AU2001249477A1 - Lactams as inhibitors of a-beta protein production - Google Patents

Lactams as inhibitors of a-beta protein production

Info

Publication number
AU2001249477A1
AU2001249477A1 AU2001249477A AU4947701A AU2001249477A1 AU 2001249477 A1 AU2001249477 A1 AU 2001249477A1 AU 2001249477 A AU2001249477 A AU 2001249477A AU 4947701 A AU4947701 A AU 4947701A AU 2001249477 A1 AU2001249477 A1 AU 2001249477A1
Authority
AU
Australia
Prior art keywords
lactams
inhibitors
protein production
beta protein
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001249477A
Inventor
Lorin Andrew Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of AU2001249477A1 publication Critical patent/AU2001249477A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU2001249477A 2000-03-28 2001-03-27 Lactams as inhibitors of a-beta protein production Abandoned AU2001249477A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19251700P 2000-03-28 2000-03-28
US60192517 2000-03-28
PCT/US2001/009703 WO2001072324A1 (en) 2000-03-28 2001-03-27 Lactams as inhibitors of a-beta protein production

Publications (1)

Publication Number Publication Date
AU2001249477A1 true AU2001249477A1 (en) 2001-10-08

Family

ID=22709993

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001249477A Abandoned AU2001249477A1 (en) 2000-03-28 2001-03-27 Lactams as inhibitors of a-beta protein production

Country Status (5)

Country Link
EP (1) EP1267906A1 (en)
JP (1) JP2003528150A (en)
AU (1) AU2001249477A1 (en)
CA (1) CA2401120A1 (en)
WO (1) WO2001072324A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001261728A1 (en) * 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
TW200502221A (en) * 2002-10-03 2005-01-16 Astrazeneca Ab Novel lactams and uses thereof
US7342007B2 (en) 2003-03-14 2008-03-11 Astrazeneca Ab Lactams and uses thereof
JP2007509898A (en) * 2003-11-03 2007-04-19 プロビオドルグ エージー Useful combinations for the treatment of neurological disorders
CN101115730A (en) * 2004-12-14 2008-01-30 阿斯利康(瑞典)有限公司 Novel molecular probes
US7536962B2 (en) 2005-04-19 2009-05-26 Kamterter Ii, L.L.C. Systems for the control and use of fluids and particles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000069654A (en) * 1996-12-23 2000-11-25 엘란 파마슈티칼스, 인크. Cycloalkyl, Lactam, Lactone and Related Compounds, Pharmaceutical Compositions Comprising Same and Methods for Inhibiting β-Amyloid Peptide Release and/or Its Synthesis by Use of Such Compounds
WO1999067221A1 (en) * 1998-06-22 1999-12-29 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
HRP990246A2 (en) * 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production

Also Published As

Publication number Publication date
CA2401120A1 (en) 2001-10-04
EP1267906A1 (en) 2003-01-02
JP2003528150A (en) 2003-09-24
WO2001072324A1 (en) 2001-10-04

Similar Documents

Publication Publication Date Title
AU2001257006A1 (en) Substituted lactams as inhibitors of abeta protein production
IL151576A0 (en) Cyclic lactams as inhibitors of a-beta protein production
HK1049333A1 (en) Lactams substituted by cyclic succinates as inhibitors of a-beta protein production
AU2001239791A1 (en) Succinoylamino carbocycles and heterocycles as inhibitors of abeta protein production
IL142816A0 (en) SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
AU7997600A (en) Amino lactam sulfonamides as inhibitors of abeta protein production
AU2003265235A1 (en) Non-affinity purification of proteins
AU2002235189A1 (en) Production of 6-aminocaproic acid
GB0322515D0 (en) Enzymes for specific fragmentation of proteins
AU2001228309A1 (en) N-substituted 2-cyanopyroles and -pyrrolines which are inhibitors of the enzyme dpp-iv
AU2002341989A1 (en) Process to produce derivatives from uk-2a derivatives
AU2002339348A1 (en) Inhibition of STAT-1
AU2002367147A1 (en) Beta-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS
AU2001260674A1 (en) TNF-alpha production inhibitors
AU2002232819A1 (en) Methods for the production of multimeric proteins, and related compositions
AU2001290075A1 (en) Novel alkanoic acid derivatives
AU2002214286A1 (en) Method of profiling protein
HUP0202519A2 (en) Production of proteins
AU2001230207A1 (en) Method for the production of 1-amino-3-aryl-uracils
AU2001288092A1 (en) Method of crystallization
AU2001249477A1 (en) Lactams as inhibitors of a-beta protein production
AU2002303265A1 (en) Small molecule inhibitors of secretion of proteins encoded by are-mrnas
AU2001265935A1 (en) Production of biohydrolysates
AU2001280436A1 (en) Process to increase protein stability
AU2002234066A1 (en) Process for the production of amides