HK1014986A1 - Production of enzymatically active recombinant carboxypeptidase b - Google Patents
Production of enzymatically active recombinant carboxypeptidase bInfo
- Publication number
- HK1014986A1 HK1014986A1 HK98119240A HK98119240A HK1014986A1 HK 1014986 A1 HK1014986 A1 HK 1014986A1 HK 98119240 A HK98119240 A HK 98119240A HK 98119240 A HK98119240 A HK 98119240A HK 1014986 A1 HK1014986 A1 HK 1014986A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- procpb
- enzymatically active
- production
- active recombinant
- active cpb
- Prior art date
Links
- 102000003670 Carboxypeptidase B Human genes 0.000 title 1
- 108090000087 Carboxypeptidase B Proteins 0.000 title 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37823395A | 1995-01-25 | 1995-01-25 | |
PCT/US1996/000995 WO1996023064A1 (en) | 1995-01-25 | 1996-01-25 | Production of enzymatically active recombinant carboxypeptidase b |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1014986A1 true HK1014986A1 (en) | 1999-10-08 |
Family
ID=23492292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98119240A HK1014986A1 (en) | 1995-01-25 | 1998-12-30 | Production of enzymatically active recombinant carboxypeptidase b |
Country Status (22)
Country | Link |
---|---|
US (1) | US5948668A (de) |
EP (1) | EP0871718B1 (de) |
JP (1) | JP4250716B2 (de) |
KR (1) | KR100566136B1 (de) |
CN (1) | CN1144874C (de) |
AT (1) | ATE358717T1 (de) |
AU (1) | AU698889B2 (de) |
BR (1) | BR9606795A (de) |
CA (1) | CA2210242C (de) |
CZ (1) | CZ292541B6 (de) |
DE (1) | DE69637011T2 (de) |
DK (1) | DK0871718T3 (de) |
ES (1) | ES2284167T3 (de) |
HK (1) | HK1014986A1 (de) |
HU (1) | HU225673B1 (de) |
IL (1) | IL116696A (de) |
MX (1) | MX9705279A (de) |
NZ (1) | NZ302874A (de) |
PL (1) | PL183228B1 (de) |
PT (1) | PT871718E (de) |
WO (1) | WO1996023064A1 (de) |
ZA (1) | ZA96515B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ315713A (en) | 1995-08-16 | 1999-08-30 | Zeneca Ltd | A conjugate comprising an antibody as targeting moiety linked to a carboxypeptidase b (cpb) |
CN1896231B (zh) | 1998-08-06 | 2012-09-05 | 山景药品公司 | 分离四聚体尿酸氧化酶的方法 |
US20040117863A1 (en) * | 1998-09-18 | 2004-06-17 | Edge Michael D. | Transgenically produced fusion proteins |
DE19915938A1 (de) | 1999-04-09 | 2000-10-19 | Aventis Pharma Gmbh | Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung |
US6441153B1 (en) | 1999-09-29 | 2002-08-27 | Lexicon Genetics Incorporated | Human carboxypeptidases and polynucleotides encoding the same |
CN1414970A (zh) * | 1999-09-17 | 2003-04-30 | Gtc生物治疗学公司 | 以转基因方式生产的融合蛋白 |
EP1632575B1 (de) * | 1999-09-29 | 2009-01-28 | Lexicon Pharmaceuticals, Inc. | Humane Carboxypeptidasen und diese kodierende Polynukleotide |
AU2001229253A1 (en) * | 2000-01-12 | 2001-07-24 | Eli Lilly And Company | Carboxypeptidase b free of animal products and contaminating enyzme activity |
EP1538203B1 (de) * | 2003-12-05 | 2010-01-20 | Roche Diagnostics GmbH | Rekombinante Carboxypeptidase B und ihre Aufreinigung |
JP4411192B2 (ja) * | 2003-12-05 | 2010-02-10 | エフ.ホフマン−ラ ロシュ アーゲー | 組換えで発現されるカルボキシペプチダーゼbおよびその精製 |
SI1794294T1 (sl) * | 2004-09-27 | 2011-11-30 | Sanofi Aventis Deutschland | Rekombinantna karboksipeptidaza B |
US20080159976A1 (en) * | 2005-04-11 | 2008-07-03 | Jacob Hartman | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
BRPI0612942A2 (pt) | 2005-04-11 | 2012-10-09 | Savient Pharmaceuticals Inc | forma variante de oxidase de urato e uso do mesmo |
LT3321359T (lt) | 2005-04-11 | 2021-05-10 | Horizon Pharma Rheumatology Llc | Urato oksidazės variantinės formos ir jų panaudojimas |
JP2008545665A (ja) * | 2005-05-23 | 2008-12-18 | ユニベルシテ ドゥ ジュネーブ | 高体温による処置のための注入可能な超常磁性ナノ粒子および高体温インプラントを形成するための使用 |
EP2013225B1 (de) | 2006-04-12 | 2014-12-17 | Crealta Pharmaceuticals LLC | Proteinaufreiningung mit hilfe von kationischen tensiden |
CN101058805B (zh) * | 2007-03-21 | 2011-09-07 | 北京贯虹科技有限公司 | 突变羧肽酶原b及突变羧肽酶b的生产方法 |
US8993714B2 (en) * | 2007-10-26 | 2015-03-31 | Imiplex Llc | Streptavidin macromolecular adaptor and complexes thereof |
US9102526B2 (en) | 2008-08-12 | 2015-08-11 | Imiplex Llc | Node polypeptides for nanostructure assembly |
US9285363B2 (en) | 2009-05-11 | 2016-03-15 | Imiplex Llc | Method of protein nanostructure fabrication |
HUP1200205A3 (en) | 2009-06-25 | 2012-09-28 | Savient Pharmaceuticals | Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy |
CN101967467B (zh) * | 2009-07-28 | 2012-11-14 | 上海雅心生物技术有限公司 | 一种高稳定性的重组羧肽酶b的生产及应用 |
US11918624B2 (en) * | 2020-06-10 | 2024-03-05 | Kelsius Laboratories LLC | Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK124483B (da) * | 1967-12-04 | 1972-10-23 | Bayer Ag | Fremgangsmåde til rensning af carboxypeptidase B. |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
HU190129B (en) * | 1983-07-11 | 1986-08-28 | Reanal Finomvegyszergyar,Hu | Process for the isolation of carboxypeptidase b enzyme from mammal pancreas |
US5206161A (en) * | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
FR2692907B1 (fr) * | 1992-06-25 | 1995-06-30 | Rhone Poulenc Rorer Sa | Levures kluyveromyces modifiees, preparation et utilisation. |
JP3472587B2 (ja) * | 1992-08-28 | 2003-12-02 | アベンティス ファーマ株式会社 | 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法 |
EP0776369A4 (de) * | 1993-11-16 | 2000-11-22 | Lilly Co Eli | Fuer die pankreas - carboxypeptidan - b aus schweinen kodierende dna - sequenzen |
-
1996
- 1996-01-08 IL IL11669696A patent/IL116696A/xx not_active IP Right Cessation
- 1996-01-23 ZA ZA96515A patent/ZA96515B/xx unknown
- 1996-01-25 JP JP52300096A patent/JP4250716B2/ja not_active Expired - Lifetime
- 1996-01-25 NZ NZ302874A patent/NZ302874A/en not_active IP Right Cessation
- 1996-01-25 AT AT96905218T patent/ATE358717T1/de active
- 1996-01-25 DE DE69637011T patent/DE69637011T2/de not_active Expired - Lifetime
- 1996-01-25 BR BR9606795A patent/BR9606795A/pt not_active Application Discontinuation
- 1996-01-25 HU HU9800091A patent/HU225673B1/hu unknown
- 1996-01-25 CZ CZ19972258A patent/CZ292541B6/cs not_active IP Right Cessation
- 1996-01-25 KR KR1019970705046A patent/KR100566136B1/ko not_active IP Right Cessation
- 1996-01-25 ES ES96905218T patent/ES2284167T3/es not_active Expired - Lifetime
- 1996-01-25 PL PL96321499A patent/PL183228B1/pl unknown
- 1996-01-25 DK DK96905218T patent/DK0871718T3/da active
- 1996-01-25 AU AU49034/96A patent/AU698889B2/en not_active Expired
- 1996-01-25 PT PT96905218T patent/PT871718E/pt unknown
- 1996-01-25 CA CA2210242A patent/CA2210242C/en not_active Expired - Lifetime
- 1996-01-25 WO PCT/US1996/000995 patent/WO1996023064A1/en active IP Right Grant
- 1996-01-25 CN CNB961923679A patent/CN1144874C/zh not_active Expired - Lifetime
- 1996-01-25 EP EP96905218A patent/EP0871718B1/de not_active Expired - Lifetime
-
1997
- 1997-01-13 US US08/782,760 patent/US5948668A/en not_active Expired - Lifetime
- 1997-07-11 MX MX9705279A patent/MX9705279A/es unknown
-
1998
- 1998-12-30 HK HK98119240A patent/HK1014986A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0871718B1 (de) | 2007-04-04 |
PT871718E (pt) | 2007-06-26 |
HUP9800091A3 (en) | 2004-03-29 |
KR100566136B1 (ko) | 2006-11-10 |
EP0871718A1 (de) | 1998-10-21 |
EP0871718A4 (de) | 2000-06-07 |
DE69637011D1 (de) | 2007-05-16 |
IL116696A0 (en) | 1996-05-14 |
KR19980701652A (ko) | 1998-06-25 |
PL183228B1 (pl) | 2002-06-28 |
CZ292541B6 (cs) | 2003-10-15 |
PL321499A1 (en) | 1997-12-08 |
JP4250716B2 (ja) | 2009-04-08 |
NZ302874A (en) | 1998-11-25 |
HUP9800091A2 (hu) | 1998-05-28 |
JPH11503002A (ja) | 1999-03-23 |
AU698889B2 (en) | 1998-11-12 |
MX9705279A (es) | 1998-06-30 |
HU225673B1 (en) | 2007-06-28 |
BR9606795A (pt) | 1997-12-30 |
US5948668A (en) | 1999-09-07 |
CA2210242A1 (en) | 1996-08-01 |
ES2284167T3 (es) | 2007-11-01 |
CZ225897A3 (cs) | 1998-10-14 |
ATE358717T1 (de) | 2007-04-15 |
WO1996023064A1 (en) | 1996-08-01 |
DK0871718T3 (da) | 2007-07-02 |
CA2210242C (en) | 2010-04-27 |
CN1177377A (zh) | 1998-03-25 |
AU4903496A (en) | 1996-08-14 |
ZA96515B (en) | 1996-08-15 |
CN1144874C (zh) | 2004-04-07 |
IL116696A (en) | 1999-08-17 |
DE69637011T2 (de) | 2007-12-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20160124 |