HK1020672A1 - Pharmaceutical compositions containing sulphamate derivatives as steroid sulphatase inhibitors - Google Patents

Pharmaceutical compositions containing sulphamate derivatives as steroid sulphatase inhibitors

Info

Publication number
HK1020672A1
HK1020672A1 HK99104906A HK99104906A HK1020672A1 HK 1020672 A1 HK1020672 A1 HK 1020672A1 HK 99104906 A HK99104906 A HK 99104906A HK 99104906 A HK99104906 A HK 99104906A HK 1020672 A1 HK1020672 A1 HK 1020672A1
Authority
HK
Hong Kong
Prior art keywords
sub
compound
steroid sulphatase
pharmaceutical compositions
compositions containing
Prior art date
Application number
HK99104906A
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Llyod Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of HK1020672A1 publication Critical patent/HK1020672A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK99104906A 1991-08-29 1999-11-01 Pharmaceutical compositions containing sulphamate derivatives as steroid sulphatase inhibitors HK1020672A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
HK1020672A1 true HK1020672A1 (en) 2000-05-19

Family

ID=10700604

Family Applications (3)

Application Number Title Priority Date Filing Date
HK99104905A HK1019753A1 (en) 1991-08-29 1999-11-01 Steroid sulphatase inhibitors
HK99104906A HK1020672A1 (en) 1991-08-29 1999-11-01 Pharmaceutical compositions containing sulphamate derivatives as steroid sulphatase inhibitors
HK00104302A HK1025051A1 (en) 1991-08-29 2000-07-12 Use of a sterol compound comprising a sulphamic acid ester group for the manufacture of medicaments for the control of oestrogen production

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK99104905A HK1019753A1 (en) 1991-08-29 1999-11-01 Steroid sulphatase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK00104302A HK1025051A1 (en) 1991-08-29 2000-07-12 Use of a sterol compound comprising a sulphamic acid ester group for the manufacture of medicaments for the control of oestrogen production

Country Status (26)

Country Link
US (3) US5616574A (sk)
EP (6) EP0921130B1 (sk)
JP (6) JP3219408B2 (sk)
KR (4) KR100258396B1 (sk)
AT (5) ATE278704T1 (sk)
AU (2) AU689043B2 (sk)
BR (1) BR9206434A (sk)
CA (4) CA2305758A1 (sk)
CY (4) CY2253B1 (sk)
CZ (1) CZ295939B6 (sk)
DE (5) DE69233020T2 (sk)
DK (4) DK0921130T3 (sk)
ES (4) ES2193475T3 (sk)
FI (5) FI940903A (sk)
GB (1) GB9118478D0 (sk)
GE (6) GEP20063773B (sk)
GR (1) GR3034579T3 (sk)
HK (3) HK1019753A1 (sk)
HU (1) HUT66097A (sk)
LV (1) LV12618B (sk)
NO (6) NO307301B1 (sk)
RU (4) RU2210574C2 (sk)
SG (7) SG115508A1 (sk)
SK (4) SK282189B6 (sk)
UA (4) UA41875C2 (sk)
WO (1) WO1993005064A1 (sk)

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GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
US6083978A (en) * 1996-03-05 2000-07-04 Sterix Limited Compounds with a sulfamate group
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6903084B2 (en) * 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
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US6642220B1 (en) * 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
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GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
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ES2310943T3 (es) 1998-06-10 2009-01-16 Sterix Limited Composicion farmaceutica con factor de necrosis tumoral a y 2-metoxiestrona-3-o-sulfamato para la inhibicion de la estrona sulfatasa.
US6248780B1 (en) * 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
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US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
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DE60023740T2 (de) * 1999-12-13 2006-07-27 Sterix Ltd. Halogenierte sulphamat-, phoshonat-, thiophosphonat-, sulphonat- und sulphonamid- verbindungen als inhibitoren von steroidsulfatase
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
JPWO2001081364A1 (ja) * 2000-04-24 2004-01-08 協和醗酵工業株式会社 エストラ−１，３，５（１０）−トリエン誘導体
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
JP2004521951A (ja) 2001-07-13 2004-07-22 シエーリング アクチエンゲゼルシャフト Ｈｒｔのためのドロスピレノン及びエストロゲンスルファメートの組み合わせ
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
ES2258174T3 (es) 2001-10-18 2006-08-16 Sterix Limited Compuestos esteroideos para la inhibicion de la sulfatasa esteroidea.
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PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
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Also Published As

Publication number Publication date
EP1522543A1 (en) 2005-04-13
EP1099706B1 (en) 2004-10-06
NO20044458L (no) 1994-04-29
CY2397B1 (en) 2004-09-10
UA41875C2 (uk) 2001-10-15
CZ44094A3 (en) 1995-01-18
BR9206434A (pt) 1994-09-27
DE69233431T2 (de) 2006-02-23
ES2193475T3 (es) 2003-11-01
HK1025051A1 (en) 2000-11-03
FI940903A0 (fi) 1994-02-25
FI940903A (fi) 1994-04-20
SG106116A1 (en) 2004-09-30
GEP20033094B (en) 2003-10-27
GB9118478D0 (en) 1991-10-16
RU2207134C2 (ru) 2003-06-27
JPH07501515A (ja) 1995-02-16
EP0921130A2 (en) 1999-06-09
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
JP3219408B2 (ja) 2001-10-15
JP2000355598A (ja) 2000-12-26
NO995075D0 (no) 1999-10-18
EP0982032A2 (en) 2000-03-01
GEP20022766B (en) 2002-08-26
GR3034579T3 (en) 2001-01-31
GEP20022802B (en) 2002-09-25
NO314287B1 (no) 2003-03-03
LV12618A (en) 2001-02-20
DK0982032T3 (da) 2003-11-03
EP0928609A2 (en) 1999-07-14
SG103374A1 (en) 2004-04-29
DE69233020T2 (de) 2003-11-06
EP0928609A3 (en) 2001-11-07
SG88783A1 (en) 2002-05-21
HUT66097A (en) 1994-09-28
ATE237333T1 (de) 2003-05-15
KR100321019B1 (ko) 2002-03-20
NO2595A (no) 1994-04-29
SG115508A1 (en) 2005-10-28
NO995076D0 (no) 1999-10-18
GEP20063773B (en) 2006-03-27
JP3581821B2 (ja) 2004-10-27
FI20002260A (fi) 2000-10-13
NO20002595D0 (no) 2000-05-19
NO308774B1 (no) 2000-10-30
SG88782A1 (en) 2002-05-21
RU2210574C2 (ru) 2003-08-20
KR100322650B1 (ko) 2002-03-20
UA70956C2 (uk) 2004-11-15
NO940635D0 (no) 1994-02-24
AU5837396A (en) 1996-09-05
GEP20022803B (en) 2002-09-25
KR100321018B1 (ko) 2002-03-20
DE69231280D1 (de) 2000-08-24
CY2394B1 (en) 2004-09-10
EP0641355A1 (en) 1995-03-08
NO308903B1 (no) 2000-11-13
AU717116B2 (en) 2000-03-16
WO1993005064A1 (en) 1993-03-18
CY2253B1 (en) 2003-07-04
JP2003176297A (ja) 2003-06-24
EP0982032A3 (en) 2002-03-20
JP2002255993A (ja) 2002-09-11
SK282189B6 (sk) 2001-12-03
ATE278704T1 (de) 2004-10-15
NO995075L (no) 1994-04-29
SK282187B6 (sk) 2001-12-03
EP0921130A3 (en) 2001-09-05
SG73391A1 (en) 2006-08-30
NO940635L (sk) 1994-04-29
ES2204059T3 (es) 2004-04-16
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
US5830886A (en) 1998-11-03
CA2305758A1 (en) 1993-03-18
EP0641355B1 (en) 2000-07-19
ES2148178T3 (es) 2000-10-16
GEP20022637B (en) 2002-02-25
NO307301B1 (no) 2000-03-13
SK24694A3 (en) 1994-11-09
CA2305749A1 (en) 1993-03-18
NO20025725D0 (no) 2002-11-28
DE69233149T2 (de) 2004-06-24
US6159960A (en) 2000-12-12
ATE246706T1 (de) 2003-08-15
FI20050991A (fi) 2005-10-03
JP2000355542A (ja) 2000-12-26
FI20002259A (fi) 2000-10-13
ATE239753T1 (de) 2003-05-15
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
CY2398B1 (en) 2004-09-10
HK1019753A1 (en) 2000-02-25
NO20025725L (no) 1994-04-29
SG103820A1 (en) 2004-05-26
ES2196483T3 (es) 2003-12-16
DK0928609T3 (da) 2003-07-21
HU9400583D0 (en) 1994-05-30
ATE194843T1 (de) 2000-08-15
AU2490592A (en) 1993-04-05
SK282188B6 (sk) 2001-12-03
US5616574A (en) 1997-04-01
JP2000038341A (ja) 2000-02-08
JP3581802B2 (ja) 2004-10-27
RU2182152C2 (ru) 2002-05-10
DE69231280T2 (de) 2000-11-30
NO318009B1 (no) 2005-01-17
CA2114630C (en) 2003-09-30
EP1099706A3 (en) 2002-09-04
DE69233020D1 (de) 2003-05-22
NO995076L (no) 1994-04-29
UA70957C2 (uk) 2004-11-15
AU668882B2 (en) 1996-05-23
EP1099706A2 (en) 2001-05-16
CZ295939B6 (cs) 2005-12-14
LV12618B (en) 2001-07-20
DE69233053T2 (de) 2003-11-20
DK0921130T3 (da) 2003-07-21
FI20002261A (fi) 2000-10-13
DE69233053D1 (de) 2003-06-12
EP0921130B1 (en) 2003-05-07
CA2114630A1 (en) 1993-03-18
KR100258396B1 (ko) 2000-08-01
EP0982032B1 (en) 2003-08-06
JP3581820B2 (ja) 2004-10-27
CA2305767A1 (en) 1993-03-18
AU689043B2 (en) 1998-03-19
AU1007799A (en) 1999-03-04
SK282186B6 (sk) 2001-12-03
RU2001125673A (ru) 2003-06-27

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