HK1017692A1 - Endothelial cell proliferation inhibitor and method of use - Google Patents

Endothelial cell proliferation inhibitor and method of use

Info

Publication number
HK1017692A1
HK1017692A1 HK99102688.5A HK99102688A HK1017692A1 HK 1017692 A1 HK1017692 A1 HK 1017692A1 HK 99102688 A HK99102688 A HK 99102688A HK 1017692 A1 HK1017692 A1 HK 1017692A1
Authority
HK
Hong Kong
Prior art keywords
cell proliferation
endothelial cell
proliferation inhibitor
inhibitor
endothelial
Prior art date
Application number
HK99102688.5A
Other languages
English (en)
Inventor
Cao Y Yihai
Moses Judah Folkman
Michael S O'reilly
Original Assignee
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/763,528 external-priority patent/US5854221A/en
Application filed by Childrens Medical Center filed Critical Childrens Medical Center
Publication of HK1017692A1 publication Critical patent/HK1017692A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicines Containing Plant Substances (AREA)
HK99102688.5A 1995-12-13 1999-06-23 Endothelial cell proliferation inhibitor and method of use HK1017692A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US851995P 1995-12-13 1995-12-13
US08/763,528 US5854221A (en) 1996-12-12 1996-12-12 Endothelial cell proliferation inhibitor and method of use
PCT/US1996/020447 WO1997023500A1 (en) 1995-12-13 1996-12-13 Endothelial cell proliferation inhibitor and method of use

Publications (1)

Publication Number Publication Date
HK1017692A1 true HK1017692A1 (en) 1999-11-26

Family

ID=26678280

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99102688.5A HK1017692A1 (en) 1995-12-13 1999-06-23 Endothelial cell proliferation inhibitor and method of use

Country Status (20)

Country Link
US (1) US20010016644A1 (no)
EP (1) EP0869970B1 (no)
JP (1) JP3684371B2 (no)
KR (1) KR100477280B1 (no)
CN (1) CN1554444A (no)
AT (1) ATE262537T1 (no)
AU (1) AU710612B2 (no)
BR (1) BR9612115A (no)
CA (1) CA2240296C (no)
CZ (1) CZ298612B6 (no)
DE (1) DE69631972T2 (no)
DK (1) DK0869970T3 (no)
ES (1) ES2217340T3 (no)
HK (1) HK1017692A1 (no)
HU (1) HUP9900979A3 (no)
NO (1) NO321775B1 (no)
NZ (1) NZ330537A (no)
PL (1) PL188719B1 (no)
PT (1) PT869970E (no)
WO (1) WO1997023500A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ298612B6 (cs) * 1995-12-13 2007-11-21 The Children's Medical Center Corporation Inhibitor proliferace endothelových bunek a jeho použití
US5801146A (en) * 1996-05-03 1998-09-01 Abbott Laboratories Compound and method for inhibiting angiogenesis
EP0910571B1 (en) * 1996-05-03 2005-07-20 Abbott Laboratories Novel antiangiogenic peptides, polynucleotides encoding same and methods for inhibiting angiogenesis
US6699838B1 (en) 1996-05-03 2004-03-02 Abbott Laboratories Antiangiogenic peptides
US5801012A (en) 1996-09-17 1998-09-01 Northwestern University Methods and compositions for generating angiostatin
EP1001985A1 (en) * 1997-06-26 2000-05-24 Karolinska Innovations AB Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo
AU1598599A (en) * 1997-11-20 1999-06-15 Genetix Pharmaceuticals, Inc. Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases
US6632961B1 (en) 1998-05-22 2003-10-14 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
CA2373252C (en) * 1999-05-17 2007-08-07 Conjuchem Inc. Long lasting anti-angiogenic peptides
DK1180121T3 (da) 1999-05-17 2004-03-01 Conjuchem Inc Langtidsvirkende insulinotrope peptider
US7144854B1 (en) 1999-09-10 2006-12-05 Conjuchem, Inc. Long lasting anti-angiogenic peptides
WO2001044294A2 (en) * 1999-12-15 2001-06-21 Entremed, Inc. Compositions and methods for inhibiting endothelial cell proliferation
AU8591901A (en) 2000-09-05 2002-03-22 Karolinska Innovations Ab Materials and methods relating to endothelial cell growth inhibitors
AU2002239414A1 (en) * 2000-11-02 2002-05-27 Bristol-Myers Squibb Company Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
US20060014211A1 (en) * 2004-01-21 2006-01-19 Fujirebio Diagnostics, Inc. Detection of mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of the peritoneum and the peritoneal cavity
CN100355458C (zh) * 2005-03-16 2007-12-19 北京大学 人增殖抑制基因－腺病毒表达载体的应用
EP2435562A1 (en) 2009-05-26 2012-04-04 Biolex Therapeutics, Inc. Compositions and methods for production of aglycosylated plasminogen
CN103060265B (zh) * 2013-01-23 2014-12-03 山东大学 老年大鼠脑血管内皮细胞原代培养方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
CA2101614A1 (en) * 1992-07-30 1994-01-31 Shmuel Shaltiel Synthetic peptides derived from vitronectin and pharmaceutical compositions comprising them
AU2355895A (en) * 1994-04-26 1995-11-16 Pharmacia & Upjohn Company Mac-1 i-domain protein useful in blocking adhesion and migration of neutrophils
CN1636594B (zh) * 1994-04-26 2012-08-29 儿童医学中心公司 血管生成抑制素和用于抑制血管生成的方法
NZ307044A (en) * 1995-04-26 2002-03-01 Childrens Medical Center Angiostatin fragments with antiangiogenic activity
CZ298612B6 (cs) * 1995-12-13 2007-11-21 The Children's Medical Center Corporation Inhibitor proliferace endothelových bunek a jeho použití

Also Published As

Publication number Publication date
CZ182898A3 (cs) 1998-10-14
DE69631972D1 (de) 2004-04-29
NO982715D0 (no) 1998-06-12
HUP9900979A3 (en) 2001-10-29
EP0869970A1 (en) 1998-10-14
HUP9900979A2 (hu) 1999-07-28
NZ330537A (en) 2001-06-29
DE69631972T2 (de) 2005-01-05
DK0869970T3 (da) 2004-07-05
KR100477280B1 (ko) 2005-07-18
JP2002502359A (ja) 2002-01-22
NO321775B1 (no) 2006-07-03
ES2217340T3 (es) 2004-11-01
ATE262537T1 (de) 2004-04-15
CA2240296C (en) 2004-05-04
US20010016644A1 (en) 2001-08-23
EP0869970B1 (en) 2004-03-24
AU710612B2 (en) 1999-09-23
CA2240296A1 (en) 1997-07-03
PT869970E (pt) 2004-08-31
PL188719B1 (pl) 2005-04-29
JP3684371B2 (ja) 2005-08-17
EP0869970A4 (en) 2002-01-30
CZ298612B6 (cs) 2007-11-21
AU1687097A (en) 1997-07-17
BR9612115A (pt) 1999-02-17
NO982715L (no) 1998-08-12
PL327200A1 (en) 1998-11-23
WO1997023500A1 (en) 1997-07-03
KR19990072126A (ko) 1999-09-27
CN1554444A (zh) 2004-12-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20141213