HK1014986A1 - Production of enzymatically active recombinant carboxypeptidase b - Google Patents

Production of enzymatically active recombinant carboxypeptidase b

Info

Publication number
HK1014986A1
HK1014986A1 HK98119240A HK98119240A HK1014986A1 HK 1014986 A1 HK1014986 A1 HK 1014986A1 HK 98119240 A HK98119240 A HK 98119240A HK 98119240 A HK98119240 A HK 98119240A HK 1014986 A1 HK1014986 A1 HK 1014986A1
Authority
HK
Hong Kong
Prior art keywords
procpb
enzymatically active
production
active recombinant
active cpb
Prior art date
Application number
HK98119240A
Other languages
English (en)
Inventor
Jacob Hartman
Netta Fulga
Simona Mendelovitch
Marian Gorecki
Original Assignee
Ferring Int Ct Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Int Ct Sa filed Critical Ferring Int Ct Sa
Publication of HK1014986A1 publication Critical patent/HK1014986A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK98119240A 1995-01-25 1998-12-30 Production of enzymatically active recombinant carboxypeptidase b HK1014986A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37823395A 1995-01-25 1995-01-25
PCT/US1996/000995 WO1996023064A1 (en) 1995-01-25 1996-01-25 Production of enzymatically active recombinant carboxypeptidase b

Publications (1)

Publication Number Publication Date
HK1014986A1 true HK1014986A1 (en) 1999-10-08

Family

ID=23492292

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98119240A HK1014986A1 (en) 1995-01-25 1998-12-30 Production of enzymatically active recombinant carboxypeptidase b

Country Status (22)

Country Link
US (1) US5948668A (xx)
EP (1) EP0871718B1 (xx)
JP (1) JP4250716B2 (xx)
KR (1) KR100566136B1 (xx)
CN (1) CN1144874C (xx)
AT (1) ATE358717T1 (xx)
AU (1) AU698889B2 (xx)
BR (1) BR9606795A (xx)
CA (1) CA2210242C (xx)
CZ (1) CZ292541B6 (xx)
DE (1) DE69637011T2 (xx)
DK (1) DK0871718T3 (xx)
ES (1) ES2284167T3 (xx)
HK (1) HK1014986A1 (xx)
HU (1) HU225673B1 (xx)
IL (1) IL116696A (xx)
MX (1) MX9705279A (xx)
NZ (1) NZ302874A (xx)
PL (1) PL183228B1 (xx)
PT (1) PT871718E (xx)
WO (1) WO1996023064A1 (xx)
ZA (1) ZA96515B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436691B1 (en) 1995-08-16 2002-08-20 Zeneca Limited Chemical compounds
ES2361190T3 (es) 1998-08-06 2011-06-14 Mountain View Pharmaceuticals, Inc. Conjugados de peg-oxidasa de urato y su uso.
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
DE19915938A1 (de) 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
WO2001019846A1 (en) * 1999-09-17 2001-03-22 Genzyme Transgenics Corporation Transgenically produced fusion proteins
JP2003512027A (ja) 1999-09-29 2003-04-02 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトカルボキシペプチダーゼおよびそれをコードするポリヌクレオチド
EP1632575B1 (en) * 1999-09-29 2009-01-28 Lexicon Pharmaceuticals, Inc. Human carboxypeptidases and polynucleotides encoding the same
AU2001229253A1 (en) * 2000-01-12 2001-07-24 Eli Lilly And Company Carboxypeptidase b free of animal products and contaminating enyzme activity
DE602004025192D1 (de) * 2003-12-05 2010-03-11 Roche Diagnostics Gmbh Rekombinante Carboxypeptidase B und ihre Aufreinigung
EP1538203B1 (en) * 2003-12-05 2010-01-20 Roche Diagnostics GmbH Recombinantly expressed carboxypeptidase B and purification thereof
EP1794294B1 (de) * 2004-09-27 2011-07-20 Sanofi-Aventis Deutschland GmbH Rekombinante carboxypeptidase b
CZ2007695A3 (cs) 2005-04-11 2008-02-27 Savient Pharmaceuticals, Inc. Variantní formy urátoxidázy a jejich použití
WO2006110761A2 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. A variant form of urate oxidase and use thereof
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
WO2006125452A1 (en) * 2005-05-23 2006-11-30 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
HU230758B1 (hu) 2006-04-12 2018-03-28 Crealta Pharmaceuticals LLC 100% Fehérjék tisztítása kationos felületaktív anyaggal
CN101058805B (zh) * 2007-03-21 2011-09-07 北京贯虹科技有限公司 突变羧肽酶原b及突变羧肽酶b的生产方法
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
US9285363B2 (en) 2009-05-11 2016-03-15 Imiplex Llc Method of protein nanostructure fabrication
SG176897A1 (en) 2009-06-25 2012-01-30 Savient Pharmaceuticals Inc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN101967467B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组羧肽酶b的生产及应用
US11918624B2 (en) * 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK124483B (da) * 1967-12-04 1972-10-23 Bayer Ag Fremgangsmåde til rensning af carboxypeptidase B.
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
HU190129B (en) * 1983-07-11 1986-08-28 Reanal Finomvegyszergyar,Hu Process for the isolation of carboxypeptidase b enzyme from mammal pancreas
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
FR2692907B1 (fr) * 1992-06-25 1995-06-30 Rhone Poulenc Rorer Sa Levures kluyveromyces modifiees, preparation et utilisation.
JP3472587B2 (ja) * 1992-08-28 2003-12-02 アベンティス ファーマ株式会社 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
JPH09505998A (ja) * 1993-11-16 1997-06-17 イーライ・リリー・アンド・カンパニー ブタ膵臓カルボキシペプチダーゼｂをコードするｄｎａ配列

Also Published As

Publication number Publication date
NZ302874A (en) 1998-11-25
IL116696A0 (en) 1996-05-14
DE69637011D1 (de) 2007-05-16
HUP9800091A3 (en) 2004-03-29
HUP9800091A2 (hu) 1998-05-28
ZA96515B (en) 1996-08-15
AU4903496A (en) 1996-08-14
PL183228B1 (pl) 2002-06-28
MX9705279A (es) 1998-06-30
HU225673B1 (en) 2007-06-28
CZ225897A3 (cs) 1998-10-14
JP4250716B2 (ja) 2009-04-08
CN1144874C (zh) 2004-04-07
AU698889B2 (en) 1998-11-12
IL116696A (en) 1999-08-17
CA2210242C (en) 2010-04-27
EP0871718B1 (en) 2007-04-04
KR100566136B1 (ko) 2006-11-10
WO1996023064A1 (en) 1996-08-01
CA2210242A1 (en) 1996-08-01
CN1177377A (zh) 1998-03-25
ES2284167T3 (es) 2007-11-01
ATE358717T1 (de) 2007-04-15
PT871718E (pt) 2007-06-26
US5948668A (en) 1999-09-07
JPH11503002A (ja) 1999-03-23
CZ292541B6 (cs) 2003-10-15
KR19980701652A (ko) 1998-06-25
PL321499A1 (en) 1997-12-08
DK0871718T3 (da) 2007-07-02
BR9606795A (pt) 1997-12-30
EP0871718A4 (en) 2000-06-07
DE69637011T2 (de) 2007-12-13
EP0871718A1 (en) 1998-10-21

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20160124