HK1047575B - 二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑 - Google Patents

二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑 Download PDF

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Publication number
HK1047575B
HK1047575B HK02108652.0A HK02108652A HK1047575B HK 1047575 B HK1047575 B HK 1047575B HK 02108652 A HK02108652 A HK 02108652A HK 1047575 B HK1047575 B HK 1047575B
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Hong Kong
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hydrogen
carbon atoms
formula
alkyl
group
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HK02108652.0A
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English (en)
Chinese (zh)
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HK1047575A1 (en
Inventor
J‧布兰德尔
J‧布蘭德爾
U‧格兰克
H‧U‧斯蒂尔兹
U‧格蘭克
H-J‧兰
H‧U‧斯蒂爾兹
H-J‧蘭
Original Assignee
萨诺费－阿文蒂斯德国有限公司
薩諾費-阿文蒂斯德國有限公司
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Publication of HK1047575A1 publication Critical patent/HK1047575A1/xx
Publication of HK1047575B publication Critical patent/HK1047575B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/26—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
HK02108652.0A 1999-06-25 2000-06-10 二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑 HK1047575B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19929076A DE19929076A1 (de) 1999-06-25 1999-06-25 Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE19929076.8 1999-06-25
PCT/EP2000/005370 WO2001000573A1 (de) 1999-06-25 2000-06-10 Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen

Publications (2)

Publication Number Publication Date
HK1047575A1 HK1047575A1 (en) 2003-02-28
HK1047575B true HK1047575B (zh) 2004-12-31

Family

ID=7912468

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02108652.0A HK1047575B (zh) 1999-06-25 2000-06-10 二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑

Country Status (31)

Country Link
US (1) US6221866B1 (https=)
EP (1) EP1194403B1 (https=)
JP (1) JP4527918B2 (https=)
KR (1) KR20020023962A (https=)
CN (1) CN1157372C (https=)
AR (1) AR024443A1 (https=)
AT (1) ATE248811T1 (https=)
AU (1) AU771601B2 (https=)
BR (1) BR0011938A (https=)
CA (1) CA2377087A1 (https=)
CZ (1) CZ20014523A3 (https=)
DE (2) DE19929076A1 (https=)
DK (1) DK1194403T3 (https=)
EE (1) EE04464B1 (https=)
ES (1) ES2200886T3 (https=)
HK (1) HK1047575B (https=)
HU (1) HUP0201711A3 (https=)
IL (1) IL147220A0 (https=)
MX (1) MXPA01012281A (https=)
NO (1) NO20015816L (https=)
NZ (1) NZ516347A (https=)
PL (1) PL352985A1 (https=)
PT (1) PT1194403E (https=)
RU (1) RU2238934C2 (https=)
SI (1) SI1194403T1 (https=)
SK (1) SK19092001A3 (https=)
TR (1) TR200103701T2 (https=)
TW (1) TWI256950B (https=)
WO (1) WO2001000573A1 (https=)
YU (1) YU88801A (https=)
ZA (1) ZA200109732B (https=)

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JP5756800B2 (ja) 2009-06-16 2015-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するアゼチジン２−カルボキサミド誘導体
JP2013505295A (ja) * 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
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Publication number Publication date
DK1194403T3 (da) 2003-12-08
AU771601B2 (en) 2004-03-25
CN1358172A (zh) 2002-07-10
HUP0201711A2 (en) 2002-09-28
EP1194403B1 (de) 2003-09-03
YU88801A (sh) 2004-09-03
PL352985A1 (en) 2003-09-22
EE04464B1 (et) 2005-04-15
SI1194403T1 (en) 2003-12-31
NZ516347A (en) 2004-01-30
NO20015816D0 (no) 2001-11-29
IL147220A0 (en) 2002-08-14
KR20020023962A (ko) 2002-03-29
PT1194403E (pt) 2004-01-30
JP4527918B2 (ja) 2010-08-18
EE200100684A (et) 2003-04-15
US6221866B1 (en) 2001-04-24
ES2200886T3 (es) 2004-03-16
TR200103701T2 (tr) 2002-05-21
NO20015816L (no) 2001-11-29
DE50003555D1 (de) 2003-10-09
ZA200109732B (en) 2002-08-30
HK1047575A1 (en) 2003-02-28
HUP0201711A3 (en) 2005-05-30
JP2003503385A (ja) 2003-01-28
AR024443A1 (es) 2002-10-02
CZ20014523A3 (cs) 2002-04-17
WO2001000573A1 (de) 2001-01-04
BR0011938A (pt) 2002-03-19
TWI256950B (en) 2006-06-21
EP1194403A1 (de) 2002-04-10
AU5531800A (en) 2001-01-31
SK19092001A3 (sk) 2002-06-04
ATE248811T1 (de) 2003-09-15
CA2377087A1 (en) 2001-01-04
MXPA01012281A (es) 2002-07-30
RU2238934C2 (ru) 2004-10-27
DE19929076A1 (de) 2000-12-28
CN1157372C (zh) 2004-07-14

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