NO20021501L - Fibrinolyttisk aktivt polypeptid - Google Patents
Fibrinolyttisk aktivt polypeptidInfo
- Publication number
- NO20021501L NO20021501L NO20021501A NO20021501A NO20021501L NO 20021501 L NO20021501 L NO 20021501L NO 20021501 A NO20021501 A NO 20021501A NO 20021501 A NO20021501 A NO 20021501A NO 20021501 L NO20021501 L NO 20021501L
- Authority
- NO
- Norway
- Prior art keywords
- active polypeptide
- fibrinolytically active
- fibrinolytically
- termed
- vivo
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000003527 fibrinolytic agent Substances 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000003480 fibrinolytic effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002934 lysing effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 229960000103 thrombolytic agent Drugs 0.000 abstract 1
- 239000002023 wood Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Marine Sciences & Fisheries (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Det beskrives et fibrinolyttisk aktivt. metalloproteinasepolypeptid (betegnet "trombolyttisk middel med ny virkningstype") som er anvendbart for lysering av blodkoagler in vivo, samt fremgangsmåter og materialer for fremstilling derav for ved. rekombinant ekspresjon.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/411,329 US6261820B1 (en) | 1999-10-01 | 1999-10-01 | Fibronolytically active polypeptide |
PCT/US2000/027029 WO2001025445A1 (en) | 1999-10-01 | 2000-09-29 | Fibrinolytically active polypeptide |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20021501D0 NO20021501D0 (no) | 2002-03-26 |
NO20021501L true NO20021501L (no) | 2002-05-31 |
Family
ID=23628486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20021501A NO20021501L (no) | 1999-10-01 | 2002-03-26 | Fibrinolyttisk aktivt polypeptid |
Country Status (29)
Country | Link |
---|---|
US (4) | US6261820B1 (no) |
EP (2) | EP1605049A3 (no) |
JP (1) | JP2003511034A (no) |
KR (2) | KR100700753B1 (no) |
CN (2) | CN100357430C (no) |
AT (1) | ATE292180T1 (no) |
AU (1) | AU767827B2 (no) |
BG (1) | BG106577A (no) |
BR (1) | BR0014414A (no) |
CA (1) | CA2386185A1 (no) |
CZ (1) | CZ298502B6 (no) |
DE (1) | DE60019147T2 (no) |
DK (1) | DK1224298T3 (no) |
EA (2) | EA005944B1 (no) |
ES (1) | ES2240167T3 (no) |
HK (1) | HK1049351B (no) |
HU (1) | HUP0202650A3 (no) |
IL (1) | IL148787A0 (no) |
MX (1) | MXPA02003126A (no) |
NO (1) | NO20021501L (no) |
NZ (1) | NZ517951A (no) |
PL (1) | PL355017A1 (no) |
PT (1) | PT1224298E (no) |
RS (1) | RS20060033A (no) |
SG (1) | SG127720A1 (no) |
SK (1) | SK4232002A3 (no) |
WO (1) | WO2001025445A1 (no) |
YU (2) | YU22502A (no) |
ZA (1) | ZA200202206B (no) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440414B1 (en) | 1999-10-01 | 2002-08-27 | Amgen Inc. | Pharmaceutical compositions of fibrinolytic agent |
US6261820B1 (en) | 1999-10-01 | 2001-07-17 | Amgen Inc. | Fibronolytically active polypeptide |
US6455269B1 (en) * | 1999-12-17 | 2002-09-24 | Amgen, Inc. | Method for localized administration of fibrinolytic metalloproteinases |
US7033776B2 (en) | 1999-12-17 | 2006-04-25 | Amgen Inc. | Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases |
US6523647B2 (en) * | 2001-05-21 | 2003-02-25 | Hydro Mobile Inc. | Elevating platform assembly |
AU2003215119B2 (en) * | 2002-02-11 | 2008-11-20 | Gold-T Tech, Inc. | Method for preventing thrombus formation |
US7016409B2 (en) * | 2003-11-12 | 2006-03-21 | Sony Corporation | Apparatus and method for use in providing dynamic bit rate encoding |
ES2239532B1 (es) * | 2004-02-06 | 2006-11-01 | Proyecto De Biomedicina Cima S.L. | Metodo para evaluar el riesgo y la predisposicion a desarrollar una patologia relacionada con la presencia de autoanticuerpos frente a epcr. |
US20070141625A1 (en) * | 2005-02-03 | 2007-06-21 | Santos Jose H | Method for assessing risk of and predisposition to development of a pathology related to the presence of anti-epcr autoantibodies |
WO2007092820A2 (en) | 2006-02-03 | 2007-08-16 | Lazarus Effect, Inc. | Methods and devices for restoring blood flow within blocked vasculature |
EP2403583B1 (en) | 2009-03-06 | 2016-10-19 | Lazarus Effect, Inc. | Retrieval systems |
US10207240B2 (en) | 2009-11-03 | 2019-02-19 | Gen9, Inc. | Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly |
WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
EP4105337A1 (en) | 2014-09-09 | 2022-12-21 | The Broad Institute, Inc. | A droplet-based method and apparatus for composite single-cell nucleic acid analysis |
EP3256200A1 (en) | 2015-02-11 | 2017-12-20 | Covidien LP | Expandable tip medical devices and methods |
WO2016145409A1 (en) | 2015-03-11 | 2016-09-15 | The Broad Institute, Inc. | Genotype and phenotype coupling |
WO2017075297A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | High-throughput dynamic reagent delivery system |
US11092607B2 (en) | 2015-10-28 | 2021-08-17 | The Board Institute, Inc. | Multiplex analysis of single cell constituents |
EP3402902B1 (en) | 2016-01-15 | 2021-10-27 | Massachusetts Institute Of Technology | Semi-permeable arrays for analyzing biological systems and methods of using same |
US11072816B2 (en) | 2017-05-03 | 2021-07-27 | The Broad Institute, Inc. | Single-cell proteomic assay using aptamers |
Family Cites Families (35)
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FR2310133A2 (fr) | 1975-05-05 | 1976-12-03 | Fabre Sa Pierre | Nouveau medicament comportant un activateur du plasminogene perfectionne |
US4447236A (en) | 1982-02-05 | 1984-05-08 | Cordis Corporation | Infusion catheter system |
DE3330699A1 (de) * | 1983-08-25 | 1985-03-07 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma |
US4610879A (en) | 1984-01-06 | 1986-09-09 | University Of Southern California | Fibrinolytic enzyme from snake vernom |
CA1237482A (en) | 1984-03-09 | 1988-05-31 | Frank B. Stiles | Catheter for effecting removal of obstructions from a biological duct |
US4755167A (en) | 1984-04-10 | 1988-07-05 | Research Corporation | In vivo method for distribution and stirring of therapeutic agents |
US4837148A (en) | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
US4885242A (en) | 1984-10-30 | 1989-12-05 | Phillips Petroleum Company | Genes from pichia histidine pathway and uses thereof |
US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
US4818700A (en) | 1985-10-25 | 1989-04-04 | Phillips Petroleum Company | Pichia pastoris argininosuccinate lyase gene and uses thereof |
US4812405A (en) | 1986-02-18 | 1989-03-14 | Phillips Petroleum Company | Double auxotrophic mutants of Pichia pastoris and methods for preparation |
US5000185A (en) | 1986-02-28 | 1991-03-19 | Cardiovascular Imaging Systems, Inc. | Method for intravascular two-dimensional ultrasonography and recanalization |
ZA889415B (en) | 1987-12-18 | 1989-09-27 | Chiron Corp | Compositions and method for recombinant production of crotalidus venum fibrolase |
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US5222941A (en) | 1990-01-12 | 1993-06-29 | Don Michael T Anthony | Method of dissolving an obstruction in a vessel |
EP0438200B1 (en) * | 1990-01-16 | 2002-07-17 | Centro De Ingenieria Genetica Y Biotecnologia | Method for the expression of heterologous genes in the yeast Pichia pastoris, expression vectors and transformed microorganisms |
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US5380273A (en) | 1992-05-19 | 1995-01-10 | Dubrul; Will R. | Vibrating catheter |
EP0624642B1 (en) | 1993-05-12 | 1999-01-20 | Indian Council For Medical Research | Novel thrombolytic agent, process for preparing same and its use for the preparation of a thrombi dissolving medicament |
US5370653A (en) | 1993-07-22 | 1994-12-06 | Micro Therapeutics, Inc. | Thrombectomy method and apparatus |
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US6261820B1 (en) | 1999-10-01 | 2001-07-17 | Amgen Inc. | Fibronolytically active polypeptide |
US6440414B1 (en) | 1999-10-01 | 2002-08-27 | Amgen Inc. | Pharmaceutical compositions of fibrinolytic agent |
US6455269B1 (en) | 1999-12-17 | 2002-09-24 | Amgen, Inc. | Method for localized administration of fibrinolytic metalloproteinases |
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-
1999
- 1999-10-01 US US09/411,329 patent/US6261820B1/en not_active Expired - Fee Related
-
2000
- 2000-09-20 YU YU22502A patent/YU22502A/sh unknown
- 2000-09-20 YU YU59604A patent/YU59604A/sh unknown
- 2000-09-29 CN CNB008163219A patent/CN100357430C/zh not_active Expired - Fee Related
- 2000-09-29 JP JP2001528597A patent/JP2003511034A/ja not_active Withdrawn
- 2000-09-29 EP EP05006771A patent/EP1605049A3/en not_active Withdrawn
- 2000-09-29 RS YUP-2006/0033A patent/RS20060033A/sr unknown
- 2000-09-29 PT PT00965554T patent/PT1224298E/pt unknown
- 2000-09-29 EA EA200200410A patent/EA005944B1/ru not_active IP Right Cessation
- 2000-09-29 NZ NZ517951A patent/NZ517951A/en unknown
- 2000-09-29 KR KR1020067019636A patent/KR100700753B1/ko not_active IP Right Cessation
- 2000-09-29 PL PL00355017A patent/PL355017A1/xx not_active IP Right Cessation
- 2000-09-29 DK DK00965554T patent/DK1224298T3/da active
- 2000-09-29 BR BR0014414-2A patent/BR0014414A/pt not_active Application Discontinuation
- 2000-09-29 AT AT00965554T patent/ATE292180T1/de not_active IP Right Cessation
- 2000-09-29 SK SK423-2002A patent/SK4232002A3/sk not_active Application Discontinuation
- 2000-09-29 EA EA200400290A patent/EA006487B1/ru unknown
- 2000-09-29 WO PCT/US2000/027029 patent/WO2001025445A1/en active IP Right Grant
- 2000-09-29 SG SG200401889A patent/SG127720A1/en unknown
- 2000-09-29 KR KR1020027004225A patent/KR100711312B1/ko not_active IP Right Cessation
- 2000-09-29 EP EP00965554A patent/EP1224298B1/en not_active Expired - Lifetime
- 2000-09-29 AU AU76254/00A patent/AU767827B2/en not_active Ceased
- 2000-09-29 HU HU0202650A patent/HUP0202650A3/hu unknown
- 2000-09-29 CA CA002386185A patent/CA2386185A1/en not_active Abandoned
- 2000-09-29 CN CNA2008100053253A patent/CN101230340A/zh active Pending
- 2000-09-29 MX MXPA02003126A patent/MXPA02003126A/es active IP Right Grant
- 2000-09-29 CZ CZ20021034A patent/CZ298502B6/cs not_active IP Right Cessation
- 2000-09-29 DE DE60019147T patent/DE60019147T2/de not_active Expired - Fee Related
- 2000-09-29 ES ES00965554T patent/ES2240167T3/es not_active Expired - Lifetime
- 2000-09-29 IL IL14878700A patent/IL148787A0/xx unknown
-
2001
- 2001-05-01 US US09/846,729 patent/US6617145B2/en not_active Expired - Fee Related
-
2002
- 2002-03-19 ZA ZA200202206A patent/ZA200202206B/en unknown
- 2002-03-26 NO NO20021501A patent/NO20021501L/no not_active Application Discontinuation
- 2002-04-04 BG BG106577A patent/BG106577A/bg unknown
-
2003
- 2003-01-24 HK HK03100667.9A patent/HK1049351B/zh not_active IP Right Cessation
- 2003-05-20 US US10/441,667 patent/US7195903B2/en not_active Expired - Fee Related
-
2007
- 2007-02-06 US US11/702,972 patent/US20080058256A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |