Nv | Plasminogen and plasmin variants |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
MX2021007843A (es) * | 2018-12-28 | 2021-08-11 | Vertex Pharma | Polipeptidos de activador de plasminogeno, tipo urocinasa, modificados y metodos de uso. |
Family Cites Families (56)
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US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
AR241654A1 (es) | 1982-05-05 | 1992-10-30 | Genentech Inc | Procedimiento para producir activador de plasminogeno de tejido humano. |
US5244806A (en) * | 1985-08-26 | 1993-09-14 | Eli Lilly And Company | DNA encoding novel tissue plasminogen activator derivatives having kringles 1 and 2 deleted, vectors and host cells |
DE3643158A1 (de) | 1986-04-21 | 1987-11-19 | Boehringer Mannheim Gmbh | Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung |
JPH087179B2 (ja) * | 1986-09-27 | 1996-01-29 | 日本碍子株式会社 | ガスセンサ |
WO1988005081A2 (en) * | 1986-12-30 | 1988-07-14 | Cetus Corporation | Novel plasminogen activator |
IL87276A (en) * | 1987-08-03 | 1995-07-31 | Fujisawa Pharmaceutical Co | Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it |
EP0386240B1 (en) * | 1987-10-29 | 1995-07-19 | Yamanouchi Pharmaceutical Co. Ltd. | Novel polypeptide compounds |
US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
IE69054B1 (en) * | 1988-07-20 | 1996-08-07 | Schering Ag | Vampire bat salivary plasminogen activators |
DE3825253A1 (de) | 1988-07-25 | 1990-02-01 | Boehringer Mannheim Gmbh | T-pa-derivat und seine herstellung |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
JPH0273774A (ja) * | 1988-09-09 | 1990-03-13 | Nec Corp | ファクシミリ装置 |
GB8901422D0 (en) * | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | New tissue plasminogen activator |
DE3903581A1 (de) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | Gewebs-plasminogenaktivator-derivat |
US5676947A (en) * | 1989-02-07 | 1997-10-14 | Boehringer Manneheim Gmbh | Method for treating thromboembolic conditions using thrombolytically active proteins |
DE3917949A1 (de) * | 1989-05-30 | 1991-01-24 | Schering Ag | Neues thrombolytikum |
AU642404B2 (en) * | 1989-02-13 | 1993-10-21 | Schering Aktiengesellschaft Berlin Und Bergkamen | Novel thrombolytic |
US6008019A (en) | 1989-02-13 | 1999-12-28 | Schering Aktiengesellschaft | Plasminogen activator from saliva of the vampire bat |
DE3904580A1 (de) | 1989-02-13 | 1990-08-16 | Schering Ag | Neues thrombolytikum |
US5891664A (en) * | 1989-04-07 | 1999-04-06 | Cancerforskningsfondet Af 1989 | Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR) |
WO1990012091A1 (en) * | 1989-04-07 | 1990-10-18 | Cancerforskningsfondet Af 1989 | Urokinase-type plasminogen activator receptor |
JPH0352119A (ja) * | 1989-07-19 | 1991-03-06 | Matsushita Electric Ind Co Ltd | 光学式記録再生装置 |
NL8902454A (nl) | 1989-10-03 | 1991-05-01 | Stichting Centraal Lab | Mutanten van de humane plasminogeen activator inhibitor 1 (pai-1), hun bereiding en toepassing, en recombinante polynucleotiden die voor deze mutanten coderende genetische informatie omvatten. |
US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
WO1992018157A1 (de) | 1991-04-16 | 1992-10-29 | Boehringer Mannheim Gmbh | Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe |
DE4123845A1 (de) * | 1991-07-18 | 1993-01-21 | Boehringer Mannheim Gmbh | Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe |
US5595736A (en) * | 1991-04-22 | 1997-01-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders |
NL9101520A (nl) * | 1991-09-09 | 1993-04-01 | Stork Fibron Bv | Werkwijze voor het vervaardigen van een eetbaar produkt. |
ATE145669T1 (de) | 1991-12-16 | 1996-12-15 | Genentech Inc | T-pa substitutionsvarianten mit verbesserter fibrinspezifität |
DK0677107T3 (da) * | 1992-12-04 | 1998-03-16 | Schering Ag | Thrombininhibitor fra protostomispyt |
US5510330A (en) * | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
GB9412131D0 (en) * | 1994-06-17 | 1994-08-10 | British Bio Technology | Thrombolytic composition |
DE4423574A1 (de) | 1994-07-05 | 1996-01-11 | Boehringer Mannheim Gmbh | Nicht-glykosylierte Plasminogenaktivator-Derivate und ihre Verwendung bei erhöhtem Blutungsrisiko |
US5827832A (en) | 1995-03-06 | 1998-10-27 | Interneuron Pharmaceuticals, Inc. | Method of protecting brain tissue from cerebral infarction subsequent to ischemia |
US5786187A (en) * | 1995-09-21 | 1998-07-28 | The Research Foundation Of State University Of New York | Method for reducing neuronal degeneration associated with seizure |
US5945432A (en) * | 1995-12-22 | 1999-08-31 | The University Of Vermont And State Agricultural College | Thrombolytic agents and thienopyridine derivatives in acute stroke |
US20020081294A1 (en) * | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
US5731186A (en) | 1996-02-05 | 1998-03-24 | Schering Aktiengesellschaft | Method for the production of rDSPA α1 |
US6235947B1 (en) * | 1997-04-14 | 2001-05-22 | Takeda Chemical Industries, Ltd. | D-mannitol and its preparation |
US5830349A (en) * | 1996-07-22 | 1998-11-03 | Dana Corporation | Flow inverter for filters |
WO1998014578A1 (en) | 1996-10-01 | 1998-04-09 | University Of Georgia Research Foundation, Inc. | Biological insect control agents expressing insect-specific mite toxin genes, methods and compositions |
US6008109A (en) * | 1997-12-19 | 1999-12-28 | Advanced Micro Devices, Inc. | Trench isolation structure having a low K dielectric encapsulated by oxide |
KR20010069066A (ko) * | 2000-01-12 | 2001-07-23 | 이종원 | 저산소 농도하에서 생존이 가능하도록 하는 동물세포의배양방법 |
DE10008646A1 (de) | 2000-02-24 | 2001-09-13 | Kempten Elektroschmelz Gmbh | Beschichteter Formkörper aus Siliciumnitrid |
GB0025473D0 (en) * | 2000-10-17 | 2000-11-29 | Pfizer Ltd | Pharmaceutical combinations |
US20020089179A1 (en) * | 2000-12-30 | 2002-07-11 | Levon Guyumjan | Hose coupling apparatus and method |
DE10153601A1 (de) * | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA zur Behandlung von Schlaganfall |
AU2003227721A1 (en) | 2003-05-02 | 2004-11-23 | Paion Gmbh | Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke |
CA2524573A1 (en) | 2003-05-02 | 2004-11-11 | Paion Deutschland Gmbh | Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke |
US20060135425A1 (en) | 2003-05-02 | 2006-06-22 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
US20080057050A1 (en) | 2003-05-02 | 2008-03-06 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
MXPA05011762A (es) | 2003-05-05 | 2006-03-30 | Paion Deutschland Gmbh | Antagonistas de receptor de glutamato como neuroprotectores. |
WO2005018564A2 (en) | 2003-08-22 | 2005-03-03 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage |
DE10342518A1 (de) | 2003-09-12 | 2005-05-12 | Paion Gmbh | Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität |
AR068914A1 (es) | 2007-10-18 | 2009-12-16 | Paion Deutschland Gmbh | Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia |
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2001
- 2001-11-02 DE DE10153601A patent/DE10153601A1/de not_active Ceased
- 2001-12-17 ES ES01130006T patent/ES2332576T3/es not_active Expired - Lifetime
- 2001-12-17 AT AT01130006T patent/ATE440614T1/de active
- 2001-12-17 DE DE50115077T patent/DE50115077D1/de not_active Expired - Lifetime
- 2001-12-17 EP EP01130006A patent/EP1308166B1/de not_active Expired - Lifetime
- 2001-12-17 DK DK01130006T patent/DK1308166T3/da active
- 2001-12-17 PT PT01130006T patent/PT1308166E/pt unknown
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2002
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