HK1046271A1 - 2，2-二甲基-1，3-二氧雜環乙烷半成品的鹽及有關製劑加工 - Google Patents

2，2-二甲基-1，3-二氧雜環乙烷半成品的鹽及有關製劑加工 Download PDF

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Publication number
HK1046271A1
HK1046271A1 HK02105736.6A HK02105736A HK1046271A1 HK 1046271 A1 HK1046271 A1 HK 1046271A1 HK 02105736 A HK02105736 A HK 02105736A HK 1046271 A1 HK1046271 A1 HK 1046271A1
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HK
Hong Kong
Prior art keywords
salts
dimethyl
preparation
dioxane
formula
Prior art date
Application number
HK02105736.6A
Other languages
English (en)
Chinese (zh)
Inventor
Kotay Nagy Peter
Greff Zoltan
Barkoczy Jozsef
Simig Gyula
Balazs Laszlo
Doman Imre
Ratkai Zoltan
Seres Peter
Bartha Ferenc
Vereczkeyne Donath Gyorgyi
Nagy Kalman
Original Assignee
Egis Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.
Publication of HK1046271A1 publication Critical patent/HK1046271A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK02105736.6A 1999-05-06 2000-05-05 2，2-二甲基-1，3-二氧雜環乙烷半成品的鹽及有關製劑加工 HK1046271A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP9901526 1999-05-06
HU9901526A HU227840B1 (en) 1999-05-06 1999-05-06 Intermediates of atorvastatin synthesis and process for producing them
PCT/HU2000/000042 WO2000068221A1 (en) 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof

Publications (1)

Publication Number Publication Date
HK1046271A1 true HK1046271A1 (zh) 2003-01-03

Family

ID=89998261

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02105736.6A HK1046271A1 (zh) 1999-05-06 2000-05-05 2，2-二甲基-1，3-二氧雜環乙烷半成品的鹽及有關製劑加工

Country Status (14)

Country Link
EP (1) EP1178980A1 (cs)
JP (1) JP2002544207A (cs)
KR (1) KR20020033617A (cs)
CN (1) CN1349522A (cs)
AU (1) AU4600200A (cs)
CA (1) CA2373077A1 (cs)
CZ (1) CZ20013965A3 (cs)
HK (1) HK1046271A1 (cs)
HR (1) HRP20010846A2 (cs)
HU (1) HU227840B1 (cs)
PL (1) PL351145A1 (cs)
RU (1) RU2001133066A (cs)
SK (1) SK15842001A3 (cs)
WO (1) WO2000068221A1 (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
EP1406860A1 (en) 2001-07-06 2004-04-14 Teva Pharmaceutical Industries Limited Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
CA2601111A1 (en) 2005-03-14 2006-09-21 Pfizer Science And Technology Ireland Limited Preparation of an atorvastatin intermediate using a paal-knorr condensation
WO2007034909A1 (ja) * 2005-09-22 2007-03-29 Kaneka Corporation （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法
MX2013002674A (es) 2010-09-09 2013-06-13 Dsm Sinochem Pharm Bv Sales de esteres de acido 7-amino-3,5-dihidroxiheptanoico.
JP6704916B2 (ja) 2015-08-05 2020-06-03 株式会社エーピーアイ コーポレーション ピタバスタチンカルシウムの製造方法
CN108191813B (zh) * 2017-12-20 2020-01-17 帕潘纳(北京)科技有限公司 一种缩酮的制备方法
CN109232354A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种高纯度阿托伐他汀钙原料药的制备方法
CN109232353A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种阿托伐他汀钙缩合物的制备方法
CN110940764B (zh) * 2019-12-31 2022-06-28 湖南九典制药股份有限公司 一种他汀类药物光学异构体的分离方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
JP3652394B2 (ja) * 1995-01-27 2005-05-25 高砂香料工業株式会社 Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法
IL127058A (en) * 1996-07-29 2001-07-24 Warner Lambert Co Process for the synthesis of protected esters of acid (S) - 4,3 dehydroxybutyric
US6344569B1 (en) * 1998-04-30 2002-02-05 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives

Also Published As

Publication number Publication date
HUP9901526A2 (hu) 2001-04-28
CA2373077A1 (en) 2000-11-16
JP2002544207A (ja) 2002-12-24
HU227840B1 (en) 2012-05-02
CN1349522A (zh) 2002-05-15
PL351145A1 (en) 2003-03-24
KR20020033617A (ko) 2002-05-07
SK15842001A3 (sk) 2002-04-04
CZ20013965A3 (cs) 2002-04-17
WO2000068221A1 (en) 2000-11-16
HRP20010846A2 (en) 2003-02-28
EP1178980A1 (en) 2002-02-13
RU2001133066A (ru) 2004-02-27
HU9901526D0 (en) 1999-07-28
AU4600200A (en) 2000-11-21

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