HRP20010846A2 - Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof - Google Patents

Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof Download PDF

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Publication number
HRP20010846A2
HRP20010846A2 HR20010846A HRP20010846A HRP20010846A2 HR P20010846 A2 HRP20010846 A2 HR P20010846A2 HR 20010846 A HR20010846 A HR 20010846A HR P20010846 A HRP20010846 A HR P20010846A HR P20010846 A2 HRP20010846 A2 HR P20010846A2
Authority
HR
Croatia
Prior art keywords
acid
dimethyl
carboxylic acid
formula
ethyl
Prior art date
Application number
HR20010846A
Other languages
English (en)
Croatian (hr)
Inventor
Puter K Tay Nagy
Zoltsn Greff
J Zsef Bark Czy
Gyula Simig
Lsszl Balszs
Imre Domsn
Zoltsn Rstkai
Puter Seres
Ferenc Bartha
Gy Rgyi Vereczkeynu Donsth
Kslmsn Nagy
Original Assignee
Egis Gy Gyszergysr Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gy Gyszergysr Rt filed Critical Egis Gy Gyszergysr Rt
Publication of HRP20010846A2 publication Critical patent/HRP20010846A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20010846A 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof HRP20010846A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9901526A HU227840B1 (en) 1999-05-06 1999-05-06 Intermediates of atorvastatin synthesis and process for producing them
PCT/HU2000/000042 WO2000068221A1 (en) 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof

Publications (1)

Publication Number Publication Date
HRP20010846A2 true HRP20010846A2 (en) 2003-02-28

Family

ID=89998261

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010846A HRP20010846A2 (en) 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof

Country Status (14)

Country Link
EP (1) EP1178980A1 (cs)
JP (1) JP2002544207A (cs)
KR (1) KR20020033617A (cs)
CN (1) CN1349522A (cs)
AU (1) AU4600200A (cs)
CA (1) CA2373077A1 (cs)
CZ (1) CZ20013965A3 (cs)
HK (1) HK1046271A1 (cs)
HR (1) HRP20010846A2 (cs)
HU (1) HU227840B1 (cs)
PL (1) PL351145A1 (cs)
RU (1) RU2001133066A (cs)
SK (1) SK15842001A3 (cs)
WO (1) WO2000068221A1 (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
EP1406860A1 (en) 2001-07-06 2004-04-14 Teva Pharmaceutical Industries Limited Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) * 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
JP2008533128A (ja) 2005-03-14 2008-08-21 ファイザー・サイエンス・アンド・テクノロジー・アイルランド・リミテッド Ｐａａｌ−Ｋｎｏｒｒ縮合を用いた、アトルバスタチン中間体の製造
WO2007034909A1 (ja) * 2005-09-22 2007-03-29 Kaneka Corporation （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法
CN103153976B (zh) 2010-09-09 2015-07-08 中化帝斯曼制药有限公司荷兰公司 7-氨基-3,5-二羟基庚酸酯的盐
CN113620871A (zh) 2015-08-05 2021-11-09 株式会社Api 生产匹伐他汀钙的方法
CN108191813B (zh) * 2017-12-20 2020-01-17 帕潘纳(北京)科技有限公司 一种缩酮的制备方法
CN109232353A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种阿托伐他汀钙缩合物的制备方法
CN109232354A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种高纯度阿托伐他汀钙原料药的制备方法
CN110940764B (zh) * 2019-12-31 2022-06-28 湖南九典制药股份有限公司 一种他汀类药物光学异构体的分离方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
JP3652394B2 (ja) * 1995-01-27 2005-05-25 高砂香料工業株式会社 Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法
ATE215078T1 (de) * 1996-07-29 2002-04-15 Warner Lambert Co Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern
US6344569B1 (en) * 1998-04-30 2002-02-05 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives

Also Published As

Publication number Publication date
CZ20013965A3 (cs) 2002-04-17
HU227840B1 (en) 2012-05-02
CA2373077A1 (en) 2000-11-16
PL351145A1 (en) 2003-03-24
HU9901526D0 (en) 1999-07-28
WO2000068221A1 (en) 2000-11-16
SK15842001A3 (sk) 2002-04-04
RU2001133066A (ru) 2004-02-27
CN1349522A (zh) 2002-05-15
KR20020033617A (ko) 2002-05-07
JP2002544207A (ja) 2002-12-24
HK1046271A1 (zh) 2003-01-03
HUP9901526A2 (hu) 2001-04-28
AU4600200A (en) 2000-11-21
EP1178980A1 (en) 2002-02-13

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