HK1047127B - 經過自身蛋白溶解剪切的蛋白生產方法 - Google Patents

經過自身蛋白溶解剪切的蛋白生產方法

Info

Publication number
HK1047127B
HK1047127B HK02106953.0A HK02106953A HK1047127B HK 1047127 B HK1047127 B HK 1047127B HK 02106953 A HK02106953 A HK 02106953A HK 1047127 B HK1047127 B HK 1047127B
Authority
HK
Hong Kong
Prior art keywords
proteins
production
autoproteolytic cleavage
autoproteolytic
cleavage
Prior art date
Application number
HK02106953.0A
Other languages
English (en)
Other versions
HK1047127A1 (zh
Inventor
Rumenapf Tillmann
Thiel Heinz-Jurgen
Windisch Jorg
Knauseder Franz
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of HK1047127A1 publication Critical patent/HK1047127A1/zh
Publication of HK1047127B publication Critical patent/HK1047127B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
HK02106953.0A 1999-08-09 2002-09-24 經過自身蛋白溶解剪切的蛋白生產方法 HK1047127B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT136899 1999-08-09
PCT/EP2000/007642 WO2001011056A1 (en) 1999-08-09 2000-08-07 Production of proteins by autoproteolytic cleavage

Publications (2)

Publication Number Publication Date
HK1047127A1 HK1047127A1 (zh) 2003-02-07
HK1047127B true HK1047127B (zh) 2015-08-21

Family

ID=3512383

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106953.0A HK1047127B (zh) 1999-08-09 2002-09-24 經過自身蛋白溶解剪切的蛋白生產方法

Country Status (17)

Country Link
US (1) US7378512B2 (zh)
EP (1) EP1200603B1 (zh)
JP (1) JP5480458B2 (zh)
KR (1) KR100735791B1 (zh)
CN (1) CN1230542C (zh)
AU (1) AU775681B2 (zh)
CA (1) CA2380302C (zh)
CZ (1) CZ303341B6 (zh)
HK (1) HK1047127B (zh)
HU (1) HU230117B1 (zh)
IL (2) IL147411A0 (zh)
MX (1) MXPA02001425A (zh)
NO (1) NO329246B1 (zh)
PL (1) PL203708B1 (zh)
SK (1) SK288290B6 (zh)
TR (1) TR200200048T2 (zh)
WO (1) WO2001011056A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
US20060204523A1 (en) * 2001-11-26 2006-09-14 Khromykh Alexander A Flavivirus vaccine delivery system
WO2006113957A2 (en) * 2005-04-26 2006-11-02 Sandoz Ag Production of recombinant proteins by autoproteolytic cleavage of a fusion protein
GB0508434D0 (en) * 2005-04-26 2005-06-01 Sandoz Ag Organic compounds
AU2011253661B2 (en) * 2005-04-26 2013-06-13 Boehringer Ingelheim Rcv Gmbh & Co Kg Production of recombinant proteins by autoproteolytic cleavage of a fusion protein
GB0508435D0 (en) * 2005-04-26 2005-06-01 Sandoz Ag Organic compounds
US20100137563A1 (en) 2008-12-03 2010-06-03 Northwestern University Cysteine Protease Autoprocessing of Fusion Proteins
EP2684951A1 (en) 2012-07-13 2014-01-15 Sandoz Ag Method for producing a recombinant protein of interest
EP2746390A1 (en) 2012-12-19 2014-06-25 Sandoz Ag Method for producing a recombinant protein of interest
EP2746391A1 (en) 2012-12-19 2014-06-25 Sandoz Ag Method for producing a recombinant protein of interest
UY35874A (es) 2013-12-12 2015-07-31 Novartis Ag Un proceso para la preparación de una composición de proteínas pegiladas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
DE3885431D1 (de) 1987-12-23 1993-12-09 Boehringer Ingelheim Int Expression der viral kodierten Protease P2A des HRV2.
US6077694A (en) * 1990-09-21 2000-06-20 The United States Of America As Represented By The Department Of Health And Human Services Method for over-expression and rapid purification of biosynthetic proteins
IL132259A0 (en) * 1997-04-25 2001-03-19 Sembiosys Genetics Inc Method for cleavage of fusion proteins
AU9260598A (en) 1997-08-22 1999-03-16 Boehringer Mannheim Gmbh Zymogenic protease precursors that can be autocatalytically activated and their use
AU9341398A (en) * 1997-08-22 1999-03-16 Boehringer Mannheim Gmbh Protease precursors that can be autocatalytically activated and their use
JP4820512B2 (ja) * 1999-08-09 2011-11-24 サンド・アクチエンゲゼルシヤフト タンパク質の製造

Also Published As

Publication number Publication date
HUP0203051A2 (hu) 2002-12-28
KR20020021175A (ko) 2002-03-18
PL203708B1 (pl) 2009-11-30
WO2001011056A1 (en) 2001-02-15
HK1047127A1 (zh) 2003-02-07
SK1872002A3 (en) 2002-07-02
JP2003506092A (ja) 2003-02-18
MXPA02001425A (es) 2002-08-12
JP5480458B2 (ja) 2014-04-23
EP1200603B1 (en) 2014-12-24
HU230117B1 (hu) 2015-08-28
IL147411A (en) 2013-12-31
TR200200048T2 (tr) 2002-04-22
KR100735791B1 (ko) 2007-07-06
US20040215008A1 (en) 2004-10-28
NO20020507L (no) 2002-04-05
SK288290B6 (sk) 2015-07-01
AU6699800A (en) 2001-03-05
NO329246B1 (no) 2010-09-20
AU775681B2 (en) 2004-08-12
CZ2002480A3 (cs) 2002-05-15
CA2380302A1 (en) 2001-02-15
HUP0203051A3 (en) 2003-12-29
CA2380302C (en) 2013-02-26
NO20020507D0 (no) 2002-01-31
EP1200603A1 (en) 2002-05-02
CZ303341B6 (cs) 2012-08-08
CN1367837A (zh) 2002-09-04
PL353090A1 (en) 2003-10-06
IL147411A0 (en) 2002-08-14
CN1230542C (zh) 2005-12-07
US7378512B2 (en) 2008-05-27

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Legal Events

Date Code Title Description
AS Change of ownership

Owner name: SANDOZ AG

Free format text: FORMER OWNER(S): SANDOZ GMBH

CHPA Change of a particular in the register (except of change of ownership)
PE Patent expired

Effective date: 20200806